{"id":"https://openalex.org/W2014334266","doi":"https://doi.org/10.1097/00000542-200502000-00014","title":"Human Kidneys Play an Important Role in the Elimination of Propofol","display_name":"Human Kidneys Play an Important Role in the Elimination of Propofol","publication_year":2005,"publication_date":"2005-01-19","ids":{"openalex":"https://openalex.org/W2014334266","doi":"https://doi.org/10.1097/00000542-200502000-00014","mag":"2014334266","pmid":"https://pubmed.ncbi.nlm.nih.gov/15681947"},"language":"en","primary_location":{"id":"doi:10.1097/00000542-200502000-00014","doi":"https://doi.org/10.1097/00000542-200502000-00014","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00000542-200502000-00014","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/102/2/327/357292/0000542-200502000-00014.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pubs.asahq.org/anesthesiology/article-pdf/102/2/327/357292/0000542-200502000-00014.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089169196","display_name":"Daisuke Takizawa","orcid":"https://orcid.org/0000-0002-2004-8285","observed_orcids":["https://orcid.org/0000-0002-2004-8285"]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Takizawa","raw_affiliation_strings":["Instructor Anesthetist, Departments of Anesthesiology and Clinical Pharmacology","Department of Anesthesiology and Clinical Pharmacology, Graduate School of Medicine, Gunma University, Maebashi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instructor Anesthetist, Departments of Anesthesiology and Clinical Pharmacology","institution_ids":[]},{"raw_affiliation_string":"Department of Anesthesiology and Clinical Pharmacology, Graduate School of Medicine, Gunma University, Maebashi, Japan","institution_ids":["https://openalex.org/I165735259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049819464","display_name":"Haruhiko Hiraoka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haruhiko Hiraoka","raw_affiliation_strings":["Instructor Anesthetist"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instructor Anesthetist","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111672513","display_name":"Fumio Goto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fumio Goto","raw_affiliation_strings":["Professor, Department of Anesthesiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor, Department of Anesthesiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100866790","display_name":"Koujirou Yamamoto","orcid":"https://orcid.org/0009-0005-3746-0232","observed_orcids":["https://orcid.org/0009-0005-3746-0232"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koujirou Yamamoto","raw_affiliation_strings":["Assistant Professor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026529233","display_name":"Ryuya Horiuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165735259","display_name":"Gunma University","ror":"https://ror.org/046fm7598","country_code":"JP","type":"education","lineage":["https://openalex.org/I165735259"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryuya Horiuchi","raw_affiliation_strings":["Professor, Department of Clinical Pharmacology, Graduate School of Medicine, Gunma University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor, Department of Clinical Pharmacology, Graduate School of Medicine, Gunma University","institution_ids":["https://openalex.org/I165735259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.697,"has_fulltext":true,"cited_by_count":82,"citation_normalized_percentile":{"value":0.97187767,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"102","issue":"2","first_page":"327","last_page":"330"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propofol","display_name":"propofol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/renal-clearance","display_name":"renal clearance","score":0.7799999713897705},{"id":"https://openalex.org/keywords/para-aminohippurate","display_name":"para-aminohippurate","score":0.781000018119812},{"id":"https://openalex.org/keywords/renal-blood-flow","display_name":"renal blood flow","score":0.7549999952316284},{"id":"https://openalex.org/keywords/total-body-clearance","display_name":"body clearance","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.9802083373069763},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8785253763198853},{"id":"https://openalex.org/C142225936","wikidata":"https://www.wikidata.org/wiki/Q1129139","display_name":"Renal blood flow","level":3,"score":0.6186974048614502},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5796107053756714},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.5263458490371704},{"id":"https://openalex.org/C2778218979","wikidata":"https://www.wikidata.org/wiki/Q662857","display_name":"Radial artery","level":3,"score":0.4863162934780121},{"id":"https://openalex.org/C2779537118","wikidata":"https://www.wikidata.org/wiki/Q618362","display_name":"Arterial