{"id":"https://openalex.org/W201445770","doi":null,"title":"ANGIOTENSIN II SIGNALING TO PHOSPHOLIPASE D IN A MODEL OF GENETIC HYPERTENSION","display_name":"ANGIOTENSIN II SIGNALING TO PHOSPHOLIPASE D IN A MODEL OF GENETIC HYPERTENSION","publication_year":2002,"publication_date":"2002-09-26","ids":{"openalex":"https://openalex.org/W201445770","mag":"201445770"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:7990","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/7990/1/Thesis.pdf","pdf_url":"https://d-scholarship.pitt.edu/7990/1/Thesis.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009668864","display_name":"Bradley T. Andresen","orcid":"https://orcid.org/0000-0002-3948-7456","observed_orcids":["https://orcid.org/0000-0002-3948-7456"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bradley T. Andresen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3948-7456","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5009668864"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii-signaling","display_name":"angiotensin II signaling","score":0.9129999876022339},{"id":"https://openalex.org/keywords/phospholipase-d","display_name":"phospholipase D","score":1.0},{"id":"https://openalex.org/keywords/hereditary-hypertension","display_name":"genetic hypertension","score":0.734000027179718},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.9950000047683716},{"id":"https://openalex.org/keywords/angiotensin-ii-type-2-receptor","display_name":"angiotensin II type 2 receptor","score":0.7990000247955322},{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.9089999794960022},{"id":"https://openalex.org/keywords/rhoa","display_name":"RhoA","score":0.9559999704360962},{"id":"https://openalex.org/keywords/rhogdi","display_name":"RhoGDI","score":0.8809999823570251},{"id":"https://openalex.org/keywords/nitric-oxide-cgmp-signaling","display_name":"nitric oxide/cGMP signaling","score":0.8679999709129333},{"id":"https://openalex.org/keywords/phosphatidic-acid","display_name":"phosphatidic acid","score":0.8849999904632568},{"id":"https://openalex.org/keywords/renal-vasculature","display_name":"renal vasculature","score":0.7609999775886536},{"id":"https://openalex.org/keywords/smooth-muscle-contraction","display_name":"smooth muscle contraction","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.7781116962432861},{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.7551367282867432},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7211222648620605},{"id":"https://openalex.org/C6182249","wikidata":"https://www.wikidata.org/wiki/Q700007","display_name":"Phospholipase D","level":3,"score":0.6949121952056885},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.687551736831665},{"id":"https://openalex.org/C2776909261","wikidata":"https://www.wikidata.org/wiki/Q66000256","display_name":"Phosphatidic acid","level":4,"score":0.6791508197784424},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5537989139556885},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5190839767456055},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5170567631721497},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.4659940004348755},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.41891977190971375},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.39389196038246155},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32688599824905396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2920494079589844},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26021429896354675},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18037018179893494},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.11193975806236267},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0692664384841919},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:7990","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/7990/1/Thesis.pdf","pdf_url":"https://d-scholarship.pitt.edu/7990/1/Thesis.