{"id":"https://openalex.org/W2014137490","doi":"https://doi.org/10.1007/s11102-009-0173-3","title":"Self-limited acute hepatotoxicity caused by pegvisomant","display_name":"Self-limited acute hepatotoxicity caused by pegvisomant","publication_year":2009,"publication_date":"2009-03-05","ids":{"openalex":"https://openalex.org/W2014137490","doi":"https://doi.org/10.1007/s11102-009-0173-3","mag":"2014137490","pmid":"https://pubmed.ncbi.nlm.nih.gov/19266286"},"language":"en","primary_location":{"id":"doi:10.1007/s11102-009-0173-3","doi":"https://doi.org/10.1007/s11102-009-0173-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11102-009-0173-3","pdf_url":null,"source":{"id":"https://openalex.org/S142774597","display_name":"Pituitary","issn_l":"1386-341X","issn":["1386-341X","1573-7403"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pituitary","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110021839","display_name":"A. Soto Moreno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"A. Soto Moreno","raw_affiliation_strings":["Department of Endocrinology and Nutrition, Instituto de Biomedicina de Sevilla (IBIS), Virgen del Rocio University Hospital, Seville, Spain. alfonsom.soto.sspa@juntadeandalucia.es","Department of Endocrinology and Nutrition, Instituto de Biomedicina de Sevilla (IBIS), Virgen del Rocio University Hospital, Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Nutrition, Instituto de Biomedicina de Sevilla (IBIS), Virgen del Rocio University Hospital, Seville, Spain. alfonsom.soto.sspa@juntadeandalucia.es","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139"]},{"raw_affiliation_string":"Department of Endocrinology and Nutrition, Instituto de Biomedicina de Sevilla (IBIS), Virgen del Rocio University Hospital, Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103520910","display_name":"Raquel Guerrero V\u00e1zquez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"R. Guerrero V\u00e1zquez","raw_affiliation_strings":["Department of Endocrinology and Nutrition, Instituto de Biomedicina de Sevilla (IBIS), Virgen del Rocio University Hospital, Manuel Siurot S/N Avenue, 41013, Seville, Spain","Department of Endocrinology and Nutrition, Instituto de Biomedicina de Sevilla (IBIS), Virgen del Rocio University Hospital, Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Nutrition, Instituto de Biomedicina de Sevilla (IBIS), Virgen del Rocio University Hospital, Manuel Siurot S/N Avenue, 41013, Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139"]},{"raw_affiliation_string":"Department of Endocrinology and Nutrition, Instituto de Biomedicina de Sevilla (IBIS), Virgen del Rocio University Hospital, Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060076454","display_name":"Eva Venegas Moreno","orcid":"https://orcid.org/0000-0001-7093-4990","observed_orcids":["https://orcid.org/0000-0001-7093-4990"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E. Venegas Moreno","raw_affiliation_strings":["Department of Endocrinology and Nutrition, Instituto de Biomedicina de Sevilla (IBIS), Virgen del Rocio University Hospital, Manuel Siurot S/N Avenue, 41013, Seville, Spain","Department of Endocrinology and Nutrition, Instituto de Biomedicina de Sevilla (IBIS), Virgen del Rocio University Hospital, Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Nutrition, Instituto de Biomedicina de Sevilla (IBIS), Virgen del Rocio University Hospital, Manuel Siurot S/N Avenue, 41013, Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139"]},{"raw_affiliation_string":"Department of Endocrinology and Nutrition, Instituto de Biomedicina de Sevilla (IBIS), Virgen del Rocio University Hospital, Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011506505","display_name":"Samara Palma Milla","orcid":"https://orcid.org/0000-0002-0187-1495","observed_orcids":["https://orcid.org/0000-0002-0187-1495"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"S. Palma Milla","raw_affiliation_strings":["Department of Endocrinology and Nutrition, Instituto de Biomedicina de Sevilla (IBIS), Virgen del Rocio University Hospital, Manuel Siurot S/N Avenue, 41013, Seville, Spain","Department of Endocrinology and Nutrition, Instituto de Biomedicina de Sevilla (IBIS), Virgen del Rocio University Hospital, Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Nutrition, Instituto de Biomedicina de Sevilla (IBIS), Virgen del Rocio University Hospital, Manuel Siurot S/N Avenue, 41013, Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139"]},{"raw_affiliation_string":"Department of Endocrinology and Nutrition, Instituto de Biomedicina de Sevilla (IBIS), Virgen del Rocio University Hospital, Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059027410","display_name":"Justo Pastor Castano","orcid":"https://orcid.org/0000-0002-3145-7287","observed_orcids":["https://orcid.org/0000-0002-3145-7287"]},"institutions":[{"id":"https://openalex.org/I53110688","display_name":"University of C\u00f3rdoba","ror":"https://ror.org/05yc77b46","country_code":"ES","type":"education","lineage":["https://openalex.org/I53110688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J. P. Casta\u00f1o","raw_affiliation_strings":["Department of Cell Biology, Physiology and Immunology, University of C\u00f3rdoba, C\u00f3rdoba, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Physiology and Immunology, University of C\u00f3rdoba, C\u00f3rdoba, Spain","institution_ids":["https://openalex.org/I53110688"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058049390","display_name":"Alfonso