{"id":"https://openalex.org/W2014254198","doi":"https://doi.org/10.4238/vol8-3gmr638","title":"Gene silencing during development of in vitro-produced female bovine embryos","display_name":"Gene silencing during development of in vitro-produced female bovine embryos","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2014254198","doi":"https://doi.org/10.4238/vol8-3gmr638","mag":"2014254198","pmid":"https://pubmed.ncbi.nlm.nih.gov/19768674"},"language":"en","primary_location":{"id":"doi:10.4238/vol8-3gmr638","doi":"https://doi.org/10.4238/vol8-3gmr638","is_oa":true,"landing_page_url":"https://doi.org/10.4238/vol8-3gmr638","pdf_url":"https://doi.org/10.4238/vol8-3gmr638","source":{"id":"https://openalex.org/S206553565","display_name":"Genetics and Molecular Research","issn_l":"1676-5680","issn":["1676-5680"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4322633623","host_organization_name":"Research Foundation of Ribeir\u00e3o Preto","host_organization_lineage":["https://openalex.org/P4322633623"],"host_organization_lineage_names":["Research Foundation of Ribeir\u00e3o Preto"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics and Molecular Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.4238/vol8-3gmr638","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057356273","display_name":"Giovana Krempel Fonseca Merighe","orcid":"https://orcid.org/0000-0002-2996-4677","observed_orcids":["https://orcid.org/0000-0002-2996-4677"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"G.K.F. Merighe","raw_affiliation_strings":["Departamento de Ci\u00eancias B\u00e1sicas, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de S\u00e3o Paulo, Pirassununga, SP, Brasil gkrempel@usp.br","Departamento de Ci\u00eancias B\u00e1sicas,","Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de S\u00e3o Paulo, Pirassununga, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ci\u00eancias B\u00e1sicas, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de S\u00e3o Paulo, Pirassununga, SP, Brasil gkrempel@usp.br","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Departamento de Ci\u00eancias B\u00e1sicas,","institution_ids":[]},{"raw_affiliation_string":"Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de S\u00e3o Paulo, Pirassununga, SP, Brasil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014151906","display_name":"Fernando H. Biase","orcid":"https://orcid.org/0000-0001-7895-0223","observed_orcids":["https://orcid.org/0000-0001-7895-0223"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"F.H. Biase","raw_affiliation_strings":["Departamento de Ci\u00eancias B\u00e1sicas,","Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de S\u00e3o Paulo, Pirassununga, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ci\u00eancias B\u00e1sicas,","institution_ids":[]},{"raw_affiliation_string":"Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de S\u00e3o Paulo, Pirassununga, SP, Brasil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050134041","display_name":"Weruska Karyna Freitas Santos-Biase","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"W.K.F. Santos-Biase","raw_affiliation_strings":["Departamento de Ci\u00eancias B\u00e1sicas,","Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de S\u00e3o Paulo, Pirassununga, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ci\u00eancias B\u00e1sicas,","institution_ids":[]},{"raw_affiliation_string":"Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de S\u00e3o Paulo, Pirassununga, SP, Brasil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079570333","display_name":"Moys\u00e9s dos Santos Miranda","orcid":"https://orcid.org/0000-0001-7771-8174","observed_orcids":["https://orcid.org/0000-0001-7771-8174"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"M.S. Miranda","raw_affiliation_strings":["Departamento de Ci\u00eancias B\u00e1sicas,","Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de S\u00e3o Paulo, Pirassununga, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ci\u00eancias B\u00e1sicas,","institution_ids":[]},{"raw_affiliation_string":"Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de S\u00e3o Paulo, Pirassununga, SP, Brasil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023974259","display_name":"Tiago Henrique Camara De","orcid":"https://orcid.org/0000-0001-5969-6514","observed_orcids":["https://orcid.org/0000-0001-5969-6514"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"T.H.C. de Bem","raw_affiliation_strings":["Departamento de Ci\u00eancias B\u00e1sicas,","Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de S\u00e3o Paulo, Pirassununga, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ci\u00eancias B\u00e1sicas,","institution_ids":[]},{"raw_affiliation_string":"Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de