{"id":"https://openalex.org/W2014338584","doi":"https://doi.org/10.1074/jbc.m110.210757","title":"Compromised Myocardial Energetics in Hypertrophied Mouse Hearts Diminish the Beneficial Effect of Overexpressing SERCA2a","display_name":"Compromised Myocardial Energetics in Hypertrophied Mouse Hearts Diminish the Beneficial Effect of Overexpressing SERCA2a","publication_year":2011,"publication_date":"2011-01-30","ids":{"openalex":"https://openalex.org/W2014338584","doi":"https://doi.org/10.1074/jbc.m110.210757","mag":"2014338584","pmid":"https://pubmed.ncbi.nlm.nih.gov/21278384","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3060468"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m110.210757","doi":"https://doi.org/10.1074/jbc.m110.210757","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.210757","pdf_url":"http://www.jbc.org/article/S0021925820538404/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820538404/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081361228","display_name":"Ilka M. Pinz","orcid":"https://orcid.org/0000-0002-9064-8649","observed_orcids":["https://orcid.org/0000-0002-9064-8649"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ilka Pinz","raw_affiliation_strings":["NMR Laboratory for Physiological Chemistry, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. pinzi@mmc.org","NMR Laboratory for Physiological Chemistry, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NMR Laboratory for Physiological Chemistry, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. pinzi@mmc.org","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"NMR Laboratory for Physiological Chemistry, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029700686","display_name":"Rong Tian","orcid":"https://orcid.org/0000-0002-3676-3830","observed_orcids":["https://orcid.org/0000-0002-3676-3830"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Tian","raw_affiliation_strings":["From the NMR Laboratory for Physiological Chemistry, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the NMR Laboratory for Physiological Chemistry, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115 and","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036991580","display_name":"Darrell D. Belke","orcid":"https://orcid.org/0009-0002-4418-7201","observed_orcids":["https://orcid.org/0009-0002-4418-7201"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darrell Belke","raw_affiliation_strings":["the Division of Endocrine and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Division of Endocrine and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California 92093","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Eric Swanson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Swanson","raw_affiliation_strings":["the Division of Endocrine and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Division of Endocrine and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California 92093","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029880524","display_name":"WOLFGANG H. DILLMANN","orcid":"https://orcid.org/0000-0003-0361-6946","observed_orcids":["https://orcid.org/0000-0003-0361-6946"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wolfgang Dillmann","raw_affiliation_strings":["the Division of Endocrine and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Division of Endocrine and Metabolism, Department of Medicine, University of California San Diego, La Jolla, California 92093","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057568972","display_name":"Joanne S. Ingwall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanne S. Ingwall","raw_affiliation_strings":["From the NMR Laboratory for Physiological Chemistry, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the NMR Laboratory for Physiological Chemistry, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115 and","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081361228"],"corresponding_institution_ids":["https://openalex.org/I1283280774"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.5084,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.95152057,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"286","issue":"12","first_page":"10163","last_page":"10168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.5156000256538391,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.5156000256538391,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.33009999990463257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0957999974489212,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serca2a","display_name":"SERCA2a","score":0.996999979019165},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.8159999847412109},{"id":"https://openalex.org/keywords/myocardial-energy-metabolism","display_name":"myocardial energy metabolism","score":0.8190000057220459},{"id":"https://openalex.org/keywords/calcium-handling","display_name":"calcium handling","score":0.675000011920929},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.7760000228881836},{"id":"https://openalex.org/keywords/pressure-overload","display_name":"pressure overload","score":0.7599999904632568},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.7059999704360962},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.6629999876022339},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.5059999823570251},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.746999979019165},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C2781414619","wikidata":"https://www.wikidata.org/wiki/Q24785512","display_name":"SERCA","level":4,"score":0.9291346073150635},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7928191423416138},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.6764508485794067},{"id":"https://openalex.org/C155710745","wikidata":"https://www.wikidata.org/wiki/Q575278","display_name":"Inotrope","level":2,"score":0.6476719975471497},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6038200259208679},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.5965520143508911},{"id":"https://openalex.org/C2778271984","wikidata":"https://www.wikidata.org/wiki/Q17126794","display_name":"Pressure