{"id":"https://openalex.org/W2014433705","doi":"https://doi.org/10.1172/jci104679","title":"PLATELET PHOSPHATIDES. THEIR FATTY ACID AND ALDEHYDE COMPOSITION AND ACTIVITY IN DIFFERENT CLOTTING SYSTEMS*","display_name":"PLATELET PHOSPHATIDES. THEIR FATTY ACID AND ALDEHYDE COMPOSITION AND ACTIVITY IN DIFFERENT CLOTTING SYSTEMS*","publication_year":1962,"publication_date":"1962-12-01","ids":{"openalex":"https://openalex.org/W2014433705","doi":"https://doi.org/10.1172/jci104679","mag":"2014433705","pmid":"https://pubmed.ncbi.nlm.nih.gov/13932911","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/291155"},"language":"en","primary_location":{"id":"doi:10.1172/jci104679","doi":"https://doi.org/10.1172/jci104679","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci104679","pdf_url":"http://www.jci.org/articles/view/104679/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/104679/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110038371","display_name":"Aaron J. Marcus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron J. Marcus","raw_affiliation_strings":["(From the Hematology Section, N. Y. Veterans Administration Hospital, and the Department of Medicine, Cornell University Medical College, New York, N. Y"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(From the Hematology Section, N. Y. Veterans Administration Hospital, and the Department of Medicine, Cornell University Medical College, New York, N. Y","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110186334","display_name":"HARRIS L. ULLMAN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harris L. Ullman","raw_affiliation_strings":["(From the Hematology Section, N. Y. Veterans Administration Hospital, and the Department of Medicine, Cornell University Medical College, New York, N. Y"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(From the Hematology Section, N. Y. Veterans Administration Hospital, and the Department of Medicine, Cornell University Medical College, New York, N. Y","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110037554","display_name":"Lenore B. Safier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lenore B. Safier","raw_affiliation_strings":["(From the Hematology Section, N. Y. Veterans Administration Hospital, and the Department of Medicine, Cornell University Medical College, New York, N. Y"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(From the Hematology Section, N. Y. Veterans Administration Hospital, and the Department of Medicine, Cornell University Medical College, New York, N. Y","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082092302","display_name":"Harold S. Ballard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harold S. Ballard","raw_affiliation_strings":["(From the Hematology Section, N. Y. Veterans Administration Hospital, and the Department of Medicine, Cornell University Medical College, New York, N. Y"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(From the Hematology Section, N. Y. Veterans Administration Hospital, and the Department of Medicine, Cornell University Medical College, New York, N. Y","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":11.3839,"has_fulltext":true,"cited_by_count":104,"citation_normalized_percentile":{"value":0.98886414,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"41","issue":"12","first_page":"2198","last_page":"2212"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.7070000171661377,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.7070000171661377,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.218299999833107,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-phospholipids","display_name":"platelet phospholipids","score":0.9639999866485596},{"id":"https://openalex.org/keywords/phosphatidylserine","display_name":"phosphatidylserine","score":0.9649999737739563},{"id":"https://openalex.org/keywords/phosphatidylethanolamine","display_name":"phosphatidylethanolamine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/fatty-acid-composition","display_name":"fatty acid composition","score":0.8730000257492065},{"id":"https://openalex.org/keywords/fatty-aldehydes","display_name":"fatty aldehydes","score":0.7480000257492065},{"id":"https://openalex.org/keywords/plasmalogens","display_name":"plasmalogens","score":0.9070000052452087},{"id":"https://openalex.org/keywords/thromboplastin-generation","display_name":"thromboplastin generation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/prothrombin-consumption","display_name":"prothrombin consumption","score":0.9810000061988831},{"id":"https://openalex.org/keywords/platelet-poor-plasma","display_name":"platelet-poor plasma","score":0.6859999895095825},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.6399999856948853},{"id":"https://openalex.org/keywords/phospholipid-separation","display_name":"phospholipid separation","score":0.5960000157356262},{"id":"https://openalex.org/keywords/oxidative-degradation","display_name":"oxidative degradation","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6760315895080566},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5786437392234802},{"id":"https://openalex.org/C40231798","wikidata":"https://www.wikidata.org/wiki/Q1333743","display_name":"Composition (language)","level":2,"score":0.5758780241012573},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5413799285888672},{"id":"https://openalex.org/C2992139802","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Clotting