{"id":"https://openalex.org/W2014215819","doi":"https://doi.org/10.1016/j.ajog.2009.05.035","title":"Cell encapsulation as a potential nondietary therapy for maternal phenylketonuria","display_name":"Cell encapsulation as a potential nondietary therapy for maternal phenylketonuria","publication_year":2009,"publication_date":"2009-07-25","ids":{"openalex":"https://openalex.org/W2014215819","doi":"https://doi.org/10.1016/j.ajog.2009.05.035","mag":"2014215819","pmid":"https://pubmed.ncbi.nlm.nih.gov/19631922","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8928171"},"language":"en","primary_location":{"id":"doi:10.1016/j.ajog.2009.05.035","doi":"https://doi.org/10.1016/j.ajog.2009.05.035","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajog.2009.05.035","pdf_url":"http://www.ajog.org/article/S0002937809005432/pdf","source":{"id":"https://openalex.org/S122347013","display_name":"American Journal of Obstetrics and Gynecology","issn_l":"0002-9378","issn":["0002-9378","1085-8709","1097-6868"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Obstetrics and Gynecology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.ajog.org/article/S0002937809005432/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011911130","display_name":"Donna Ann Santillan","orcid":"https://orcid.org/0000-0002-6180-9714","observed_orcids":["https://orcid.org/0000-0002-6180-9714"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I2802216851","display_name":"University of Iowa Hospitals and Clinics","ror":"https://ror.org/04g2swc55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I2802216851","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donna A. Santillan","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA","Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I2802216851"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, IA","institution_ids":["https://openalex.org/I2802216851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015401066","display_name":"Mark Kharim Orcullo Santillan","orcid":"https://orcid.org/0000-0002-3991-8017","observed_orcids":["https://orcid.org/0000-0002-3991-8017"]},"institutions":[{"id":"https://openalex.org/I2802216851","display_name":"University of Iowa Hospitals and Clinics","ror":"https://ror.org/04g2swc55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I2802216851","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark K. Santillan","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, IA","Division of Maternal-Fetal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, IA","institution_ids":["https://openalex.org/I2802216851"]},{"raw_affiliation_string":"Division of Maternal-Fetal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA","institution_ids":["https://openalex.org/I2802216851"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087934444","display_name":"Stephen K. Hunter","orcid":"https://orcid.org/0000-0002-4188-9569","observed_orcids":["https://orcid.org/0000-0002-4188-9569"]},"institutions":[{"id":"https://openalex.org/I2802216851","display_name":"University of Iowa Hospitals and Clinics","ror":"https://ror.org/04g2swc55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I2802216851","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen K. Hunter","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, IA","Division of Maternal-Fetal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, IA","institution_ids":["https://openalex.org/I2802216851"]},{"raw_affiliation_string":"Division of Maternal-Fetal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA","institution_ids":["https://openalex.org/I2802216851"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087934444"],"corresponding_institution_ids":["https://openalex.org/I2802216851"],"apc_list":{"value":5410,"currency":"USD","value_usd":5410},"apc_paid":null,"fwci":1.3963,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.77812696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"201","issue":"3","first_page":"289.e1","last_page":"289.e6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maternal-phenylketonuria","display_name":"maternal phenylketonuria","score":0.8920000195503235},{"id":"https://openalex.org/keywords/phenylalanine-hydroxylase","display_name":"phenylalanine hydroxylase","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cell-encapsulation","display_name":"cell encapsulation","score":0.9589999914169312},{"id":"https://openalex.org/keywords/sodium-alginate-microspheres","display_name":"sodium alginate microspheres","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.39800000190734863},{"id":"https://openalex.org/keywords/teratogenicity","display_name":"teratogenicity","score":0.609000027179718},{"id":"https://openalex.org/keywords/enzyme-overexpression","display_name":"enzyme overexpression","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8819987773895264}],"mesh":[{"descriptor_ui":"D000464","descriptor_name":"Alginates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006603","descriptor_name":"Hexuronic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010651","descriptor_name":"Phenylalanine Hydroxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010661","descriptor_name":"Phenylketonurias","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D020723","descriptor_name":"Glucuronic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ajog.2009.05.035","doi":"https://doi.org/10.1016/j.ajog.2009.05.035","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajog.2009.05.035","pdf_url":"http://www.ajog.org/article/S0002937809005432/pdf","source":{"id":"https://openalex.org/S122347013","display_name":"American Journal of Obstetrics and Gynecology","issn_l":"0002-9378","issn":["0002-9378","1085-8709","1097-6868"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Obstetrics and Gynecology","raw_type":"journal-article"},{"id":"pmid:19631922","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19631922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of obstetrics and gynecology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8928171","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8928171","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Am J Obstet Gynecol","raw_type":"Text"},{"id":"pmh:oai:ir.uiowa.edu:obgyn_pubs-2106","doi":null,"is_oa":false,"landing_page_url":"https://ir.uiowa.edu/obgyn_pubs/1102","pdf_url":null,"source":{"id":"https://openalex.org/S4306401239","display_name":"Iowa Research Online (The University of Iowa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126307644","host_organization_name":"University of Iowa","host_organization_lineage":["https://openalex.org/I126307644"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Obstetrics and Gynecology Publications","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.ajog.2009.05.035","doi":"https://doi.org/10.1016/j.ajog.2009.05.035","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajog.2009.05.035","pdf_url":"http://www.ajog.org/article/S0002937809005432/pdf","source":{"id":"https://openalex.org/S122347013","display_name":"American Journal of Obstetrics and Gynecology","issn_l":"0002-9378","issn":["0002-9378","1085-8709","1097-6868"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Obstetrics and Gynecology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5233045129","display_name":null,"funder_award_id":"AI-07260-22","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7222354713","display_name":"Cardiovascular Institutional Research Fellowship","funder_award_id":"T32HL007121","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7837928610","display_name":"Interdisciplinary Immunology Postdoctoral Training Program","funder_award_id":"T32AI007260","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320318046","display_name":"Children's Miracle Network Hospitals","ror":"https://ror.org/02ksjb929"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014215819.pdf","grobid_xml":"https://content.openalex.org/works/W2014215819.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W203149856","https://openalex.org/W1483242733","https://openalex.org/W1538563886","https://openalex.org/W1552443360","https://openalex.org/W1564477996","https://openalex.org/W1809794398","https://openalex.org/W1966779240","https://openalex.org/W1967452832","https://openalex.org/W1971248353","https://openalex.org/W1972655969","https://openalex.org/W1980911362","https://openalex.org/W1983049414","https://openalex.org/W1991203864","https://openalex.org/W1991854600","https://openalex.org/W2008580257","https://openalex.org/W2028944397","https://openalex.org/W2029251989","https://openalex.org/W2030414180","https://openalex.org/W2036064499","https://openalex.org/W2039889926","https://openalex.org/W2045113381","https://openalex.org/W2045502182","https://openalex.org/W2046252579","https://openalex.org/W2047608515","https://openalex.org/W2051270913","https://openalex.org/W2058582572","https://openalex.org/W2060418959","https://openalex.org/W2065933439","https://openalex.org/W2085459917","https://openalex.org/W2098135346","https://openalex.org/W2099863559","https://openalex.org/W2101972169","https://openalex.org/W2102848435","https://openalex.org/W2125018502","https://openalex.org/W2126537899","https://openalex.org/W2127281471","https://openalex.org/W2134321589","https://openalex.org/W2140095849","https://openalex.org/W2150930054","https://openalex.org/W2163051649","https://openalex.org/W2319807273","https://openalex.org/W2468685580","https://openalex.org/W2981523768","https://openalex.org/W3045917976","https://openalex.org/W3209992856","https://openalex.org/W4213167025","https://openalex.org/W6638256629"],"related_works":["https://openalex.org/W2116513914","https://openalex.org/W2014732401","https://openalex.org/W2028406897","https://openalex.org/W2315750634","https://openalex.org/W2068270541","https://openalex.org/W2021688647","https://openalex.org/W2322763350","https://openalex.org/W2001751227","https://openalex.org/W2014764798","https://openalex.org/W7046744221"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
