{"id":"https://openalex.org/W2014064941","doi":"https://doi.org/10.1042/bst20120328","title":"Mechanism and function of DHHC S-acyltransferases","display_name":"Mechanism and function of DHHC S-acyltransferases","publication_year":2013,"publication_date":"2013-01-29","ids":{"openalex":"https://openalex.org/W2014064941","doi":"https://doi.org/10.1042/bst20120328","mag":"2014064941","pmid":"https://pubmed.ncbi.nlm.nih.gov/23356254"},"language":"en","primary_location":{"id":"doi:10.1042/bst20120328","doi":"https://doi.org/10.1042/bst20120328","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bst20120328","pdf_url":null,"source":{"id":"https://openalex.org/S137670264","display_name":"Biochemical Society Transactions","issn_l":"0300-5127","issn":["0300-5127","1470-8752"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society Transactions","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021448016","display_name":"Maurine E. Linder","orcid":"https://orcid.org/0000-0003-2202-9712","observed_orcids":["https://orcid.org/0000-0003-2202-9712"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maurine\u00a0E. Linder","raw_affiliation_strings":["Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, U.S.A","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018282904","display_name":"Benjamin C. Jennings","orcid":"https://orcid.org/0000-0002-7255-2715","observed_orcids":["https://orcid.org/0000-0002-7255-2715"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin\u00a0C. Jennings","raw_affiliation_strings":["Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, U.S.A","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8802,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.94503696,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"41","issue":"1","first_page":"29","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.4832000136375427,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.4832000136375427,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.2533999979496002,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.0771000012755394,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-s-palmitoylation","display_name":"protein S-palmitoylation","score":0.972000002861023},{"id":"https://openalex.org/keywords/protein-acyltransferase","display_name":"protein acyltransferase","score":0.7770000100135803},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8069999814033508},{"id":"https://openalex.org/keywords/fatty-acid-modification","display_name":"fatty acid modification","score":0.5410000085830688},{"id":"https://openalex.org/keywords/enzyme-mechanism","display_name":"enzyme mechanism","score":0.6940000057220459},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.8960000276565552},{"id":"https://openalex.org/keywords/enzyme-regulation","display_name":"enzyme regulation","score":0.6980000138282776},{"id":"https://openalex.org/keywords/intellectual-disability","display_name":"intellectual disability","score":0.7250000238418579},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":1.0},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.9629999995231628},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C146727910","wikidata":"https://www.wikidata.org/wiki/Q501620","display_name":"Palmitoylation","level":4,"score":0.9889458417892456},{"id":"https://openalex.org/C2910079589","wikidata":"https://www.wikidata.org/wiki/Q2609152","display_name":"Acyltransferases","level":4,"score":0.8553861379623413},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47085708379745483},{"id":"https://openalex.org/C171897839","wikidata":"https://www.wikidata.org/wiki/Q417841","display_name":"Protein family","level":3,"score":0.47005903720855713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45883670449256897},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45477908849716187},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4494563639163971},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.44011813402175903},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.4191800355911255},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36734718084335327},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3599846363067627},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19644701480865479},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.08809104561805725},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bst20120328","doi":"https://doi.org/10.1042/bst20120328","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bst20120328","pdf_url":null,"source":{"id":"https://openalex.org/S137670264","display_name":"Biochemical Society Transactions","issn_l":"0300-5127","issn":["0300-5127","1470-8752"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society Transactions","raw_type":"journal-article"},{"id":"pmid:23356254","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23356254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society transactions","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.955.3788","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.955.3788","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.biochemsoctrans.org/content/ppbiost/41/1/29.