{"id":"https://openalex.org/W2014310871","doi":"https://doi.org/10.1002/cmdc.201500100","title":"Aryloxyethyl Thiocyanates Are Potent Growth Inhibitors of Trypanosoma cruzi and Toxoplasma gondii","display_name":"Aryloxyethyl Thiocyanates Are Potent Growth Inhibitors of Trypanosoma cruzi and Toxoplasma gondii","publication_year":2015,"publication_date":"2015-04-27","ids":{"openalex":"https://openalex.org/W2014310871","doi":"https://doi.org/10.1002/cmdc.201500100","mag":"2014310871","pmid":"https://pubmed.ncbi.nlm.nih.gov/25914175","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4447534"},"language":"en","primary_location":{"id":"doi:10.1002/cmdc.201500100","doi":"https://doi.org/10.1002/cmdc.201500100","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.201500100","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11336/31544","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022431062","display_name":"Mar\u00eda N. Chao","orcid":"https://orcid.org/0000-0003-4222-2093","observed_orcids":["https://orcid.org/0000-0003-4222-2093"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Mar\u00eda N. Chao","raw_affiliation_strings":["Departamento de Qu\u00edmica Org\u00e1nica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n\u20052, Ciudad Universitaria, C1428EHA, Buenos Aires (Argentina)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n\u20052, Ciudad Universitaria, C1428EHA, Buenos Aires (Argentina)","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008613258","display_name":"Carolina Exeni Matiuzzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Carolina Exeni Matiuzzi","raw_affiliation_strings":["Departamento de Qu\u00edmica Org\u00e1nica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n\u20052, Ciudad Universitaria, C1428EHA, Buenos Aires (Argentina)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n\u20052, Ciudad Universitaria, C1428EHA, Buenos Aires (Argentina)","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042834568","display_name":"Melissa Storey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Storey","raw_affiliation_strings":["Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA, 30602 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA, 30602 (USA)","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101726101","display_name":"Catherine Li","orcid":"https://orcid.org/0000-0002-1579-649X","observed_orcids":["https://orcid.org/0000-0002-1579-649X"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Li","raw_affiliation_strings":["Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA, 30602 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA, 30602 (USA)","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080749101","display_name":"Sergio H. Szajnman","orcid":"https://orcid.org/0000-0001-6989-4768","observed_orcids":["https://orcid.org/0000-0001-6989-4768"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Sergio H. Szajnman","raw_affiliation_strings":["Departamento de Qu\u00edmica Org\u00e1nica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n\u20052, Ciudad Universitaria, C1428EHA, Buenos Aires (Argentina)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n\u20052, Ciudad Universitaria, C1428EHA, Buenos Aires (Argentina)","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000842323","display_name":"Roberto Docampo","orcid":"https://orcid.org/0000-0003-4229-8784","observed_orcids":["https://orcid.org/0000-0003-4229-8784"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roberto Docampo","raw_affiliation_strings":["Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA, 30602 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA, 30602 (USA)","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032324284","display_name":"Silvia N.J. Moreno","orcid":"https://orcid.org/0000-0002-2041-6295","observed_orcids":["https://orcid.org/0000-0002-2041-6295"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Silvia N. J. Moreno","raw_affiliation_strings":["Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA, 30602 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, GA, 30602 (USA)","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060367228","display_name":"Juan B. Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-5180-096X","observed_orcids":["https://orcid.org/0000-0002-5180-096X"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Juan B. Rodriguez","raw_affiliation_strings":["Departamento de Qu\u00edmica Org\u00e1nica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n\u20052, Ciudad Universitaria, C1428EHA, Buenos Aires (Argentina). jbr@qo.fcen.uba.ar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica and UMYMFOR (CONICET-FCEyN), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabell\u00f3n\u20052, Ciudad Universitaria, C1428EHA, Buenos Aires (Argentina). jbr@qo.fcen.uba.ar","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060367228"],"corresponding_institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.4393,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.81138367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":"6","first_page":"1094","last_page":"1108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.02250000089406967,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trypanosoma-cruzi","display_name":"Trypanosoma