{"id":"https://openalex.org/W2014130451","doi":"https://doi.org/10.3892/ijmm.2014.1743","title":"MicroRNAs play a role in chondrogenesis and osteoarthritis (Review)","display_name":"MicroRNAs play a role in chondrogenesis and osteoarthritis (Review)","publication_year":2014,"publication_date":"2014-04-15","ids":{"openalex":"https://openalex.org/W2014130451","doi":"https://doi.org/10.3892/ijmm.2014.1743","mag":"2014130451","pmid":"https://pubmed.ncbi.nlm.nih.gov/24736803"},"language":"en","primary_location":{"id":"doi:10.3892/ijmm.2014.1743","doi":"https://doi.org/10.3892/ijmm.2014.1743","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijmm.2014.1743","pdf_url":"http://www.spandidos-publications.com/ijmm/34/1/13/download","source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.spandidos-publications.com/ijmm/34/1/13/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103398603","display_name":"Chuanlong Wu","orcid":"https://orcid.org/0000-0002-7513-8536","observed_orcids":["https://orcid.org/0000-0002-7513-8536"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"CHUANLONG WU","raw_affiliation_strings":["Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101797645","display_name":"Bo Tian","orcid":"https://orcid.org/0000-0002-8936-6783","observed_orcids":["https://orcid.org/0000-0002-8936-6783"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"BO TIAN","raw_affiliation_strings":["Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053872563","display_name":"Xinhua Qu","orcid":"https://orcid.org/0000-0002-8889-0890","observed_orcids":["https://orcid.org/0000-0002-8889-0890"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XINHUA QU","raw_affiliation_strings":["Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100611625","display_name":"Fengxiang Liu","orcid":"https://orcid.org/0000-0002-2841-9861","observed_orcids":["https://orcid.org/0000-0002-2841-9861"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"FENGXIANG LIU","raw_affiliation_strings":["Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062413297","display_name":"Tingting Tang","orcid":"https://orcid.org/0000-0002-1670-7452","observed_orcids":["https://orcid.org/0000-0002-1670-7452"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"TINGTING TANG","raw_affiliation_strings":["Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072527166","display_name":"An Qin","orcid":"https://orcid.org/0000-0002-8785-8848","observed_orcids":["https://orcid.org/0000-0002-8785-8848"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"AN QIN","raw_affiliation_strings":["Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101893161","display_name":"Zhenan Zhu","orcid":"https://orcid.org/0000-0001-6593-4742","observed_orcids":["https://orcid.org/0000-0001-6593-4742"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"ZHENAN ZHU","raw_affiliation_strings":["Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110041176","display_name":"Kerong Dai","orcid":"https://orcid.org/0000-0001-6206-1149","observed_orcids":["https://orcid.org/0000-0001-6206-1149"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"KERONG DAI","raw_affiliation_strings":["Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5922,"has_fulltext":true,"cited_by_count":118,"citation_normalized_percentile":{"value":0.81832298,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"34","issue":"1","first_page":"13","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":1.0},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/chondrogenesis","display_name":"chondrogenesis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.9369999766349792},{"id":"https://openalex.org/keywords/chondrocyte-hypertrophy","display_name":"chondrocyte hypertrophy","score":0.8619999885559082},{"id":"https://openalex.org/keywords/endochondral-ossification","display_name":"endochondral ossification","score":0.8960000276565552},{"id":"https://openalex.org/keywords/protease","display_name":"proteolytic enzymes","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cartilage","display_name":"cartilage","score":0.628000020980835},{"id":"https://openalex.org/keywords/microrna-therapy","display_name":"miRNA-based therapy","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C35496256","wikidata":"https://www.wikidata.org/wiki/Q5104524","display_name":"Chondrogenesis","level":3,"score":0.8665894269943237},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8160203695297241},{"id":"https://openalex.org/C17938293","wikidata":"https://www.wikidata.org/wiki/Q3312710","display_name":"Endochondral