{"id":"https://openalex.org/W2014185444","doi":"https://doi.org/10.1371/journal.pone.0117268","title":"Application of the C3-Binding Motif of Streptococcal Pyrogenic Exotoxin B to Protect Mice from Invasive Group A Streptococcal Infection","display_name":"Application of the C3-Binding Motif of Streptococcal Pyrogenic Exotoxin B to Protect Mice from Invasive Group A Streptococcal Infection","publication_year":2015,"publication_date":"2015-01-28","ids":{"openalex":"https://openalex.org/W2014185444","doi":"https://doi.org/10.1371/journal.pone.0117268","mag":"2014185444","pmid":"https://pubmed.ncbi.nlm.nih.gov/25629609","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4309557"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0117268","doi":"https://doi.org/10.1371/journal.pone.0117268","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0117268","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117268&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2014185444"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117268&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110482426","display_name":"Chih-Feng Kuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98298690","display_name":"I-Shou University","ror":"https://ror.org/04d7e4m76","country_code":"TW","type":"education","lineage":["https://openalex.org/I98298690"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chih-Feng Kuo","raw_affiliation_strings":["Department of Nursing, I-Shou University, Kaohsiung City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, I-Shou University, Kaohsiung City, Taiwan","institution_ids":["https://openalex.org/I98298690"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032846040","display_name":"Nina Tsao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98298690","display_name":"I-Shou University","ror":"https://ror.org/04d7e4m76","country_code":"TW","type":"education","lineage":["https://openalex.org/I98298690"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Nina Tsao","raw_affiliation_strings":["Department of Biological Science and Technology, I-Shou University, Kaohsiung City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science and Technology, I-Shou University, Kaohsiung City, Taiwan","institution_ids":["https://openalex.org/I98298690"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064892010","display_name":"Miao-Hui Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98298690","display_name":"I-Shou University","ror":"https://ror.org/04d7e4m76","country_code":"TW","type":"education","lineage":["https://openalex.org/I98298690"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Miao-Hui Cheng","raw_affiliation_strings":["Department of Biological Science and Technology, I-Shou University, Kaohsiung City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science and Technology, I-Shou University, Kaohsiung City, Taiwan","institution_ids":["https://openalex.org/I98298690"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001801066","display_name":"Hsiu-Chen Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98298690","display_name":"I-Shou University","ror":"https://ror.org/04d7e4m76","country_code":"TW","type":"education","lineage":["https://openalex.org/I98298690"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsiu-Chen Yang","raw_affiliation_strings":["Department of Biological Science and Technology, I-Shou University, Kaohsiung City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science and Technology, I-Shou University, Kaohsiung City, Taiwan","institution_ids":["https://openalex.org/I98298690"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102908332","display_name":"Yu-Chieh Wang","orcid":"https://orcid.org/0000-0002-7445-4561","observed_orcids":["https://orcid.org/0000-0002-7445-4561"]},"institutions":[{"id":"https://openalex.org/I98298690","display_name":"I-Shou University","ror":"https://ror.org/04d7e4m76","country_code":"TW","type":"education","lineage":["https://openalex.org/I98298690"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Chieh Wang","raw_affiliation_strings":["Department of Biological Science and Technology, I-Shou University, Kaohsiung City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science and Technology, I-Shou University, Kaohsiung City, Taiwan","institution_ids":["https://openalex.org/I98298690"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063750800","display_name":"Ying\u2010Pin Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98298690","display_name":"I-Shou University","ror":"https://ror.org/04d7e4m76","country_code":"TW","type":"education","lineage":["https://openalex.org/I98298690"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ying-Pin Chen","raw_affiliation_strings":["Department of Biological Science and Technology, I-Shou University, Kaohsiung City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science and Technology, I-Shou University, Kaohsiung City, Taiwan","institution_ids":["https://openalex.org/I98298690"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034907385","display_name":"Kai-Jen Lin","orcid":"https://orcid.org/0000-0001-6430-0721","observed_orcids":["https://orcid.org/0000-0001-6430-0721"]},"institutions":[{"id":"https://openalex.org/I4210091198","display_name":"E-Da Hospital","ror":"https://ror.org/00eh7f421","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210091198"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kai-Jen