{"id":"https://openalex.org/W2014230992","doi":"https://doi.org/10.1021/jf0528207","title":"Pomegranate Byproduct Administration to Apolipoprotein E-Deficient Mice Attenuates Atherosclerosis Development as a Result of Decreased Macrophage Oxidative Stress and Reduced Cellular Uptake of Oxidized Low-Density Lipoprotein","display_name":"Pomegranate Byproduct Administration to Apolipoprotein E-Deficient Mice Attenuates Atherosclerosis Development as a Result of Decreased Macrophage Oxidative Stress and Reduced Cellular Uptake of Oxidized Low-Density Lipoprotein","publication_year":2006,"publication_date":"2006-02-02","ids":{"openalex":"https://openalex.org/W2014230992","doi":"https://doi.org/10.1021/jf0528207","mag":"2014230992","pmid":"https://pubmed.ncbi.nlm.nih.gov/16506855"},"language":"en","primary_location":{"id":"doi:10.1021/jf0528207","doi":"https://doi.org/10.1021/jf0528207","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jf0528207","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082462956","display_name":"Mira Rosenblat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]},{"id":"https://openalex.org/I4210117163","display_name":"Rappaport Family Institute for Research in the Medical Sciences","ror":"https://ror.org/029hzjx43","country_code":"IL","type":"facility","lineage":["https://openalex.org/I4210117163"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Mira Rosenblat","raw_affiliation_strings":["The Lipid Research Laboratory and Department of Anatomy and Cell Biology, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Lipid Research Laboratory and Department of Anatomy and Cell Biology, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa, Israel","institution_ids":["https://openalex.org/I174306211","https://openalex.org/I4210117163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004547600","display_name":"Nina Volkova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]},{"id":"https://openalex.org/I4210117163","display_name":"Rappaport Family Institute for Research in the Medical Sciences","ror":"https://ror.org/029hzjx43","country_code":"IL","type":"facility","lineage":["https://openalex.org/I4210117163"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Nina Volkova","raw_affiliation_strings":["The Lipid Research Laboratory and Department of Anatomy and Cell Biology, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Lipid Research Laboratory and Department of Anatomy and Cell Biology, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa, Israel","institution_ids":["https://openalex.org/I174306211","https://openalex.org/I4210117163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111913345","display_name":"Raymond Coleman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]},{"id":"https://openalex.org/I4210117163","display_name":"Rappaport Family Institute for Research in the Medical Sciences","ror":"https://ror.org/029hzjx43","country_code":"IL","type":"facility","lineage":["https://openalex.org/I4210117163"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Raymond Coleman","raw_affiliation_strings":["The Lipid Research Laboratory and Department of Anatomy and Cell Biology, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Lipid Research Laboratory and Department of Anatomy and Cell Biology, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa, Israel","institution_ids":["https://openalex.org/I174306211","https://openalex.org/I4210117163"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111556993","display_name":"Michael Aviram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]},{"id":"https://openalex.org/I4210117163","display_name":"Rappaport Family Institute for Research in the Medical Sciences","ror":"https://ror.org/029hzjx43","country_code":"IL","type":"facility","lineage":["https://openalex.org/I4210117163"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Michael Aviram","raw_affiliation_strings":["The Lipid Research Laboratory and Department of Anatomy and Cell Biology, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Lipid Research Laboratory and Department of Anatomy and Cell Biology, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa, Israel","institution_ids":["https://openalex.org/I174306211","https://openalex.org/I4210117163"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111556993"],"corresponding_institution_ids":["https://openalex.org/I174306211","https://openalex.org/I4210117163"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":5.2756,"has_fulltext":false,"cited_by_count":119,"citation_normalized_percentile":{"value":0.95391211,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"54","issue":"5","first_page":"1928","last_page":"1935"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12638","display_name":"Pomegranate: compositions and health benefits","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12638","display_name":"Pomegranate: compositions and health benefits","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/apoe-deficient-mice","display_name":"ApoE-deficient mice","score":0.972000002861023},{"id":"https://openalex.org/keywords/polyphenolic-antioxidants","display_name":"antioxidant polyphenols","score":0.6830000281333923},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/paraoxonase-2","display_name":"paraoxonase 2","score":0.843999981880188},{"id":"https://openalex.org/keywords/reduced-glutathione","display_name":"reduced glutathione","score":0.9020000100135803},{"id":"https://openalex.org/keywords/j774a-1-macrophages","display_name":"J774A.1 macrophages","score":0.8270000219345093},{"id":"https://openalex.org/keywords/dietary-polyphenols","display_name":"dietary polyphenols","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8327056169509888},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7228882312774658},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.6179380416870117},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.606706440448761},{"id":"https://openalex.org/C2778362808","wikidata":"https://www.wikidata.org/wiki/Q375837","display_name":"Gallic