{"id":"https://openalex.org/W2014342802","doi":"https://doi.org/10.1016/j.jpba.2004.02.029","title":"Development of an LC\u2013MS based enzyme activity assay for MurC: application to evaluation of inhibitors and kinetic analysis","display_name":"Development of an LC\u2013MS based enzyme activity assay for MurC: application to evaluation of inhibitors and kinetic analysis","publication_year":2004,"publication_date":"2004-04-13","ids":{"openalex":"https://openalex.org/W2014342802","doi":"https://doi.org/10.1016/j.jpba.2004.02.029","mag":"2014342802","pmid":"https://pubmed.ncbi.nlm.nih.gov/15193726"},"language":"en","primary_location":{"id":"doi:10.1016/j.jpba.2004.02.029","doi":"https://doi.org/10.1016/j.jpba.2004.02.029","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jpba.2004.02.029","pdf_url":null,"source":{"id":"https://openalex.org/S174893293","display_name":"Journal of Pharmaceutical and Biomedical Analysis","issn_l":"0731-7085","issn":["0731-7085","1873-264X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical and Biomedical Analysis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038725344","display_name":"Gejing Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gejing Deng","raw_affiliation_strings":["Infection Discovery, Department of Biochemistry, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA. gejing.deng@astrazeneca.com","Infection Discovery, Department of Biochemistry, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infection Discovery, Department of Biochemistry, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA. gejing.deng@astrazeneca.com","institution_ids":["https://openalex.org/I4210150756"]},{"raw_affiliation_string":"Infection Discovery, Department of Biochemistry, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022205498","display_name":"Rong-Fang Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong-Fang Gu","raw_affiliation_strings":["Infection Discovery, Department of Biochemistry, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infection Discovery, Department of Biochemistry, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079851628","display_name":"Stephen Marmor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Marmor","raw_affiliation_strings":["Infection Discovery, Department of Biochemistry, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infection Discovery, Department of Biochemistry, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046974786","display_name":"Stewart L. Fisher","orcid":"https://orcid.org/0009-0005-5167-5213","observed_orcids":["https://orcid.org/0009-0005-5167-5213"]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stewart L. Fisher","raw_affiliation_strings":["Infection Discovery, Department of Biochemistry, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infection Discovery, Department of Biochemistry, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110044367","display_name":"Haris Jahi\u0107","orcid":"https://orcid.org/0009-0005-3755-8889","observed_orcids":["https://orcid.org/0009-0005-3755-8889"]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haris Jahic","raw_affiliation_strings":["Infection Discovery, Department of Biochemistry, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infection Discovery, Department of Biochemistry, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014345880","display_name":"Gautam Sanyal","orcid":"https://orcid.org/0000-0002-0789-1489","observed_orcids":["https://orcid.org/0000-0002-0789-1489"]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gautam Sanyal","raw_affiliation_strings":["Infection Discovery, Department of Biochemistry, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infection Discovery, Department of Biochemistry, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA","institution_ids":["https://openalex.org/I4210150756"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038725344"],"corresponding_institution_ids":["https://openalex.org/I4210150756"],"apc_list":{"value":3680,"currency":"USD","value_usd":3680},"apc_paid":null,"fwci":2.0573,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.82727395,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"35","issue":"4","first_page":"817","last_page":"828"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.4115999937057495,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.4115999937057495,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.2858999967575073,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.07660000026226044,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/murc","display_name":"MurC","score":0.9520000219345093},{"id":"https://openalex.org/keywords/enzyme-activity-assay","display_name":"enzyme activity assay","score":0.9229999780654907},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.49300000071525574},{"id":"https://openalex.org/keywords/peptidoglycan-synthesis","display_name":"peptidoglycan biosynthesis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8949999809265137},{"id":"https://openalex.org/keywords/false-positive-removal","display_name":"false positive elimination","score":0.6449999809265137},{"id":"https://openalex.org/keywords/enzyme-inhibitors","display_name":"enzyme inhibitors","score":0.5180000066757202},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9342583417892456},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7859182953834534},{"id":"https://openalex.org/C2780704308","wikidata":"https://www.wikidata.org/wiki/Q408815","display_name":"Malachite green","level":3,"score":0.6596107482910156},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5876683592796326},{"id":"https://openalex.org/C51323132","wikidata":"https://www.wikidata.org/wiki/Q626251","display_name":"High-throughput screening","level":2,"score":0.551219642162323},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.5193077921867371},{"id":"https://openalex.org/C64489805","wikidata":"https://www.wikidata.org/wiki/Q873864","display_name":"Liquid chromatography\u2013mass spectrometry","level":3,"score":0.4868023097515106},{"id":"https://openalex.org/C56856141","wikidata":"https://www.wikidata.org/wiki/Q883112","display_name":"Enzyme kinetics","level":4,"score":0.47236043214797974},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.46651044487953186},{"id":"https://openalex.org/C2776634448","wikidata":"https://www.wikidata.org/wiki/Q206920","display_name":"Peptidoglycan","level":3,"score":0.4608649015426636},{"id":"https://openalex.org/C71043704","wikidata":"https://www.wikidata.org/wiki/Q17144692","display_name":"Selected reaction monitoring","level":4,"score":0.44486480951309204},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.43097788095474243},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3944654166698456},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.3880947530269623},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.11630263924598694},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D010453","descriptor_name":"Peptide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jpba.2004.02.029","doi":"https://doi.org/10.1016/j.jpba.2004.02.029","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jpba.2004.02.029","pdf_url":null,"source":{"id":"https://openalex.org/S174893293","display_name":"Journal of Pharmaceutical and Biomedical Analysis","issn_l":"0731-7085","issn":["0731-7085","1873-264X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical and Biomedical Analysis","raw_type":"journal-article"},{"id":"pmid:15193726","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15193726","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmaceutical and biomedical analysis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1981674561","https://openalex.org/W1991909685","https://openalex.org/W1993934748","https://openalex.org/W2006128804","https://openalex.org/W2022703044","https://openalex.org/W2029584311","https://openalex.org/W2037622735","https://openalex.org/W2038019632","https://openalex.org/W2042760000","https://openalex.org/W2057251269","https://openalex.org/W2085827150","https://openalex.org/W2090361869","https://openalex.org/W2091277482","https://openalex.org/W2091498910","https://openalex.org/W2093448775","https://openalex.org/W2110921177","https://openalex.org/W2148961076","https://openalex.org/W2398997448","https://openalex.org/W2408873636","https://openalex.org/W2949699102","https://openalex.org/W4245778084","https://openalex.org/W4254333536"],"related_works":["https://openalex.org/W2961628186","https://openalex.org/W2158768415","https://openalex.org/W2169657688","https://openalex.org/W2080841125","https://openalex.org/W2075380110","https://openalex.org/W2126358172","https://openalex.org/W2090361869","https://openalex.org/W2138395382","https://openalex.org/W893743789","https://openalex.org/W2074297096"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
