{"id":"https://openalex.org/W2014344801","doi":"https://doi.org/10.1371/journal.pone.0100627","title":"L-Carnitine Prevents Progression of Non-Alcoholic Steatohepatitis in a Mouse Model with Upregulation of Mitochondrial Pathway","display_name":"L-Carnitine Prevents Progression of Non-Alcoholic Steatohepatitis in a Mouse Model with Upregulation of Mitochondrial Pathway","publication_year":2014,"publication_date":"2014-07-01","ids":{"openalex":"https://openalex.org/W2014344801","doi":"https://doi.org/10.1371/journal.pone.0100627","mag":"2014344801","pmid":"https://pubmed.ncbi.nlm.nih.gov/24983359","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4077577"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0100627","doi":"https://doi.org/10.1371/journal.pone.0100627","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0100627","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0100627&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0100627&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hisashi Ishikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisashi Ishikawa","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065713817","display_name":"Akinobu Takaki","orcid":"https://orcid.org/0000-0003-2921-454X","observed_orcids":["https://orcid.org/0000-0003-2921-454X"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Akinobu Takaki","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045471624","display_name":"Ryuichiro Tsuzaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryuichiro Tsuzaki","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046217608","display_name":"Tetsuya Yasunaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuya Yasunaka","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112786411","display_name":"KAZUKO A. KOIKE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuko Koike","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102262641","display_name":"Yasuyuki Shimomura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuyuki Shimomura","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085366598","display_name":"Hiroyuki Seki","orcid":"https://orcid.org/0000-0001-5311-5088","observed_orcids":["https://orcid.org/0000-0001-5311-5088"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Seki","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021398823","display_name":"Hiroshi Matsushita","orcid":"https://orcid.org/0000-0002-8219-9011","observed_orcids":["https://orcid.org/0000-0002-8219-9011"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Matsushita","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yasuhiro Miyake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Miyake","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078325813","display_name":"Fusao Ikeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fusao Ikeda","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038986832","display_name":"Hidenori Shiraha","orcid":"https://orcid.org/0000-0001-5098-8123","observed_orcids":["https://orcid.org/0000-0001-5098-8123"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidenori Shiraha","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028697785","display_name":"Kazuhiro Nouso","orcid":"https://orcid.org/0000-0002-2018-0008","observed_orcids":["https://orcid.org/0000-0002-2018-0008"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiro Nouso","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108401253","display_name":"Kazuhide Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhide Yamamoto","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065713817"],"corresponding_institution_ids":["https://openalex.org/I163770644"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":4.1882,"has_fulltext":true,"cited_by_count":83,"citation_normalized_percentile":{"value":0.95052866,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"9","issue":"7","first_page":"e100627","last_page":"e100627"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-carnitine","display_name":"L-carnitine","score":0.9890000224113464},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":1.0},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7379999756813049},{"id":"https://openalex.org/keywords/mitochondrial-fatty-acid-beta-oxidation","display_name":"mitochondrial beta-oxidation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.7749999761581421},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.5929999947547913},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.875},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.6380000114440918},{"id":"https://openalex.org/keywords/alpha-tocopherol","display_name":"alpha-tocopherol","score":0.8880000114440918},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.796999990940094},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7820000052452087},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.6539999842643738},{"id":"https://openalex.org/keywords/long-chain-fatty-acid-transport","display_name":"long-chain