acid","level":3,"score":0.6004409790039062},{"id":"https://openalex.org/C2993790521","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxide","level":4,"score":0.5592390298843384},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5255212783813477},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.489971786737442},{"id":"https://openalex.org/C2779620165","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Low-density lipoprotein","level":3,"score":0.4827277362346649},{"id":"https://openalex.org/C2781048764","wikidata":"https://www.wikidata.org/wiki/Q107429","display_name":"Peroxide","level":2,"score":0.4815119206905365},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.4653972089290619},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4617237448692322},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.45081883668899536},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.4403999447822571},{"id":"https://openalex.org/C2780541478","wikidata":"https://www.wikidata.org/wiki/Q410020","display_name":"High-density lipoprotein","level":3,"score":0.43549400568008423},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3846719264984131},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3611414134502411},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3388834595680237},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.3104209899902344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17334219813346863},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14503148198127747},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0855647623538971},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005638","descriptor_name":"Fruit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029561","descriptor_name":"Lythraceae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jf0528207","doi":"https://doi.org/10.1021/jf0528207","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jf0528207","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},{"id":"pmid:16506855","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16506855","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of agricultural and food chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W78545189","https://openalex.org/W935405159","https://openalex.org/W1590457525","https://openalex.org/W1601128598","https://openalex.org/W1653408396","https://openalex.org/W1775749144","https://openalex.org/W1841006369","https://openalex.org/W1869991540","https://openalex.org/W1934775191","https://openalex.org/W1979655335","https://openalex.org/W1981079353","https://openalex.org/W1982530453","https://openalex.org/W2007064404","https://openalex.org/W2012152876","https://openalex.org/W2015207234","https://openalex.org/W2017609932","https://openalex.org/W2022456632","https://openalex.org/W2029085730","https://openalex.org/W2031596649","https://openalex.org/W2046378700","https://openalex.org/W2047913492","https://openalex.org/W2051054763","https://openalex.org/W2057810394","https://openalex.org/W2058125953","https://openalex.org/W2073703119","https://openalex.org/W2085097245","https://openalex.org/W2087736738","https://openalex.org/W2093979977","https://openalex.org/W2095840354","https://openalex.org/W2099040294","https://openalex.org/W2100022178","https://openalex.org/W2110457085","https://openalex.org/W2111966003","https://openalex.org/W2123262892","https://openalex.org/W2141462478","https://openalex.org/W2143950092","https://openalex.org/W2155762751","https://openalex.org/W2158221444","https://openalex.org/W2158601635","https://openalex.org/W2504116210","https://openalex.org/W3022864527"],"related_works":["https://openalex.org/W2155762751","https://openalex.org/W1992484846","https://openalex.org/W2110457085","https://openalex.org/W2046877827","https://openalex.org/W2945096803","https://openalex.org/W1971066657","https://openalex.org/W2995397995","https://openalex.org/W1945441451","https://openalex.org/W2140957970","https://openalex.org/W63516289"],"abstract_inverted_index":{"The":[0],"effects":[1],"of":[2,30,36,131,140],"a":[3,45],"pomegranate":[4,11],"byproduct":[5],"(PBP,":[6],"which":[7],"includes":[8],"the":[9,41,63,77,115],"whole":[10],"fruit":[12],"left":[13],"after":[14],"juice":[15],"preparation)":[16],"on":[17],"atherosclerosis":[18,161],"development":[19,162],"in":[20,44,48,62,128],"apolipoprotein":[21],"E-deficient":[22],"(E":[23],"degrees":[24,102],")":[25],"mice":[26,42,64,103],"were":[27,125],"studied.":[28],"Consumption":[29],"PBP":[31,56,135,158],"(17":[32],"or":[33,137],"51.5":[34],"microg":[35],"gallic":[37],"acid":[38],"equiv/kg/day)":[39],"by":[40,52,73,82,92,114,119,163],"resulted":[43],"significant":[46],"reduction":[47],"atherosclerotic":[49],"lesion":[50],"size":[51],"up":[53,74,83,93,120],"to":[54,75,84,94,98,121],"57%.":[55],"consumption":[57],"significantly":[58,143,159],"reduced":[59,78,118],"oxidative":[60],"stress":[61],"peritoneal":[65],"macrophages":[66,133],"(MPM):":[67],"Cellular":[68],"lipid":[69],"peroxide":[70,148],"content":[71,149],"decreased":[72,144],"42%,":[76],"glutathione":[79],"levels":[80],"increased":[81,91],"53%,":[85],"and":[86,150],"paraoxonase":[87],"2":[88],"lactonase":[89],"activity":[90],"50%,":[95],"as":[96],"compared":[97],"MPM":[99,116],"from":[100],"E":[101],"that":[104,157],"consumed":[105],"only":[106],"water.":[107],"Furthermore,":[108],"oxidized":[109],"low-density":[110],"lipoprotein":[111],"(Ox-LDL)":[112],"uptake":[113],"was":[117,154],"19%.":[122],"Similar":[123],"results":[124],"observed":[126],"also":[127],"vitro.":[129],"Treatment":[130],"J774A.1":[132],"with":[134],"(10":[136],"50":[138],"micromol/L":[139],"total":[141,147],"polyphenols)":[142],"both":[145],"cellular":[146],"Ox-LDL":[151],"uptake.":[152],"It":[153],"thus":[155],"concluded":[156],"attenuates":[160],"its":[164],"antioxidant":[165],"properties.":[166]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