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:201445770","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/7990/1/Thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":233,"referenced_works":["https://openalex.org/W1813918","https://openalex.org/W114522406","https://openalex.org/W164612407","https://openalex.org/W912507531","https://openalex.org/W1481438484","https://openalex.org/W1489297798","https://openalex.org/W1493531388","https://openalex.org/W1507341638","https://openalex.org/W1512964013","https://openalex.org/W1528720934","https://openalex.org/W1537459781","https://openalex.org/W1546336086","https://openalex.org/W1561131854","https://openalex.org/W1569291911","https://openalex.org/W1577261854","https://openalex.org/W1586099293","https://openalex.org/W1589391295","https://openalex.org/W1589866689","https://openalex.org/W1597787921","https://openalex.org/W1601455272","https://openalex.org/W1633066991","https://openalex.org/W1665534178","https://openalex.org/W1773214071","https://openalex.org/W1789636131","https://openalex.org/W1818334985","https://openalex.org/W1822066871","https://openalex.org/W1837479159","https://openalex.org/W1896224567","https://openalex.org/W1915650964","https://openalex.org/W1925229827","https://openalex.org/W1926745530","https://openalex.org/W1957331891","https://openalex.org/W1963817582","https://openalex.org/W1967044710","https://openalex.org/W1967345870","https://openalex.org/W1967622958","https://openalex.org/W1967625995","https://openalex.org/W1967979328","https://openalex.org/W1970245357","https://openalex.org/W1970677658","https://openalex.org/W1971646616","https://openalex.org/W1972750612","https://openalex.org/W1973624256","https://openalex.org/W1973770590","https://openalex.org/W1974030744","https://openalex.org/W1974081806","https://openalex.org/W1975199357","https://openalex.org/W1976555160","https://openalex.org/W1976695667","https://openalex.org/W1977071631","https://openalex.org/W1977951315","https://openalex.org/W1978279440","https://openalex.org/W1979073238","https://openalex.org/W1979945257","https://openalex.org/W1980182090","https://openalex.org/W1983561419","https://openalex.org/W1983616507","https://openalex.org/W1984905038","https://openalex.org/W1984906223","https://openalex.org/W1986292558","https://openalex.org/W1987909966","https://openalex.org/W1988018358","https://openalex.org/W1988642373","https://openalex.org/W1990249744","https://openalex.org/W1992628345","https://openalex.org/W1994863832","https://openalex.org/W1997449279","https://openalex.org/W1999157780","https://openalex.org/W2000816990","https://openalex.org/W2002019101","https://openalex.org/W2002111899","https://openalex.org/W2004873860","https://openalex.org/W2007375100","https://openalex.org/W2008346251","https://openalex.org/W2008924522","https://openalex.org/W2012564759","https://openalex.org/W2013690237","https://openalex.org/W2015057079","https://openalex.org/W2017304954","https://openalex.org/W2017800047","https://openalex.org/W2018149384","https://openalex.org/W2020815929","https://openalex.org/W2021327355","https://openalex.org/W2021810915","https://openalex.org/W2023578877","https://openalex.org/W2024878957","https://openalex.org/W2026039614","https://openalex.org/W2027455512","https://openalex.org/W2029954557","https://openalex.org/W2032266156","https://openalex.org/W2032295238","https://openalex.org/W2035493043","https://openalex.org/W2036176695","https://openalex.org/W2038838027","https://openalex.org/W2039086575","https://openalex.org/W2039983290","https://openalex.org/W2041075406","https://openalex.org/W2041797033","https://openalex.org/W2044155353","https://openalex.org/W2046770930","https://openalex.org/W2048741586","https://openalex.org/W2048814899","https://openalex.org/W2048863292","https://openalex.org/W2050202210","https://openalex.org/W2050378706","https://openalex.org/W2050621406","https://openalex.org/W2053072327","https://openalex.org/W2054067779","https://openalex.org/W2054779757","https://openalex.org/W2055109959","https://openalex.org/W2055675854","https://openalex.org/W2055932468","https://openalex.org/W2058278329","https://openalex.org/W2058285897","https://openalex.org/W2058931058","https://openalex.org/W2059039694","https://openalex.org/W2060611693","https://openalex.org/W2060720909","https://openalex.org/W2061234826","https://openalex.org/W2061637057","https://openalex.org/W2062227118","https://openalex.org/W2064129448","https://openalex.org/W2064850685","https://openalex.org/W2067157370","https://openalex.org/W2067577192","https://openalex.org/W2067921577","https://openalex.org/W2068570002","https://openalex.org/W2069359028","https://openalex.org/W2071422331","https://openalex.org/W2071950393","https://openalex.org/W2074623822","https://openalex.org/W2074628308","https://openalex.org/W2075517913","https://openalex.org/W2076257088","https://openalex.org/W2076718022","https://openalex.org/W2077538389","https://openalex.org/W2080697422","https://openalex.org/W2082649057","https://openalex.org/W2084570265","https://openalex.org/W2085391208","https://openalex.org/W2086389958","https://openalex.org/W2086887431","https://openalex.org/W2087079345","https://openalex.org/W2087081676","https://openalex.org/W2089742414","https://openalex.org/W2089929323","https://openalex.org/W2090336026","https://openalex.org/W2092171289","https://openalex.org/W2093254238","https://openalex.org/W2093987846","https://openalex.org/W2095368090","https://openalex.org/W2099192887","https://openalex.org/W2101745219","https://openalex.org/W2102052376","https://openalex.org/W2102604313","https://openalex.org/W2104302589","https://openalex.org/W2104608392","https://openalex.org/W2105300577","https://openalex.org/W2107457780","https://openalex.org/W2109283410","https://openalex.org/W2110182057","https://openalex.org/W2110802793","https://openalex.org/W2110827050","https://openalex.org/W2112860187","https://openalex.org/W2112919363","https://openalex.org/W2114497687","https://openalex.org/W2114630275","https://openalex.org/W2118689626","https://openalex.org/W2119008675","https://openalex.org/W2119534102","https://openalex.org/W2121452261","https://openalex.org/W2121486402","https://openalex.org/W2121671210","https://openalex.org/W2122054605","https://openalex.org/W2123799914","https://openalex.org/W2124284996","https://openalex.org/W2124655410","https://openalex.org/W2126578889","https://openalex.org/W2127230663","https://openalex.org/W2128250758","https://openalex.org/W2128716954","https://openalex.org/W2132518765","https://openalex.org/W2137000100","https://openalex.org/W2137377367","https://openalex.org/W2137630689","https://openalex.org/W2138172708","https://openalex.org/W2138443098","https://openalex.org/W2139273898","https://openalex.org/W2140812062","https://openalex.org/W2142889758","https://openalex.org/W2143293940","https://openalex.org/W2144130192","https://openalex.org/W2145120474","https://openalex.org/W2145121923","https://openalex.org/W2145242708","https://openalex.org/W2145402242","https://openalex.org/W2145898095","https://openalex.org/W2149194612","https://openalex.org/W2150388314","https://openalex.org/W2151312020","https://openalex.org/W2153889396","https://openalex.org/W2153899018","https://openalex.org/W2155866739","https://openalex.org/W2157598056","https://openalex.org/W2159335638","https://openalex.org/W2159829358","https://openalex.org/W2160401113","https://openalex.org/W2162049443","https://openalex.org/W2163133008","https://openalex.org/W2163352150","https://openalex.org/W2164139183","https://openalex.org/W2168909179","https://openalex.org/W2169235788","https://openalex.org/W2170794217","https://openalex.org/W2171428673","https://openalex.org/W2201929838","https://openalex.org/W2220602578","https://openalex.org/W2236009233","https://openalex.org/W2236