{"id":"https://openalex.org/W2014201253","doi":"https://doi.org/10.1371/journal.pone.0063581","title":"Elevated Maspin Expression Is Associated with Better Overall Survival in Esophageal Squamous Cell Carcinoma (ESCC)","display_name":"Elevated Maspin Expression Is Associated with Better Overall Survival in Esophageal Squamous Cell Carcinoma (ESCC)","publication_year":2013,"publication_date":"2013-05-22","ids":{"openalex":"https://openalex.org/W2014201253","doi":"https://doi.org/10.1371/journal.pone.0063581","mag":"2014201253","pmid":"https://pubmed.ncbi.nlm.nih.gov/23717449","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3661574"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0063581","doi":"https://doi.org/10.1371/journal.pone.0063581","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0063581","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0063581&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0063581&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060404389","display_name":"Yang Wang","orcid":"https://orcid.org/0000-0001-6440-0204","observed_orcids":["https://orcid.org/0000-0001-6440-0204"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Wang","raw_affiliation_strings":["Thoracic Surgery, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Surgery, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100784811","display_name":"Shijie Sheng","orcid":"https://orcid.org/0000-0001-9338-0652","observed_orcids":["https://orcid.org/0000-0001-9338-0652"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shijie Sheng","raw_affiliation_strings":["Department of Pathology, Wayne State University School of Medicine, Tumor and Microenvironment Program of Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Wayne State University School of Medicine, Tumor and Microenvironment Program of Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jianzhi Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianzhi Zhang","raw_affiliation_strings":["Thoracic Surgery, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Surgery, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030245240","display_name":"Sijana H. Dzinic","orcid":"https://orcid.org/0009-0000-7543-694X","observed_orcids":["https://orcid.org/0009-0000-7543-694X"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sijana Dzinic","raw_affiliation_strings":["Department of Pathology, Wayne State University School of Medicine, Tumor and Microenvironment Program of Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Wayne State University School of Medicine, Tumor and Microenvironment Program of Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States of America","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038928268","display_name":"Shaolei Li","orcid":"https://orcid.org/0000-0003-1122-9292","observed_orcids":["https://orcid.org/0000-0003-1122-9292"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaolei Li","raw_affiliation_strings":["Thoracic Surgery, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Surgery, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fang Fang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Fang","raw_affiliation_strings":["Thoracic Surgery, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Surgery, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087939993","display_name":"Nan Wu","orcid":"https://orcid.org/0000-0002-3531-1656","observed_orcids":["https://orcid.org/0000-0002-3531-1656"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Wu","raw_affiliation_strings":["Thoracic Surgery, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Surgery, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001341163","display_name":"Qingfeng Zheng","orcid":"https://orcid.org/0000-0002-9236-6178","observed_orcids":["https://orcid.org/0000-0002-9236-6178"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingfeng Zheng","raw_affiliation_strings":["Thoracic Surgery, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Surgery, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100633320","display_name":"Yue Yang","orcid":"https://orcid.org/0000-0002-1110-6025","observed_orcids":["https://orcid.org/0000-0002-1110-6025"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yue Yang","raw_affiliation_strings":["Thoracic Surgery, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Surgery, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China","institution_ids":["https://openalex.org/I4210093964"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100633320","https://openalex.org/A5100784811"],"corresponding_institution_ids":["https://openalex.org/I185443292","https://openalex.org/I4210090317","https://openalex.org/I4210093964"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.8054,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.88986735,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"8","issue":"5","first_page":"e63581","last_page":"e63581"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.7157999873161316,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.7157999873161316,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.23890000581741333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maspin","display_name":"maspin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/esophageal-squamous-cell-carcinoma","display_name":"esophageal squamous cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.843999981880188},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8379999995231628},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.7519999742507935},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7860000133514404},{"id":"https://openalex.org/keywords/cell-motility","display_name":"cell motility","score":0.972000002861023},{"id":"https://openalex.org/keywords/matrigel-invasion","display_name":"Matrigel invasion","score":0.7919999957084656},{"id":"https://openalex.org/keywords/esophageal-cancer-cell-lines","display_name":"esophageal cancer cell lines","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C2778900538","wikidata":"https://www.wikidata.org/wiki/Q15320674","display_name":"Maspin","level":4,"score":0.9960504770278931},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5672985315322876},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5367914438247681},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5326005816459656},{"id":"https://openalex.org/C2779742542","wikidata":"https://www.wikidata.org/wiki/Q372701","display_name":"Esophageal cancer","level":3,"score":0.528942346572876},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5038225054740906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.431984543800354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43104174733161926},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38809382915496826},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38166171312332153},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33951812982559204}],"mesh":[{"descriptor_ui":"D000077277","descriptor_name":"Esophageal Squamous Cell Carcinoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004947","descriptor_name":"Esophagus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015843","descriptor_name":"Serpins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0063581","doi":"https://doi.org/10.1371/journal.pone.0063581","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0063581","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0063581&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2659892","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3661574","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:23717449","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23717449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3661574","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3661574/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.783.4492","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.783.4492","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/82/ee/pone.0063581.PMC3661574.