{"id":"https://openalex.org/W2014107261","doi":"https://doi.org/10.1002/art.30234","title":"Functional mesenchymal stem cell niches in adult mouse knee joint synovium in vivo","display_name":"Functional mesenchymal stem cell niches in adult mouse knee joint synovium in vivo","publication_year":2011,"publication_date":"2011-01-11","ids":{"openalex":"https://openalex.org/W2014107261","doi":"https://doi.org/10.1002/art.30234","mag":"2014107261","pmid":"https://pubmed.ncbi.nlm.nih.gov/21538315"},"language":"en","primary_location":{"id":"doi:10.1002/art.30234","doi":"https://doi.org/10.1002/art.30234","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.30234","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Tobias B. Kurth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tobias B. Kurth","raw_affiliation_strings":["University of Aberdeen, Aberdeen, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Aberdeen, Aberdeen, UK","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074656726","display_name":"Francesco Dell\u2019Accio","orcid":"https://orcid.org/0000-0003-4137-3770","observed_orcids":["https://orcid.org/0000-0003-4137-3770"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Francesco Dell'Accio","raw_affiliation_strings":["Queen Mary University of London, London, UK#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen Mary University of London, London, UK#TAB#","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001557970","display_name":"Vicki Crouch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vicki Crouch","raw_affiliation_strings":["(University of Aberdeen, Aberdeen, UK.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(University of Aberdeen, Aberdeen, UK.)","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072006058","display_name":"Andrea Augello","orcid":"https://orcid.org/0000-0001-5959-7989","observed_orcids":["https://orcid.org/0000-0001-5959-7989"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrea Augello","raw_affiliation_strings":["(University of Aberdeen, Aberdeen, UK.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(University of Aberdeen, Aberdeen, UK.)","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030553328","display_name":"Paul Thomas Sharpe","orcid":"https://orcid.org/0000-0003-2116-9561","observed_orcids":["https://orcid.org/0000-0003-2116-9561"]},"institutions":[{"id":"https://openalex.org/I125671874","display_name":"National Health Service","ror":"https://ror.org/02wnqcb97","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I125671874","https://openalex.org/I1311074006"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul T. Sharpe","raw_affiliation_strings":["King's College London and Biomedical Research Centre, Guy's and St. Thomas National Health Service Foundation Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King's College London and Biomedical Research Centre, Guy's and St. Thomas National Health Service Foundation Trust, London, UK","institution_ids":["https://openalex.org/I125671874","https://openalex.org/I183935753","https://openalex.org/I200166805"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026623515","display_name":"Cosimo De Bari","orcid":"https://orcid.org/0000-0002-5113-862X","observed_orcids":["https://orcid.org/0000-0002-5113-862X"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cosimo De Bari","raw_affiliation_strings":["(University of Aberdeen, Aberdeen, UK.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"(University of Aberdeen, Aberdeen, UK.)","institution_ids":["https://openalex.org/I195460627"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.1771,"has_fulltext":false,"cited_by_count":192,"citation_normalized_percentile":{"value":0.98492841,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"63","issue":"5","first_page":"1289","last_page":"1300"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.043800000101327896,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/synovium","display_name":"synovium","score":0.9789999723434448},{"id":"https://openalex.org/keywords/stem-cell-niche","display_name":"stem cell niche","score":0.6570000052452087},{"id":"https://openalex.org/keywords/knee-joint","display_name":"knee joint","score":0.8420000076293945},{"id":"https://openalex.org/keywords/articular-cartilage-defects","display_name":"articular cartilage defects","score":0.9150000214576721},{"id":"https://openalex.org/keywords/chondrogenic-differentiation","display_name":"chondrogenic differentiation","score":0.875},{"id":"https://openalex.org/keywords/slow-cycling-cells","display_name":"slow-cycling cells","score":0.7639999985694885},{"id":"https://openalex.org/keywords/sox9","display_name":"SOX9","score":0.6589999794960022},{"id":"https://openalex.org/keywords/type-ii-collagen","display_name":"type II collagen","score":0.9860000014305115},{"id":"https://openalex.org/keywords/synovial-lining","display_name":"synovial lining","score":0.7120000123977661},{"id":"https://openalex.org/keywords/cartilage-repair","display_name":"cartilage repair","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8291997909545898},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5907148718833923},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5508140325546265},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5453634858131409},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.5365982055664062},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.46618884801864624},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4508136212825775},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3944248557090759},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31422746181488037},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3070860505104065},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2570202946662903},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007719","descriptor_name":"Knee Joint","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D007719","descriptor_name":"Knee Joint","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013583","descriptor_name":"Synovial