{"id":"https://openalex.org/W2014195232","doi":"https://doi.org/10.1371/journal.pone.0120879","title":"Characterization of Stimulus-Secretion Coupling in the Human Pancreatic EndoC-\u03b2H1 Beta Cell Line","display_name":"Characterization of Stimulus-Secretion Coupling in the Human Pancreatic EndoC-\u03b2H1 Beta Cell Line","publication_year":2015,"publication_date":"2015-03-24","ids":{"openalex":"https://openalex.org/W2014195232","doi":"https://doi.org/10.1371/journal.pone.0120879","mag":"2014195232","pmid":"https://pubmed.ncbi.nlm.nih.gov/25803449","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4372368"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0120879","doi":"https://doi.org/10.1371/journal.pone.0120879","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0120879","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0120879&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0120879&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026559901","display_name":"Lotta E. Andersson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Lotta E. Andersson","raw_affiliation_strings":["Department of Clinical Sciences, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022959042","display_name":"B\u00e9reng\u00e8re Valtat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"B\u00e9reng\u00e8re Valtat","raw_affiliation_strings":["Department of Clinical Sciences, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074339407","display_name":"Annika Bagge","orcid":"https://orcid.org/0000-0002-3897-9512","observed_orcids":["https://orcid.org/0000-0002-3897-9512"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Annika Bagge","raw_affiliation_strings":["Department of Clinical Sciences, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049341154","display_name":"Vladimir V. Sharoyko","orcid":"https://orcid.org/0000-0002-3717-0471","observed_orcids":["https://orcid.org/0000-0002-3717-0471"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Vladimir V. Sharoyko","raw_affiliation_strings":["Department of Clinical Sciences, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004270076","display_name":"David G. Nicholls","orcid":"https://orcid.org/0000-0001-5036-808X","observed_orcids":["https://orcid.org/0000-0001-5036-808X"]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]},{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"David G. Nicholls","raw_affiliation_strings":["Department of Clinical Sciences, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, Malm\u00f6, Sweden; Buck Institute for Research on Aging, Novato, California, United States of America","Buck Institute for Research on Aging, Novato, California, United States of America","Department of Clinical Sciences, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, Malm\u00f6, Sweden; Buck Institute for Research on Aging, Novato, California, United States of America","institution_ids":["https://openalex.org/I1337826666","https://openalex.org/I187531555"]},{"raw_affiliation_string":"Buck Institute for Research on Aging, Novato, California, United States of America","institution_ids":["https://openalex.org/I1337826666"]},{"raw_affiliation_string":"Department of Clinical Sciences, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041588029","display_name":"Philippe Ravassard","orcid":"https://orcid.org/0000-0002-0393-9262","observed_orcids":["https://orcid.org/0000-0002-0393-9262"]},"institutions":[{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe Ravassard","raw_affiliation_strings":["Universit\u00e9 Pierre et Marie Curie-Paris 6, Biotechnology and Biotherapy Team, Centre de Recherche de I'Institut du Cerveau et de la Moelle \u00e9pini\u00e9re (CRICM), UMRS 975, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Pierre et Marie Curie-Paris 6, Biotechnology and Biotherapy Team, Centre de Recherche de I'Institut du Cerveau et de la Moelle \u00e9pini\u00e9re (CRICM), UMRS 975, Paris, France","institution_ids":["https://openalex.org/I4210152724","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007387317","display_name":"Rapha\u00ebl Scharfmann","orcid":"https://orcid.org/0000-0001-7619-337X","observed_orcids":["https://orcid.org/0000-0001-7619-337X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I204730241","https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I4210141964","display_name":"Institut Cochin","ror":"https://ror.org/051sk4035","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210096427","https://openalex.org/I4210141964"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Raphael Scharfmann","raw_affiliation_strings":["INSERM U1016, Cochin Institute, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, Faculty Cochin, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U1016, Cochin Institute, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Facult\u00e9 de M\u00e9decine, Faculty Cochin, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210091437","https://openalex.org/I4210141964","https://openalex.org/I4387156284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037748733","display_name":"Peter Sp\u00e9gel","orcid":"https://orcid.org/0000-0002-6092-2387","observed_orcids":["https://orcid.org/0000-0002-6092-2387"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Peter