cruzi","score":0.9290000200271606},{"id":"https://openalex.org/keywords/toxoplasma-gondii","display_name":"Toxoplasma gondii","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antiparasitic-drugs","display_name":"antiparasitic drugs","score":0.9079999923706055},{"id":"https://openalex.org/keywords/chagas-disease","display_name":"Chagas disease","score":0.9190000295639038},{"id":"https://openalex.org/keywords/toxoplasmosis","display_name":"toxoplasmosis","score":1.0},{"id":"https://openalex.org/keywords/growth-inhibition","display_name":"growth inhibition","score":0.6579999923706055},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7559999823570251},{"id":"https://openalex.org/keywords/tachyzoites","display_name":"tachyzoites","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C2777625466","wikidata":"https://www.wikidata.org/wiki/Q150162","display_name":"Trypanosoma cruzi","level":3,"score":0.9517394304275513},{"id":"https://openalex.org/C2778128430","wikidata":"https://www.wikidata.org/wiki/Q131003","display_name":"Toxoplasma gondii","level":3,"score":0.9452718496322632},{"id":"https://openalex.org/C2781421772","wikidata":"https://www.wikidata.org/wiki/Q581102","display_name":"Antiparasitic","level":2,"score":0.8350880742073059},{"id":"https://openalex.org/C2911037157","wikidata":"https://www.wikidata.org/wiki/Q581102","display_name":"Antiparasitic agent","level":2,"score":0.7448348999023438},{"id":"https://openalex.org/C2778062946","wikidata":"https://www.wikidata.org/wiki/Q154878","display_name":"Toxoplasmosis","level":2,"score":0.5806376934051514},{"id":"https://openalex.org/C112418997","wikidata":"https://www.wikidata.org/wiki/Q649558","display_name":"Chagas disease","level":2,"score":0.56004798412323},{"id":"https://openalex.org/C2776294642","wikidata":"https://www.wikidata.org/wiki/Q77747995","display_name":"Thiocyanate","level":2,"score":0.4748677909374237},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4692627787590027},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4414348006248474},{"id":"https://openalex.org/C121587506","wikidata":"https://www.wikidata.org/wiki/Q6888113","display_name":"Mode of action","level":2,"score":0.4229598641395569},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3706199526786804},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3656630516052246},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3255900740623474},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.31657660007476807},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2544988691806793},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1488412618637085},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.1464518904685974},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11400821805000305},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.10661095380783081},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000981","descriptor_name":"Antiprotozoal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013861","descriptor_name":"Thiocyanates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014122","descriptor_name":"Toxoplasma","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014122","descriptor_name":"Toxoplasma","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/cmdc.201500100","doi":"https://doi.org/10.1002/cmdc.201500100","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cmdc.201500100","pdf_url":null,"source":{"id":"https://openalex.org/S136164820","display_name":"ChemMedChem","issn_l":"1860-7179","issn":["1860-7179","1860-7187"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"journal-article"},{"id":"pmid:25914175","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25914175","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemMedChem","raw_type":"Journal Article"},{"id":"pmh:oai:americanae.aecid.es:3925659","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/31544","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:pubmedcentral.nih.gov:4447534","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4447534","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ChemMedChem","raw_type":"Text"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/31544","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/31544","pdf_url":"http://hdl.handle.net/11336/31544","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:3925659","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/31544","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"http://purl.org/coar/resource_type/c_6501"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1034493708","display_name":"Pathogenesis of Trypanosoma cruzi infection","funder_award_id":"R56AI107663","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1279688354","display_name":null,"funder_award_id":"PICT-2012","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G1801086624","display_name":null,"funder_award_id":"AI-102254","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G292499701","display_name":"Pathogenesis of Trypanosoma cruzi infection","funder_award_id":"R01AI107663","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2995617033","display_name":"Dise\u00f1o, S\u00edntesis