ossification","level":3,"score":0.6748723387718201},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.5822365880012512},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.5082425475120544},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.48378750681877136},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4722703695297241},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.4624588191509247},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43604105710983276},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.39051035046577454},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19580182433128357},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17027410864830017},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1656319499015808},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.08472579717636108},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020219","descriptor_name":"Chondrogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055747","descriptor_name":"SOX Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055747","descriptor_name":"SOX Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/ijmm.2014.1743","doi":"https://doi.org/10.3892/ijmm.2014.1743","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijmm.2014.1743","pdf_url":"http://www.spandidos-publications.com/ijmm/34/1/13/download","source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:24736803","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24736803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/ijmm.2014.1743","doi":"https://doi.org/10.3892/ijmm.2014.1743","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijmm.2014.1743","pdf_url":"http://www.spandidos-publications.com/ijmm/34/1/13/download","source":{"id":"https://openalex.org/S192722082","display_name":"International Journal of Molecular Medicine","issn_l":"1107-3756","issn":["1107-3756","1791-244X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[{"id":"https://openalex.org/G1626601868","display_name":null,"funder_award_id":"81201364","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2840101858","display_name":null,"funder_award_id":"13YZ031","funder_id":"https://openalex.org/F4320321881","funder_display_name":"Shanghai Municipal Education Commission"},{"id":"https://openalex.org/G6775100478","display_name":null,"funder_award_id":"81171729","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7884225100","display_name":null,"funder_award_id":"J50206","funder_id":"https://openalex.org/F4320321881","funder_display_name":"Shanghai Municipal Education Commission"},{"id":"https://openalex.org/G8999216126","display_name":null,"funder_award_id":"ZZjdyx 2097","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321881","display_name":"Shanghai Municipal Education Commission","ror":"https://ror.org/05tewj457"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2014130451.pdf","grobid_xml":"https://content.openalex.org/works/W2014130451.grobid-xml"},"referenced_works_count":100,"referenced_works":["https://openalex.org/W63434408","https://openalex.org/W144423133","https://openalex.org/W1522547346","https://openalex.org/W1528604920","https://openalex.org/W1574722884","https://openalex.org/W1963906441","https://openalex.org/W1969801859","https://openalex.org/W1976027933","https://openalex.org/W1979355256","https://openalex.org/W1980269624","https://openalex.org/W1981905359","https://openalex.org/W1983464856","https://openalex.org/W1987510752","https://openalex.org/W1988036581","https://openalex.org/W1990435491","https://openalex.org/W1990868443","https://openalex.org/W1991094809","https://openalex.org/W1993846065","https://openalex.org/W1996632908","https://openalex.org/W1996970202","https://openalex.org/W1999319535","https://openalex.org/W1999382756","https://openalex.org/W2001856721","https://openalex.org/W2002995168","https://openalex.org/W2011227409","https://openalex.org/W2014028055","https://openalex.org/W2014155174","https://openalex.org/W2016144053","https://openalex.org/W2016145855","https://openalex.org/W2017593987","https://openalex.org/W2017813499","https://openalex.org/W2020963294","https://openalex.org/W2023394860","https://openalex.org/W2030565157","https://openalex.org/W2031479453","https://openalex.org/W2032151955","https://openalex.org/W2033376687","https://openalex.org/W2038167014","https://openalex.org/W2038490640","https://openalex.org/W2042604647","https://openalex.org/W2042742026","https://openalex.org/W2045402423","https://openalex.org/W2051654549","https://openalex.org/W2053662853","https://openalex.org/W2054110511","https://openalex.org/W2060876152","https://openalex.org/W2060951121","https://openalex.org/W2065455960","https://openalex.org/W2065584680","https://openalex.org/W2066378061","https://openalex.org/W2072211192","https://openalex.org/W2072595044","https://openalex.org/W2073115137","https://