S\u00e3o Paulo, Pirassununga, SP, Brasil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047014091","display_name":"Yeda Fumie Watanabe","orcid":"https://orcid.org/0000-0001-8732-4494","observed_orcids":["https://orcid.org/0000-0001-8732-4494"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Y.F. Watanabe","raw_affiliation_strings":["Faculdade de Zootecnia e Engenharia de Alimentos , Universidade de S\u00e3o Paulo , Pirassununga , SP , Brasil","Vitrogen-Pesquisa e Desenvolvimento em Biotecnologia da Reprodu\u00e7\u00e3o S/C Ltda., Cravinhos, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Zootecnia e Engenharia de Alimentos , Universidade de S\u00e3o Paulo , Pirassununga , SP , Brasil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Vitrogen-Pesquisa e Desenvolvimento em Biotecnologia da Reprodu\u00e7\u00e3o S/C Ltda., Cravinhos, SP, Brasil","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001129646","display_name":"Fl\u00e1vio Vieira Meirelles","orcid":"https://orcid.org/0000-0003-0372-4920","observed_orcids":["https://orcid.org/0000-0003-0372-4920"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"F.V. Meirelles","raw_affiliation_strings":["Departamento de Ci\u00eancias B\u00e1sicas,","Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de S\u00e3o Paulo, Pirassununga, SP, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Ci\u00eancias B\u00e1sicas,","institution_ids":[]},{"raw_affiliation_string":"Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de S\u00e3o Paulo, Pirassununga, SP, Brasil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":null,"apc_paid":null,"fwci":1.1873,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.7773875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"3","first_page":"1116","last_page":"1127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.8574000000953674,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.8574000000953674,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.11569999903440475,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/x-chromosome-inactivation","display_name":"X chromosome inactivation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/x-linked-gene-expression","display_name":"X-linked gene expression","score":0.6980000138282776},{"id":"https://openalex.org/keywords/xist","display_name":"XIST","score":0.6869999766349792},{"id":"https://openalex.org/keywords/glucose-6-phosphate-dehydrogenase","display_name":"glucose-6-phosphate dehydrogenase","score":0.8970000147819519},{"id":"https://openalex.org/keywords/hprt","display_name":"HPRT","score":0.968999981880188},{"id":"https://openalex.org/keywords/interferon-tau","display_name":"interferon-tau","score":0.9539999961853027},{"id":"https://openalex.org/keywords/bovine-embryos","display_name":"bovine embryos","score":0.6320000290870667},{"id":"https://openalex.org/keywords/nuclear-transfer","display_name":"nuclear transfer","score":0.6800000071525574},{"id":"https://openalex.org/keywords/in-vitro-fertilization","display_name":"in vitro fertilization","score":0.9409999847412109},{"id":"https://openalex.org/keywords/blastocyst","display_name":"blastocyst","score":0.6380000114440918},{"id":"https://openalex.org/keywords/epigenetic-memory","display_name":"epigenetic memory","score":0.8069999814033508},{"id":"https://openalex.org/keywords/nuclear-reprogramming","display_name":"nuclear reprogramming","score":0.875},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.7824106216430664},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7469593286514282},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.6934794187545776},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.6277798414230347},{"id":"https://openalex.org/C202438428","wikidata":"https://www.wikidata.org/wiki/Q1939923","display_name":"Somatic cell nuclear transfer","level":5,"score":0.5650805234909058},{"id":"https://openalex.org/C2779335785","wikidata":"https://www.wikidata.org/wiki/Q5370217","display_name":"Embryo culture","level":4,"score":0.5514378547668457},{"id":"https://openalex.org/C159399396","wikidata":"https://www.wikidata.org/wiki/Q1335221","display_name":"Inner cell mass","level":5,"score":0.5372139811515808},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.4805094003677368},{"id":"https://openalex.org/C48679268","wikidata":"https://www.wikidata.org/wiki/Q3375169","display_name":"Percoll","level":3,"score":0.47859594225883484},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.47718727588653564},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.47034409642219543},{"id":"https://openalex.org/C73247094","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Transgenesis","level":5,"score":0.4538626968860626},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.4465213418006897},{"id":"https://openalex.org/C2994278967","wikidata":"https://www.wikidata.org/wiki/Q7314318","display_name":"Reproductive