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3302573325","display_name":null,"funder_award_id":"GM 51466","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4609550054","display_name":"Protein Palmitoylation in Signaling Systems","funder_award_id":"R01GM051466","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1538547420","https://openalex.org/W1554226168","https://openalex.org/W1603362495","https://openalex.org/W1979212433","https://openalex.org/W1981625060","https://openalex.org/W1993556675","https://openalex.org/W1998917031","https://openalex.org/W2002569944","https://openalex.org/W2004438254","https://openalex.org/W2006060580","https://openalex.org/W2016364188","https://openalex.org/W2028606847","https://openalex.org/W2031375592","https://openalex.org/W2045703352","https://openalex.org/W2046538616","https://openalex.org/W2048559110","https://openalex.org/W2050419119","https://openalex.org/W2058369885","https://openalex.org/W2063115478","https://openalex.org/W2064994601","https://openalex.org/W2065354104","https://openalex.org/W2077141717","https://openalex.org/W2081706656","https://openalex.org/W2088638468","https://openalex.org/W2100139095","https://openalex.org/W2100743467","https://openalex.org/W2112830343","https://openalex.org/W2123294439","https://openalex.org/W2124792702","https://openalex.org/W2126134129","https://openalex.org/W2129096803","https://openalex.org/W2131281845","https://openalex.org/W2139472455","https://openalex.org/W2141764344","https://openalex.org/W2144056966","https://openalex.org/W2145129762","https://openalex.org/W2148053098","https://openalex.org/W2157251457","https://openalex.org/W2159850904","https://openalex.org/W2164702862","https://openalex.org/W2168457547","https://openalex.org/W2182059649","https://openalex.org/W6678117553"],"related_works":["https://openalex.org/W2182059649","https://openalex.org/W2792861492","https://openalex.org/W2144056966","https://openalex.org/W2055965228","https://openalex.org/W1139495770","https://openalex.org/W1582736993","https://openalex.org/W3154350377","https://openalex.org/W3170800709","https://openalex.org/W2905331559","https://openalex.org/W2068347916"],"abstract_inverted_index":{"Protein":[0],"S-palmitoylation":[1],"is":[2,59,87,102],"a":[3,80],"reversible":[4],"post-translational":[5],"modification":[6],"of":[7,24,55,75,91,97,99,120],"proteins":[8,25,63],"with":[9,64,107],"fatty":[10,69],"acids.":[11],"In":[12,128],"the":[13,22,72,88,92,118,129],"last":[14],"5":[15],"years,":[16],"improved":[17],"proteomic":[18],"methods":[19],"have":[20],"increased":[21],"number":[23],"identified":[26],"as":[27,123],"substrates":[28],"for":[29,61,125],"palmitoylation":[30],"from":[31],"tens":[32],"to":[33],"hundreds.":[34],"Palmitoylation":[35],"regulates":[36],"protein":[37],"membrane":[38],"interactions,":[39],"activity,":[40],"trafficking":[41],"and":[42,44,112,116,141],"stability":[43],"can":[45],"be":[46],"constitutive":[47],"or":[48,66],"regulated":[49],"by":[50,104],"signalling":[51],"inputs.":[52],"A":[53],"family":[54,101],"PATs":[56,78,122],"(protein":[57],"acyltransferases)":[58],"responsible":[60],"modifying":[62],"palmitate":[65],"other":[67],"long-chain":[68],"acids":[70],"on":[71],"cytoplasmic":[73],"face":[74],"cellular":[76],"membranes.":[77],"share":[79],"signature":[81],"DHHC":[82,121],"(Asp-His-His-Cys)":[83],"cysteine-rich":[84],"domain":[85],"that":[86],"catalytic":[89],"centre":[90],"enzyme.":[93],"The":[94],"biomedical":[95],"importance":[96],"members":[98],"this":[100],"underscored":[103],"their":[105],"association":[106],"intellectual":[108],"disability,":[109],"Huntington's":[110],"disease":[111],"cancer":[113],"in":[114,136],"humans,":[115],"raises":[117],"possibility":[119],"targets":[124],"therapeutic":[126],"intervention.":[127],"present":[130],"paper,":[131],"we":[132],"discuss":[133],"recent":[134],"progress":[135],"understanding":[137],"enzyme":[138],"mechanism,":[139],"regulation":[140],"substrate":[142],"specificity.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
