{"id":"https://openalex.org/W2014096936","doi":"https://doi.org/10.1111/j.1572-0241.1998.465_q.x","title":"Slow-Release Lanreotide Treatment in Endocrine Gastrointestinal Tumors","display_name":"Slow-Release Lanreotide Treatment in Endocrine Gastrointestinal Tumors","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W2014096936","doi":"https://doi.org/10.1111/j.1572-0241.1998.465_q.x","mag":"2014096936","pmid":"https://pubmed.ncbi.nlm.nih.gov/9732927"},"language":"en","primary_location":{"id":"doi:10.1111/j.1572-0241.1998.465_q.x","doi":"https://doi.org/10.1111/j.1572-0241.1998.465_q.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1572-0241.1998.465_q.x","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003301205","display_name":"Paola Tomassetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Tomassetti","raw_affiliation_strings":["Department of Internal Medicine and Gastroenterology, University of Bologna, Italy","Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Gastroenterology, University of Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103507382","display_name":"Marina Migliori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marina Migliori","raw_affiliation_strings":["Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110048376","display_name":"Lucio Gullo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Lucio Gullo","raw_affiliation_strings":["Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy","Department of Internal Medicine and Gastroenterology, University of Bologna, Via Massarenti, 9, 40138 Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]},{"raw_affiliation_string":"Department of Internal Medicine and Gastroenterology, University of Bologna, Via Massarenti, 9, 40138 Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110048376"],"corresponding_institution_ids":["https://openalex.org/I9360294"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":2.7758,"has_fulltext":false,"cited_by_count":101,"citation_normalized_percentile":{"value":0.90666432,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"93","issue":"9","first_page":"1468","last_page":"1471"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lanreotide","display_name":"lanreotide","score":1.0},{"id":"https://openalex.org/keywords/somatostatin-analogs","display_name":"somatostatin analogues","score":0.8240000009536743},{"id":"https://openalex.org/keywords/gastrointestinal-endocrine-tumors","display_name":"gastrointestinal endocrine tumors","score":0.8930000066757202},{"id":"https://openalex.org/keywords/carcinoid-tumor","display_name":"carcinoid tumor","score":0.9350000023841858},{"id":"https://openalex.org/keywords/glucagonoma","display_name":"glucagonoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gastrinoma","display_name":"gastrinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/octreotide","display_name":"octreotide","score":0.7519999742507935},{"id":"https://openalex.org/keywords/somatostatin-receptors","display_name":"somatostatin receptors","score":0.6359999775886536},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.7860000133514404},{"id":"https://openalex.org/keywords/treatment-tolerability","display_name":"treatment tolerability","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9582939743995667},{"id":"https://openalex.org/C2779609023","wikidata":"https://www.wikidata.org/wiki/Q1707877","display_name":"Lanreotide","level":5,"score":0.9431675672531128},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.7825595736503601},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4301985502243042},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.35411563515663147},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32724320888519287},{"id":"https://openalex.org/C2777433750","wikidata":"https://www.wikidata.org/wiki/Q189580","display_name":"Acromegaly","level":4,"score":0.26438188552856445},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.1717032492160797},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.10802516341209412}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002276","descriptor_name":"Carcinoid Tumor","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004701","descriptor_name":"Endocrine Gland Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005935","descriptor_name":"Glucagonoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015408","descriptor_name":"Gastrinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1572-0241.1998.465_q.x","doi":"https://doi.org/10.1111/j.1572-0241.1998.465_q.