overload","level":4,"score":0.5159319043159485},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4974401295185089},{"id":"https://openalex.org/C17137333","wikidata":"https://www.wikidata.org/wiki/Q410105","display_name":"Phospholamban","level":3,"score":0.48602062463760376},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39735662937164307},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3530488908290863},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.32819628715515137},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27782243490219116},{"id":"https://openalex.org/C3018791406","wikidata":"https://www.wikidata.org/wiki/Q945225","display_name":"Cardiac hypertrophy","level":3,"score":0.14441823959350586},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08689078688621521},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019906","descriptor_name":"Nuclear Magnetic Resonance, Biomolecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053498","descriptor_name":"Sarcoplasmic Reticulum Calcium-Transporting ATPases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D053498","descriptor_name":"Sarcoplasmic Reticulum Calcium-Transporting ATPases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m110.210757","doi":"https://doi.org/10.1074/jbc.m110.210757","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.210757","pdf_url":"http://www.jbc.org/article/S0021925820538404/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2317078","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3060468","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3060468","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3060468","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:21278384","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21278384","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m110.210757","doi":"https://doi.org/10.1074/jbc.m110.210757","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m110.210757","pdf_url":"http://www.jbc.org/article/S0021925820538404/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014338584.pdf","grobid_xml":"https://content.openalex.org/works/W2014338584.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W105678245","https://openalex.org/W1964522609","https://openalex.org/W1989463892","https://openalex.org/W2047350415","https://openalex.org/W2048303185","https://openalex.org/W2048867275","https://openalex.org/W2055117340","https://openalex.org/W2057994632","https://openalex.org/W2059769358","https://openalex.org/W2078612430","https://openalex.org/W2089676520","https://openalex.org/W2097216911","https://openalex.org/W2102780353","https://openalex.org/W2103446573","https://openalex.org/W2107590406","https://openalex.org/W2116483248","https://openalex.org/W2118089140","https://openalex.org/W2123177072","https://openalex.org/W2126308098","https://openalex.org/W2144792784","https://openalex.org/W2161120104","https://openalex.org/W2272825298","https://openalex.org/W2284015878","https://openalex.org/W2414462737"],"related_works":["https://openalex.org/W2025096909","https://openalex.org/W2087796811","https://openalex.org/W2106040905","https://openalex.org/W2097216911","https://openalex.org/W2144792784","https://openalex.org/W2064581526","https://openalex.org/W7099722681","https://openalex.org/W2095980208","https://openalex.org/W2048411336","https://openalex.org/W2078612430"],"abstract_inverted_index":{"The":[0],"sarcoplasmic":[1],"reticulum":[2],"calcium":[3],"ATPase":[4,67],"(SERCA)":[5],"plays":[6],"a":[7,43,65,229],"central":[8],"role":[9],"in":[10,25,34,49,85,138,154,161,173,184,187,205,213,238],"regulating":[11],"intracellular":[12],"Ca(2+)":[13,23],"homeostasis":[14],"and":[15,52,97,104,136,176],"myocardial":[16,83,134],"contractility.":[17],"Several":[18],"studies":[19],"show":[20],"that":[21,40,130,224],"improving":[22],"handling":[24],"hypertrophied":[26,239],"rodent":[27],"hearts":[28,87,100,141,186,209],"by":[29],"increasing":[30,82,158,247],"SERCA":[31,41,75,113,203,236,248],"activity":[32,249],"results":[33,222],"enhanced":[35,167],"contractile":[36,155],"function.":[37,156],"This":[38],"suggests":[39],"is":[42],"potential":[44],"target":[45],"for":[46,232,255],"gene":[47],"therapy":[48],"cardiac":[50,110],"hypertrophy":[51,90,123],"failure.":[53,257],"However,":[54,178],"it":[55],"raises":[56],"the":[57,78,109,152,162,189,195,200,233,252],"issue":[58],"of":[59,81,112,197,202,235],"increased":[60],"energy":[61,79,174,225],"cost":[62,80],"resulting":[63],"from":[64,101],"higher":[66],"activity.":[68],"In":[69],"this":[70,179],"study,":[71],"we":[72],"determined":[73],"whether":[74],"overexpression":[76,196,237],"alters":[77],"contraction":[84,135],"mouse":[86,99,140],"with":[88,145,170,218,246],"pressure-overload":[89],"using":[91],"(31)P":[92],"NMR":[93],"spectroscopy.":[94],"We":[95,128],"isolated":[96],"perfused":[98],"wild-type":[102],"(WT)":[103],"transgenic":[105],"(TG)":[106],"mice":[107],"overexpressing":[108,131],"isoform":[111],"(SERCA2a)":[114],"8":[115],"weeks":[116],"after":[117],"ascending":[118],"aortic":[119],"constriction":[120],"(left":[121],"ventricular":[122],"(LVH))":[124],"or":[125],"sham":[126],"operation.":[127],"found":[129],"SERCA2a":[132,159,198],"enhances":[133],"relaxation":[137],"normal":[139,163],"during":[142],"inotropic":[143,168,214],"stimulation":[144],"isoproterenol.":[146],"Energy":[147],"consumption":[148],"was":[149,181,192],"proportionate":[150],"to":[151],"increase":[153,212],"Thus,":[157,241],"expression":[160],"heart":[164,256],"allows":[165],"an":[166],"response":[169,215],"no":[171,211],"compromise":[172],"supply":[175,226],"demand.":[177],"advantage":[180],"not":[182],"sustained":[183],"LVH":[185,206],"which":[188],"energetic":[190,244],"status":[191],"compromised.":[193],"Although":[194],"prevented":[199],"down-regulation":[201],"protein":[204],"hearts,":[207],"TG-LVH":[208],"showed":[210],"when":[216],"compared":[217],"WT-LVH":[219],"hearts.":[220,240],"Our":[221],"suggest":[223],"may":[227,250],"be":[228],"limiting":[230],"factor":[231],"benefit":[234],"strategies":[242],"combining":[243],"support":[245],"improve":[251],"therapeutic":[253],"effectiveness":[254]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}