{"id":"https://openalex.org/W2014432472","doi":"https://doi.org/10.1271/bbb.80841","title":"The Roles of HSP27 and Annexin II in Resistance to UVC-Induced Cell Death: Comparative Studies of the Human UVC-Sensitive and -Resistant Cell Lines RSa and APr-1","display_name":"The Roles of HSP27 and Annexin II in Resistance to UVC-Induced Cell Death: Comparative Studies of the Human UVC-Sensitive and -Resistant Cell Lines RSa and APr-1","publication_year":2009,"publication_date":"2009-06-23","ids":{"openalex":"https://openalex.org/W2014432472","doi":"https://doi.org/10.1271/bbb.80841","mag":"2014432472","pmid":"https://pubmed.ncbi.nlm.nih.gov/19502736"},"language":"en","primary_location":{"id":"doi:10.1271/bbb.80841","doi":"https://doi.org/10.1271/bbb.80841","is_oa":false,"landing_page_url":"https://doi.org/10.1271/bbb.80841","pdf_url":null,"source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026204775","display_name":"Yuan\u2010Hu Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuan-Hu JIN","raw_affiliation_strings":["Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University, Chiba, Japan","Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062506283","display_name":"K Kita","orcid":"https://orcid.org/0000-0002-1569-7555","observed_orcids":["https://orcid.org/0000-0002-1569-7555"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuko KITA","raw_affiliation_strings":["Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103112499","display_name":"Zhuo Ran Sun","orcid":"https://orcid.org/0000-0002-8987-1288","observed_orcids":["https://orcid.org/0000-0002-8987-1288"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Zhuo SUN","raw_affiliation_strings":["Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054644380","display_name":"Xiaobo Tong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Xiao-Bo TONG","raw_affiliation_strings":["Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103151337","display_name":"Hua Nie","orcid":"https://orcid.org/0000-0003-3197-7917","observed_orcids":["https://orcid.org/0000-0003-3197-7917"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hua NIE","raw_affiliation_strings":["Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Diagnosis, Graduate School of Medicine, Chiba University","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039391837","display_name":"Nobuo Suzuki","orcid":"https://orcid.org/0000-0003-0283-9910","observed_orcids":["https://orcid.org/0000-0003-0283-9910"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuo SUZUKI","raw_affiliation_strings":["Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University","institution_ids":["https://openalex.org/I159385669"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I159385669"],"apc_list":{"value":3272,"currency":"USD","value_usd":3272},"apc_paid":null,"fwci":0.6436,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.61714826,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"73","issue":"6","first_page":"1318","last_page":"1322"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.019600000232458115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp27","display_name":"HSP27","score":0.9359999895095825},{"id":"https://openalex.org/keywords/annexin-a2","display_name":"annexin A2","score":0.9810000061988831},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cdna-transfection","display_name":"cDNA transfection","score":0.7689999938011169},{"id":"https://openalex.org/keywords/phototoxicity","display_name":"phototoxicity","score":0.4180000126361847},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.3050000071525574},{"id":"https://openalex.org/keywords/heat-shock-proteins","display_name":"heat shock proteins","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.7650591135025024},{"id":"https://openalex.org/C2779559962","wikidata":"https://www.wikidata.org/wiki/Q14905263","display_name":"Hsp27","level":5,"score":0.7331758141517639},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.6973147392272949},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6310040354728699},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.5495803952217102},{"id":"https://openalex.org/C30345302","wikidata":"https://www.wikidata.org/wiki/Q14908233","display_name":"Annexin A2","level":4,"score":0.5459269285202026},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5426841378211975},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.536608874797821},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.48981019854545593},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.46526291966438293},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43047067523002625},{"id":"https://openalex.org/C2780670749","wikidata":"https://www.wikidata.org/wiki/Q14908239","display_name":"Annexin