{"id":"https://openalex.org/W2014475853","doi":"https://doi.org/10.1111/j.1365-2249.2004.02599.x","title":"Imbalance between interleukin-1 agonists and antagonists: relationship to severity of inflammatory bowel disease","display_name":"Imbalance between interleukin-1 agonists and antagonists: relationship to severity of inflammatory bowel disease","publication_year":2004,"publication_date":"2004-09-27","ids":{"openalex":"https://openalex.org/W2014475853","doi":"https://doi.org/10.1111/j.1365-2249.2004.02599.x","mag":"2014475853","pmid":"https://pubmed.ncbi.nlm.nih.gov/15498044","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1809217"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2249.2004.02599.x","doi":"https://doi.org/10.1111/j.1365-2249.2004.02599.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2249.2004.02599.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1809217","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008657460","display_name":"Othmar Ludwiczek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]},{"id":"https://openalex.org/I4210162546","display_name":"University Hospital Innsbruck","ror":"https://ror.org/05wjv2104","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210162546"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"O LUDWICZEK","raw_affiliation_strings":["Department of Medicine, University Hospital Innsbruck, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University Hospital Innsbruck, Innsbruck, Austria","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I190249584","https://openalex.org/I4210162546"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070134622","display_name":"Edouard G. Vannier","orcid":"https://orcid.org/0000-0001-6654-9053","observed_orcids":["https://orcid.org/0000-0001-6654-9053"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E VANNIER","raw_affiliation_strings":["Division of Geographic Medicine and Infectious Disease, Tufts-New England Medical Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geographic Medicine and Infectious Disease, Tufts-New England Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055039609","display_name":"Ingo Borggraefe","orcid":"https://orcid.org/0000-0002-8484-5945","observed_orcids":["https://orcid.org/0000-0002-8484-5945"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I BORGGRAEFE","raw_affiliation_strings":["Division of Geographic Medicine and Infectious Disease, Tufts-New England Medical Center, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geographic Medicine and Infectious Disease, Tufts-New England Medical Center, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050963621","display_name":"Arthur Kaser","orcid":"https://orcid.org/0000-0003-1419-3344","observed_orcids":["https://orcid.org/0000-0003-1419-3344"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]},{"id":"https://openalex.org/I4210162546","display_name":"University Hospital Innsbruck","ror":"https://ror.org/05wjv2104","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210162546"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"A KASER","raw_affiliation_strings":["Department of Medicine, University Hospital Innsbruck, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University Hospital Innsbruck, Innsbruck, Austria","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I190249584","https://openalex.org/I4210162546"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031092899","display_name":"Britta Siegmund","orcid":"https://orcid.org/0000-0002-0055-958X","observed_orcids":["https://orcid.org/0000-0002-0055-958X"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B SIEGMUND","raw_affiliation_strings":["Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO","institution_ids":["https://openalex.org/I4210087413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028234430","display_name":"Charles Anthony Dinarello","orcid":"https://orcid.org/0000-0002-5073-8316","observed_orcids":["https://orcid.org/0000-0002-5073-8316"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C A DINARELLO","raw_affiliation_strings":["Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO","institution_ids":["https://openalex.org/I4210087413"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050626665","display_name":"Herbert Tilg","orcid":"https://orcid.org/0000-0002-4235-2579","observed_orcids":["https://orcid.org/0000-0002-4235-2579"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]},{"id":"https://openalex.org/I4210162546","display_name":"University Hospital Innsbruck","ror":"https://ror.org/05wjv2104","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210162546"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"H TILG","raw_affiliation_strings":["Department of Medicine, University Hospital Innsbruck, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University Hospital Innsbruck, Innsbruck, Austria","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I190249584","https://openalex.org/I4210162546"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5050626665"],"corresponding_institution_ids":["https://openalex.org/I143397708","https://openalex.org/I190249584","https://openalex.org/I4210162546"],"apc_list":{"value":2894,"currency":"GBP","value_usd":3816},"apc_paid":null,"fwci":2.6691,"has_fulltext":false,"cited_by_count":139,"citation_normalized_percentile":{"value":0.8938916,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"138","issue":"2","first_page":"323","last_page":"329"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.9710000157356262},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.8040000200271606},{"id":"https://openalex.org/keywords/il1rap","display_name":"IL1RAP","score":0.8059999942779541},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.8339999914169312},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9390000104904175},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.5600000023841858},{"id":"https://openalex.org/keywords/colonic-inflammation","display_name":"colonic inflammation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.4659999907016754},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.7229999899864197},{"id":"https://openalex.org/keywords/alpha-1-acid-glycoprotein","display_name":"alpha-1-acid glycoprotein","score":0.9549999833106995}],"concepts":[{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.7816076874732971},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5943399667739868},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5921097993850708},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.5854525566101074},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.5535269975662231},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.5443041920661926},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5353538990020752},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5343286991119385},{"id":"https://openalex.org/C149892131","wikidata":"https://www.wikidata.org/wiki/Q14914156","display_name":"Interleukin 