{"id":"https://openalex.org/W2014339999","doi":"https://doi.org/10.1186/1741-7015-9-28","title":"Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer","display_name":"Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer","publication_year":2011,"publication_date":"2011-03-26","ids":{"openalex":"https://openalex.org/W2014339999","doi":"https://doi.org/10.1186/1741-7015-9-28","mag":"2014339999","pmid":"https://pubmed.ncbi.nlm.nih.gov/21439080"},"language":"en","primary_location":{"id":"doi:10.1186/1741-7015-9-28","doi":"https://doi.org/10.1186/1741-7015-9-28","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1741-7015-9-28","pdf_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/1741-7015-9-28","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/1741-7015-9-28","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037022718","display_name":"Callinice D. Capo\u2010chichi","orcid":"https://orcid.org/0000-0003-4941-7301","observed_orcids":["https://orcid.org/0000-0003-4941-7301"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Callinice D Capo-chichi","raw_affiliation_strings":["Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA","Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"]},{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079001775","display_name":"Kathy Qi Cai","orcid":"https://orcid.org/0000-0002-6034-3377","observed_orcids":["https://orcid.org/0000-0002-6034-3377"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathy Q Cai","raw_affiliation_strings":["Ovarian Cancer Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA","Ovarian Cancer Program, Fox Chase Cancer Center, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ovarian Cancer Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Ovarian Cancer Program, Fox Chase Cancer Center, Philadelphia, USA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034050457","display_name":"Fiona A. Simpkins","orcid":"https://orcid.org/0000-0002-0840-2368","observed_orcids":["https://orcid.org/0000-0002-0840-2368"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fiona Simpkins","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA","Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, 33136, USA","Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, 33136, USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"]},{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074778600","display_name":"Parvin Ganjei\u2010Azar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parvin Ganjei-Azar","raw_affiliation_strings":["Department of Pathology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA","Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, 33136, USA","Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, 33136, USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"]},{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033625395","display_name":"Andrew K. Godwin","orcid":"https://orcid.org/0000-0002-3987-9580","observed_orcids":["https://orcid.org/0000-0002-3987-9580"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew K Godwin","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA","Ovarian Cancer Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA","Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, USA","Ovarian Cancer Program, Fox Chase Cancer Center, Philadelphia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Ovarian Cancer Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, USA","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Ovarian Cancer Program, Fox Chase Cancer Center, Philadelphia, USA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110184359","display_name":"Xiang\u2010Xi Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiang-Xi Xu","raw_affiliation_strings":["Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, 33136, USA","Department of Obstetrics and Gynecology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA","Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, 33136, USA","Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, 33136, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, 33136, USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"]},{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5110184359"],"corresponding_institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":1.7639,"has_fulltext":true,"cited_by_count":99,"citation_normalized_percentile":{"value":0.84013997,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"28","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.828000009059906},{"id":"https://openalex.org/keywords/lamin-a-c","display_name":"lamin A/C","score":0.9760000109672546},{"id":"https://openalex.org/keywords/nuclear-envelope","display_name":"nuclear envelope","score":0.7960000038146973},{"id":"https://openalex.org/keywords/nuclear-lamina","display_name":"nuclear lamina","score":0.8560000061988831},{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.9279999732971191},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.9330000281333923},{"id":"https://openalex.org/keywords/nuclear-morphology","display_name":"nuclear morphology","score":0.9480000138282776},{"id":"https://openalex.org/keywords/ovarian-surface-epithelial-cells","display_name":"ovarian surface epithelial cells","score":0.9480000138282776},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8659999966621399},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hallmarks-of-cancer","display_name":"cancer