{"id":"https://openalex.org/W201419276","doi":null,"title":"Alteration of mucin in human conjunctival epithelia in dry eye.","display_name":"Alteration of mucin in human conjunctival epithelia in dry eye.","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W201419276","mag":"201419276","pmid":"https://pubmed.ncbi.nlm.nih.gov/9856770"},"language":"en","primary_location":{"id":"pmid:9856770","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9856770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048272552","display_name":"Yukitaka Danjo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Danjo","raw_affiliation_strings":["Schepens Eye Research Institute and the Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schepens Eye Research Institute and the Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101796159","display_name":"Hiroki Watanabe","orcid":"https://orcid.org/0000-0003-4283-1470","observed_orcids":["https://orcid.org/0000-0003-4283-1470"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Watanabe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108619346","display_name":"Ann S. Tisdale","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A S Tisdale","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026094123","display_name":"Michelle A. George","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M George","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T Tsumura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Tsumura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111407954","display_name":"Mark B. Abelson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M B Abelson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5064160717","display_name":"Ilene K. Gipson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I K Gipson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.9144,"has_fulltext":false,"cited_by_count":214,"citation_normalized_percentile":{"value":0.9319183,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"39","issue":"13","first_page":"2602","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dry-eye-disease","display_name":"dry eye","score":0.9459999799728394},{"id":"https://openalex.org/keywords/conjunctival-epithelium","display_name":"conjunctival epithelium","score":0.878000020980835},{"id":"https://openalex.org/keywords/mucin","display_name":"mucin","score":0.847000002861023},{"id":"https://openalex.org/keywords/mucin-glycosylation","display_name":"mucin glycosylation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/glycan-epitopes","display_name":"carbohydrate epitopes","score":0.7649999856948853},{"id":"https://openalex.org/keywords/impression-cytology","display_name":"imprint cytology","score":0.9279999732971191},{"id":"https://openalex.org/keywords/goblet-cells","display_name":"goblet cells","score":0.8799999952316284},{"id":"https://openalex.org/keywords/aqueous-deficient-dry-eye","display_name":"aqueous-deficient dry eye","score":0.8619999885559082},{"id":"https://openalex.org/keywords/rose-bengal-staining","display_name":"rose bengal staining","score":0.9279999732971191}],"concepts":[{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.8391042947769165},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.528039813041687},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5242736339569092},{"id":"https://openalex.org/C2775984611","wikidata":"https://www.wikidata.org/wiki/Q273554","display_name":"Conjunctiva","level":2,"score":0.5189328193664551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5014257431030273},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.4963539242744446},{"id":"https://openalex.org/C2993140218","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Immunoelectron microscopy","level":3,"score":0.47508659958839417},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.46952882409095764},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4397992789745331},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.43369826674461365},{"id":"https://openalex.org/C2775941134","wikidata":"https://www.wikidata.org/wiki/Q813622","display_name":"Goblet cell","level":3,"score":0.43244558572769165},{"id":"https://openalex.org/C2780898351","wikidata":"https://www.wikidata.org/wiki/Q11350933","display_name":"Rose bengal","level":2,"score":0.42957261204719543},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3925599157810211},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3582923412322998},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.33892491459846497},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2766142189502716},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.22719812393188477},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06613233685493469}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003228","descriptor_name":"Conjunctiva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003228","descriptor_name":"Conjunctiva","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009077","descriptor_name":"Mucins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012395","descriptor_name":"Rose