{"id":"https://openalex.org/W2014065250","doi":"https://doi.org/10.1097/00005537-200204000-00019","title":"Intralesional Cidofovir Therapy for Laryngeal Papilloma in an Adult Cohort","display_name":"Intralesional Cidofovir Therapy for Laryngeal Papilloma in an Adult Cohort","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W2014065250","doi":"https://doi.org/10.1097/00005537-200204000-00019","mag":"2014065250","pmid":"https://pubmed.ncbi.nlm.nih.gov/12150526"},"language":"en","primary_location":{"id":"doi:10.1097/00005537-200204000-00019","doi":"https://doi.org/10.1097/00005537-200204000-00019","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005537-200204000-00019","pdf_url":null,"source":{"id":"https://openalex.org/S86387881","display_name":"The Laryngoscope","issn_l":"0023-852X","issn":["0023-852X","1091-756X","1531-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Laryngoscope","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070569839","display_name":"Steven A. Bielamowicz","orcid":"https://orcid.org/0000-0003-3108-8538","observed_orcids":["https://orcid.org/0000-0003-3108-8538"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven Bielamowicz","raw_affiliation_strings":["Division of Otolaryngology-Head and Neck Surgery, George Washington University, Washington, DC 20037, USA. sursxb@gwumc.edu","Steven Bielamowicz, MD, Division of Otolaryngology\u2014Head and Neck Surgery, George Washington University, 2150 Pennsylvania Avenue Northwest, Suite 6\u2010301, Washington, DC 20037, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Otolaryngology-Head and Neck Surgery, George Washington University, Washington, DC 20037, USA. sursxb@gwumc.edu","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"Steven Bielamowicz, MD, Division of Otolaryngology\u2014Head and Neck Surgery, George Washington University, 2150 Pennsylvania Avenue Northwest, Suite 6\u2010301, Washington, DC 20037, U.S.A","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062009518","display_name":"Vicente J. Villagomez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vicente Villagomez","raw_affiliation_strings":["Division of Otolaryngology\u2014Head and Neck Surgery, George Washington University, Washington, DC, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Otolaryngology\u2014Head and Neck Surgery, George Washington University, Washington, DC, U.S.A","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002397045","display_name":"Sheila V. Stager","orcid":"https://orcid.org/0000-0002-4294-2114","observed_orcids":["https://orcid.org/0000-0002-4294-2114"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheila V. Stager","raw_affiliation_strings":["Division of Otolaryngology\u2014Head and Neck Surgery, George Washington University, Washington, DC, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Otolaryngology\u2014Head and Neck Surgery, George Washington University, Washington, DC, U.S.A","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"last","author":{"id":null,"display_name":"William R. Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William R. Wilson","raw_affiliation_strings":["Division of Otolaryngology\u2014Head and Neck Surgery, George Washington University, Washington, DC, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Otolaryngology\u2014Head and Neck Surgery, George Washington University, Washington, DC, U.S.A","institution_ids":["https://openalex.org/I193531525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070569839"],"corresponding_institution_ids":["https://openalex.org/I193531525"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":8.1022,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.97901391,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"112","issue":"4","first_page":"696","last_page":"699"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11713","display_name":"Genital Health and Disease","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10863","display_name":"Voice and Speech Disorders","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laryngeal-papillomatosis","display_name":"recurrent respiratory papillomatosis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.6380000114440918},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.7070000171661377},{"id":"https://openalex.org/keywords/number-of-injections","display_name":"number of injections","score":0.6650000214576721},{"id":"https://openalex.org/keywords/disease-duration","display_name":"disease duration","score":0.671999990940094},{"id":"https://openalex.org/keywords/adult-patients","display_name":"adult