{"id":"https://openalex.org/W2014413787","doi":"https://doi.org/10.1074/jbc.m109.081125","title":"Direct Transfer of \u03b1-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies","display_name":"Direct Transfer of \u03b1-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies","publication_year":2010,"publication_date":"2010-01-13","ids":{"openalex":"https://openalex.org/W2014413787","doi":"https://doi.org/10.1074/jbc.m109.081125","mag":"2014413787","pmid":"https://pubmed.ncbi.nlm.nih.gov/20071342","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2838344"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m109.081125","doi":"https://doi.org/10.1074/jbc.m109.081125","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.081125","pdf_url":"http://www.jbc.org/article/S0021925820873207/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820873207/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111695603","display_name":"He-Jin Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"He-Jin Lee","raw_affiliation_strings":["Department of Anatomy, School of Medicine, Konkuk University, Seoul 143-701, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, School of Medicine, Konkuk University, Seoul 143-701, Korea","institution_ids":["https://openalex.org/I24062138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076913668","display_name":"Ji\u2010Eun Suk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ji-Eun Suk","raw_affiliation_strings":["Department of Biomedical Science and Technology, IBST, Seoul 143-701, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science and Technology, IBST, Seoul 143-701, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109168412","display_name":"Christina Patrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Patrick","raw_affiliation_strings":["Department of Neurosciences and Pathology, School of Medicine, University of California San Diego, La Jolla, California 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences and Pathology, School of Medicine, University of California San Diego, La Jolla, California 92093","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064550946","display_name":"Eun-Jin Bae","orcid":"https://orcid.org/0000-0002-4369-7405","observed_orcids":["https://orcid.org/0000-0002-4369-7405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eun-Jin Bae","raw_affiliation_strings":["Department of Biomedical Science and Technology, IBST, Seoul 143-701, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science and Technology, IBST, Seoul 143-701, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101735756","display_name":"Ji-Hoon Cho","orcid":"https://orcid.org/0000-0001-7063-9617","observed_orcids":["https://orcid.org/0000-0001-7063-9617"]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji-Hoon Cho","raw_affiliation_strings":["School of Interdisciplinary Bioscience and Bioengineering, Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Kyoungbuk 790-784, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Interdisciplinary Bioscience and Bioengineering, Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Kyoungbuk 790-784, Korea","institution_ids":["https://openalex.org/I123900574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032007740","display_name":"Sangchul Rho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sangchul Rho","raw_affiliation_strings":["School of Interdisciplinary Bioscience and Bioengineering, Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Kyoungbuk 790-784, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Interdisciplinary Bioscience and Bioengineering, Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Kyoungbuk 790-784, Korea","institution_ids":["https://openalex.org/I123900574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027374744","display_name":"Daehee Hwang","orcid":"https://orcid.org/0000-0002-7553-0044","observed_orcids":["https://orcid.org/0000-0002-7553-0044","https://orcid.org/0000-0003-3608-0885","https://orcid.org/0000-0003-1038-9200"]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Daehee Hwang","raw_affiliation_strings":["School of Interdisciplinary Bioscience and Bioengineering, Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Kyoungbuk 790-784, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Interdisciplinary Bioscience and Bioengineering, Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Kyoungbuk 790-784, Korea","institution_ids":["https://openalex.org/I123900574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074775445","display_name":"Eliezer Masliah","orcid":"https://orcid.org/0000-0002-2117-5569","observed_orcids":["https://orcid.org/0000-0002-2117-5569"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eliezer Masliah","raw_affiliation_strings":["Department of Neurosciences and Pathology, School of Medicine, University of California San Diego, La Jolla, California 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences and Pathology, School of Medicine, University of California San Diego, La Jolla, California 92093","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100434398","display_name":"Seung\u2010Jae Lee","orcid":"https://orcid.org/0000-0002-5155-5335","observed_orcids":["https://orcid.org/0000-0002-5155-5335"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Seung-Jae Lee","raw_affiliation_strings":["Department