{"id":"https://openalex.org/W2014383294","doi":"https://doi.org/10.1002/eji.1830270614","title":"A retro\u2010inverso analog mimicks the cognate peptide epitope of a CD4+ T cell clone","display_name":"A retro\u2010inverso analog mimicks the cognate peptide epitope of a CD4+ T cell clone","publication_year":1997,"publication_date":"1997-06-01","ids":{"openalex":"https://openalex.org/W2014383294","doi":"https://doi.org/10.1002/eji.1830270614","mag":"2014383294","pmid":"https://pubmed.ncbi.nlm.nih.gov/9209489"},"language":"en","primary_location":{"id":"doi:10.1002/eji.1830270614","doi":"https://doi.org/10.1002/eji.1830270614","is_oa":true,"landing_page_url":"https://doi.org/10.1002/eji.1830270614","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.1830270614","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.1830270614","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000506157","display_name":"Kristian Bartnes","orcid":"https://orcid.org/0000-0003-3203-1840","observed_orcids":["https://orcid.org/0000-0003-3203-1840"]},"institutions":[{"id":"https://openalex.org/I78037679","display_name":"UiT The Arctic University of Norway","ror":"https://ror.org/00wge5k78","country_code":"NO","type":"education","lineage":["https://openalex.org/I78037679"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Kristian Bartnes","raw_affiliation_strings":["Department of Immunology, University of Troms\u00f8, School of Medicine, Norway","Department of Immunology, Institute of Medical Biology, University of Tromso, School of Medicine, Tromso, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Troms\u00f8, School of Medicine, Norway","institution_ids":["https://openalex.org/I78037679"]},{"raw_affiliation_string":"Department of Immunology, Institute of Medical Biology, University of Tromso, School of Medicine, Tromso, Norway","institution_ids":["https://openalex.org/I78037679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053700114","display_name":"Kristian Hannestad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78037679","display_name":"UiT The Arctic University of Norway","ror":"https://ror.org/00wge5k78","country_code":"NO","type":"education","lineage":["https://openalex.org/I78037679"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Kristian Hannestad","raw_affiliation_strings":["Department of Immunology, Institute of Medical Biology, University of Troms\u00f8, School of Medicine, Troms\u00f8, Norway","Department of Immunology, Institute of Medical Biology, University of Tromso, School of Medicine, Tromso, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Institute of Medical Biology, University of Troms\u00f8, School of Medicine, Troms\u00f8, Norway","institution_ids":["https://openalex.org/I78037679"]},{"raw_affiliation_string":"Department of Immunology, Institute of Medical Biology, University of Tromso, School of Medicine, Tromso, Norway","institution_ids":["https://openalex.org/I78037679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068599704","display_name":"Gilles Guichard","orcid":"https://orcid.org/0000-0002-2584-7502","observed_orcids":["https://orcid.org/0000-0002-2584-7502"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210137205","display_name":"Immunologie, Immunopathologie et Chimie Th\u00e9rapeutique","ror":"https://ror.org/041v2hk34","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210137205","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I4210158086","display_name":"Institut de Biologie Mol\u00e9culaire et Cellulaire","ror":"https://ror.org/05qpmg879","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210158086","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gilles Guichard","raw_affiliation_strings":["Institut de Biologie Moleculaire et Cellulaire, UPR 9021 CNRS, Strasbourg, France","Institut de Biologie Mol\u00e9culaire et Cellulaire, UPR 9021\u2010CNRS, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biologie Moleculaire et Cellulaire, UPR 9021 CNRS, Strasbourg, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210137205","https://openalex.org/I4210158086"]},{"raw_affiliation_string":"Institut de Biologie Mol\u00e9culaire et Cellulaire, UPR 9021\u2010CNRS, Strasbourg, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210137205","https://openalex.org/I4210158086"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109070824","display_name":"Jean