technology","level":4,"score":0.4333884119987488},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.4244837462902069},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42422378063201904},{"id":"https://openalex.org/C110411900","wikidata":"https://www.wikidata.org/wiki/Q18032385","display_name":"XIST","level":5,"score":0.42279762029647827},{"id":"https://openalex.org/C33922130","wikidata":"https://www.wikidata.org/wiki/Q419232","display_name":"Housekeeping gene","level":4,"score":0.4224083125591278},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3602481186389923},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.31817537546157837},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3180677890777588},{"id":"https://openalex.org/C35158069","wikidata":"https://www.wikidata.org/wiki/Q61333","display_name":"X chromosome","level":3,"score":0.14754748344421387},{"id":"https://openalex.org/C4323932","wikidata":"https://www.wikidata.org/wiki/Q898914","display_name":"X-inactivation","level":4,"score":0.08631613850593567},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.4238/vol8-3gmr638","doi":"https://doi.org/10.4238/vol8-3gmr638","is_oa":true,"landing_page_url":"https://doi.org/10.4238/vol8-3gmr638","pdf_url":"https://doi.org/10.4238/vol8-3gmr638","source":{"id":"https://openalex.org/S206553565","display_name":"Genetics and Molecular Research","issn_l":"1676-5680","issn":["1676-5680"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4322633623","host_organization_name":"Research Foundation of Ribeir\u00e3o Preto","host_organization_lineage":["https://openalex.org/P4322633623"],"host_organization_lineage_names":["Research Foundation of Ribeir\u00e3o Preto"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics and Molecular Research","raw_type":"journal-article"},{"id":"pmh:001780988","doi":null,"is_oa":true,"landing_page_url":"http://www.funpecrp.com.br/gmr/year2009/vol8-3//pdf/gmr638.pdf","pdf_url":"http://www.funpecrp.com.br/gmr/year2009/vol8-3//pdf/gmr638.pdf","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:USP","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmid:19768674","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19768674","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics and molecular research : GMR","raw_type":"Journal Article"},{"id":"pmh:oai:www.producao.usp.br:BDPI/15543","doi":null,"is_oa":false,"landing_page_url":"http://producao.usp.br/handle/BDPI/15543","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da USP","raw_type":"publishedVersion"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.571.7514","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.571.7514","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.funpecrp.com.br/gmr/year2009/vol8-3/pdf/gmr638.pdf","raw_type":"text"},{"id":"mag:2185555096","doi":null,"is_oa":false,"landing_page_url":"https://www.funpecrp.com.br/gmr/year2009/vol8-3//pdf/gmr638.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.4238/vol8-3gmr638","doi":"https://doi.org/10.4238/vol8-3gmr638","is_oa":true,"landing_page_url":"https://doi.org/10.4238/vol8-3gmr638","pdf_url":"https://doi.org/10.4238/vol8-3gmr638","source":{"id":"https://openalex.org/S206553565","display_name":"Genetics and Molecular Research","issn_l":"1676-5680","issn":["1676-5680"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4322633623","host_organization_name":"Research Foundation of Ribeir\u00e3o Preto","host_organization_lineage":["https://openalex.org/P4322633623"],"host_organization_lineage_names":["Research Foundation of Ribeir\u00e3o Preto"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics and Molecular Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320336963","display_name":"Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de S\u00e3o Paulo","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014254198.pdf","grobid_xml":"https://content.openalex.org/works/W2014254198.