of Biomedical Science and Technology, IBST, Seoul 143-701, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science and Technology, IBST, Seoul 143-701, Korea","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100434398"],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":22.613,"has_fulltext":true,"cited_by_count":898,"citation_normalized_percentile":{"value":0.99753768,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"285","issue":"12","first_page":"9262","last_page":"9272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.996999979019165},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8830000162124634},{"id":"https://openalex.org/keywords/neurons","display_name":"neurons","score":0.5109999775886536},{"id":"https://openalex.org/keywords/synucleinopathies","display_name":"synucleinopathies","score":0.8880000114440918},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/dementia-with-lewy-bodies","display_name":"dementia with Lewy bodies","score":0.996999979019165},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.5910000205039978},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.8190000057220459},{"id":"https://openalex.org/keywords/glial-uptake","display_name":"glial uptake","score":0.460999995470047},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7590000033378601},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.9900000095367432},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.7620000243186951},{"id":"https://openalex.org/keywords/neuronal-glial-interactions","display_name":"neuron-glia interactions","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C2777440831","wikidata":"https://www.wikidata.org/wiki/Q2376264","display_name":"Synucleinopathies","level":5,"score":0.8076006174087524},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.6903228163719177},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6138929724693298},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.582729697227478},{"id":"https://openalex.org/C2779097696","wikidata":"https://www.wikidata.org/wiki/Q1822234","display_name":"Lewy body","level":4,"score":0.5318458080291748},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.5068359971046448},{"id":"https://openalex.org/C2780884517","wikidata":"https://www.wikidata.org/wiki/Q177105","display_name":"Neuroglia","level":3,"score":0.5004332065582275},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.489391028881073},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.43560653924942017},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3574921488761902},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2936936318874359},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22877678275108337},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.22129526734352112}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m109.081125","doi":"https://doi.org/10.1074/jbc.m109.081125","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.081125","pdf_url":"http://www.jbc.org/article/S0021925820873207/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2838344","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2838344","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:20071342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20071342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:oasis.postech.ac.kr:2014.oak/26370","doi":null,"is_oa":false,"landing_page_url":"https://oasis.postech.ac.kr/handle/2014.oak/26370","pdf_url":null,"source":{"id":"https://openalex.org/S4306401965","display_name":"Open Access System for Information Sharing (Pohang University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123900574","host_organization_name":"Pohang University of Science and Technology","host_organization_lineage":["https://openalex.org/I123900574"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m109.081125","doi":"https://doi.org/10.1074/jbc.m109.081125","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.081125","pdf_url":"http://www.jbc.org/article/S0021925820873207/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2793432280","display_name":"a-synuclein clearance strategies for the treatment of Lewy body disease","funder_award_id":"R37AG018440","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2937085932","display_name":null,"funder_award_id":"AG5131","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2976272768","display_name":"a-Synuclein vulnerability mechanisms and therapeutics in Alzheimer's Disease","funder_award_id":"R01AG018440","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3317175073","display_name":"UCSD Alzheimer's Disease Research Center P50","funder_award_id":"P50AG005131","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3457996028","display_name":null,"funder_award_id":"AG-5131","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G486772123","display_name":null,"funder_award_id":"AG 18440","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000035899","display_name":null,"funder_award_id":"AG\u201018440","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320322348","display_name":"Korea Science and Engineering Foundation","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320322349","display_name":"Ministry of Education, Science and Technology","ror":"https://ror.org/01p262204"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014413787.pdf","grobid_xml":"https://content.openalex.org/works/W2014413787.