{"id":"https://openalex.org/W2014277779","doi":"https://doi.org/10.1074/jbc.270.27.16315","title":"Substrate Specificity and Expression Profile of Amino Acid Transporters (AAPs) in Arabidopsis","display_name":"Substrate Specificity and Expression Profile of Amino Acid Transporters (AAPs) in Arabidopsis","publication_year":1995,"publication_date":"1995-07-01","ids":{"openalex":"https://openalex.org/W2014277779","doi":"https://doi.org/10.1074/jbc.270.27.16315","mag":"2014277779","pmid":"https://pubmed.ncbi.nlm.nih.gov/7608199"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.270.27.16315","doi":"https://doi.org/10.1074/jbc.270.27.16315","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.270.27.16315","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021925817488648/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0021925817488648/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071568502","display_name":"Wolf\u2010N. Fischer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wolf-N. Fischer","raw_affiliation_strings":["Institut f\u00fcr Genbiologische Forschung, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Genbiologische Forschung, Berlin, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001070027","display_name":"Marion Kwart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marion Kwart","raw_affiliation_strings":["Institut f\u0252r Genbiologische Forschung, Ihnestra63, D-14195 Berlin, Germany","From the (1)Institut f\u00fcr Genbiologische Forschung, Ihnestra63, D-14195 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u0252r Genbiologische Forschung, Ihnestra63, D-14195 Berlin, Germany","institution_ids":[]},{"raw_affiliation_string":"From the (1)Institut f\u00fcr Genbiologische Forschung, Ihnestra63, D-14195 Berlin, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046208178","display_name":"Sabine Hummel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sabine Hummel","raw_affiliation_strings":["Institut f\u0252r Genbiologische Forschung, Ihnestra63, D-14195 Berlin, Germany","From the (1)Institut f\u00fcr Genbiologische Forschung, Ihnestra63, D-14195 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u0252r Genbiologische Forschung, Ihnestra63, D-14195 Berlin, Germany","institution_ids":[]},{"raw_affiliation_string":"From the (1)Institut f\u00fcr Genbiologische Forschung, Ihnestra63, D-14195 Berlin, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078963967","display_name":"Wolf Bernd Frommer","orcid":"https://orcid.org/0000-0001-6465-0115","observed_orcids":["https://orcid.org/0000-0001-6465-0115","https://orcid.org/0000-0002-7622-1139"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wolf B. Frommer","raw_affiliation_strings":["Institut f\u0252r Genbiologische Forschung, Ihnestra63, D-14195 Berlin, Germany","From the (1)Institut f\u00fcr Genbiologische Forschung, Ihnestra63, D-14195 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u0252r Genbiologische Forschung, Ihnestra63, D-14195 Berlin, Germany","institution_ids":[]},{"raw_affiliation_string":"From the (1)Institut f\u00fcr Genbiologische Forschung, Ihnestra63, D-14195 Berlin, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5078963967"],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":15.3035,"has_fulltext":true,"cited_by_count":256,"citation_normalized_percentile":{"value":0.99208733,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"270","issue":"27","first_page":"16315","last_page":"16320"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11247","display_name":"Plant nutrient uptake and metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11247","display_name":"Plant nutrient uptake and metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12566","display_name":"Nitrogen and Sulfur Effects on Brassica","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amino-acid-transporters","display_name":"amino acid transporters","score":0.9990000128746033},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.902999997138977},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.871999979019165},{"id":"https://openalex.org/keywords/histidine-uptake","display_name":"histidine uptake","score":0.7929999828338623},{"id":"https://openalex.org/keywords/glutamine-transport","display_name":"glutamine transport","score":0.7739999890327454},{"id":"https://openalex.org/keywords/glutamate-uptake","display_name":"glutamate uptake","score":0.9980000257492065},{"id":"https://openalex.org/keywords/organ-specific-gene-expression","display_name":"organ-specific gene expression","score":0.7120000123977661},{"id":"https://openalex.org/keywords/root-expression","display_name":"root expression","score":0.44200000166893005},{"id":"https://openalex.org/keywords/transporter-structure","display_name":"transporter structure","score":0.37599998712539673}],"concepts":[{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.7714732885360718},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.7571945190429688},{"id":"https://openalex.org/C2781313199","wikidata":"https://www.wikidata.org/wiki/Q4746435","display_name":"Amino acid