A5","level":4,"score":0.42686304450035095},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3611750900745392},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34089475870132446},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.29096218943595886},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19238579273223877},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.16295289993286133},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.1308627724647522},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12625819444656372},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12182196974754333},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D017306","descriptor_name":"Annexin A2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055551","descriptor_name":"HSP27 Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055551","descriptor_name":"HSP27 Heat-Shock Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1271/bbb.80841","doi":"https://doi.org/10.1271/bbb.80841","is_oa":false,"landing_page_url":"https://doi.org/10.1271/bbb.80841","pdf_url":null,"source":{"id":"https://openalex.org/S94095188","display_name":"Bioscience Biotechnology and Biochemistry","issn_l":"0916-8451","issn":["0916-8451","1347-6947"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, Biotechnology, and Biochemistry","raw_type":"journal-article"},{"id":"pmid:19502736","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19502736","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience, biotechnology, and biochemistry","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8334000110626221,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322555","display_name":"Smoking Research Foundation","ror":"https://ror.org/04q4hbm31"},{"id":"https://openalex.org/F4320325275","display_name":"Hamaguchi Foundation for the Advancement of Biochemistry","ror":"https://ror.org/01t80ed43"},{"id":"https://openalex.org/F4320327432","display_name":"Tokyu Foundation for a Better Environment","ror":"https://ror.org/0008z5b39"},{"id":"https://openalex.org/F4320327435","display_name":"Tsuchiya Foundation","ror":"https://ror.org/011r7vr09"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1547374970","https://openalex.org/W1932669647","https://openalex.org/W1996107761","https://openalex.org/W1996812847","https://openalex.org/W2000530514","https://openalex.org/W2008175811","https://openalex.org/W2023296859","https://openalex.org/W2048248298","https://openalex.org/W2061374050","https://openalex.org/W2076475322","https://openalex.org/W2077672936","https://openalex.org/W2079796760","https://openalex.org/W2082383429","https://openalex.org/W2096121200","https://openalex.org/W2099781963","https://openalex.org/W2110069671","https://openalex.org/W2117193174","https://openalex.org/W2117998622","https://openalex.org/W2133586085","https://openalex.org/W2147464247","https://openalex.org/W2151278366","https://openalex.org/W2157894520"],"related_works":["https://openalex.org/W2061374050","https://openalex.org/W2346104470","https://openalex.org/W1996107761","https://openalex.org/W1890590547","https://openalex.org/W2340721078","https://openalex.org/W2616296637","https://openalex.org/W2027234772","https://openalex.org/W2142489040","https://openalex.org/W2019791345","https://openalex.org/W2082383653"],"abstract_inverted_index":{"We":[0],"have":[1],"reported":[2],"that":[3],"heat":[4],"shock":[5],"protein":[6],"27":[7],"(HSP27)":[8],"and":[9,36,79,103],"annexin":[10,37,54,82,106,112,147],"II":[11,38,55,83,107,113,148],"are":[12],"involved":[13],"in":[14,39,62,114,118,133,142],"the":[15,31,127,134],"protection":[16],"of":[17,34,53,91,111,129,137,146],"human":[18,138],"cells":[19,47,64,73,93,116],"against":[20],"UVC-induced":[21],"cell":[22,40],"death.":[23],"In":[24,45,88],"this":[25],"study":[26,125],"we":[27],"tried":[28],"to":[29,50,68,76,100,121],"confirm":[30],"combined":[32],"roles":[33],"HSP27":[35,70,95,131],"death":[41],"after":[42,57,85],"UVC":[43,58,77,86,101,122,135],"irradiation.":[44,87],"RSa":[46,92,115],"with":[48,65,94,144],"sensitivity":[49],"UVC,":[51],"expression":[52,84,132],"decreased":[56,81],"irradiation,":[59],"but":[60],"not":[61],"AP(r)-1":[63,72],"increased":[66,97,105,119],"resistance":[67,99,120],"UVC.":[69],"siRNA-transfected":[71],"were":[74],"sensitized":[75],"lethality":[78,102],"showed":[80],"contrast,":[89],"transfection":[90],"cDNA":[96],"their":[98],"caused":[104],"expression.":[108,149],"Furthermore,":[109],"over-production":[110],"resulted":[117],"lethality.":[123],"This":[124],"indicates":[126],"involvement":[128],"cellular":[130],"susceptibility":[136],"cells,":[139],"which":[140],"occurs":[141],"association":[143],"regulation":[145]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}