Lin","raw_affiliation_strings":["Department of Pathology, E-DA Hospital, Kaohsiung City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, E-DA Hospital, Kaohsiung City, Taiwan","institution_ids":["https://openalex.org/I4210091198"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110482426"],"corresponding_institution_ids":["https://openalex.org/I98298690"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.4613,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.62803042,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"1","first_page":"e0117268","last_page":"e0117268"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptococcus-pyogenes","display_name":"Streptococcus pyogenes","score":0.8500000238418579},{"id":"https://openalex.org/keywords/pyrogenic-exotoxin-b","display_name":"pyrogenic exotoxin B","score":0.9430000185966492},{"id":"https://openalex.org/keywords/streptolysin-s","display_name":"streptolysin S","score":0.8650000095367432},{"id":"https://openalex.org/keywords/invasive-group-a-streptococcal-disease","display_name":"invasive group A streptococcal disease","score":0.8610000014305115},{"id":"https://openalex.org/keywords/protein-subunit-vaccines","display_name":"subunit vaccine","score":0.7730000019073486},{"id":"https://openalex.org/keywords/protective-epitopes","display_name":"protective epitopes","score":0.5550000071525574},{"id":"https://openalex.org/keywords/peptide-immunization","display_name":"peptide immunization","score":0.503000020980835},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C2779306812","wikidata":"https://www.wikidata.org/wiki/Q131271","display_name":"Streptococcus pyogenes","level":4,"score":0.736716628074646},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6811456680297852},{"id":"https://openalex.org/C2778723905","wikidata":"https://www.wikidata.org/wiki/Q408649","display_name":"Exotoxin","level":3,"score":0.6689434051513672},{"id":"https://openalex.org/C2778276568","wikidata":"https://www.wikidata.org/wiki/Q190161","display_name":"Streptococcus","level":3,"score":0.6429352760314941},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.5965846180915833},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.582423985004425},{"id":"https://openalex.org/C2781090273","wikidata":"https://www.wikidata.org/wiki/Q1623405","display_name":"Virulence factor","level":4,"score":0.565093457698822},{"id":"https://openalex.org/C2776993315","wikidata":"https://www.wikidata.org/wiki/Q418187","display_name":"Streptolysin","level":4,"score":0.5035943388938904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49808716773986816},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4547105133533478},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.4292204976081848},{"id":"https://openalex.org/C2780678043","wikidata":"https://www.wikidata.org/wiki/Q743241","display_name":"Group A","level":2,"score":0.42279693484306335},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.4144613742828369},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3289017081260681},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2806321680545807},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.2804288864135742},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.24866634607315063},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23201793432235718},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20046794414520264},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.19202730059623718},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1363838016986847},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.12485608458518982},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2993175405","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Bacterial protein","level":3,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005098","descriptor_name":"Exotoxins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013290","descriptor_name":"Streptococcal Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013290","descriptor_name":"Streptococcal Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013297","descriptor_name":"Streptococcus pyogenes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D022541","descriptor_name":"Streptococcal Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0117268","doi":"https://doi.org/10.1371/journal.pone.0117268","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0117268","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117268&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmid:25629609","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25629609","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4309557","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4309557/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:bb95efa1c077499d8e9055c1dba0a86f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bb95efa1c077499d8e9055c1dba0a86f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 1, p e0117268 (2015)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1296941","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Application_of_the_C3_Binding_Motif_of_Streptococcal_Pyrogenic_Exotoxin_B_to_Protect_Mice_from_Invasive_Group_A_Streptococcal_Infection_/1296941","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0117268","doi":"https://doi.org/10.1371/journal.pone.0117268","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0117268","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0117268&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2637067611","display_name":"Role of Cyclooxygenase-2 in Invasive Group a Streptococcal Infection---Study the Mechanism of Streptolysin S/Streptococcal pyrogenic Exotoxin B-Mediated Cyclooxygenase-2 Expression and Bactericidal Suppression in Macrophages.","funder_award_id":"MOST103-2320-B214-006","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320322201","display_name":"I-Shou University","ror":"https://ror.org/04d7e4m76"},{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014185444.pdf","grobid_xml":"https://content.openalex.org/works/W2014185444.