factor","level":2,"score":0.4751053750514984},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.4663507044315338},{"id":"https://openalex.org/C2779825165","wikidata":"https://www.wikidata.org/wiki/Q101497","display_name":"Aldehyde","level":3,"score":0.429842084646225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2707480788230896},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15715771913528442},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1437186300754547},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09623414278030396},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci104679","doi":"https://doi.org/10.1172/jci104679","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci104679","pdf_url":"http://www.jci.org/articles/view/104679/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:291155","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/291155","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:13932911","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13932911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci104679","doi":"https://doi.org/10.1172/jci104679","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci104679","pdf_url":"http://www.jci.org/articles/view/104679/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014433705.pdf","grobid_xml":"https://content.openalex.org/works/W2014433705.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W147084894","https://openalex.org/W191947686","https://openalex.org/W196418352","https://openalex.org/W284966350","https://openalex.org/W1499554004","https://openalex.org/W1510366899","https://openalex.org/W1513897103","https://openalex.org/W1536351310","https://openalex.org/W1551282646","https://openalex.org/W1915795894","https://openalex.org/W1970321918","https://openalex.org/W1975635881","https://openalex.org/W2009473879","https://openalex.org/W2025480042","https://openalex.org/W2032219820","https://openalex.org/W2036562343","https://openalex.org/W2051842381","https://openalex.org/W2068421001","https://openalex.org/W2078801380","https://openalex.org/W2085795708","https://openalex.org/W2159981422","https://openalex.org/W2225443389","https://openalex.org/W2321768482","https://openalex.org/W2330282308","https://openalex.org/W2332004378","https://openalex.org/W2338460968","https://openalex.org/W2341588881","https://openalex.org/W2343695155","https://openalex.org/W2344117163","https://openalex.org/W2408779462","https://openalex.org/W2414614877","https://openalex.org/W2418896230","https://openalex.org/W2805483551","https://openalex.org/W2992341642","https://openalex.org/W4232563616","https://openalex.org/W6751306947"],"related_works":["https://openalex.org/W2343695155","https://openalex.org/W7098965789","https://openalex.org/W3011864385","https://openalex.org/W191947686","https://openalex.org/W2098026003","https://openalex.org/W2062306466","https://openalex.org/W2018624854","https://openalex.org/W4292438129","https://openalex.org/W125599838","https://openalex.org/W2068887026"],"abstract_inverted_index":{"Previous":[0],"studies":[1,92],"from":[2,11,76,239],"this":[3],"laboratory":[4],"revealed":[5],"that":[6,47,183,200,226],"phosphatidyl":[7,48],"serine":[8],"(PS)":[9],"isolated":[10],"plate-":[12],"let":[13],"phospholipid":[14],"extracts":[15,193],"by":[16,78,236],"silicic-acid":[17],"column":[18,83],"chromatography":[19],"could":[20,104,207],"replace":[21],"blood":[22],"platelets":[23],"in":[24,195,245],"tests":[25],"of":[26,32,40,54,74,80,98,117,121,135,155,164,189,229],"thromboplastin":[27],"generation":[28],"and":[29,65,88,110,131,142,162,179],"prothrombin":[30],"consumption":[31],"platelet-poor":[33],"\"native\"":[34],"plasma":[35],"(1,":[36],"2).When":[37],"rigorous":[38],"criteria":[39],"identification":[41],"were":[42,59,93,133,147,194],"employed,":[43],"it":[44,222],"was":[45,128,168,215,223,231],"found":[46],"ethanolamine":[49],"(PE)":[50],"fractions":[51],"contained":[52],"traces":[53],"PS":[55,77,132],"(2);":[56],"coagulant":[57],"properties":[58],"therefore":[60],"difficult":[61],"to":[62,107,159,166],"evaluate.Rouser,":[63],"O'Brien,":[64],"Heller":[66],"(3)":[67],"recently":[68],"accomplished":[69],"the":[70,102,118,144,153,175,196,213,227,240,248],"complete":[71],"separa-":[72],"tion":[73],"PE":[75],"means":[79],"a":[81,139,171,237],"double":[82],"technique":[84],"using":[85],"silicic":[86,90],"acid":[87],"ammoniated":[89],"acid.Their":[91],"carried":[94],"out":[95],"on":[96,205],"lipids":[97],"beef":[99],"brain,":[100],"but":[101],"methods":[103],"be":[105,210],"applied":[106],"human":[108],"brain":[109],"platelet":[111,122,191],"extracts.In":[112],"1961,":[113],"an":[114],"earlier":[115],"study":[116],"fatty":[119,203],"acids":[120],"phosphatides":[123,146],"with":[124],"gas-liquid":[125],"chromatog-":[126],"raphy":[127],"reported":[129,182],"(4).PE":[130],"then,":[134],"necessity,":[136],"studied":[137],"as":[138],"combined":[140],"fraction,":[141],"similarly":[143],"choline":[145],"not":[148,169],"ade-":[149],"quately":[150],"separated.In":[151],"addition,":[152],"significance":[154],"oxidative":[156],"changes":[157],"consequent":[158],"prolonged":[160],"separations":[161],"exposure":[163],"phospholipids":[165],"air":[167],"appreciated,":[170],"factor":[172],"which":[173],"influenced":[174],"over-all":[176],"results.Zilversmit,":[177],"Marcus,":[178],"Ullman":[180],"(5)":[181],"16":[184],"per":[185],"cent":[186],"(dry":[187],"weight)":[188],"total":[190],"lipid":[192],"plasmalogen":[197,214,230],"form":[198],"(phospholipids":[199],"liberate":[201],"higher":[202],"aldehydes":[204],"hydrolysis).It":[206],"not,":[208],"however,":[209],"determined":[211],"how":[212],"distributed":[216],"among":[217],"indi-":[218],"vidual":[219],"phosphoglycerides,":[220],"although":[221],"known":[224],"(2)":[225],"b)ulk":[228],"associated":[232],"*":[233],"Investigation":[234],"supported":[235],"grant":[238],"New":[241],"York":[242],"Heart":[243],"Association.Presented":[244],"part":[246],"at":[247],"meet-":[249]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