Sp\u00e9gel","raw_affiliation_strings":["Department of Clinical Sciences, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089567143","display_name":"Hindrik Mulder","orcid":"https://orcid.org/0000-0002-6593-8417","observed_orcids":["https://orcid.org/0000-0002-6593-8417"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Hindrik Mulder","raw_affiliation_strings":["Department of Clinical Sciences, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, Malm\u00f6, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Unit of Molecular Metabolism, Lund University Diabetes Centre, CRC, Malm\u00f6, Sweden","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5026559901"],"corresponding_institution_ids":["https://openalex.org/I187531555"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":10.8942,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.98940481,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"10","issue":"3","first_page":"e0120879","last_page":"e0120879"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stimulus-secretion-coupling","display_name":"stimulus-secretion coupling","score":0.9649999737739563},{"id":"https://openalex.org/keywords/endoc-betah1-cells","display_name":"EndoC-\u03b2H1 cells","score":0.9229999780654907},{"id":"https://openalex.org/keywords/ins-1-832-13-cells","display_name":"INS-1 832/13 cells","score":0.9079999923706055},{"id":"https://openalex.org/keywords/human-beta-cells","display_name":"human beta cells","score":0.7020000219345093},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.8709999918937683},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.5669999718666077},{"id":"https://openalex.org/keywords/pyruvate","display_name":"pyruvate","score":0.968999981880188},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.8820000290870667},{"id":"https://openalex.org/keywords/plasma-membrane-potential","display_name":"plasma membrane potential","score":0.7570000290870667},{"id":"https://openalex.org/keywords/calcium-oscillations","display_name":"calcium oscillations","score":0.8529999852180481},{"id":"https://openalex.org/keywords/human-islets","display_name":"human islets","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5675907135009766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5582543015480042},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.55260169506073},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4938533902168274},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.46671196818351746},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.45898377895355225},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4390409588813782},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.43641045689582825},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4256068766117096},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4125775396823883},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3499619662761688},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.2658933401107788},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0120879","doi":"https://doi.org/10.1371/journal.pone.0120879","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0120879","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0120879&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3350523","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4372368","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4372368","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4372368","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:25803449","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25803449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.799.4106","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.799.4106","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/dc/df/pone.0120879.PMC4372368.pdf","raw_type":"text"},{"id":"pmh:oai:HAL:inserm-01137919v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/inserm-01137919v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 2015, pp.e0120879. &#x27E8;10.1371/journal.pone.0120879.s004&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:1dce2a75662a436da2a7511d4e83b1f0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1dce2a75662a436da2a7511d4e83b1f0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 3, p e0120879 (2015)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1353330","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Characterization_of_Stimulus_Secretion_Coupling_in_the_Human_Pancreatic_EndoC_946_H1_Beta_Cell_Line_/1353330","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:lup.lub.lu.se:c1d70d58-fd2c-4296-9033-ff251be42f95","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/5257744","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1932-6203","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0120879","doi":"https://doi.org/10.1371/journal.pone.0120879","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0120879","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0120879&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321806","display_name":"Lunds Universitet","ror":"https://ror.org/012a77v79"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014195232.pdf","grobid_xml":"https://content.openalex.org/works/W2014195232.