1 receptor antagonist","level":5,"score":0.5074841380119324},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4462069571018219},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.4204868674278259},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.4191119968891144},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.41241782903671265},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3583157956600189},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.30234119296073914},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2832428216934204},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2658080756664276}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D053573","descriptor_name":"Receptors, Interleukin-1 Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053574","descriptor_name":"Receptors, Interleukin-1 Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053577","descriptor_name":"Interleukin-1 Receptor Accessory Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2249.2004.02599.x","doi":"https://doi.org/10.1111/j.1365-2249.2004.02599.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2249.2004.02599.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1809217","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1809217","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:15498044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15498044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1809217","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1809217","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7799999713897705}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W91526211","https://openalex.org/W1520223434","https://openalex.org/W1549464896","https://openalex.org/W1565787660","https://openalex.org/W1574290496","https://openalex.org/W1601001606","https://openalex.org/W1606491845","https://openalex.org/W1855512575","https://openalex.org/W1910189841","https://openalex.org/W1977926034","https://openalex.org/W1981398391","https://openalex.org/W1981568232","https://openalex.org/W1986337203","https://openalex.org/W1986608520","https://openalex.org/W1994099910","https://openalex.org/W1999701898","https://openalex.org/W2005211946","https://openalex.org/W2007210793","https://openalex.org/W2010463972","https://openalex.org/W2014257728","https://openalex.org/W2021045520","https://openalex.org/W2035445024","https://openalex.org/W2041005913","https://openalex.org/W2045267433","https://openalex.org/W2048362161","https://openalex.org/W2053067638","https://openalex.org/W2053212420","https://openalex.org/W2057264565","https://openalex.org/W2063672588","https://openalex.org/W2066268250","https://openalex.org/W2067295738","https://openalex.org/W2078136106","https://openalex.org/W2079092923","https://openalex.org/W2090376792","https://openalex.org/W2093566767","https://openalex.org/W2098015378","https://openalex.org/W2116802019","https://openalex.org/W2118152367","https://openalex.org/W2134566020","https://openalex.org/W2135483305","https://openalex.org/W2160875559","https://openalex.org/W2166930089","https://openalex.org/W2206659032","https://openalex.org/W2267316137","https://openalex.org/W2332739634","https://openalex.org/W2404854108","https://openalex.org/W4233017111","https://openalex.org/W6693350584"],"related_works":["https://openalex.org/W1996697769","https://openalex.org/W2033695756","https://openalex.org/W2065498716","https://openalex.org/W2171322382","https://openalex.org/W1977926034","https://openalex.org/W1802868417","https://openalex.org/W2039912593","https://openalex.org/W1984189215","https://openalex.org/W2135483305","https://openalex.org/W1965989642"],"abstract_inverted_index":{"Interleukin":[0],"(IL)-1":[1],"is":[2,233],"a":[3,234],"key":[4],"mediator":[5],"in":[6,46,92,96,110,121,162,181,187,200,207,241,256,260],"the":[7,229,248],"pathogenesis":[8],"of":[9,40,237,247],"inflammatory":[10],"bowel":[11],"disease":[12,61,135],"(IBD).":[13],"Naturally":[14],"occurring":[15],"IL-1":[16,19,23,31,41],"modulators":[17],"include":[18],"receptor":[20,25,32],"antagonist":[21,250],"(IL-1Ra),":[22],"soluble":[24,42],"Type":[26],"I":[27],"(IL-1sRI),":[28],"IL-1sRII":[29,105,196,251],"and":[30,37,67,73,85,100,113,146,157,165,168,172,177,191,211,221,239,243],"accessory":[33],"protein":[34,142],"(AcP).":[35],"Systemic":[36],"mucosal":[38],"levels":[39,89,106,118,127,159,197,215],"receptors":[43],"remain":[44],"unknown":[45],"IBD.":[47],"Plasma":[48,72,87,125],"or":[49,63],"colonic":[50,74,153,254],"tissues":[51],"were":[52,78,90,102,107,119,160,198],"obtained":[53],"from":[54,68],"185":[55],"consecutive":[56],"unselected":[57],"patients":[58],"with":[59,133],"Crohn's":[60,134],"(CD)":[62],"ulcerative":[64],"colitis":[65],"(UC)":[66],"52":[69],"control":[70,222],"subjects.":[71,98],"explant":[75,154],"culture":[76],"supernatants":[77],"assessed":[79],"for":[80],"IL-1alpha,":[81],"IL-1beta,":[82],"IL-1Ra,":[83],"IL-1sRI":[84,117,126,214,232],"IL-1sRII.":[86],"IL-1Ra":[88,158],"higher":[91],"UC":[93,114,175,189],"(+93%)":[94],"than":[95],"healthy":[97],"IL-1alpha":[99,156],"IL-1beta":[101,184],"not":[103,180,217,259],"detected.":[104],"marginally":[108],"lower":[109],"CD":[111,122,170,192,202,242],"(-10%)":[112],"(-9%),":[115],"whereas":[116],"elevated":[120,161,186,199],"(+28%)":[123],"only.":[124],"correlated":[128],"positively":[129],"(P":[130],"<":[131],"0.01)":[132],"activity":[136,240],"index":[137],"(r":[138,143,149],"=":[139,144,150],"0.53),":[140],"C-reactive":[141],"0.46)":[145],"alpha1-acid":[147],"glycoprotein":[148],"0.42).":[151],"In":[152,194],"cultures,":[155],"non-lesional":[163,182,201,210],"(+233%":[164],"+185%":[166],"respectively)":[167],"lesional":[169,174,188,208,212],"(+353%":[171],"+1069%),":[173],"(+604%":[176],"+1138%),":[178],"but":[179,204,258],"UC.":[183,213,261],"was":[185],"(+152%)":[190],"(+128%).":[193],"contrast,":[195],"(+65%),":[203],"remained":[205],"unchanged":[206],"CD,":[209,257],"did":[216],"differ":[218],"between":[219],"patient":[220],"groups.":[223],"These":[224],"results":[225],"indicate":[226],"that":[227],"(i)":[228],"proinflammatory":[230],"moiety":[231],"systemic":[235],"marker":[236],"inflammation":[238,255],"(ii)":[244],"local":[245],"shedding":[246],"functional":[249],"may":[252],"dampen":[253]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