hallmarks","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C179093185","wikidata":"https://www.wikidata.org/wiki/Q424506","display_name":"Lamin","level":3,"score":0.89043790102005},{"id":"https://openalex.org/C94912109","wikidata":"https://www.wikidata.org/wiki/Q687194","display_name":"Nuclear lamina","level":5,"score":0.7691162824630737},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6354822516441345},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6036276817321777},{"id":"https://openalex.org/C2779672484","wikidata":"https://www.wikidata.org/wiki/Q529622","display_name":"Aneuploidy","level":4,"score":0.5948284864425659},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5946367383003235},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5762483477592468},{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.5539268851280212},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5169100761413574},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49933338165283203},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48862582445144653},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.4819771647453308},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.47844886779785156},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.346300333738327},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.24920767545700073},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24235424399375916},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.19625288248062134},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1513161063194275},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.08436980843544006},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000782","descriptor_name":"Aneuploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000782","descriptor_name":"Aneuploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000782","descriptor_name":"Aneuploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009685","descriptor_name":"Nuclear Envelope","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009685","descriptor_name":"Nuclear Envelope","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009685","descriptor_name":"Nuclear Envelope","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009685","descriptor_name":"Nuclear Envelope","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009685","descriptor_name":"Nuclear Envelope","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009685","descriptor_name":"Nuclear Envelope","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034904","descriptor_name":"Lamin Type A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D034904","descriptor_name":"Lamin Type A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D034904","descriptor_name":"Lamin Type A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1741-7015-9-28","doi":"https://doi.org/10.1186/1741-7015-9-28","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1741-7015-9-28","pdf_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/1741-7015-9-28","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},{"id":"pmid:21439080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21439080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medicine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2083437","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3072346","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3072346","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3072346","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e8bab66187484d9ea60526c24d388b57","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e8bab66187484d9ea60526c24d388b57","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medicine, Vol 9, Iss 1, p 28 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1741-7015-9-28","doi":"https://doi.org/10.1186/1741-7015-9-28","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1741-7015-9-28","pdf_url":"https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/1741-7015-9-28","source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7799999713897705,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2117686485","display_name":null,"funder_award_id":"CA79716","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2737981367","display_name":"Exploiting Biological Networks to Improve Clinical Treatment of Ovarian Cancer","funder_award_id":"R01CA140323","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G296135677","display_name":null,"funder_award_id":"P50 CA83638","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6865111213","display_name":null,"funder_award_id":"R01 CA079716","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G818408268","display_name":null,"funder_award_id":"R01 CA095071","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8393222994","display_name":"Gonadotropins & Cox-2 in Ovarian Cancer Prevention","funder_award_id":"R01CA099471","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309249","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014339999.pdf","grobid_xml":"https://content.openalex.org/works/W2014339999.