y Evaluaci\u00f3n Biol\u00f3gica de Agentes Antiparasitarios","funder_award_id":"PICT-2012-0457","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G3607768814","display_name":null,"funder_award_id":"20020130100223BA","funder_id":"https://openalex.org/F4320323257","funder_display_name":"Universidad de Buenos Aires"},{"id":"https://openalex.org/G4955245509","display_name":"Targeting Host and Apicomplexan Isoprenoid Pathways","funder_award_id":"R33AI102254","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6531919598","display_name":null,"funder_award_id":"PICT 2012","funder_id":"https://openalex.org/F4320323257","funder_display_name":"Universidad de Buenos Aires"},{"id":"https://openalex.org/G6619182746","display_name":"Targeting Host and Apicomplexan Isoprenoid Pathways","funder_award_id":"R21AI102254","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000006649","display_name":null,"funder_award_id":"AI-102254","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000244898","display_name":null,"funder_award_id":"AI-107663","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G972917976","display_name":null,"funder_award_id":"AI107663","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320323257","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334832","display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","ror":"https://ror.org/03stxzb56"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014310871.pdf","grobid_xml":"https://content.openalex.org/works/W2014310871.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1966976273","https://openalex.org/W1985580893","https://openalex.org/W1986371873","https://openalex.org/W1989480008","https://openalex.org/W1997239486","https://openalex.org/W2000367696","https://openalex.org/W2000762807","https://openalex.org/W2001889835","https://openalex.org/W2004390050","https://openalex.org/W2009940912","https://openalex.org/W2015799029","https://openalex.org/W2015810688","https://openalex.org/W2020375323","https://openalex.org/W2025292712","https://openalex.org/W2031714541","https://openalex.org/W2032388023","https://openalex.org/W2032911852","https://openalex.org/W2035331592","https://openalex.org/W2035723109","https://openalex.org/W2053190507","https://openalex.org/W2054953645","https://openalex.org/W2060967563","https://openalex.org/W2062895519","https://openalex.org/W2066143173","https://openalex.org/W2080412910","https://openalex.org/W2082722598","https://openalex.org/W2083759849","https://openalex.org/W2089449814","https://openalex.org/W2112356673","https://openalex.org/W2113113337","https://openalex.org/W2119461394","https://openalex.org/W2122908267","https://openalex.org/W2142468661","https://openalex.org/W2146727245","https://openalex.org/W2157643399","https://openalex.org/W2166050191","https://openalex.org/W2171183947","https://openalex.org/W4292671502"],"related_works":["https://openalex.org/W2089449814","https://openalex.org/W2062895519","https://openalex.org/W2080412910","https://openalex.org/W2066143173","https://openalex.org/W2549323674","https://openalex.org/W2766263699","https://openalex.org/W2915162781","https://openalex.org/W2009940912","https://openalex.org/W2113113337","https://openalex.org/W2020375323"],"abstract_inverted_index":{"As":[0],"a":[1,162],"part":[2],"of":[3,50,59,62,87,103,108,119],"our":[4,76],"project":[5],"aimed":[6],"at":[7,31,153],"searching":[8],"for":[9,169],"new":[10],"safe":[11],"chemotherapeutic":[12],"agents":[13],"against":[14,44,92,101,113,146],"parasitic":[15],"diseases,":[16],"several":[17],"compounds":[18],"structurally":[19],"related":[20],"to":[21,134],"the":[22,32,47,56,63,123,129,135,139,154],"antiparasitic":[23,68],"agent":[24,49],"WC-9":[25,120],"(4-phenoxyphenoxyethyl":[26],"thiocyanate),":[27],"which":[28,122,159],"were":[29,36,71],"modified":[30],"terminal":[33,124],"phenyl":[34],"ring,":[35],"designed,":[37],"synthesized,":[38],"and":[39,53,70,89,110,150],"evaluated":[40],"as":[41],"growth":[42],"inhibitors":[43],"Trypanosoma":[45],"cruzi,":[46,95],"etiological":[48],"Chagas":[51],"disease,":[52],"Toxoplasma":[54],"gondii,":[55],"parasite":[57],"responsible":[58],"toxoplasmosis.":[60],"Most":[61],"synthetic":[64],"analogues":[65,118],"exhibited":[66,84],"similar":[67],"activity":[69],"slightly":[72],"more":[73],"potent":[74,99,143],"than":[75],"lead":[77],"WC-9.":[78],"For":[79],"example,":[80],"two":[81],"trifluoromethylated":[82],"derivatives":[83],"ED50":[85],"values":[86,107],"10.0":[88],"9.2":[90],"\u03bcM":[91,112],"intracellular":[93],"T.":[94,104,114,148,151],"whereas":[96],"they":[97],"showed":[98,142],"action":[100,145],"tachyzoites":[102],"gondii":[105,152],"(ED50":[106],"1.6":[109],"1.9":[111],"gondii).":[115],"In":[116],"addition,":[117],"in":[121,128],"aryl":[125],"group":[126,141],"is":[127,166],"meta":[130],"position":[131],"with":[132],"respect":[133],"alkyl":[136],"chain":[137],"bearing":[138],"thiocyanate":[140],"inhibitory":[144],"both":[147],"cruzi":[149],"very":[155],"low":[156],"micromolar":[157],"range,":[158],"suggests":[160],"that":[161],"para-phenyl":[163],"substitution":[164],"pattern":[165],"not":[167],"necessary":[168],"biological":[170],"activity.":[171]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}