patients","score":0.49000000953674316},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.4440000057220459},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C2776824251","wikidata":"https://www.wikidata.org/wiki/Q423445","display_name":"Cidofovir","level":3,"score":0.9800190925598145},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9046832323074341},{"id":"https://openalex.org/C2776350393","wikidata":"https://www.wikidata.org/wiki/Q912796","display_name":"Papilloma","level":2,"score":0.7539950609207153},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.6365146636962891},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5471890568733215},{"id":"https://openalex.org/C2780474809","wikidata":"https://www.wikidata.org/wiki/Q9637","display_name":"Larynx","level":2,"score":0.5128293633460999},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5036680102348328},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4535178244113922},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.43510323762893677},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2539878487586975},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.23858866095542908},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12812703847885132},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.06201091408729553},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077404","descriptor_name":"Cidofovir","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010212","descriptor_name":"Papilloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015552","descriptor_name":"Injections, Intralesional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00005537-200204000-00019","doi":"https://doi.org/10.1097/00005537-200204000-00019","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005537-200204000-00019","pdf_url":null,"source":{"id":"https://openalex.org/S86387881","display_name":"The Laryngoscope","issn_l":"0023-852X","issn":["0023-852X","1091-756X","1531-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Laryngoscope","raw_type":"journal-article"},{"id":"pmid:12150526","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12150526","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Laryngoscope","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.979200005531311}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W176424557","https://openalex.org/W1985444027","https://openalex.org/W1993271840","https://openalex.org/W2023292121","https://openalex.org/W2032532331","https://openalex.org/W2071712331","https://openalex.org/W2072087884","https://openalex.org/W2111047399","https://openalex.org/W2131504489","https://openalex.org/W2168611355","https://openalex.org/W2171834193"],"related_works":["https://openalex.org/W2005787766","https://openalex.org/W2329917316","https://openalex.org/W176424557","https://openalex.org/W125794768","https://openalex.org/W2143104495","https://openalex.org/W2144479467","https://openalex.org/W112240058","https://openalex.org/W2010962647","https://openalex.org/W2007007915","https://openalex.org/W2327288712"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"confirm":[2],"the":[3,11,37,170],"safety":[4],"and":[5,16,164,191,203],"efficacy":[6,38],"of":[7,13,24,36,39,61,77,84,90,172,181,206],"intralesional":[8,40,62],"cidofovir":[9,41,85,182],"in":[10,42,57,95,211],"management":[12],"laryngeal":[14,45,53,145,214],"papilloma":[15,54,106],"to":[17,27,70,158],"identify":[18],"variables":[19],"that":[20],"correlate":[21],"with":[22,44,51,73,86,169,188,213],"number":[23,171],"injections":[25,83,126,155,173],"needed":[26],"achieve":[28,159],"remission.":[29,160,177],"STUDY":[30],"DESIGN:":[31],"An":[32],"open-trial":[33],"prospective":[34],"evaluation":[35],"subjects":[43,50,120,133],"papilloma.":[46,215],"METHODS:":[47],"Fourteen":[48],"adult":[49],"biopsy-proven":[52],"were":[55,102,156],"enrolled":[56],"a":[58,74,87],"treatment":[59,141,186],"study":[60],"cidofovir.":[63],"Preprotocol":[64,161],"disease":[65,116,136,162,176,207],"duration":[66,76,163],"ranged":[67],"from":[68,200],"1":[69],"30":[71],"years":[72],"mean":[75],"7":[78],"years.":[79],"Subjects":[80],"received":[81,121],"monthly":[82],"maximum":[88],"dose":[89],"37.5":[91],"mg":[92],"per":[93],"injection":[94,180,195],"6":[96,154],"cc":[97],"saline":[98],"(6.25":[99],"mg/mL).":[100],"Injections":[101],"repeated":[103],"until":[104],"no":[105],"could":[107],"be":[108,209],"visually":[109],"identified":[110],"during":[111,128],"an":[112,122,139,184],"intraoperative":[113],"evaluation.":[114],"After":[115],"remission":[117,137],"was":[118,150],"achieved,":[119],"additional":[123,144],"injection.":[124],"All":[125,132],"occurred":[127],"suspension":[129],"microlaryngoscopy.":[130],"RESULTS:":[131],"have":[134],"achieved":[135,210],"using":[138],"injection-only":[140],"protocol.":[142],"No":[143],"scarring":[146],"or":[147],"systemic":[148,192],"toxicity":[149],"identified.":[151],"On":[152],"average,":[153],"required":[157,174],"anatomical":[165],"staging":[166],"correlated":[167],"positively":[168],"for":[175],"CONCLUSIONS:":[178],"Intralesional":[179],"is":[183],"excellent":[185],"option":[187],"limited":[189],"local":[190],"toxicities.":[193],"The":[194],"therapy":[196],"regimen":[197],"requires":[198],"perseverance":[199],"both":[201],"patient":[202],"surgeon.":[204],"Remission":[205],"can":[208],"adults":[212]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