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1487741670","https://openalex.org/W1583265575","https://openalex.org/W1665551917","https://openalex.org/W1823005638","https://openalex.org/W1961928411","https://openalex.org/W1965505970","https://openalex.org/W1965773410","https://openalex.org/W1966171454","https://openalex.org/W1966669440","https://openalex.org/W1974113446","https://openalex.org/W1975423001","https://openalex.org/W1975488723","https://openalex.org/W1983533553","https://openalex.org/W1984542357","https://openalex.org/W1987557545","https://openalex.org/W1988049837","https://openalex.org/W2003111937","https://openalex.org/W2003719123","https://openalex.org/W2005554180","https://openalex.org/W2009306385","https://openalex.org/W2009985804","https://openalex.org/W2010399610","https://openalex.org/W2017046792","https://openalex.org/W2017408894","https://openalex.org/W2017926450","https://openalex.org/W2021588766","https://openalex.org/W2022542106","https://openalex.org/W2025849091","https://openalex.org/W2034619620","https://openalex.org/W2036379096","https://openalex.org/W2045802318","https://openalex.org/W2046109468","https://openalex.org/W2052373675","https://openalex.org/W2053206914","https://openalex.org/W2058265440","https://openalex.org/W2059909908","https://openalex.org/W2062214822","https://openalex.org/W2070863960","https://openalex.org/W2072308003","https://openalex.org/W2072810104","https://openalex.org/W2074548008","https://openalex.org/W2077268181","https://openalex.org/W2079092579","https://openalex.org/W2085308158","https://openalex.org/W2092549115","https://openalex.org/W2094806530","https://openalex.org/W2102502996","https://openalex.org/W2102766053","https://openalex.org/W2108356291","https://openalex.org/W2110781930","https://openalex.org/W2111605690","https://openalex.org/W2113791211","https://openalex.org/W2119208710","https://openalex.org/W2119932131","https://openalex.org/W2124944508","https://openalex.org/W2136490523","https://openalex.org/W2138359752","https://openalex.org/W2138591519","https://openalex.org/W2140950011","https://openalex.org/W2141365953","https://openalex.org/W2145283260","https://openalex.org/W2151022113","https://openalex.org/W2154457084","https://openalex.org/W2160224424","https://openalex.org/W3035130918","https://openalex.org/W4212835986"],"related_works":["https://openalex.org/W3048691952","https://openalex.org/W4241001882","https://openalex.org/W1971934332","https://openalex.org/W2065776621","https://openalex.org/W2029188803","https://openalex.org/W4387442799","https://openalex.org/W1483522171","https://openalex.org/W2149467639","https://openalex.org/W2152859477","https://openalex.org/W2427881106"],"abstract_inverted_index":{"BACKGROUND:":[0],"Despite":[1],"our":[2],"substantial":[3],"understanding":[4],"of":[5,21,29,44,47,58,67,76,87,109,125,164,201,212,228,244,257,269,281,284],"molecular":[6,80],"mechanisms":[7],"and":[8,19,49,55,95,121,155,186,242,289],"gene":[9],"mutations":[10],"involved":[11],"in":[12,98,116,131,138,157,182,189,231,286],"cancer,":[13,30,193],"the":[14,31,45,59,63,79,93,107,110,123,165,194,199,213,222,258,267,282],"technical":[15],"approaches":[16],"for":[17],"diagnosis":[18,28],"prognosis":[20],"cancer":[22,68,89,118,184,206],"are":[23,100,178],"limited.":[24],"In":[25,204],"routine":[26],"clinical":[27],"procedure":[32],"is":[33,38,70,90,196],"very":[34],"basic:":[35],"nuclear":[36,65,111,146,173,270,287],"morphology":[37,66,288],"used":[39,141],"as":[40,52,275],"a":[41,53,74,209,254],"common":[42,85],"assessment":[43],"degree":[46],"malignancy,":[48],"hence":[50],"acts":[51],"prognostic":[54],"predictive":[56],"indicator":[57],"disease.":[60],"Furthermore,":[61],"though":[62],"atypical":[64],"cells":[69,137,185,237,248],"believed":[71],"to":[72,144,150,160,219,239,253],"be":[73],"consequence":[75,124],"oncogenic":[77],"signaling,":[78],"basis":[81],"remains":[82],"unclear.":[83],"Another":[84],"characteristic":[86],"human":[88,133],"aneuploidy,":[91],"but":[92],"causes":[94],"its":[96],"role":[97],"carcinogenesis":[99],"not":[101],"well":[102],"established.":[103],"METHODS:":[104],"We":[105,140,170,264],"investigated":[106],"expression":[108,195],"envelope":[112,271],"proteins":[113,175],"lamin":[114,126,166,176,190,214,223,229,276],"A/C":[115,127,177,230],"ovarian":[117,134,183,192,234],"by":[119],"immunohistochemistry":[120],"studied":[122],"suppression":[128],"using":[129],"siRNA":[130],"primary":[132,233],"surface":[135,235],"epithelial":[136,236],"culture.":[139],"immunofluorescence":[142],"microscopy":[143],"analyze":[145,151],"morphology,":[147],"flow":[148],"cytometry":[149],"cellular":[152],"DNA":[153],"content,":[154],"fluorescence":[156],"situ":[158],"hybridization":[159],"examine":[161],"cell":[162,207,259],"ploidy":[163],"A/C-suppressed":[167],"cells.":[168,203,225],"RESULTS:":[169],"found":[171],"that":[172,266],"lamina":[174],"often":[179],"absent":[180],"(47%)":[181],"tissues.":[187],"Even":[188],"A/C-positive":[191,224],"heterogeneous":[197],"within":[198],"population":[200,216],"tumor":[202],"most":[205],"lines,":[208],"significant":[210],"fraction":[211],"A/C-negative":[215],"was":[217],"observed":[218],"intermix":[220],"with":[221],"Down":[226],"regulation":[227],"non-cancerous":[232],"led":[238],"morphological":[240],"deformation":[241],"development":[243],"aneuploidy.":[245,290],"The":[246],"aneuploid":[247],"became":[249],"growth":[250],"retarded":[251],"due":[252],"p53-dependent":[255],"induction":[256],"cycle":[260],"inhibitor":[261],"p21.":[262],"CONCLUSIONS:":[263],"conclude":[265],"loss":[268],"structural":[272],"proteins,":[273],"such":[274],"A/C,":[277],"may":[278],"underlie":[279],"two":[280],"hallmarks":[283],"cancer--aberrations":[285]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
