{"id":"https://openalex.org/W2014276753","doi":"https://doi.org/10.2174/1381612820666140130201734","title":"Increase of Oxidation and Inflammation in Nervous and Immune Systems with Aging and Anxiety","display_name":"Increase of Oxidation and Inflammation in Nervous and Immune Systems with Aging and Anxiety","publication_year":2014,"publication_date":"2014-08-12","ids":{"openalex":"https://openalex.org/W2014276753","doi":"https://doi.org/10.2174/1381612820666140130201734","mag":"2014276753","pmid":"https://pubmed.ncbi.nlm.nih.gov/24588831"},"language":"en","primary_location":{"id":"doi:10.2174/1381612820666140130201734","doi":"https://doi.org/10.2174/1381612820666140130201734","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612820666140130201734","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003510265","display_name":"Carmen Vida","orcid":"https://orcid.org/0000-0002-0942-8076","observed_orcids":["https://orcid.org/0000-0002-0942-8076"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carmen Vida","raw_affiliation_strings":["Department of Physiology (Animal Physiology II), Faculty of Biological Sciences, Madrid Complutense University, Jos\u00e9 Antonio Novais, 2, 28040 Madrid, Spain.,Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology (Animal Physiology II), Faculty of Biological Sciences, Madrid Complutense University, Jos\u00e9 Antonio Novais, 2, 28040 Madrid, Spain.,Spain","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Eva Gonzalez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eva Gonzalez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063424030","display_name":"M\u00f3nica De la Fuente","orcid":"https://orcid.org/0000-0002-5969-097X","observed_orcids":["https://orcid.org/0000-0002-5969-097X"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Monica Fuente","raw_affiliation_strings":["Department of Physiology (Animal Physiology II), Faculty of Biological Sciences, Madrid Complutense University, Jos\u00e9 Antonio Novais, 2, 28040 Madrid, Spain. mondelaf@bio.ucm.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology (Animal Physiology II), Faculty of Biological Sciences, Madrid Complutense University, Jos\u00e9 Antonio Novais, 2, 28040 Madrid, Spain. mondelaf@bio.ucm.es","institution_ids":["https://openalex.org/I121748325"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5331,"has_fulltext":false,"cited_by_count":115,"citation_normalized_percentile":{"value":0.93942857,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"20","issue":"29","first_page":"4656","last_page":"4678"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.663100004196167,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.663100004196167,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.08609999716281891,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.05420000106096268,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8880000114440918},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6660000085830688},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.9660000205039978},{"id":"https://openalex.org/keywords/neuroimmune-interactions","display_name":"neuroimmune interactions","score":0.8230000138282776},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.984000027179718},{"id":"https://openalex.org/keywords/premature-aging","display_name":"premature aging","score":0.753000020980835},{"id":"https://openalex.org/keywords/immune-cells","display_name":"immune cells","score":0.5870000123977661},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.6930000185966492},{"id":"https://openalex.org/keywords/life-expectancy","display_name":"life expectancy","score":0.5699999928474426},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C2779056147","wikidata":"https://www.wikidata.org/wiki/Q1660191","display_name":"Immunosenescence","level":3,"score":0.9638245105743408},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.8257865905761719},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.750346302986145},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7174797058105469},{"id":"https://openalex.org/C2909947164","wikidata":"https://www.wikidata.org/wiki/Q6139748","display_name":"Premature aging","level":2,"score":0.5912810564041138},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5456316471099854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47594738006591797},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4540948271751404},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33106255531311035},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2705034017562866},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1930197775363922},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.13571280241012573}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/1381612820666140130201734","doi":"https://doi.org/10.2174/1381612820666140130201734","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612820666140130201734","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},{"id":"pmid:24588831","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24588831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current pharmaceutical design","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9430000185966492}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4246828824","https://openalex.org/W2494134352","https://openalex.org/W2063954678","https://openalex.org/W2130007036","https://openalex.org/W2029311183","https://openalex.org/W2157114720","https://openalex.org/W3210061905","https://openalex.org/W2912385011","https://openalex.org/W3152967619","https://openalex.org/W7214061897"],"abstract_inverted_index":{"According":[0],"to":[1,139,169],"the":[2,29,32,41,50,55,59,93,101,116,119,200,206,229],"oxidation-inflammation":[3],"theory":[4],"of":[5,17,31,35,40,49,62,67,95,118,143,153,157,174,214,231],"aging,":[6],"chronic":[7,215],"oxidative":[8,177,216],"stress":[9,12,170,178,217],"and":[10,19,22,25,43,58,64,82,87,103,106,135,146,171,183,191,218,223,226],"inflammatory":[11,20,73],"situations":[13],"(with":[14],"higher":[15],"levels":[16,173],"oxidant":[18,68],"compounds":[21,69],"lower":[23],"antioxidant":[24],"anti-inflammatory":[26],"defenses)":[27],"are":[28,77,84],"basis":[30],"agerelated":[33],"impairment":[34],"organism":[36],"functions,":[37],"including":[38],"those":[39],"nervous":[42],"immune":[44,104,181,224],"systems,":[45],"as":[46,48,185,187],"well":[47,186],"neuroimmune":[51,120],"communication,":[52,121],"which":[53,163],"explains":[54],"altered":[56],"homeostasis":[57],"resulting":[60],"increase":[61],"morbidity":[63],"mortality.":[65],"Overproduction":[66],"can":[70,210],"induce":[71],"an":[72,127,140,151,176],"response,":[74],"since":[75],"oxidants":[76],"inflammation":[78,83],"effectors.":[79],"Thus,":[80],"oxidation":[81],"interlinked":[85],"processes":[86],"have":[88],"many":[89],"feedback":[90],"loops.":[91],"However,":[92],"nature":[94],"their":[96,107,180],"potential":[97],"interactions,":[98],"mainly":[99],"in":[100,110,115,131,160,162,179,199,221],"brain":[102,222],"cells,":[105,225],"key":[108],"involvement":[109],"aging":[111,159],"remain":[112],"unclear.":[113],"Moreover,":[114],"context":[117],"it":[122],"has":[123],"been":[124],"described":[125],"that":[126,208],"oxidative-inflammatory":[128],"situation":[129,137,213],"occurs":[130],"subjects":[132],"with":[133],"anxiety,":[134,175],"this":[136,227],"contributes":[138],"immunosenescence,":[141],"alteration":[142],"survival":[144],"responses":[145],"shorter":[147,193],"life":[148,194],"span.":[149],"As":[150],"example":[152],"this,":[154],"a":[155,166,188,192,212],"model":[156,204],"premature":[158,189],"mice,":[161],"animals":[164],"show":[165],"poor":[167],"response":[168],"high":[172],"cells":[182],"tissues,":[184],"immunosenescence":[190],"expectancy,":[195],"will":[196],"be":[197,211],"commented":[198],"present":[201],"review.":[202],"This":[203],"supports":[205],"hypothesis":[207],"anxiety":[209],"inflammation,":[219],"especially":[220],"accelerates":[228],"rate":[230],"aging.":[232]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}