fatty acid transport","score":0.7699999809265137},{"id":"https://openalex.org/keywords/4-hydroxynonenal","display_name":"4-hydroxynonenal","score":0.8450000286102295},{"id":"https://openalex.org/keywords/8-hydroxy-2-deoxyguanosine","display_name":"8-hydroxy-2'-deoxyguanosine","score":0.8479999899864197},{"id":"https://openalex.org/keywords/hepatocyte-apoptosis","display_name":"hepatocyte apoptosis","score":0.3319999873638153}],"concepts":[{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.8467991948127747},{"id":"https://openalex.org/C2778435403","wikidata":"https://www.wikidata.org/wiki/Q243309","display_name":"Carnitine","level":2,"score":0.8186644315719604},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.6840363144874573},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.6332284212112427},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.6023624539375305},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5784858465194702},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5226778388023376},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4679635465145111},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4400201439857483},{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.42670461535453796},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40907877683639526},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.366824746131897},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23391565680503845},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11853769421577454}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002331","descriptor_name":"Carnitine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004041","descriptor_name":"Dietary Fats","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004041","descriptor_name":"Dietary Fats","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014803","descriptor_name":"Vitamin B Complex","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0100627","doi":"https://doi.org/10.1371/journal.pone.0100627","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0100627","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0100627&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3056596","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4077577","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24983359","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24983359","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4077577","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4077577/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:irdb.nii.ac.jp:01081:0000662514","doi":null,"is_oa":true,"landing_page_url":"https://ousar.lib.okayama-u.ac.jp/53141","pdf_url":"https://ousar.lib.okayama-u.ac.jp/files/public/5/53141/20160528121207684029/PLOSONE_9_7_e100627.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE","raw_type":"journal article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.788.9560","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.788.9560","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ab/5d/pone.0100627.PMC4077577.pdf","raw_type":"text"},{"id":"pmh:oai:EPrintsOUDIR.lib.okayama-u.ac.jp:53141","doi":null,"is_oa":true,"landing_page_url":"https://ousar.lib.okayama-u.ac.jp/53141","pdf_url":null,"source":{"id":"https://openalex.org/S4377196325","display_name":"Okayama University Scientific Achievement Repository (Okayama University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I163770644","host_organization_name":"Okayama University","host_organization_lineage":["https://openalex.org/I163770644"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:dad0947e4ac54e0398d5dbc3e85d2bcf","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/dad0947e4ac54e0398d5dbc3e85d2bcf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 7, p e100627 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0100627","doi":"https://doi.org/10.1371/journal.pone.0100627","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0100627","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0100627&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014344801.pdf","grobid_xml":"https://content.openalex.org/works/W2014344801.