Paul Briand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210137205","display_name":"Immunologie, Immunopathologie et Chimie Th\u00e9rapeutique","ror":"https://ror.org/041v2hk34","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210137205","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I4210158086","display_name":"Institut de Biologie Mol\u00e9culaire et Cellulaire","ror":"https://ror.org/05qpmg879","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210158086","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean Paul Briand","raw_affiliation_strings":["Institut de Biologie Moleculaire et Cellulaire, UPR 9021 CNRS, Strasbourg, France","Institut de Biologie Mol\u00e9culaire et Cellulaire, UPR 9021\u2010CNRS, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Biologie Moleculaire et Cellulaire, UPR 9021 CNRS, Strasbourg, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210137205","https://openalex.org/I4210158086"]},{"raw_affiliation_string":"Institut de Biologie Mol\u00e9culaire et Cellulaire, UPR 9021\u2010CNRS, Strasbourg, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210137205","https://openalex.org/I4210158086"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5000506157"],"corresponding_institution_ids":["https://openalex.org/I78037679"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":2.6538,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.88824986,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"27","issue":"6","first_page":"1387","last_page":"1391"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.029600000008940697,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/d-amino-acids","display_name":"D-amino acids","score":0.8019999861717224},{"id":"https://openalex.org/keywords/peptide-epitopes","display_name":"peptide epitopes","score":0.675000011920929},{"id":"https://openalex.org/keywords/cd4-t-cell-clones","display_name":"CD4+ T cell clones","score":0.8330000042915344},{"id":"https://openalex.org/keywords/mhc-class-ii-binding","display_name":"MHC class II binding","score":0.8410000205039978},{"id":"https://openalex.org/keywords/i-ad","display_name":"I-Ad","score":0.9110000133514404},{"id":"https://openalex.org/keywords/protease-resistance","display_name":"protease resistance","score":0.6779999732971191},{"id":"https://openalex.org/keywords/peptide-mhc-binding","display_name":"peptide-MHC binding","score":0.3959999978542328},{"id":"https://openalex.org/keywords/t-cell-antigen-recognition","display_name":"T cell antigen recognition","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2777392089","wikidata":"https://www.wikidata.org/wiki/Q690548","display_name":"Cognate","level":2,"score":0.7778717279434204},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7604285478591919},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.7287869453430176},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.704679012298584},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5447756052017212},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43292760848999023},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2536900043487549},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.20457148551940918},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2041434943675995},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14837899804115295},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/eji.1830270614","doi":"https://doi.org/10.1002/eji.1830270614","is_oa":true,"landing_page_url":"https://doi.org/10.1002/eji.1830270614","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.1830270614","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:9209489","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9209489","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/eji.1830270614","doi":"https://doi.org/10.1002/eji.1830270614","is_oa":true,"landing_page_url":"https://doi.org/10.1002/eji.1830270614","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.1830270614","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6919999718666077}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014383294.pdf","grobid_xml":"https://content.openalex.org/works/W2014383294.