blood","level":2,"score":0.47756296396255493},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.41241899132728577},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.34413665533065796},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24379485845565796},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.21454468369483948}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015742","descriptor_name":"Propofol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015742","descriptor_name":"Propofol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/00000542-200502000-00014","doi":"https://doi.org/10.1097/00000542-200502000-00014","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00000542-200502000-00014","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/102/2/327/357292/0000542-200502000-00014.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:15681947","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15681947","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Journal Article"},{"id":"mag:2292482747","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/500000356153?l=ja","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1097/00000542-200502000-00014","doi":"https://doi.org/10.1097/00000542-200502000-00014","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00000542-200502000-00014","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/102/2/327/357292/0000542-200502000-00014.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014334266.pdf","grobid_xml":"https://content.openalex.org/works/W2014334266.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1982806204","https://openalex.org/W1985963215","https://openalex.org/W1990424351","https://openalex.org/W2003770023","https://openalex.org/W2011315882","https://openalex.org/W2026270269","https://openalex.org/W2031370653","https://openalex.org/W2045483577","https://openalex.org/W2051029221","https://openalex.org/W2060357972","https://openalex.org/W2070469839","https://openalex.org/W2084943479","https://openalex.org/W2113613939","https://openalex.org/W2134833122","https://openalex.org/W2147184595","https://openalex.org/W2150466610","https://openalex.org/W2162247848"],"related_works":["https://openalex.org/W2063074191","https://openalex.org/W2104794323","https://openalex.org/W2073300947","https://openalex.org/W7065954297","https://openalex.org/W1967044677","https://openalex.org/W2116863602","https://openalex.org/W2129466787","https://openalex.org/W149285678","https://openalex.org/W1990424351","https://openalex.org/W20087341"],"abstract_inverted_index":{"BACKGROUND:":[0],"Extrahepatic":[1],"clearance":[2,12,28,41,173],"of":[3,29,42,47,108,153,162,174,191,205],"propofol":[4,58,89,109,120,154,163,175],"has":[5],"been":[6],"suggested":[7],"because":[8],"its":[9],"total":[10,192],"body":[11,193],"exceeds":[13],"hepatic":[14],"blood":[15,75,118],"flow.":[16],"However,":[17],"it":[18],"remains":[19],"uncertain":[20],"which":[21],"organs":[22],"are":[23],"involved":[24],"in":[25,57,60,71,103,130,202],"the":[26,36,40,131,139,146,150,203],"extrahepatic":[27],"propofol.":[30,206],"In":[31],"vitro":[32],"studies":[33],"suggest":[34],"that":[35],"kidneys":[37,55,197],"contribute":[38],"to":[39,51,66],"this":[43,48,72],"drug.":[44],"The":[45,134,158,171],"purpose":[46],"study":[49],"was":[50,77,82,124,155,164,176],"confirm":[52],"whether":[53],"human":[54],"participate":[56],"disposition":[59],"vivo.":[61],"METHODS:":[62],"Ten":[63],"patients":[64],"scheduled":[65],"undergo":[67],"nephrectomy":[68],"were":[69,143],"enrolled":[70],"study.":[73],"Renal":[74],"flow":[76],"measured":[78],"using":[79],"para-aminohippurate.":[80],"Anesthesia":[81],"induced":[83],"with":[84,95],"vecuronium":[85],"(0.1":[86],"mg/kg)":[87,91],"and":[88,92,105,121,138],"(2":[90,110],"then":[93],"maintained":[94],"nitrous":[96],"oxide":[97],"(60%),":[98],"sevoflurane":[99],"(1":[100],"approximately":[101],"2%)":[102],"oxygen,":[104],"an":[106,199],"infusion":[107],"mg":[111],".":[112,114],"kg":[113],"h).":[115],"Radial":[116],"arterial":[117,141],"for":[119],"para-aminohippurate":[122],"analysis":[123],"collected":[125],"from":[126],"a":[127],"cannula":[128],"inserted":[129],"radial":[132,140],"artery.":[133],"renal":[135,159,172],"venous":[136],"sample":[137,142],"obtained":[144],"at":[145],"same":[147],"time":[148],"after":[149],"steady":[151],"state":[152],"established.":[156],"RESULTS:":[157],"extraction":[160],"ratio":[161],"0.58":[165],"+/-":[166,169,178,182,186,189],"0.15":[167,179],"(mean":[168,181,188],"SD).":[170],"0.41":[177],"l/min":[180],"SD),":[183],"or":[184],"27":[185],"9.9%":[187],"SD)":[190],"clearance.":[194],"CONCLUSION:":[195],"Human":[196],"play":[198],"important":[200],"role":[201],"elimination":[204]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}