transporter","level":4,"score":0.7062776684761047},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.6478205919265747},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.6382198333740234},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.622161865234375},{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.6033276319503784},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.5634035468101501},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5603320598602295},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.556925356388092},{"id":"https://openalex.org/C2778460671","wikidata":"https://www.wikidata.org/wiki/Q485277","display_name":"Histidine","level":3,"score":0.5450329184532166},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.5283884406089783},{"id":"https://openalex.org/C2777573094","wikidata":"https://www.wikidata.org/wiki/Q483752","display_name":"Valine","level":3,"score":0.48576048016548157},{"id":"https://openalex.org/C120405084","wikidata":"https://www.wikidata.org/wiki/Q285307","display_name":"Symporter","level":4,"score":0.47986048460006714},{"id":"https://openalex.org/C2779815552","wikidata":"https://www.wikidata.org/wiki/Q484583","display_name":"Proline","level":3,"score":0.45153695344924927},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4080263674259186},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20800277590751648}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015139","descriptor_name":"Blotting, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018745","descriptor_name":"Genome, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D026905","descriptor_name":"Amino Acid Transport Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.270.27.16315","doi":"https://doi.org/10.1074/jbc.270.27.16315","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.270.27.16315","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021925817488648/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:7608199","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7608199","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1074/jbc.270.27.16315","doi":"https://doi.org/10.1074/jbc.270.27.16315","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.270.27.16315","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021925817488648/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.40450000762939453,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014277779.pdf","grobid_xml":"https://content.openalex.org/works/W2014277779.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W39327047","https://openalex.org/W1489021348","https://openalex.org/W1594943659","https://openalex.org/W1975304761","https://openalex.org/W1981664026","https://openalex.org/W1982839737","https://openalex.org/W1995683339","https://openalex.org/W1997575982","https://openalex.org/W2007427363","https://openalex.org/W2009310436","https://openalex.org/W2014950132","https://openalex.org/W2040119364","https://openalex.org/W2047219099","https://openalex.org/W2069271336","https://openalex.org/W2075922301","https://openalex.org/W2079929532","https://openalex.org/W2086986007","https://openalex.org/W2093679492","https://openalex.org/W2095216655","https://openalex.org/W2107834116","https://openalex.org/W2163237722","https://openalex.org/W4232785649"],"related_works":["https://openalex.org/W2107834116","https://openalex.org/W2063251169","https://openalex.org/W2139332239","https://openalex.org/W2037929919","https://openalex.org/W183286062","https://openalex.org/W2131849298","https://openalex.org/W1978511976","https://openalex.org/W2076579920","https://openalex.org/W1996493030","https://openalex.org/W2042923803"],"abstract_inverted_index":{"Three":[0],"amino":[1,91,114,182],"acid":[2,92,115],"transporter":[3],"genes":[4,123],"(AAP3-5)":[5],"were":[6],"isolated":[7],"from":[8],"Arabidopsis":[9,113],"by":[10],"complementation":[11],"of":[12,32,50,97,121,165,181],"a":[13,24,41,125],"yeast":[14],"mutant":[15],"defective":[16],"in":[17,89,129,136,141,151,157],"histidine":[18],"uptake.":[19],"Transport":[20],"is":[21,133,149],"driven":[22],"against":[23],"concentration":[25],"gradient":[26],"and":[27,55,65,76,79,84,86,108,118,138,145,160,175],"sensitive":[28],"to":[29,71,112],"protonophores.":[30],"Analysis":[31],"the":[33,38,46,122,130,158,161],"substrate":[34,43,163],"specificity":[35,44],"demonstrates":[36],"that":[37,170],"carriers":[39],"have":[40,59],"broad":[42],"covering":[45],"major":[47],"transport":[48,82],"forms":[49],"reduced":[51],"nitrogen,":[52],"i.e.":[53],"glutamine":[54],"glutamate.":[56],"The":[57,94,154],"transporters":[58,116,167],"similar":[60],"affinities":[61],"for":[62],"glutamate,":[63],"glutamine,":[64],"alanine":[66],"but":[67],"differ":[68,172],"with":[69,103],"respect":[70],"valine,":[72],"phenylalanine,":[73],"histidine,":[74],"arginine,":[75],"lysine.":[77],"AAP3":[78,132],"AAP5":[80,148],"efficiently":[81],"arginine":[83],"lysine":[85],"are":[87,100],"involved":[88],"basic":[90],"transport.":[93],"predicted":[95],"polypeptides":[96],"53":[98],"kDa":[99],"highly":[101],"hydrophobic":[102],"12":[104],"putative":[105],"membrane-spanning":[106],"regions":[107],"show":[109],"significant":[110],"homologies":[111],"AAP1":[117],"AAP2.":[119],"Each":[120],"has":[124],"different":[126,162],"organ-specific":[127],"expression":[128],"plant.":[131],"exclusively":[134],"expressed":[135],"roots":[137],"AAP4":[139],"mainly":[140],"source":[142],"leaves,":[143],"stems,":[144],"flowers,":[146],"whereas":[147],"found":[150],"all":[152],"tissues.":[153],"specific":[155],"distribution":[156],"plant":[159],"specificities":[164],"AAP":[166],"may":[168],"indicate":[169],"tissues":[171],"both":[173],"qualitatively":[174],"quantitatively":[176],"regarding":[177],"import":[178],"or":[179],"export":[180],"acids.":[183]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