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:60f953795d844fa99c455a8336b5d8e8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/60f953795d844fa99c455a8336b5d8e8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 5, p e63581 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0063581","doi":"https://doi.org/10.1371/journal.pone.0063581","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0063581","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0063581&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G671233510","display_name":null,"funder_award_id":"CA15431","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7790947829","display_name":"The therapeutic potential of maspin in prostate cancer","funder_award_id":"R01CA084176","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014201253.pdf","grobid_xml":"https://content.openalex.org/works/W2014201253.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1502713173","https://openalex.org/W1568669558","https://openalex.org/W1966657513","https://openalex.org/W1968484723","https://openalex.org/W1969875009","https://openalex.org/W1974245070","https://openalex.org/W1981570640","https://openalex.org/W1982301997","https://openalex.org/W1982672509","https://openalex.org/W1988125845","https://openalex.org/W1991177718","https://openalex.org/W1991457843","https://openalex.org/W1997835752","https://openalex.org/W1999873374","https://openalex.org/W2004292818","https://openalex.org/W2005400333","https://openalex.org/W2021582501","https://openalex.org/W2027781065","https://openalex.org/W2032863971","https://openalex.org/W2033707809","https://openalex.org/W2043017963","https://openalex.org/W2060619935","https://openalex.org/W2061071961","https://openalex.org/W2062392379","https://openalex.org/W2062522420","https://openalex.org/W2063319992","https://openalex.org/W2064554783","https://openalex.org/W2068036625","https://openalex.org/W2069452349","https://openalex.org/W2088461277","https://openalex.org/W2088850572","https://openalex.org/W2091657079","https://openalex.org/W2094961730","https://openalex.org/W2096202799","https://openalex.org/W2105268795","https://openalex.org/W2106887050","https://openalex.org/W2111043630","https://openalex.org/W2117025943","https://openalex.org/W2123715172","https://openalex.org/W2131597845","https://openalex.org/W2132081811","https://openalex.org/W2140676491","https://openalex.org/W2148453599","https://openalex.org/W2148870474","https://openalex.org/W2166584371","https://openalex.org/W2169753719","https://openalex.org/W2170006775"],"related_works":["https://openalex.org/W7100784019","https://openalex.org/W2063319992","https://openalex.org/W2065855633","https://openalex.org/W2371652593","https://openalex.org/W1991177718","https://openalex.org/W2032863971","https://openalex.org/W3197879732","https://openalex.org/W2045271204","https://openalex.org/W2277529702","https://openalex.org/W2361128877"],"abstract_inverted_index":{"Tumor":[0],"suppressor":[1],"maspin":[2,21,34,51,76,101,120,135,148,162,169,177,193,205,234,240,274],"is":[3,28],"a":[4,122,138,283],"differentially":[5],"regulated":[6],"gene":[7],"in":[8,22,52,77,194,206,252,275],"the":[9,17,31,37,43,47,68,73,117,166,174,189,197,223,270,276],"progression":[10,57],"of":[11,14,20,33,40,50,55,75,100,116,168,176,192,204,273,279],"many":[12],"types":[13],"cancer.":[15],"While":[16],"biological":[18,48,190],"function":[19,191],"blocking":[23],"tumor":[24,41,56,297],"invasion":[25],"and":[26,46,62,87,173,218,235,261],"metastasis":[27],"consistent":[29],"with":[30,102,144,170,178],"loss":[32],"expression":[35,45,74,136,149,163,203,255],"at":[36,121,137,184],"late":[38],"stage":[39,54],"progression,":[42],"differential":[44],"significance":[49],"early":[53,277],"appear":[58],"to":[59,64,108,124,140,157,182],"be":[60,65,183,282],"complex":[61],"remain":[63],"elucidated.":[66],"In":[67],"current":[69],"study,":[70],"we":[71,186],"examined":[72,221],"84":[78],"esophageal":[79,91,110,209],"squamous":[80,111,210],"cell":[81,200,212,227,258],"carcinoma":[82],"(ESCC)":[83],"cases":[84,118],"(stages":[85],"I-III)":[86],"55":[88],"non-tumor":[89],"adjacent":[90],"tissue":[92,112],"specimens":[93,129],"by":[94,222,239],"immunohistochemical":[95],"(IHC)":[96],"staining.":[97],"The":[98,202,246],"correlation":[99,167,175],"clinicopathological":[103],"parameters":[104],"was":[105,220,236],"analyzed.":[106],"Compared":[107],"normal":[109],"where":[113],"80%":[114],"(47/55)":[115],"expressed":[119],"low":[123,145],"moderate":[125,139,147],"level,":[126],"all":[127],"ESCC":[128,143,171,179,195,199,226,280,296],"(100%":[130],"(84/84))":[131],"were":[132,250],"positive":[133],"for":[134],"high":[141,161],"level.":[142],"or":[146,242],"had":[150,160],"significantly":[151,256],"shorter":[152],"postoperative":[153],"survival":[154],"rates":[155],"compared":[156],"those":[158],"that":[159,230,269],"(p<0.001).":[164],"Since":[165],"histology":[172],"prognosis":[180],"seem":[181],"odds,":[185],"further":[187,287],"investigated":[188],"using":[196],"established":[198],"lines.":[201],"five":[207],"human":[208],"cancer":[211],"lines":[213],"(T12,":[214],"E450,":[215],"KYSE150,":[216],"EC109,":[217],"KYSE510)":[219],"Western":[224],"blot.":[225],"line":[228],"KYSE510":[229],"did":[231],"not":[232],"express":[233],"stably":[237],"transfected":[238,248],"cDNA":[241],"an":[243],"empty":[244],"vector.":[245],"resulting":[247],"cells":[249],"characterized":[251],"vitro.":[253],"Maspin":[254],"inhibited":[257],"proliferation,":[259],"motility":[260],"matrigel":[262],"invasion.":[263],"Taken":[264],"together,":[265],"our":[266],"data":[267],"suggest":[268],"transient":[271],"up-regulation":[272],"development":[278],"may":[281],"defense":[284],"mechanism":[285],"against":[286],"transition":[288],"towards":[289],"more":[290],"malignant":[291],"phenotypes,":[292],"ultimately":[293],"slowing":[294],"down":[295],"progression.":[298]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}