{"id":"https://openalex.org/W2014150849","doi":"https://doi.org/10.1016/0898-6568(89)90045-4","title":"Inhibition of PI-kinase in rat liver membranes by F\u2212","display_name":"Inhibition of PI-kinase in rat liver membranes by F\u2212","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2014150849","doi":"https://doi.org/10.1016/0898-6568(89)90045-4","mag":"2014150849","pmid":"https://pubmed.ncbi.nlm.nih.gov/2561945"},"language":"en","primary_location":{"id":"doi:10.1016/0898-6568(89)90045-4","doi":"https://doi.org/10.1016/0898-6568(89)90045-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0898-6568(89)90045-4","pdf_url":null,"source":{"id":"https://openalex.org/S113768434","display_name":"Cellular Signalling","issn_l":"0898-6568","issn":["0898-6568","1873-3913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Signalling","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041388463","display_name":"Mark Biffen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Mark Biffen","raw_affiliation_strings":["Department of Biochemistry, University of Cambridge, U.K","Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Cambridge, U.K","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW U.K","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":null,"display_name":"B.Richard Martin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B.Richard Martin","raw_affiliation_strings":["Department of Biochemistry, University of Cambridge, Cambridge CB2, 1QW, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Cambridge, Cambridge CB2, 1QW, U.K","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041388463"],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":0.1289,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.39819297,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"3","first_page":"283","last_page":"287"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphoinositide-kinases","display_name":"phosphoinositide kinases","score":0.7490000128746033},{"id":"https://openalex.org/keywords/fluoride-inhibition","display_name":"fluoride inhibition","score":0.6800000071525574},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.8209999799728394},{"id":"https://openalex.org/keywords/inositol-trisphosphate","display_name":"inositol trisphosphate","score":0.7879999876022339},{"id":"https://openalex.org/keywords/diacylglycerol","display_name":"diacylglycerol","score":0.9909999966621399},{"id":"https://openalex.org/keywords/polyphosphoinositides","display_name":"polyphosphoinositides","score":0.8240000009536743},{"id":"https://openalex.org/keywords/liver-membranes","display_name":"liver membranes","score":0.7070000171661377},{"id":"https://openalex.org/keywords/g-proteins","display_name":"G proteins","score":0.5699999928474426},{"id":"https://openalex.org/keywords/second-messengers","display_name":"second messengers","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C36020004","wikidata":"https://www.wikidata.org/wiki/Q106951674","display_name":"Diacylglycerol kinase","level":4,"score":0.8151326179504395},{"id":"https://openalex.org/C53009064","wikidata":"https://www.wikidata.org/wiki/Q167","display_name":"Pi","level":2,"score":0.6973336338996887},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.6921528577804565},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.6204496026039124},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.599734902381897},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.58689284324646},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.5792191028594971},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4891648590564728},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4811893105506897},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.4746164381504059},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.471231073141098},{"id":"https://openalex.org/C78297661","wikidata":"https://www.wikidata.org/wiki/Q10760862","display_name":"Phosphoinositide phospholipase C","level":4,"score":0.4457463026046753},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41458308696746826},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.401205450296402},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39611268043518066},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.35059767961502075}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005459","descriptor_name":"Fluorides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010716","descriptor_name":"Phosphatidylinositols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010770","descriptor_name":"Phosphotransferases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D010770","descriptor_name":"Phosphotransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019269","descriptor_name":"Phosphatidylinositol 4,5-Diphosphate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019870","descriptor_name":"1-Phosphatidylinositol 4-Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0898-6568(89)90045-4","doi":"https://doi.org/10.1016/0898-6568(89)90045-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0898-6568(89)90045-4","pdf_url":null,"source":{"id":"https://openalex.org/S113768434","display_name":"Cellular Signalling","issn_l":"0898-6568","issn":["0898-6568","1873-3913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Signalling","raw_type":"journal-article"},{"id":"pmid:2561945","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2561945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular signalling","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W5462217","https://openalex.org/W121512958","https://openalex.org/W1150848503","https://openalex.org/W1480938203","https://openalex.org/W1492988786","https://openalex.org/W1498162448","https://openalex.org/W1506728145","https://openalex.org/W1513905140","https://openalex.org/W1527297959","https://openalex.org/W1549240981","https://openalex.org/W1559556161","https://openalex.org/W1562998862","https://openalex.org/W1567061008","https://openalex.org/W1772576610","https://openalex.org/W1775749144","https://openalex.org/W2001687067","https://openalex.org/W2043072598","https://openalex.org/W2056795577","https://openalex.org/W2072482644","https://openalex.org/W2171152987","https://openalex.org/W2229264558","https://openalex.org/W2238525991","https://openalex.org/W2333359926","https://openalex.org/W2398877864","https://openalex.org/W2405348828","https://openalex.org/W2412184730"],"related_works":["https://openalex.org/W2056795577","https://openalex.org/W2003299833","https://openalex.org/W2227839878","https://openalex.org/W2067175052","https://openalex.org/W2011083411","https://openalex.org/W2050878442","https://openalex.org/W2065989299","https://openalex.org/W2054046168","https://openalex.org/W2009808003","https://openalex.org/W1981182586"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