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W188321927","https://openalex.org/W1842752430","https://openalex.org/W1970096539","https://openalex.org/W1970224691","https://openalex.org/W1970396767","https://openalex.org/W1976053959","https://openalex.org/W1978045299","https://openalex.org/W1980608258","https://openalex.org/W1988495129","https://openalex.org/W1993676495","https://openalex.org/W1996482353","https://openalex.org/W2006999442","https://openalex.org/W2007472273","https://openalex.org/W2018600888","https://openalex.org/W2019369579","https://openalex.org/W2026450587","https://openalex.org/W2032240191","https://openalex.org/W2047470062","https://openalex.org/W2052356187","https://openalex.org/W2052385124","https://openalex.org/W2059932852","https://openalex.org/W2062522914","https://openalex.org/W2062565730","https://openalex.org/W2062812115","https://openalex.org/W2081347924","https://openalex.org/W2090834142","https://openalex.org/W2096155297","https://openalex.org/W2097961562","https://openalex.org/W2098689751","https://openalex.org/W2106061083","https://openalex.org/W2117968100","https://openalex.org/W2121075670","https://openalex.org/W2125504640","https://openalex.org/W2132406938","https://openalex.org/W2144275312","https://openalex.org/W2144404692","https://openalex.org/W2145842201","https://openalex.org/W2157671355","https://openalex.org/W2164394064","https://openalex.org/W2166842799","https://openalex.org/W2253667517"],"related_works":["https://openalex.org/W4394807815","https://openalex.org/W1970224691","https://openalex.org/W3120240619","https://openalex.org/W2951134069","https://openalex.org/W3007593810","https://openalex.org/W2917164250","https://openalex.org/W4411662435","https://openalex.org/W2274467680","https://openalex.org/W2990265167","https://openalex.org/W2078734483"],"abstract_inverted_index":{"Non-alcoholic":[0],"steatohepatitis":[1,254],"(NASH)":[2],"is":[3],"a":[4,37,91,256],"severe":[5],"form":[6],"of":[7,69,81,156,161,184,199,252],"non-alcoholic":[8,253],"fatty":[9,189],"liver":[10,65,216],"disease":[11],"characterized":[12],"by":[13,259],"lobular":[14],"inflammation,":[15],"hepatocellular":[16,29],"ballooning,":[17],"and":[18,28,78,100,118,137,141,146,158,165,171,194,204,209,235,241,264],"fibrosis":[19],"with":[20,113,122,212],"an":[21,50],"inherent":[22],"risk":[23],"for":[24,168,246],"progression":[25,41,251],"to":[26,35,45,63,74,151,187,243],"cirrhosis":[27],"carcinoma":[30],"(HCC).":[31],"Mitochondrial":[32],"dysfunction":[33],"appears":[34],"play":[36],"role":[38],"in":[39,58,83,207,221,224,255],"the":[40,70,76,225,261],"from":[42],"simple":[43],"steatosis":[44],"NASH.":[46],"L-carnitine":[47,82,115,180,213,249],"(L-b-hydroxy-g-N-trimethylaminobutyric":[48],"acid),":[49],"essential":[51],"nutrient":[52],"that":[53],"converts":[54],"fat":[55],"into":[56,96],"energy":[57],"mitochondria,":[59],"has":[60],"been":[61],"shown":[62],"ameliorate":[64],"damage.":[66],"The":[67,174],"aim":[68],"present":[71],"study":[72],"was":[73,177],"explore":[75],"preventive":[77],"therapeutic":[79],"effect":[80],"NASH":[84,222],"model":[85,258],"mice.":[86],"Eight-week-old":[87],"male":[88],"STAM":[89],"mice,":[90],"NASH-cirrhosis-hepatocarcinogenic":[92],"model,":[93],"were":[94,133,139,144,149],"divided":[95],"3":[97],"experimental":[98],"groups":[99],"fed":[101],"as":[102,228],"follows:":[103],"1)":[104],"high-fat":[105],"diet":[106],"(HFD)":[107],"(control":[108],"group);":[109,117],"2)":[110],"HFD":[111,120],"mixed":[112,121],"0.28%":[114],"(L-carnitine":[116],"3)":[119],"0.01%":[123],"\u03b1-tocopherol":[124,219],"(\u03b1-tocopherol":[125],"group).":[126],"After":[127],"4":[128],"or":[129],"8":[130],"weeks,":[131],"mice":[132,210],"sacrificed.":[134],"Blood":[135],"samples":[136],"livers":[138],"collected,":[140],"hepatic":[142,182,200,236],"tumors":[143],"counted":[145],"measured.":[147],"Livers":[148],"subjected":[150],"histological":[152],"study,":[153],"immunohistochemical":[154],"staining":[155],"4-hydroxynonenal":[157],"ferritin,":[159],"determination":[160],"8-OHdG":[162],"levels,":[163],"mRNA":[164],"protein":[166],"expressions":[167],"multiple":[169],"genes,":[170],"metabolomic":[172],"analysis.":[173],"intestinal":[175],"microbiome":[176],"also":[178],"analyzed.":[179],"increased":[181,231],"expression":[183,240],"genes":[185],"related":[186],"long-chain":[188],"acid":[190],"transport,":[191],"mitochondrial":[192,262],"\u03b2-oxidation,":[193],"antioxidant":[195],"enzymes":[196],"following":[197],"suppression":[198],"oxidative":[201],"stress":[202],"markers":[203],"inflammatory":[205],"cytokines":[206],"NASH,":[208],"treated":[211],"developed":[214],"fewer":[215],"tumors.":[217],"Although":[218],"resulted":[220],"improvement":[223],"same":[226],"manner":[227],"L-carnitine,":[229],"it":[230],"periodontitis-related":[232],"microbiotic":[233],"changes":[234],"iron":[237],"transport-related":[238],"gene":[239],"led":[242],"less":[244],"effective":[245],"anti-hepatocarcinogenesis.":[247],"Conclusion:":[248],"prevents":[250],"mouse":[257],"upregulating":[260],"\u03b2-oxidation":[263],"redox":[265],"system.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