373896","https://openalex.org/W2255551144","https://openalex.org/W2261611449","https://openalex.org/W2294861213","https://openalex.org/W2338134631","https://openalex.org/W2398132406","https://openalex.org/W2403195379","https://openalex.org/W2409109693","https://openalex.org/W2409242657","https://openalex.org/W2411407835","https://openalex.org/W2413996212","https://openalex.org/W2420778433","https://openalex.org/W2436775512","https://openalex.org/W2474103501","https://openalex.org/W3104531246"],"related_works":["https://openalex.org/W2021327355","https://openalex.org/W2736476878","https://openalex.org/W1988642373","https://openalex.org/W1968911384","https://openalex.org/W2157509955","https://openalex.org/W2000367135","https://openalex.org/W2108520084","https://openalex.org/W2119008675","https://openalex.org/W2116311332","https://openalex.org/W2035493043"],"abstract_inverted_index":{"In":[0],"spontaneously":[1],"hypertensive":[2],"rats":[3,19],"(SHR)":[4],"the":[5,8,24,28,38,94,142,174,181,217,273,276,297],"hypersensitivity":[6,274],"of":[7,32,45,58,65,99,125,164,173,186,202,224,231,240,275],"renal":[9],"vasculature":[10],"to":[11,17,22,103,129,184,267,278,284],"angiotensin":[12],"II":[13,144,200,206,280,289],"(Ang":[14],"II),":[15],"compared":[16,82],"Wistar-Kyoto":[18],"(WKY),":[20],"appears":[21],"be":[23,282],"determining":[25],"factor":[26],"in":[27,49,63,76,93,111,114,139,157,169,190,211,287],"development":[29],"and":[30,41,53,67,116,152,159,192,194,250,261,270],"progression":[31],"hypertension.":[33],"Recent":[34],"evidence":[35],"indicates":[36,179,215],"that":[37,180,216],"ERK":[39,66,175],"cascade":[40],"NAD(P)H":[42],"oxidase":[43],"generation":[44,57,163],"superoxide":[46],"are":[47,155,188,264],"involved":[48,62,110,168],"smooth":[50,78,119],"muscle":[51,79,120],"contraction,":[52],"Phospholipase":[54],"D":[55],"(PLD)":[56],"phosphatidic":[59,165],"acid":[60,166],"is":[61,74,137,167,196],"activation":[64,172,185,201,223],"NAD(P)H.":[68],"Importantly,":[69],"Ang":[70,105,133,143,170,199,205,279,288],"II-mediated":[71,106,134],"PLD":[72,112,135,150,187,195,210,225],"activity":[73,136],"greater":[75,138],"aortic":[77],"from":[80],"SHR":[81,117,193,251,254,263,277],"with":[83],"WKY;":[84],"however,":[85,204],"this":[86,126],"signaling":[87,145,295],"pathway":[88],"has":[89],"not":[90],"been":[91],"examined":[92],"kidney":[95,298],"vasculature.":[96,299],"The":[97,123,177],"purpose":[98],"these":[100],"studies":[101],"were":[102,128],"define":[104],"signal":[107],"transduction":[108],"mechanism(s)":[109],"regulation":[113],"WKY":[115,191,249],"preglomerular":[118],"cells":[121],"(PGSMCs).":[122],"goals":[124],"study":[127],"determine:":[130],"1)":[131,253],"whether":[132,153,161],"SHR;":[140,158],"2)":[141,262],"pathway(s)":[146],"responsible":[147],"for":[148,198],"regulating":[149],"activity,":[151],"they":[154],"altered":[156],"3)":[160],"PLD-mediated":[162],"II-induced":[171],"cascade.":[176],"data":[178],"mechanisms":[182],"leading":[183],"similar":[189],"required":[197],"ERK;":[203],"more":[207],"potently":[208],"activates":[209],"SHR.":[212],"Further":[213],"analysis":[214],"AT2":[218,293],"receptor":[219,259],"inhibits":[220],"AT1":[221],"receptor/RhoA-dependent":[222],"through":[226],"a":[227],"nitric":[228,268],"oxide/cGMP-dependent":[229],"phosphorylation":[230],"RhoA":[232],"at":[233],"serine":[234],"188,":[235],"which":[236],"promotes":[237],"RhoGDI":[238],"inhibition":[239],"RhoA.":[241],"These":[242],"experiments":[243],"expose":[244],"two":[245],"key":[246],"differences":[247],"between":[248],"PGSMCs:":[252],"have":[255],"an":[256,285],"increased":[257],"AT1/AT2":[258],"ratio;":[260],"less":[265],"sensitive":[266],"oxide":[269],"cGMP.":[271],"Therefore,":[272],"may":[281],"due":[283],"imbalance":[286],"receptors":[290],"and/or":[291],"impaired":[292],"receptor-mediated":[294],"within":[296]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