openalex.org/W2074019038","https://openalex.org/W2074277756","https://openalex.org/W2074549189","https://openalex.org/W2082478286","https://openalex.org/W2083372879","https://openalex.org/W2086013207","https://openalex.org/W2086227770","https://openalex.org/W2086525397","https://openalex.org/W2088120545","https://openalex.org/W2089453524","https://openalex.org/W2089605568","https://openalex.org/W2089653114","https://openalex.org/W2093036435","https://openalex.org/W2093955502","https://openalex.org/W2094975290","https://openalex.org/W2095099053","https://openalex.org/W2099748956","https://openalex.org/W2100467261","https://openalex.org/W2102308673","https://openalex.org/W2102884982","https://openalex.org/W2103438816","https://openalex.org/W2103890520","https://openalex.org/W2104792384","https://openalex.org/W2108768458","https://openalex.org/W2109321140","https://openalex.org/W2109871379","https://openalex.org/W2117840333","https://openalex.org/W2121678285","https://openalex.org/W2121834393","https://openalex.org/W2123073561","https://openalex.org/W2123345024","https://openalex.org/W2128818253","https://openalex.org/W2133032095","https://openalex.org/W2133915381","https://openalex.org/W2135909712","https://openalex.org/W2136991248","https://openalex.org/W2140529952","https://openalex.org/W2144154026","https://openalex.org/W2154355618","https://openalex.org/W2156159264","https://openalex.org/W2163106706","https://openalex.org/W2166972310","https://openalex.org/W2417486004","https://openalex.org/W3022355476","https://openalex.org/W4211112402","https://openalex.org/W6668931360","https://openalex.org/W6716679198"],"related_works":["https://openalex.org/W2118335497","https://openalex.org/W2556342998","https://openalex.org/W3166307322","https://openalex.org/W2021387873","https://openalex.org/W2004914633","https://openalex.org/W2060737808","https://openalex.org/W2112781395","https://openalex.org/W4241528344","https://openalex.org/W2130103573","https://openalex.org/W7096801408"],"abstract_inverted_index":{"Osteoarthritis":[0],"(OA)":[1],"is":[2,24,206],"one":[3],"of":[4,22,42,62,68,80,111,119,200,219,228],"the":[5,12,16,20,29,39,55,60,96,109,217,220],"most":[6],"widespread":[7],"degenerative":[8],"joint":[9],"diseases":[10],"affecting":[11],"elderly.":[13],"Research":[14],"into":[15],"regulatory":[17],"mechanisms":[18],"underlying":[19],"pathogenesis":[21,61,218],"OA":[23,192],"therefore":[25],"warranted,":[26],"and":[27,64,70,88,95,115,133,146,179,202,211,225],"over":[28],"past":[30],"decade,":[31],"there":[32],"has":[33],"been":[34,129,164,177],"an":[35],"increased":[36],"focus":[37,107],"on":[38,108],"functional":[40],"role":[41,110],"microRNAs":[43],"(miRNAs":[44],"or":[45,152],"miRs).":[46],"In":[47,135],"this":[48,120,171],"systematic":[49],"review,":[50],"we":[51],"aimed":[52],"to":[53,74,106,166,183,196,231],"review":[54,121],"evidence":[56],"implicating":[57],"miRNAs":[58,112,127,194,229],"in":[59,113,131,209,216],"chondrogenesis":[63,114,132,201],"OA.":[65,89,116,134,203],"Systematic":[66],"reviews":[67],"PubMed":[69],"Embase":[71],"were":[72,93,99,104],"performed":[73,165],"search":[75],"for":[76,170],"studies":[77,92,103],"using":[78],"strings":[79],"miRNAs,":[81,186],"non-coding":[82],"RNAs,":[83],"cartilage,":[84],"chondrocytes,":[85],"chondrogenesis,":[86],"chondrocytogenesis":[87],"The":[90,101,117,222],"identified":[91],"retrieved,":[94],"references":[97],"provided":[98],"searched.":[100],"selected":[102],"required":[105],"results":[118],"indicated":[122],"that":[123],"more":[124,155],"than":[125,156],"25":[126],"have":[128,163,176],"implicated":[130,215],"particular,":[136],"chondrocytogenesis,":[137],"chondrogenic":[138],"differentiation,":[139],"chondrocyte":[140,142],"proliferation,":[141],"hypertrophy,":[143],"endochondral":[144],"ossification,":[145],"proteolytic":[147],"enzyme":[148],"regulation":[149],"are":[150,180,213],"targeted":[151],"facilitated":[153],"by":[154],"1":[157],"miRNA.":[158],"To":[159],"date,":[160],"limited":[161],"efforts":[162],"evaluate":[167],"translational":[168,223],"applications":[169],"knowledge.":[172],"Novel":[173],"therapeutic":[174,226],"strategies":[175],"developed":[178],"under":[181],"investigation":[182],"selectively":[184],"modulate":[185],"which":[187],"could":[188],"potentially":[189],"enable":[190],"personalized":[191],"therapy.":[193],"appear":[195],"be":[197,232],"important":[198],"modulators":[199],"Their":[204],"expression":[205],"frequently":[207],"altered":[208],"OA,":[210],"many":[212],"functionally":[214],"disease.":[221],"roles":[224],"potential":[227],"remains":[230],"evaluated.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":6}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}