Membrane","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013583","descriptor_name":"Synovial Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020219","descriptor_name":"Chondrogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055153","descriptor_name":"Stem Cell Niche","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D055153","descriptor_name":"Stem Cell Niche","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/art.30234","doi":"https://doi.org/10.1002/art.30234","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.30234","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatism","raw_type":"journal-article"},{"id":"pmid:21538315","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21538315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis and rheumatism","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unimore.it:11380/1381423","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11380/1381423","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/7d81dc30-a7b6-4e2b-9a73-c7bc8c906e83","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/7d81dc30-a7b6-4e2b-9a73-c7bc8c906e83","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kurth, T B, Dell&apos;Accio, F, Crouch, V, Augello, A, Sharpe, P T & De Bari, C 2011, 'Functional Mesenchymal Stem Cell Niches in Adult Mouse Knee Joint Synovium In Vivo', Arthritis & Rheumatism, vol. 63, no. 5, pp. 1289 - 1300. https://doi.org/10.1002/art.30234","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1502939644","https://openalex.org/W1965953554","https://openalex.org/W1972736348","https://openalex.org/W1976176371","https://openalex.org/W1978477306","https://openalex.org/W1979782761","https://openalex.org/W1985508401","https://openalex.org/W1990336673","https://openalex.org/W2000097208","https://openalex.org/W2000468514","https://openalex.org/W2001733628","https://openalex.org/W2003299661","https://openalex.org/W2005876661","https://openalex.org/W2012549032","https://openalex.org/W2015856405","https://openalex.org/W2017635145","https://openalex.org/W2019433659","https://openalex.org/W2022491750","https://openalex.org/W2025371271","https://openalex.org/W2033697281","https://openalex.org/W2034004034","https://openalex.org/W2053157253","https://openalex.org/W2063090620","https://openalex.org/W2070154483","https://openalex.org/W2076491580","https://openalex.org/W2077965112","https://openalex.org/W2087578260","https://openalex.org/W2089129295","https://openalex.org/W2100112117","https://openalex.org/W2100147896","https://openalex.org/W2102343281","https://openalex.org/W2107908886","https://openalex.org/W2113887763","https://openalex.org/W2116489844","https://openalex.org/W2119774673","https://openalex.org/W2129787634","https://openalex.org/W2138385394","https://openalex.org/W2144268541","https://openalex.org/W2151708616","https://openalex.org/W2153963334","https://openalex.org/W2159999899","https://openalex.org/W2165668742","https://openalex.org/W2166724005","https://openalex.org/W4205635155"],"related_works":["https://openalex.org/W2109675822","https://openalex.org/W3019833029","https://openalex.org/W2463353259","https://openalex.org/W2334175096","https://openalex.org/W3133808419","https://openalex.org/W2115646085","https://openalex.org/W7097368145","https://openalex.org/W2064407507","https://openalex.org/W2000097208","https://openalex.org/W1988188434"],"abstract_inverted_index":{"OBJECTIVE:":[0],"We":[1],"previously":[2],"reported":[3],"that":[4,81,247],"human":[5],"synovium":[6,31,41,209,246],"contains":[7],"cells":[8,18,38,80,141,167,207],"that,":[9],"after":[10,83,107,153,203],"culture":[11],"expansion,":[12],"display":[13],"properties":[14],"of":[15,22,56,61,79,159,236,239],"mesenchymal":[16],"stem":[17,37],"(MSCs).":[19],"The":[20],"objective":[21],"this":[23],"study":[24],"was":[25,50,156],"to":[26,89,127],"identify":[27,36],"MSCs":[28,183,241],"in":[29,32,39,42,52,144,189,193,212,242,255],"native":[30],"vivo.":[33,256],"METHODS:":[34],"To":[35],"the":[40,145,194,198,221,233,237,243],"vivo,":[43],"a":[44,53,73],"double":[45,123,205],"nucleoside":[46,129],"analog":[47],"cell-labeling":[48],"scheme":[49],"used":[51],"mouse":[54],"model":[55],"joint-surface":[57],"injury.":[58],"For":[59,77],"labeling":[60,78],"slow-cycling":[62,139],"cells,":[63,161,172],"mice":[64,85],"received":[65,96],"iododeoxyuridine":[66],"(IdU)":[67],"for":[68,99,164,180,220],"30":[69],"days,":[70,101],"followed":[71],"by":[72,122],"40-day":[74],"washout":[75],"period.":[76],"proliferate":[82],"injury,":[84,154,204],"underwent":[86],"knee":[87,244],"surgery":[88],"produce":[90],"an":[91],"articular":[92],"cartilage":[93],"defect":[94],"and":[95,110,124,134,150,177,187,197,217,225,250],"chlorodeoxyuridine":[97],"(CIdU)":[98],"4":[100,148],"starting":[102],"at":[103],"multiple":[104],"time":[105],"points":[106],"surgery.":[108],"Unoperated":[109],"sham-operated":[111],"joints":[112],"served":[113],"as":[114],"controls.":[115],"Knee":[116],"joint":[117,245],"paraffin":[118],"sections":[119],"were":[120,142,168,173,184,210],"analyzed":[121],"triple":[125],"immunostaining":[126],"detect":[128],"analogs,":[130],"conventional":[131],"MSC":[132,181],"markers,":[133],"chondrocyte-lineage":[135,222],"markers.":[136,182],"RESULTS:":[137],"Long-term-retaining,":[138],"IdU-positive":[140,160,166],"detected":[143],"synovium.":[146],"At":[147],"days":[149,152,202],"8":[151],"there":[155],"marked":[157],"proliferation":[158,249],"which":[162],"costained":[163,218],"CIdU.":[165],"nonhematopoietic,":[169],"nonendothelial":[170],"stromal":[171],"distinct":[174,191],"from":[175],"pericytes,":[176],"stained":[178],"positive":[179,219],"phenotypically":[185],"heterogeneous":[186],"located":[188],"topographically":[190],"niches":[192],"lining":[195],"layer":[196],"subsynovial":[199],"tissue.":[200],"Twelve":[201],"nucleoside-labeled":[206],"within":[208],"embedded":[211],"cartilage-specific":[213],"metachromatic":[214],"extracellular":[215],"matrix":[216],"markers":[223],"Sox9":[224],"type":[226],"II":[227],"collagen.":[228],"CONCLUSION:":[229],"Our":[230],"findings":[231],"provide":[232],"first":[234],"evidence":[235],"existence":[238],"resident":[240],"undergo":[248],"chondrogenic":[251],"differentiation":[252],"following":[253],"injury":[254]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
