{"id":"https://openalex.org/W2014455968","doi":"https://doi.org/10.1117/12.711217","title":"In situ photoimmunotherapy for melanoma: an ongoing phase I clinical trial","display_name":"In situ photoimmunotherapy for melanoma: an ongoing phase I clinical trial","publication_year":2007,"publication_date":"2007-02-08","ids":{"openalex":"https://openalex.org/W2014455968","doi":"https://doi.org/10.1117/12.711217","mag":"2014455968"},"language":"fi","primary_location":{"id":"doi:10.1117/12.711217","doi":"https://doi.org/10.1117/12.711217","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.711217","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024471347","display_name":"Mark F. Naylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark F. Naylor","raw_affiliation_strings":["Univ. of Oklahoma College of Medicine (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Oklahoma College of Medicine (United States)","institution_ids":["https://openalex.org/I8692664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112541359","display_name":"Robert E. Nordquist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119755","display_name":"Advanced Cancer Therapeutics","ror":"https://ror.org/02mx1bf53","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210119755"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert E. Nordquist","raw_affiliation_strings":["Advanced Cancer Therapies L.L.C. (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Cancer Therapies L.L.C. (United States)","institution_ids":["https://openalex.org/I4210119755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013531724","display_name":"T. Kent Teague","orcid":"https://orcid.org/0000-0002-4680-5440","observed_orcids":["https://orcid.org/0000-0002-4680-5440"]},"institutions":[{"id":"https://openalex.org/I115475287","display_name":"Oklahoma State University","ror":"https://ror.org/01g9vbr38","country_code":"US","type":"education","lineage":["https://openalex.org/I115475287"]},{"id":"https://openalex.org/I74022624","display_name":"Oklahoma State University Center for Health Sciences","ror":"https://ror.org/02mfxdp77","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I74022624"]},{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Kent Teague","raw_affiliation_strings":["Oklahoma State Univ. Ctr. for Health Sciences (United States)","Univ. of Oklahoma College of Medicine (United States)","Univ. of Oklahoma College of Pharmacy (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma State Univ. Ctr. for Health Sciences (United States)","institution_ids":["https://openalex.org/I115475287","https://openalex.org/I74022624"]},{"raw_affiliation_string":"Univ. of Oklahoma College of Medicine (United States)","institution_ids":["https://openalex.org/I8692664"]},{"raw_affiliation_string":"Univ. of Oklahoma College of Pharmacy (United States)","institution_ids":["https://openalex.org/I8692664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110022494","display_name":"Lisa A. Perry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa A. Perry","raw_affiliation_strings":["Univ. of Oklahoma College of Medicine (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Oklahoma College of Medicine (United States)","institution_ids":["https://openalex.org/I8692664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001447073","display_name":"Wei R. Chen","orcid":"https://orcid.org/0000-0002-7133-5794","observed_orcids":["https://orcid.org/0000-0002-7133-5794"]},"institutions":[{"id":"https://openalex.org/I139325414","display_name":"University of Central Oklahoma","ror":"https://ror.org/02n455404","country_code":"US","type":"education","lineage":["https://openalex.org/I139325414"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei R. Chen","raw_affiliation_strings":["Univ. of Central Oklahoma (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Central Oklahoma (United States)","institution_ids":["https://openalex.org/I139325414"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.0237,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.95181908,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"6438","issue":null,"first_page":"643807","last_page":"643807"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.7294999957084656,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.7294999957084656,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.07970000058412552,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.07769999653100967,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.7400000095367432},{"id":"https://openalex.org/keywords/immune-response-modifiers","display_name":"immune response modifiers","score":0.6309999823570251},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.7509999871253967},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7979986667633057},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.728062093257904},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6452362537384033},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.615451991558075},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5962531566619873},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5405683517456055},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44857630133628845},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.43661993741989136},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3688427209854126},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.32819122076034546},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.14400500059127808},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.711217","doi":"https://doi.org/10.1117/12.711217","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.711217","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2025250037","https://openalex.org/W1983174440","https://openalex.org/W2091455435","https://openalex.org/W2134156413","https://openalex.org/W1967415936","https://openalex.org/W2016122956","https://openalex.org/W2091296153","https://openalex.org/W2017300370","https://openalex.org/W4394853691","https://openalex.org/W1987678380"],"abstract_inverted_index":{"In":[0,80],"situ":[1],"Photoimmunotherapy":[2],"(ISPI)":[3],"was":[4],"developed":[5,110],"to":[6,33,176,199],"treat":[7],"metastatic":[8],"tumors":[9,27,53],"using":[10],"a":[11,87,147,211],"combination":[12,39],"of":[13,24,133,161,180,205,214],"phototherapy":[14],"and":[15,28,54,73,126,144,172,183,208],"immunotherapy.":[16],"It":[17],"utilizes":[18],"local":[19],"intervention":[20],"through":[21,29],"photothermal":[22],"destruction":[23],"existing":[25],"solid":[26],"immune":[30],"response":[31],"modifier":[32],"elicit":[34],"host":[35],"anti-tumor":[36],"responses.":[37],"Such":[38],"in":[40,46,65,86,202],"pre-clinical":[41],"studies":[42,69],"has":[43,62,76],"shown":[44],"promise":[45],"cancer":[47,164],"treatment":[48,113,174],"by":[49,168],"eradicating":[50],"the":[51,74,118,134,162,169,178,181,197],"primary":[52],"also":[55,157],"controlling":[56],"metastases":[57],"at":[58],"distant":[59],"sites.":[60],"ISPI":[61,193],"been":[63,77],"used":[64],"our":[66,102],"preliminary":[67],"clinical":[68],"for":[70,93,114],"melanoma":[71],"patients":[72,85,121,137],"outcome":[75],"extremely":[78],"encouraging.":[79],"2006,":[81],"we":[82,108],"began":[83],"enrolling":[84],"new":[88],"phase":[89],"I":[90],"immunotherapy":[91],"trial":[92,98],"advanced":[94,115,206],"cutaneous":[95],"melanoma.":[96,116],"This":[97],"is":[99],"based":[100],"on":[101],"previous":[103],"results":[104,190],"which":[105],"indicated":[106],"that":[107,159,173,192],"had":[109],"an":[111],"effective":[112],"Of":[117],"first":[119],"six":[120],"treated,":[122],"(4":[123],"stage":[124,130,135],"IV,":[125],"2":[127,132,152],"surgically":[128],"unresectable":[129],"III),":[131],"IV":[136],"are":[138],"still":[139],"alive,":[140],"one":[141,145],"tumor":[142],"free,":[143],"with":[146],"possible":[148],"treatable":[149],"recurrence":[150],"after":[151],"1/2":[153],"years.":[154],"We":[155],"have":[156,196],"discovered":[158],"recurrences":[160],"skin":[163],"can":[165],"be":[166],"retreated":[167],"same":[170],"technique":[171],"seems":[175],"blunt":[177],"virulence":[179],"disease":[182],"make":[184],"it":[185],"more":[186],"treatable.":[187],"These":[188],"initial":[189],"indicate":[191],"probably":[194],"will":[195],"ability":[198],"prolong":[200],"survival":[201],"selected":[203],"cases":[204],"melanoma,":[207],"potentially":[209],"cure":[210],"significant":[212],"percentage":[213],"treated":[215],"patients.":[216]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}