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1572-0241.1998.465_q.x","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},{"id":"doi:10.1016/s0002-9270(98)00346-3","doi":"https://doi.org/10.1016/s0002-9270(98)00346-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0002-9270(98)00346-3","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmid:9732927","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9732927","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1991986331","https://openalex.org/W2004491989","https://openalex.org/W2021353890","https://openalex.org/W2021422677","https://openalex.org/W2022849577","https://openalex.org/W2030889613","https://openalex.org/W2041357642","https://openalex.org/W2046187870","https://openalex.org/W2062939394","https://openalex.org/W2071310612","https://openalex.org/W2077777214","https://openalex.org/W2107392208","https://openalex.org/W2131492952","https://openalex.org/W2147448522","https://openalex.org/W2337135362","https://openalex.org/W2405814648","https://openalex.org/W2418522716","https://openalex.org/W2570003316","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2158604085","https://openalex.org/W1963564676","https://openalex.org/W2594503191","https://openalex.org/W2073626627","https://openalex.org/W1977395984","https://openalex.org/W2147448522","https://openalex.org/W2107392208","https://openalex.org/W2004291258","https://openalex.org/W2977904371","https://openalex.org/W2024171665"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Lanreotide":[1,79,252],"is":[2,298],"a":[3,17,68,84,93,254],"somatostatin":[4,73],"analogue":[5],"whose":[6],"activity":[7],"persists":[8],"for":[9,92,294],"10-14":[10,284],"days.":[11],"In":[12,113,167,234],"this":[13,295],"study,":[14],"we":[15],"treated":[16,109,239],"group":[18],"of":[19,86,95,102,190,195,226,229,231,263,273,287],"patients":[20,71,105,114,162,170,237],"with":[21,25,110,115,163,171,220,240,249],"gastrointestinal":[22,264],"endocrine":[23,58,173,265],"tumors":[24],"lanreotide":[26,118,196,223],"to":[27,271],"assess":[28],"its":[29,267],"therapeutic":[30,256],"efficacy":[31,257],"and":[32,39,63,124,135,150,154,165,207,258,293],"tolerability.":[33],"METHODS:":[34],"Eighteen":[35],"patients,":[36,181],"12":[37,96],"male":[38],"six":[40],"female,":[41],"mean":[42,94],"age":[43],"58":[44],"yr":[45],"(range,":[46,98],"25-80":[47],"yr)":[48],"were":[49,185,247],"studied.":[50],"Ten":[51],"had":[52,56,61,67,72,106],"carcinoid":[53,116],"tumors,":[54,59,117,174],"five":[55,169],"nonfunctioning":[57,172],"two":[60,214],"glucagonomas,":[62],"the":[64,103,168,178,188,191,210,218,227,235,245,261],"remaining":[65],"one":[66],"gastrinoma.":[69,166],"All":[70],"receptors,":[74],"demonstrated":[75],"by":[76],"octreoscan":[77],"scintigraphy.":[78],"was":[80,129,141,158,222],"administered":[81,281],"intramuscularly":[82],"at":[83,209],"dose":[85],"30":[87],"mg":[88],"every":[89,283],"10":[90],"days,":[91,285],"months":[97],"5-18":[99],"months).":[100],"Fifteen":[101],"18":[104],"been":[107],"previously":[108,238],"octreotide.":[111,274],"RESULTS:":[112],"markedly":[119],"reduced":[120],"daily":[121,292],"bowel":[122],"movements":[123],"flushing":[125],"episodes.":[126],"A":[127,145],"reduction":[128,147],"also":[130,159],"observed":[131,160],"in":[132,148,151,161,176,187,213,217,244,260,300],"urinary":[133,136],"serotonin":[134],"5-hydroxyindoleacetic":[137],"acid,":[138],"although":[139],"it":[140,278,297],"not":[142,198],"statistically":[143],"significant.":[144],"marked":[146,232],"symptoms,":[149],"plasma":[152],"glucagon":[153],"serum":[155],"gastrin":[156],"levels,":[157],"glucagonoma":[164],"as":[175],"all":[177],"other":[179],"13":[180],"no":[182,242],"significant":[183],"effects":[184,246,268],"noted":[186,248],"size":[189],"tumor.":[192],"The":[193],"administration":[194],"did":[197],"cause":[199],"side":[200],"effects,":[201],"apart":[202],"from":[203],"transient":[204],"abdominal":[205],"pain":[206,208],"injection":[211],"site":[212],"patients.":[215],"Only":[216],"patient":[219],"gastrinoma":[221],"suspended,":[224],"because":[225],"appearance":[228],"attacks":[230],"hypoglycemia.":[233],"15":[236],"octreotide,":[241,277],"differences":[243],"lanreotide.":[250],"CONCLUSIONS:":[251],"has":[253],"satisfactory":[255],"tolerability":[259],"treatment":[262],"tumors;":[266],"are":[269],"similar":[270],"those":[272],"However,":[275],"unlike":[276],"can":[279],"be":[280],"once":[282],"instead":[286],"2":[288],"or":[289],"3":[290],"times":[291],"reason,":[296],"preferable":[299],"clinical":[301],"practice.":[302]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
