{"id":"https://openalex.org/W2014428575","doi":"https://doi.org/10.3111/13696990802645726","title":"Resource utilisation and costs in patients with type 2 diabetes mellitus treated with insulin glargine or conventional basal insulin under real-world conditions in Germany: LIVE-SPP study","display_name":"Resource utilisation and costs in patients with type 2 diabetes mellitus treated with insulin glargine or conventional basal insulin under real-world conditions in Germany: LIVE-SPP study","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2014428575","doi":"https://doi.org/10.3111/13696990802645726","mag":"2014428575","pmid":"https://pubmed.ncbi.nlm.nih.gov/19450076"},"language":"en","primary_location":{"id":"doi:10.3111/13696990802645726","doi":"https://doi.org/10.3111/13696990802645726","is_oa":true,"landing_page_url":"https://doi.org/10.3111/13696990802645726","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3111/13696990802645726?needAccess=true","source":{"id":"https://openalex.org/S155267287","display_name":"Journal of Medical Economics","issn_l":"1369-6998","issn":["1369-6998","1941-837X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-c","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Economics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.3111/13696990802645726?needAccess=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011663255","display_name":"Oliver Sch\u00f6ffski","orcid":"https://orcid.org/0000-0002-0048-0302","observed_orcids":["https://orcid.org/0000-0002-0048-0302"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Sch\u00f6ffski","raw_affiliation_strings":["Universit\u00e4t Erlangen-N\u00fcrnberg, N\u00fcrnberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4t Erlangen-N\u00fcrnberg, N\u00fcrnberg, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024200227","display_name":"Lusine Breitscheidel","orcid":"https://orcid.org/0000-0002-5868-5271","observed_orcids":["https://orcid.org/0000-0002-5868-5271"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lusine Breitscheidel","raw_affiliation_strings":["Kendle GmbH, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kendle GmbH, Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089293335","display_name":"Ursula Benter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ursula Benter","raw_affiliation_strings":["Kendle GmbH, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kendle GmbH, Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112107716","display_name":"F.W. Dippel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Franz-Werner Dippel","raw_affiliation_strings":["Sanofi-Aventis Deutschland GmbH, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi-Aventis Deutschland GmbH, Berlin, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074203623","display_name":"Markus Matthias M\u00fcller","orcid":"https://orcid.org/0000-0003-1350-3742","observed_orcids":["https://orcid.org/0000-0003-1350-3742"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Markus M\u00fcller","raw_affiliation_strings":["Axaris software & systeme GmbH, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Axaris software & systeme GmbH, Ulm, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Volk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Volk","raw_affiliation_strings":["Axaris software & systeme GmbH, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Axaris software & systeme GmbH, Ulm, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102846519","display_name":"Martin Pfohl","orcid":"https://orcid.org/0000-0002-6853-0302","observed_orcids":["https://orcid.org/0000-0002-6853-0302"]},"institutions":[{"id":"https://openalex.org/I4210091620","display_name":"Evangelisches Krankenhaus Bethesda","ror":"https://ror.org/00dawnv76","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210091620"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Pfohl","raw_affiliation_strings":["Evangelisches Bethesda-Johanniter-Klinikum, Duisburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evangelisches Bethesda-Johanniter-Klinikum, Duisburg, Germany","institution_ids":["https://openalex.org/I4210091620"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024200227"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5633,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.83480123,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"4","first_page":"695","last_page":"712"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.15379999577999115,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.08910000324249268,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.996999979019165},{"id":"https://openalex.org/keywords/insulin-glargine","display_name":"insulin glargine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nph-insulin","display_name":"NPH insulin","score":0.8339999914169312},{"id":"https://openalex.org/keywords/basal-insulin","display_name":"basal insulin","score":0.8040000200271606},{"id":"https://openalex.org/keywords/diabetes-care-costs","display_name":"diabetes care costs","score":0.7129999995231628},{"id":"https://openalex.org/keywords/cost-comparison","display_name":"cost comparison","score":0.5870000123977661},{"id":"https://openalex.org/keywords/resource-utilization-health-care","display_name":"resource utilization (health care)","score":0.7649999856948853},{"id":"https://openalex.org/keywords/blood-glucose-monitoring","display_name":"blood glucose monitoring","score":0.75},{"id":"https://openalex.org/keywords/statutory-health-insurance","display_name":"statutory health insurance","score":0.6240000128746033},{"id":"https://openalex.org/keywords/long-acting-insulin","display_name":"long-acting insulin","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9154549837112427},{"id":"https://openalex.org/C2779920387","wikidata":"https://www.wikidata.org/wiki/Q417317","display_name":"Insulin glargine","level":4,"score":0.8761938214302063},{"id":"https://openalex.org/C2778804033","wikidata":"https://www.wikidata.org/wiki/Q1929845","display_name":"NPH insulin","level":5,"score":0.7752326726913452},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6068823337554932},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5952476263046265},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5821375250816345},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.5101059079170227},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4669996500015259},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.37178704142570496},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3355717360973358}],"mesh":[{"descriptor_ui":"D000069036","descriptor_name":"Insulin