{"id":"https://openalex.org/W2014477053","doi":"https://doi.org/10.1038/1869","title":"Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites","display_name":"Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W2014477053","doi":"https://doi.org/10.1038/1869","mag":"2014477053","pmid":"https://pubmed.ncbi.nlm.nih.gov/9731778"},"language":"en","primary_location":{"id":"doi:10.1038/1869","doi":"https://doi.org/10.1038/1869","is_oa":false,"landing_page_url":"https://doi.org/10.1038/1869","pdf_url":null,"source":{"id":"https://openalex.org/S4394735520","display_name":"Nature Structural Biology","issn_l":"1072-8368","issn":["1072-8368","2331-365X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Structural Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030440789","display_name":"Stephen Curry","orcid":"https://orcid.org/0000-0002-0552-8870","observed_orcids":["https://orcid.org/0000-0002-0552-8870"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Stephen Curry","raw_affiliation_strings":["Blackett Laboratory, Imperial College, London, UK. s.curry@ic.ac.uk","Blackett Laboratory, Imperial College,London,UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blackett Laboratory, Imperial College, London, UK. s.curry@ic.ac.uk","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Blackett Laboratory, Imperial College,London,UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049706610","display_name":"Hendrik Mandelkow","orcid":"https://orcid.org/0000-0003-0274-3599","observed_orcids":["https://orcid.org/0000-0003-0274-3599"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hendrik Mandelkow","raw_affiliation_strings":["Blackett Laboratory, Imperial College, London, SW7 2BZ, Prince Consort Road, UK","Blackett Laboratory, Imperial College,London,UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blackett Laboratory, Imperial College, London, SW7 2BZ, Prince Consort Road, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Blackett Laboratory, Imperial College,London,UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085120671","display_name":"Peter Brick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter Brick","raw_affiliation_strings":["Blackett Laboratory, Imperial College, London, SW7 2BZ, Prince Consort Road, UK","Blackett Laboratory, Imperial College,London,UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blackett Laboratory, Imperial College, London, SW7 2BZ, Prince Consort Road, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Blackett Laboratory, Imperial College,London,UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052673286","display_name":"Nicholas P. Franks","orcid":"https://orcid.org/0000-0003-4874-4212","observed_orcids":["https://orcid.org/0000-0003-4874-4212"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nick Franks","raw_affiliation_strings":["Blackett Laboratory, Imperial College, London, SW7 2BZ, Prince Consort Road, UK","Blackett Laboratory, Imperial College,London,UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blackett Laboratory, Imperial College, London, SW7 2BZ, Prince Consort Road, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Blackett Laboratory, Imperial College,London,UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030440789"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":null,"apc_paid":null,"fwci":7.9449,"has_fulltext":false,"cited_by_count":1392,"citation_normalized_percentile":{"value":0.98495044,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"5","issue":"9","first_page":"827","last_page":"835"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":1.0},{"id":"https://openalex.org/keywords/fatty-acid-binding","display_name":"fatty acid binding","score":0.9129999876022339},{"id":"https://openalex.org/keywords/myristate","display_name":"myristate","score":0.9760000109672546},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.8130000233650208},{"id":"https://openalex.org/keywords/binding-site-distribution","display_name":"binding site distribution","score":0.722000002861023},{"id":"https://openalex.org/keywords/hydrophobic-pocket","display_name":"hydrophobic pocket","score":0.8159999847412109},{"id":"https://openalex.org/keywords/protein-ligand-complex","display_name":"protein-ligand complex","score":0.7310000061988831},{"id":"https://openalex.org/keywords/drug-binding","display_name":"drug binding","score":0.5130000114440918},{"id":"https://openalex.org/keywords/fatty-acid-uptake","display_name":"fatty acid uptake","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C2778597219","wikidata":"https://www.wikidata.org/wiki/Q11721976","display_name":"Human serum albumin","level":2,"score":0.828050971031189},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6637451648712158},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.6272892355918884},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5835839509963989},{"id":"https://openalex.org/C2776834966","wikidata":"https://www.wikidata.org/wiki/Q4082494","display_name":"Fatty acid-binding protein","level":3,"score":0.5429638624191284},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.5376549959182739},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.5302647352218628},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.5005764961242676},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.4985384941101074},{"id":"https://openalex.org/C165616093","wikidata":"https://www.wikidata.org/wiki/Q424232","display_name":"Serum albumin","level":2,"score":0.4883410632610321},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4814974069595337},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4676121473312378},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4276539385318756},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.41627490520477295},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.282662570476532},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10389447212219238},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019814","descriptor_name":"Myristic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019814","descriptor_name":"Myristic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/1869","doi":"https://doi.org/10.1038/1869","is_oa":false,"landing_page_url":"https://doi.org/10.1038/1869","pdf_url":null,"source":{"id":"https://openalex.org/S4394735520","display_name":"Nature Structural Biology","issn_l":"1072-8368","issn":["1072-8368","2331-365X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Structural Biology","raw_type":"journal-article"},{"id":"pmid:9731778","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9731778","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature structural biology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334759","display_name":"Deutsches Elektronen-Synchrotron","ror":"https://ror.org/01js2sh04"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1264463670","https://openalex.org/W1504792186","https://openalex.org/W1544339897","https://openalex.org/W1550692575","https://openalex.org/W1560376606","https://openalex.org/W1566111314","https://openalex.org/W1566840704","https://openalex.org/W1574451580","https://openalex.org/W1637181533","https://openalex.org/W1968167870","https://openalex.org/W1973238993","https://openalex.org/W1975914851","https://openalex.org/W1980467950","https://openalex.org/W1983289061","https://openalex.org/W1988427696","https://openalex.org/W2001114523","https://openalex.org/W2001641653","https://openalex.org/W2009746612","https://openalex.org/W2013083986","https://openalex.org/W2017215225","https://openalex.org/W2028231353","https://openalex.org/W2031338911","https://openalex.org/W2035515130","https://openalex.org/W2047867647","https://openalex.org/W2049033562","https://openalex.org/W2074774697","https://openalex.org/W2078248419","https://openalex.org/W2083524872","https://openalex.org/W2394660565","https://openalex.org/W4211146992","https://openalex.org/W4249826145"],"related_works":["https://openalex.org/W1997295916","https://openalex.org/W2041780922","https://openalex.org/W2014306643","https://openalex.org/W2067499996","https://openalex.org/W2157438880","https://openalex.org/W2126588926","https://openalex.org/W2162916870","https://openalex.org/W2016401253","https://openalex.org/W2047147332","https://openalex.org/W2055485868"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":40},{"year":2025,"cited_by_count":37},{"year":2024,"cited_by_count":57},{"year":2023,"cited_by_count":38},{"year":2022,"cited_by_count":65},{"year":2021,"cited_by_count":53},{"year":2020,"cited_by_count":66},{"year":2019,"cited_by_count":57},{"year":2018,"cited_by_count":57},{"year":2017,"cited_by_count":60},{"year":2016,"cited_by_count":60},{"year":2015,"cited_by_count":63},{"year":2014,"cited_by_count":75},{"year":2013,"cited_by_count":72},{"year":2012,"cited_by_count":53}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}