Leal Cerro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"A. Leal Cerro","raw_affiliation_strings":["Department of Endocrinology and Nutrition, Instituto de Biomedicina de Sevilla (IBIS), Virgen del Rocio University Hospital, Manuel Siurot S/N Avenue, 41013, Seville, Spain","Department of Endocrinology and Nutrition, Instituto de Biomedicina de Sevilla (IBIS), Virgen del Rocio University Hospital, Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Nutrition, Instituto de Biomedicina de Sevilla (IBIS), Virgen del Rocio University Hospital, Manuel Siurot S/N Avenue, 41013, Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139"]},{"raw_affiliation_string":"Department of Endocrinology and Nutrition, Instituto de Biomedicina de Sevilla (IBIS), Virgen del Rocio University Hospital, Seville, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5110021839"],"corresponding_institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139"],"apc_list":{"value":4490,"currency":"USD","value_usd":4490},"apc_paid":null,"fwci":0.5931,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.70513597,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"14","issue":"4","first_page":"371","last_page":"376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.8490999937057495,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.8490999937057495,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.14419999718666077,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pegvisomant","display_name":"pegvisomant","score":0.996999979019165},{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.7860000133514404},{"id":"https://openalex.org/keywords/acute-hepatitis","display_name":"acute hepatitis","score":0.6179999709129333},{"id":"https://openalex.org/keywords/acromegaly","display_name":"acromegaly","score":0.9160000085830688},{"id":"https://openalex.org/keywords/somatostatin-analogs","display_name":"somatostatin analogues","score":0.9750000238418579},{"id":"https://openalex.org/keywords/elevated-liver-enzymes","display_name":"elevated liver enzymes","score":0.9660000205039978},{"id":"https://openalex.org/keywords/treatment-continuation","display_name":"treatment continuation","score":0.38499999046325684}],"concepts":[{"id":"https://openalex.org/C2778886798","wikidata":"https://www.wikidata.org/wiki/Q409697","display_name":"Pegvisomant","level":5,"score":0.9701801538467407},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9496064186096191},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.846437931060791},{"id":"https://openalex.org/C3018886096","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Acute hepatitis","level":3,"score":0.7272365689277649},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.5428299307823181},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.5219082832336426},{"id":"https://openalex.org/C2777433750","wikidata":"https://www.wikidata.org/wiki/Q189580","display_name":"Acromegaly","level":4,"score":0.5095818042755127},{"id":"https://openalex.org/C2777203481","wikidata":"https://www.wikidata.org/wiki/Q786844","display_name":"Autoimmune hepatitis","level":3,"score":0.48970749974250793},{"id":"https://openalex.org/C3019983190","wikidata":"https://www.wikidata.org/wiki/Q157661","display_name":"Hepatitis a virus","level":3,"score":0.46446436643600464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40128037333488464},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3326992392539978},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22228789329528809},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.0},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.0},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012075","descriptor_name":"Remission, Spontaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D049912","descriptor_name":"Growth Hormone-Secreting Pituitary Adenoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11102-009-0173-3","doi":"https://doi.org/10.1007/s11102-009-0173-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11102-009-0173-3","pdf_url":null,"source":{"id":"https://openalex.org/S142774597","display_name":"Pituitary","issn_l":"1386-341X","issn":["1386-341X","1573-7403"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pituitary","raw_type":"journal-article"},{"id":"pmid:19266286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19266286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pituitary","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W108281130","https://openalex.org/W123434114","https://openalex.org/W1966058349","https://openalex.org/W1975128137","https://openalex.org/W1998767852","https://openalex.org/W2014729851","https://openalex.org/W2025569597","https://openalex.org/W2068248473","https://openalex.org/W2068704610","https://openalex.org/W2084844937","https://openalex.org/W2114461739","https://openalex.org/W2121326610","https://openalex.org/W2143791513","https://openalex.org/W2147795491","https://openalex.org/W2153200944","https://openalex.org/W2169376102","https://openalex.org/W2406477755","https://openalex.org/W4247659005"],"related_works":["https://openalex.org/W2121326610","https://openalex.org/W2269040312","https://openalex.org/W2114461739","https://openalex.org/W2118468197","https://openalex.org/W2139926910","https://openalex.org/W1985791167","https://openalex.org/W2138130548","https://openalex.org/W1994013062","https://openalex.org/W4307869112","https://openalex.org/W2109030322"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}