Glargine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005858","descriptor_name":"Germany","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006295","descriptor_name":"Health Resources","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D006295","descriptor_name":"Health Resources","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016527","descriptor_name":"Drug Costs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049528","descriptor_name":"Insulin, Long-Acting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3111/13696990802645726","doi":"https://doi.org/10.3111/13696990802645726","is_oa":true,"landing_page_url":"https://doi.org/10.3111/13696990802645726","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3111/13696990802645726?needAccess=true","source":{"id":"https://openalex.org/S155267287","display_name":"Journal of Medical Economics","issn_l":"1369-6998","issn":["1369-6998","1941-837X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-c","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Economics","raw_type":"journal-article"},{"id":"pmid:19450076","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19450076","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medical economics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3111/13696990802645726","doi":"https://doi.org/10.3111/13696990802645726","is_oa":true,"landing_page_url":"https://doi.org/10.3111/13696990802645726","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3111/13696990802645726?needAccess=true","source":{"id":"https://openalex.org/S155267287","display_name":"Journal of Medical Economics","issn_l":"1369-6998","issn":["1369-6998","1941-837X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-c","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Economics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014428575.pdf","grobid_xml":"https://content.openalex.org/works/W2014428575.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W66041704","https://openalex.org/W1968865647","https://openalex.org/W1972201827","https://openalex.org/W1981152283","https://openalex.org/W1984354386","https://openalex.org/W1984473913","https://openalex.org/W2003744723","https://openalex.org/W2010143667","https://openalex.org/W2013339698","https://openalex.org/W2015166879","https://openalex.org/W2047653891","https://openalex.org/W2059983648","https://openalex.org/W2063423309","https://openalex.org/W2074571707","https://openalex.org/W2077148563","https://openalex.org/W2085996926","https://openalex.org/W2087998138","https://openalex.org/W2115638697","https://openalex.org/W2119954342","https://openalex.org/W2121800587","https://openalex.org/W2126781806","https://openalex.org/W2181740980","https://openalex.org/W2345903479","https://openalex.org/W2411311794","https://openalex.org/W2484082886","https://openalex.org/W2752336761","https://openalex.org/W4233562854","https://openalex.org/W4239041997","https://openalex.org/W4239632743","https://openalex.org/W4247637099","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1982781631","https://openalex.org/W2134792690","https://openalex.org/W2089948911","https://openalex.org/W1565926812","https://openalex.org/W6997076650","https://openalex.org/W2033482668","https://openalex.org/W1992977777","https://openalex.org/W2955547715","https://openalex.org/W2321236305","https://openalex.org/W2095153580"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"assess":[2],"and":[3,177,201],"compare":[4],"the":[5,39,77,109],"total":[6,87,142,167],"costs":[7,88,144,169],"relevant":[8],"to":[9],"diabetes":[10,17,23,134],"care":[11],"in":[12,56,69,211],"patients":[13,120],"with":[14,25,71,130],"type":[15],"2":[16],"mellitus":[18],"(T2D)":[19],"treated":[20],"at":[21,136],"specialised":[22],"practices":[24],"either":[26],"insulin":[27,32,92,154,173,191,221],"glargine-":[28,174],"or":[29],"conventional":[30],"basal":[31],"(neutral":[33],"protamine":[34],"Hagedorn":[35],"[NPH])-based":[36],"therapies":[37,95,179,193,223],"from":[38,76,196],"German":[40,78],"statutory":[41],"health":[42],"insurance":[43],"(SHI)":[44],"perspective.":[45],"METHODS:":[46],"The":[47,139,187,207,216],"Long":[48],"Acting":[49],"Insulin":[50],"Glargine":[51],"Versus":[52],"NPH":[53],"Cost":[54],"Evaluation":[55],"Specialised":[57],"Practices":[58],"(LIVE-SPP)":[59],"study":[60,137,218],"is":[61],"an":[62,131,226],"observational,":[63],"retrolective,":[64],"multicentre":[65],"longitudinal":[66],"cost":[67,111],"comparison":[68],"adults":[70],"T2D.":[72],"Costs":[73],"were":[74,96,105,123,147,182],"evaluated":[75],"SHI":[79],"perspective":[80],"based":[81],"on":[82,124],"official":[83],"2005":[84],"prices.":[85],"Average":[86,165],"per":[89,121,145,170],"patient":[90,146,171],"for":[91,153,162,190],"glargine-versus":[93],"NPH-based":[94,163,178,230],"compared":[97],"using":[98],"multivariate":[99],"general":[100],"linear":[101],"modelling.":[102],"Sensitivity":[103],"analyses":[104],"performed":[106],"by":[107,113],"varying":[108],"main":[110],"factors":[112],"+/-":[114],"25%.":[115],"RESULTS:":[116],"Patients":[117],"(n=1,024,":[118],"512":[119],"cohort)":[122],"average":[125,132,140],"62":[126],"years":[127],"of":[128],"age,":[129],"8-year":[133],"history":[135],"start.":[138],"unadjusted":[141],"annual":[143,168],"euro":[148,157],"1,868.41":[149],"(95%":[150,159],"CI":[151,160],"1,744.27-1,992.56)":[152],"glargine-based":[155,192,222],"vs.":[156],"2,063.72":[158],"1,922.91-2,204.54)":[161],"therapies.":[164,231],"adjusted":[166],"between":[172],"(euro":[175,180],"1,241.13)":[176],"1,607.86)":[181],"statistically":[183],"significantly":[184],"different":[185],"(p=0.0004).":[186],"economic":[188,227],"advantage":[189,228],"resulted":[194],"mainly":[195],"fewer":[197],"blood":[198],"glucose":[199],"measurements":[200],"other":[202],"diabetes-related":[203],"materials":[204],"(e.g.":[205],"needles).":[206],"savings":[208],"remained":[209],"stable":[210],"one-way":[212],"sensitivity":[213],"analyses.":[214],"CONCLUSIONS:":[215],"LIVE-SPP":[217],"suggests":[219],"that":[220],"may":[224],"offer":[225],"over":[229]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}