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1968839949","https://openalex.org/W1976556495","https://openalex.org/W1982239851","https://openalex.org/W1985472523","https://openalex.org/W1986139740","https://openalex.org/W1998930337","https://openalex.org/W2001643095","https://openalex.org/W2002993124","https://openalex.org/W2004722386","https://openalex.org/W2012365327","https://openalex.org/W2022233387","https://openalex.org/W2024839220","https://openalex.org/W2030483260","https://openalex.org/W2033812959","https://openalex.org/W2071422631","https://openalex.org/W2075803196","https://openalex.org/W2079874166","https://openalex.org/W2080840270","https://openalex.org/W2082043927","https://openalex.org/W2085325491","https://openalex.org/W2087064894","https://openalex.org/W2093716260","https://openalex.org/W2095487631","https://openalex.org/W2097408755","https://openalex.org/W2099361127","https://openalex.org/W2104305294","https://openalex.org/W2104555813","https://openalex.org/W2105714045","https://openalex.org/W2107963892","https://openalex.org/W2113380603","https://openalex.org/W2115748395","https://openalex.org/W2119211468","https://openalex.org/W2119879750","https://openalex.org/W2126168699","https://openalex.org/W2127966255","https://openalex.org/W2128893067","https://openalex.org/W2134857208","https://openalex.org/W2145670947","https://openalex.org/W2153483571","https://openalex.org/W2158807107","https://openalex.org/W2158820310","https://openalex.org/W2221714924","https://openalex.org/W7073900711"],"related_works":["https://openalex.org/W2033812959","https://openalex.org/W2158820310","https://openalex.org/W1994277319","https://openalex.org/W2155894257","https://openalex.org/W2030483260","https://openalex.org/W2586812558","https://openalex.org/W2071422631","https://openalex.org/W2047453527","https://openalex.org/W1990108536","https://openalex.org/W2147848179"],"abstract_inverted_index":{"Group":[0],"A":[1,244],"streptococcus":[2],"(GAS)":[3],"is":[4],"an":[5,30],"important":[6,31,189],"human":[7,100],"pathogen":[8],"that":[9,40,83,115,205],"produces":[10],"several":[11],"extracellular":[12],"exotoxins":[13],"to":[14,28,66,181,186],"facilitate":[15],"invasion":[16],"and":[17,47,59,78,109,168,194,226],"infection.":[18,246],"Streptococcal":[19],"pyrogenic":[20],"exotoxin":[21],"B":[22,42,65,93,176,225],"(SPE":[23],"B)":[24],"has":[25],"been":[26],"demonstrated":[27],"be":[29,233],"virulence":[32],"factor":[33],"of":[34,51,63,71,91,99,120,136,157,164,174,197,212,219,223,230],"GAS.":[35,213],"Our":[36],"previous":[37],"studies":[38],"indicate":[39,216],"SPE":[41,64,72,92,175,224],"cleaves":[43],"complement":[44,52],"3":[45],"(C3)":[46],"inhibits":[48],"the":[49,68,84,95,118,125,170,195,220,227],"activation":[50],"pathways.":[53],"In":[54],"this":[55],"study,":[56],"we":[57,81],"constructed":[58],"expressed":[60],"recombinant":[61],"fragments":[62],"examine":[67],"C3-binding":[69,112,126,172,221],"site":[70,98],"B.":[73],"Using":[74],"enzyme-linked":[75],"immunosorbent":[76],"assays":[77],"pull-down":[79],"assays,":[80],"found":[82],"C-terminal":[85,162],"domain,":[86],"containing":[87],"amino-acid":[88],"residues":[89],"345-398,":[90],"was":[94,179],"major":[96,171],"binding":[97,119],"serum":[101],"C3.":[102],"We":[103],"further":[104],"identified":[105],"a":[106,110,133,155,217,236],"major,":[107],"Ala376-Pro398,":[108],"minor":[111],"motif,":[113],"Gly346-Gly360,":[114],"both":[116],"mediated":[117],"C3":[121],"complement.":[122],"Immunization":[123],"with":[124,132,208],"motifs":[127],"protected":[128],"mice":[129,204],"against":[130,150,239],"challenge":[131],"lethal":[134],"dose":[135],"non-invasive":[137],"M49":[138],"strain":[139],"GAS":[140,153],"but":[141],"not":[142],"invasive":[143,151,209,240],"M1":[144,152,210,241],"strains.":[145],"To":[146],"achieve":[147],"higher":[148],"efficiency":[149],"infection,":[154],"combination":[156,218],"synthetic":[158],"peptides":[159],"derived":[160],"from":[161,169],"epitope":[163,229],"streptolysin":[165],"S":[166],"(SLSpp)":[167],"motif":[173,222],"(PP6,":[177],"Ala376-Pro398)":[178],"used":[180,234],"elicit":[182],"specific":[183],"immune":[184],"response":[185],"those":[187],"two":[188],"streptococcal":[190,245],"exotoxins.":[191],"Death":[192],"rates":[193],"severity":[196],"skin":[198],"lesions":[199],"decreased":[200],"significantly":[201],"in":[202],"PP6/SLSpp-immunized":[203],"were":[206],"infected":[207],"strains":[211,242],"These":[214],"results":[215],"protective":[228],"SLS":[231],"could":[232],"as":[235],"subunit":[237],"vaccine":[238],"group":[243]},"counts_by_year":[{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