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1819922922","https://openalex.org/W1870996486","https://openalex.org/W1973378704","https://openalex.org/W1974837721","https://openalex.org/W1985591159","https://openalex.org/W1987813287","https://openalex.org/W1987930017","https://openalex.org/W1991003148","https://openalex.org/W1998071649","https://openalex.org/W2006131499","https://openalex.org/W2011413530","https://openalex.org/W2015001567","https://openalex.org/W2017932539","https://openalex.org/W2021162959","https://openalex.org/W2022228039","https://openalex.org/W2030845275","https://openalex.org/W2031640794","https://openalex.org/W2038619251","https://openalex.org/W2040651543","https://openalex.org/W2044067342","https://openalex.org/W2044801034","https://openalex.org/W2048591747","https://openalex.org/W2049098799","https://openalex.org/W2049583639","https://openalex.org/W2055492712","https://openalex.org/W2058601364","https://openalex.org/W2068524200","https://openalex.org/W2069409352","https://openalex.org/W2074839982","https://openalex.org/W2080908315","https://openalex.org/W2086034132","https://openalex.org/W2087357268","https://openalex.org/W2088160164","https://openalex.org/W2095130937","https://openalex.org/W2097813267","https://openalex.org/W2108488321","https://openalex.org/W2114740224","https://openalex.org/W2125058848","https://openalex.org/W2140746123","https://openalex.org/W2142228286","https://openalex.org/W2143505819","https://openalex.org/W2145986471","https://openalex.org/W2151258444","https://openalex.org/W2152637004","https://openalex.org/W2153134360","https://openalex.org/W4285719527","https://openalex.org/W7097881918"],"related_works":["https://openalex.org/W7095512770","https://openalex.org/W2181854031","https://openalex.org/W817401969","https://openalex.org/W2019649040","https://openalex.org/W2773794717","https://openalex.org/W2021162959","https://openalex.org/W2781215248","https://openalex.org/W1998071649","https://openalex.org/W2950558141","https://openalex.org/W4235694101"],"abstract_inverted_index":{"AIMS/HYPOTHESIS:":[0],"Studies":[1],"on":[2],"beta":[3,11,21,49],"cell":[4,12,22,27,39,50,183,238,256],"metabolism":[5],"are":[6,258],"often":[7],"conducted":[8],"in":[9,37,46,114,130,159,177,181,189,196,200,208,212,235,248,260,270],"rodent":[10],"lines":[13,257],"due":[14],"to":[15,61,179,193,206],"the":[16,47,224,236,264,276,280],"lack":[17],"of":[18,226,266,278,285],"stable":[19],"human":[20,26,55,115,197,209,252,281,286],"lines.":[23],"Recently,":[24],"a":[25],"line,":[28,40,51],"EndoC-\u03b2H1,":[29],"was":[30,150,203],"generated.":[31],"Here":[32],"we":[33],"investigate":[34],"stimulus-secretion":[35,221],"coupling":[36],"this":[38],"and":[41,54,63,67,95,99,109,127,133,138,152,172,230,243,251,290],"compare":[42],"it":[43],"with":[44,219,223,263],"that":[45,170,207],"rat":[48],"INS-1":[52,213],"832/13,":[53],"islets.":[56,116,198,253],"METHODS:":[57],"Cells":[58],"were":[59,104,112,187,233,246],"exposed":[60],"glucose":[62,84,122,154,180],"pyruvate.":[64],"Insulin":[65],"secretion":[66,111,137],"content":[68],"(radioimmunoassay),":[69],"gene":[70],"expression":[71],"(Gene":[72],"Chip":[73],"array),":[74],"metabolite":[75,244],"levels":[76,92,175],"(GC/MS),":[77],"respiration":[78,108,242],"(Seahorse":[79],"XF24":[80],"Extracellular":[81],"Flux":[82],"Analyzer),":[83],"utilization":[85],"(radiometric),":[86],"lactate":[87],"release":[88],"(enzymatic":[89,93],"colorimetric),":[90],"ATP":[91,125],"bioluminescence)":[94],"plasma":[96,147,164,227],"membrane":[97,148,165,228],"potential":[98,229],"cytoplasmic":[100],"Ca2+":[101,231],"responses":[102,186,245],"(microfluorometry)":[103],"measured.":[105],"Metabolite":[106,167],"levels,":[107],"insulin":[110,120,136,144,240],"examined":[113],"RESULTS:":[117],"Glucose":[118],"increased":[119,135,176],"release,":[121],"utilization,":[123],"raised":[124],"production":[126],"respiratory":[128],"rates":[129],"both":[131,182,255],"lines,":[132,184],"pyruvate":[134,156],"respiration.":[139],"EndoC-\u03b2H1":[140,190,201,249,273],"cells":[141,202,250,274],"exhibited":[142],"higher":[143],"secretion,":[145,241],"while":[146],"depolarization":[149],"attenuated,":[151],"neither":[153],"nor":[155],"induced":[157],"oscillations":[158],"intracellular":[160],"calcium":[161],"concentration":[162],"or":[163],"potential.":[166],"profiling":[168],"revealed":[169],"glycolytic":[171],"TCA-cycle":[173],"intermediate":[174],"response":[178],"but":[185],"weaker":[188],"cells,":[191],"similar":[192,205,234,247],"those":[194],"observed":[195],"Respiration":[199],"more":[204],"islets":[210],"than":[211],"832/13":[214],"cells.":[215],"CONCLUSIONS/INTERPRETATION:":[216],"Functions":[217],"associated":[218],"early":[220],"coupling,":[222],"exception":[225],"oscillations,":[232],"two":[237],"lines;":[239],"While":[254],"suitable":[259],"vitro":[261],"models,":[262],"caveat":[265],"replicating":[267],"key":[268],"findings":[269],"isolated":[271],"islets,":[272],"have":[275],"advantage":[277],"carrying":[279],"genome,":[282],"allowing":[283],"studies":[284],"genetic":[287],"variants,":[288],"epigenetics":[289],"regulatory":[291],"RNA":[292],"molecules.":[293]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