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W62603772","https://openalex.org/W82853573","https://openalex.org/W213500300","https://openalex.org/W1588125132","https://openalex.org/W1604776255","https://openalex.org/W1755125321","https://openalex.org/W1970635846","https://openalex.org/W1977267085","https://openalex.org/W1980115442","https://openalex.org/W1983166842","https://openalex.org/W1983591304","https://openalex.org/W1983768810","https://openalex.org/W1984031632","https://openalex.org/W1987549963","https://openalex.org/W1988509015","https://openalex.org/W1989208474","https://openalex.org/W1994926763","https://openalex.org/W1999385317","https://openalex.org/W1999883522","https://openalex.org/W2004349171","https://openalex.org/W2004873263","https://openalex.org/W2008321168","https://openalex.org/W2010476270","https://openalex.org/W2015705446","https://openalex.org/W2015957622","https://openalex.org/W2016816471","https://openalex.org/W2025922492","https://openalex.org/W2038890616","https://openalex.org/W2044407202","https://openalex.org/W2045147326","https://openalex.org/W2050647292","https://openalex.org/W2050786534","https://openalex.org/W2052742260","https://openalex.org/W2054588014","https://openalex.org/W2058409097","https://openalex.org/W2061154270","https://openalex.org/W2063202995","https://openalex.org/W2068147651","https://openalex.org/W2070953412","https://openalex.org/W2075997185","https://openalex.org/W2076078146","https://openalex.org/W2079320514","https://openalex.org/W2080949995","https://openalex.org/W2089900719","https://openalex.org/W2092366279","https://openalex.org/W2099340107","https://openalex.org/W2108060249","https://openalex.org/W2117626437","https://openalex.org/W2120412340","https://openalex.org/W2120997873","https://openalex.org/W2122564376","https://openalex.org/W2122683221","https://openalex.org/W2123056519","https://openalex.org/W2127216772","https://openalex.org/W2128631317","https://openalex.org/W2133068803","https://openalex.org/W2134272142","https://openalex.org/W2143257167","https://openalex.org/W2143894941","https://openalex.org/W2145907885","https://openalex.org/W2159675211","https://openalex.org/W2162353774","https://openalex.org/W2164627569","https://openalex.org/W2171311951","https://openalex.org/W2999065750","https://openalex.org/W4318373760"],"related_works":["https://openalex.org/W2052118189","https://openalex.org/W3163726770","https://openalex.org/W4306149545","https://openalex.org/W7204425908","https://openalex.org/W2606602567","https://openalex.org/W2067158104","https://openalex.org/W3097880312","https://openalex.org/W2108802551","https://openalex.org/W2033402586","https://openalex.org/W3115620428"],"abstract_inverted_index":{"Abnormal":[0],"neuronal":[1,65,88,107,149],"aggregation":[2],"of":[3,10,81,86,121,130,133,148,163],"alpha-synuclein":[4,27,42,61,82,108,141,150],"is":[5,143,158],"implicated":[6],"in":[7,51,93,111],"the":[8,36,40,45,52,84,87,112,128],"development":[9],"many":[11],"neurological":[12],"disorders,":[13],"including":[14],"Parkinson":[15],"disease":[16,33],"and":[17,29,44,49,74,124,167],"dementia":[18],"with":[19,127],"Lewy":[20],"bodies.":[21,77],"Glial":[22],"cells":[23,66],"also":[24,91],"show":[25,59],"extensive":[26],"pathology":[28,43,142],"may":[30],"contribute":[31],"to":[32,106],"progression.":[34],"However,":[35],"mechanism":[37],"that":[38,60,103,139],"produces":[39],"glial":[41,79,131,165],"interaction":[46],"between":[47],"neurons":[48],"glia":[50],"disease-inflicted":[53],"microenvironment":[54],"remain":[55],"unknown.":[56],"Here,":[57],"we":[58],"proteins":[62],"released":[63],"from":[64],"are":[67],"taken":[68],"up":[69],"by":[70,145],"astrocytes":[71,102],"through":[72,83],"endocytosis":[73],"form":[75],"inclusion":[76],"The":[78],"accumulation":[80,132],"transmission":[85,147,156],"protein":[89],"was":[90],"demonstrated":[92],"a":[94,171],"transgenic":[95],"mouse":[96],"model":[97],"expressing":[98],"human":[99],"alpha-synuclein.":[100,134],"Furthermore,":[101],"were":[104],"exposed":[105],"underwent":[109],"changes":[110],"gene":[113],"expression":[114],"profile":[115],"reflecting":[116],"an":[117,160],"inflammatory":[118,153],"response.":[119],"Induction":[120],"pro-inflammatory":[122],"cytokines":[123],"chemokines":[125],"correlated":[126],"extent":[129],"Together,":[135],"these":[136],"results":[137],"suggest":[138],"astroglial":[140],"produced":[144],"direct":[146],"aggregates,":[151],"causing":[152],"responses.":[154],"This":[155],"step":[157],"thus":[159],"important":[161],"mediator":[162],"pathogenic":[164],"responses":[166],"could":[168],"qualify":[169],"as":[170],"new":[172],"therapeutic":[173],"target.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":35},{"year":2025,"cited_by_count":50},{"year":2024,"cited_by_count":66},{"year":2023,"cited_by_count":59},{"year":2022,"cited_by_count":82},{"year":2021,"cited_by_count":72},{"year":2020,"cited_by_count":85},{"year":2019,"cited_by_count":60},{"year":2018,"cited_by_count":54},{"year":2017,"cited_by_count":56},{"year":2016,"cited_by_count":48},{"year":2015,"cited_by_count":58},{"year":2014,"cited_by_count":55},{"year":2013,"cited_by_count":38},{"year":2012,"cited_by_count":41}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}