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1535461485","https://openalex.org/W1535914077","https://openalex.org/W1576642538","https://openalex.org/W1963914570","https://openalex.org/W1976683714","https://openalex.org/W1984656331","https://openalex.org/W1986861876","https://openalex.org/W1992525863","https://openalex.org/W2003434869","https://openalex.org/W2005008049","https://openalex.org/W2005380259","https://openalex.org/W2011645592","https://openalex.org/W2013140132","https://openalex.org/W2014678665","https://openalex.org/W2032363644","https://openalex.org/W2034280649","https://openalex.org/W2045338351","https://openalex.org/W2063674189","https://openalex.org/W2064626311","https://openalex.org/W2085779184","https://openalex.org/W2089440148","https://openalex.org/W2093238513","https://openalex.org/W2099249565","https://openalex.org/W2108244474","https://openalex.org/W2119299386","https://openalex.org/W2121248812","https://openalex.org/W2121774339","https://openalex.org/W2130654445","https://openalex.org/W2133429667","https://openalex.org/W2144142672","https://openalex.org/W2149548143","https://openalex.org/W2150484960","https://openalex.org/W2153617768","https://openalex.org/W2181542280","https://openalex.org/W2332370017","https://openalex.org/W2905304170"],"related_works":["https://openalex.org/W7098295993","https://openalex.org/W2150484960","https://openalex.org/W2121774339","https://openalex.org/W2022698551","https://openalex.org/W2133429667","https://openalex.org/W2036657019","https://openalex.org/W2092376227","https://openalex.org/W7099282588","https://openalex.org/W2000007630","https://openalex.org/W7098130885"],"abstract_inverted_index":{"In":[0,322],"early":[1],"development,":[2,22,81],"female":[3,35,94,234,299,312,326],"embryos":[4,16,36,44,177,235,240,253,286,300,313,327],"(XX)":[5],"produce":[6],"twice":[7],"the":[8,19,25,32,39,61,71,88,152,201,205,214,224,265,291,319,346],"transcripts":[9],"of":[10,21,24,34,73,87,133,163,217,223,264,267,280,282,331,336,348],"X-linked":[11,75],"genes":[12,76,333,338],"compared":[13,220],"with":[14,51,119,160,186,194],"male":[15,52,92,239,252,324],"(XY).":[17],"During":[18],"course":[20],"inactivation":[23],"X":[26],"chromosome":[27],"equilibrates":[28],"gene":[29,215,229,293,306],"dosage,":[30],"making":[31,54],"development":[33,343],"viable.":[37],"Moreover,":[38],"biotechnologies":[40],"used":[41,209],"for":[42,57,66,142,149,342],"producing":[43],"in":[45,80,91,104,113,158,170,182,233,238,251,269,272,310,365],"vitro":[46,105,114],"seem":[47],"to":[48,59,212,221,315,358,362],"work":[49],"better":[50],"embryos,":[53],"it":[55,245],"easier":[56],"them":[58],"reach":[60],"blastocyst":[62],"stage":[63],"and":[64,84,86,93,102,117,136,145,196,198,236,325,334],"allow":[65],"complete":[67],"gestation.":[68],"We":[69,208],"investigated":[70],"expression":[72,216,222],"three":[74],"that":[77,109,305,339],"are":[78,340],"involved":[79],"XIST,":[82],"G6PD,":[83],"HPRT,":[85],"transcript":[89,266],"interferon-tau,":[90],"bovine":[95],"blastocysts":[96,219],"produced":[97,241,254,287,301],"by":[98,103,242,255,288,302],"nuclear":[99,366],"transfer":[100,351],"(NT)":[101],"fertilization":[106],"(IVF).":[107],"Oocytes":[108],"had":[110],"been":[111],"matured":[112],"were":[115,156,178],"enucleated":[116],"reconstructed":[118],"somatic":[120],"cells":[121,165],"from":[122,318],"adult":[123],"animals":[124],"at":[125,166,248,294],"18":[126],"h":[127],"post-maturation.":[128],"After":[129],"fusion":[130],"(two":[131],"pulses":[132],"2.25":[134],"kv/cm)":[135],"chemical":[137],"activation":[138],"(5.0":[139],"mM":[140,147],"ionomycin":[141],"5":[143],"min":[144],"2.0":[146],"6-DMAP":[148],"3":[150],"h),":[151],"oocyte-somatic":[153],"cell":[154],"units":[155],"cultivated":[157,199],"CR2":[159],"a":[161,171,183,295],"monolayer":[162],"granulosa":[164],"38.8":[167],"degrees":[168],"C,":[169],"humidified":[172],"5%":[173],"CO(2)":[174],"atmosphere.":[175],"IVF":[176,289],"inseminated,":[179],"after":[180],"centrifugation":[181],"Percoll":[184],"gradient,":[185],"2":[187],"x":[188],"10(6)":[189],"sperm/mL":[190],"TALP":[191],"medium":[192],"supplemented":[193],"BSA":[195],"PHE":[197],"under":[200],"same":[202],"conditions":[203],"as":[204],"cloned":[206],"embryos.":[207],"real-time":[210],"PCR":[211],"analyze":[213],"individual":[218],"housekeeping":[225],"gene,":[226],"GAPDH.":[227],"The":[228],"XIST":[230],"was":[231,246],"expressed":[232,247,290],"not":[237],"IVF,":[243],"though":[244],"low":[249],"levels":[250,263,330],"NT.":[256],"Unlike":[257],"previous":[258],"reports,":[259],"we":[260],"found":[261],"lower":[262],"G6PD":[268],"females":[270],"than":[271,298],"males,":[273],"suggesting":[274,304],"double":[275],"silencing":[276,307],"or":[277],"other":[278],"mechanisms":[279],"control":[281],"this":[283,354],"gene.":[284],"Female":[285],"HPRT":[292],"higher":[296],"level":[297],"NT,":[303],"proceeds":[308],"faster":[309],"NT-produced":[311],"due":[314,357],"\"inactivation":[316],"memory\"":[317],"nucleus":[320],"donor.":[321],"conclusion,":[323],"express":[328],"different":[329],"X-chromosome":[332],"failures":[335,364],"these":[337],"essential":[341],"could":[344],"reduce":[345],"viability":[347],"females.":[349],"Nuclear":[350],"can":[352],"modify":[353],"relation,":[355],"possibly":[356],"epigenetic":[359],"memory,":[360],"leading":[361],"frequent":[363],"reprogramming.":[367]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}