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1506204720","https://openalex.org/W1548757996","https://openalex.org/W1879969470","https://openalex.org/W1963655619","https://openalex.org/W1979669746","https://openalex.org/W1982034991","https://openalex.org/W1989276236","https://openalex.org/W1997053868","https://openalex.org/W2017607746","https://openalex.org/W2021002908","https://openalex.org/W2024543747","https://openalex.org/W2029012405","https://openalex.org/W2034141726","https://openalex.org/W2035194338","https://openalex.org/W2036169673","https://openalex.org/W2040188875","https://openalex.org/W2040207258","https://openalex.org/W2040728150","https://openalex.org/W2044063726","https://openalex.org/W2058071227","https://openalex.org/W2074222872","https://openalex.org/W2079150842","https://openalex.org/W2080052508","https://openalex.org/W2083120327","https://openalex.org/W2100671145","https://openalex.org/W2118600639","https://openalex.org/W2155740919","https://openalex.org/W2159404298","https://openalex.org/W2401924660"],"related_works":["https://openalex.org/W1932509374","https://openalex.org/W1964383150","https://openalex.org/W2079150842","https://openalex.org/W1989276236","https://openalex.org/W2905655469","https://openalex.org/W1977741635","https://openalex.org/W1493750131","https://openalex.org/W2071358919","https://openalex.org/W4312569113","https://openalex.org/W2090248558"],"abstract_inverted_index":{"Synthetic":[0],"analogs":[1],"of":[2,41,60,93,107,147,167,190,199,221,268],"peptide":[3,193],"epitopes":[4],"may":[5,32,262],"activate":[6],"specific":[7],"T":[8,49,125,258],"helper":[9],"cells,":[10],"antagonize":[11],"their":[12,52],"antigen":[13,260],"receptors,":[14],"or":[15],"block":[16],"recognition":[17],"by":[18,47,119,156,265],"competing":[19],"for":[20,39,155],"major":[21,235],"histocompatibility":[22],"complex":[23],"(MHC)":[24],"class":[25,216,253],"II":[26,217,254],"binding":[27,160,196,218],"sites.":[28],"Rationally":[29],"designed":[30,264],"peptides":[31,62],"therefore":[33],"prove":[34],"useful":[35],"as":[36],"vaccines":[37],"and":[38,44,86,197,226,239,257],"treatment":[40],"autoimmune":[42],"diseases":[43],"allergies":[45],"mediated":[46],"CD4+":[48],"cells.":[50],"However,":[51],"susceptibility":[53],"to":[54,172,184,212,249],"proteolytic":[55],"degradation":[56],"limits":[57],"the":[58,89,94,108,141,148,168,181,185,191,200,204,207,215,222,227,231],"applicability":[59],"conventional":[61],"in":[63,69,214],"vivo.":[64],"By":[65],"contrast,":[66],"retro-inverso":[67,105,149,201,266],"analogs,":[68],"which":[70,162],"a":[71,81,234],"native":[72,142,192,208,269],"sequence":[73],"is":[74],"substituted":[75],"with":[76,80,176,210,246,251],"D-amino":[77],"acids":[78],"linked":[79],"reversed":[82],"backbone,":[83],"resist":[84],"proteolysis":[85],"still":[87],"maintain":[88],"side":[90,224,237],"chain":[91,111,171,238],"topology":[92],"corresponding":[95,183],"natural":[96],"peptide.":[97],"We":[98],"report":[99],"here":[100],"that":[101,229],"an":[102,120,157],"end":[103],"group-modified":[104],"analog":[106,150],"IgG2ab":[109],"heavy":[110],"allopeptide":[112],"determinant":[113,209],"gamma":[114,122],"2ab":[115,123],"435-447":[116],"was":[117],"recognized":[118],"I-Ad-restricted,":[121],"435-447-reactive":[124],"cell":[126,259],"clone.":[127],"The":[128,144],"pseudopeptide":[129,205],"elicited":[130],"near-maximal":[131],"interleukin-2":[132],"responses,":[133],"although":[134],"300-fold":[135],"higher":[136],"concentrations":[137],"were":[138],"needed":[139],"than":[140],"determinant.":[143],"weaker":[145],"antigenicity":[146,198],"could":[151],"be":[152,263],"fully":[153],"accounted":[154],"impaired":[158],"I-Ad":[159,195],"capacity,":[161],"might":[163],"reflect":[164],"reduced":[165],"ability":[166],"distorted":[169],"main":[170],"form":[173],"hydrogen":[174],"bonds":[175],"I-Ad.":[177,240],"Glycine":[178],"substitution":[179],"at":[180],"residue":[182],"first":[186],"primary":[187],"anchor":[188],"(P1)":[189],"abrogated":[194],"analog.":[202],"Thus,":[203],"resembled":[206],"respect":[211],"orientation":[213],"site,":[219],"configuration":[220],"epitopic":[223],"chains,":[225],"constraints":[228],"governed":[230],"interactions":[232],"between":[233],"anchoring":[236],"In":[241],"conclusion,":[242],"proteolytically":[243],"resistant":[244],"compounds":[245],"predefined":[247],"capacity":[248],"interact":[250],"MHC":[252],"allelic":[255],"products":[256],"receptors":[261],"modification":[267],"determinants.":[270]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}