Bengal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015352","descriptor_name":"Dry Eye Syndromes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015352","descriptor_name":"Dry Eye Syndromes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016253","descriptor_name":"Microscopy, Immunoelectron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019084","descriptor_name":"Fluorescent Antibody Technique, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:9856770","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9856770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.328.9926","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.9926","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.iovs.org/content/39/13/2602.full.pdf","raw_type":"text"},{"id":"mag:201419276","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9856770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G168392053","display_name":"CELL MOTILITY AND ADHESION IN CORNEAL WOUND HEALING","funder_award_id":"R37EY003306","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W15148084","https://openalex.org/W52288874","https://openalex.org/W138641899","https://openalex.org/W145780728","https://openalex.org/W153307813","https://openalex.org/W1608837873","https://openalex.org/W1965733855","https://openalex.org/W1970430573","https://openalex.org/W1974626201","https://openalex.org/W1976878085","https://openalex.org/W1977565209","https://openalex.org/W1980004507","https://openalex.org/W1987117141","https://openalex.org/W1990576270","https://openalex.org/W2002427756","https://openalex.org/W2004815659","https://openalex.org/W2006594781","https://openalex.org/W2007976366","https://openalex.org/W2031133058","https://openalex.org/W2040242834","https://openalex.org/W2046572275","https://openalex.org/W2060661957","https://openalex.org/W2074248354","https://openalex.org/W2080839328","https://openalex.org/W2082503532","https://openalex.org/W2130394450","https://openalex.org/W2162568046","https://openalex.org/W2418727593"],"related_works":["https://openalex.org/W7100587321","https://openalex.org/W2145915971","https://openalex.org/W2004815659","https://openalex.org/W2145706944","https://openalex.org/W2411049142","https://openalex.org/W2780832935","https://openalex.org/W7099083428","https://openalex.org/W1965524311","https://openalex.org/W4391692821","https://openalex.org/W1128325766"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,186],"objective":[2],"of":[3,45,92,101,112,151,168,217,227],"this":[4],"study":[5,60],"was":[6,40,149,165],"to":[7,42,48,103,124,178],"determine":[8],"whether":[9],"alteration":[10,206],"in":[11,16,98,106,127,143,162,183,208,221],"mucins":[12,230],"could":[13],"be":[14],"detected":[15],"patients":[17,68,84,113,144],"with":[18,69,110,114,131,145,155,191,232],"dry":[19,70,82,115,146,222],"eye":[20,71,83,116,147,223],"symptoms":[21,72,148],"by":[22,52,157],"using":[23],"the":[24,93,121,152,184,215,233],"monoclonal":[25],"antibody":[26,47,122],"H185,":[27],"which":[28,163],"recognizes":[29],"carbohydrate":[30],"epitopes":[31],"on":[32,214],"mucin":[33,209,212],"molecules.":[34],"METHODS:":[35],"Immunohistochemistry":[36],"and":[37,73,85,224],"immunoelectron":[38],"microscopy":[39],"used":[41],"examine":[43],"binding":[44,99,171,177],"H185":[46,102],"conjunctival":[49,104,219],"cells":[50,105,126,132,180,220],"obtained":[51],"nitrocellulose":[53],"filter":[54],"paper":[55],"stripping":[56],"(impression":[57],"cytology).":[58],"Two":[59],"populations":[61],"were":[62],"examined.":[63],"Study":[64,77],"I":[65],"included":[66,79],"22":[67],"13":[74],"normal":[75,107,119],"volunteers.":[76],"II":[78],"16":[80],"aqueous-deficient":[81],"14":[86],"age-matched":[87],"control":[88],"subjects.":[89],"RESULTS:":[90],"Results":[91],"studies":[94,198],"demonstrated":[95],"significant":[96],"differences":[97],"patterns":[100],"eyes":[108],"compared":[109],"those":[111],"symptoms.":[117],"In":[118],"eyes,":[120],"bound":[123],"apical":[125,169,218],"a":[128,158,166],"mosaic":[129,153],"pattern,":[130],"exhibiting":[133],"either":[134,207],"light,":[135],"medium,":[136],"or":[137,211],"intense":[138],"binding.":[139],"A":[140],"predominant":[141],"pattern":[142,154,161,189],"loss":[150],"replacement":[156],"\"starry":[159],"sky\"":[160],"there":[164,203],"lack":[167],"cell":[170,229],"(hence,":[172,181],"dark":[173],"sky)":[174],"but":[175],"increased":[176],"goblet":[179,228],"stars":[182],"sky).":[185],"starry":[187],"sky":[188],"correlated":[190],"rose":[192],"bengal":[193],"staining.":[194],"CONCLUSIONS:":[195],"From":[196],"these":[197],"it":[199],"is":[200,204],"concluded":[201],"that":[202,225],"an":[205],"distribution":[210],"glycosylation":[213,226],"surfaces":[216],"changes":[231],"disease.":[234]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}