{"id":"https://openalex.org/W201405681","doi":null,"title":"[Reperfusion and postconditioning in acute ST segment elevation myocardial infarction. A new paradigm for the treatment of acute myocardial infarction. From bench to bedside?].","display_name":"[Reperfusion and postconditioning in acute ST segment elevation myocardial infarction. A new paradigm for the treatment of acute myocardial infarction. From bench to bedside?].","publication_year":2006,"publication_date":"2006-10-01","ids":{"openalex":"https://openalex.org/W201405681","mag":"201405681","pmid":"https://pubmed.ncbi.nlm.nih.gov/17469337"},"language":"es","primary_location":{"id":"pmid:17469337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17469337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archivos de cardiologia de Mexico","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111437951","display_name":"Eulo Lupi Herrera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157394","display_name":"Instituto Nacional de Cardiolog\u00eda","ror":"https://ror.org/046e90j34","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210157394"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Eulo Lupi Herrera","raw_affiliation_strings":["Del Instituto Nacional de Cardiologia \"lgnacio Ch\u00e1vez\", M\u00e9xico, D.F"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Del Instituto Nacional de Cardiologia \"lgnacio Ch\u00e1vez\", M\u00e9xico, D.F","institution_ids":["https://openalex.org/I4210157394"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103010008","display_name":"Jorge Gaspar","orcid":"https://orcid.org/0000-0001-9864-4071","observed_orcids":["https://orcid.org/0000-0001-9864-4071"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jorge Gaspar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065152786","display_name":"H\u00e9ctor Gonz\u00e1lez\u2010Pacheco","orcid":"https://orcid.org/0000-0002-4370-9963","observed_orcids":["https://orcid.org/0000-0002-4370-9963"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H\u00e9ctor Gonz\u00e1lez Pacheco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077881280","display_name":"Carlos Mart\u00ednez S\u00e1nchez","orcid":"https://orcid.org/0000-0002-0909-0909","observed_orcids":["https://orcid.org/0000-0002-0909-0909"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos Mart\u00ednez S\u00e1nchez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074979918","display_name":"Gustavo Pastel\u00edn Hern\u00e1ndez","orcid":"https://orcid.org/0000-0002-8270-7514","observed_orcids":["https://orcid.org/0000-0002-8270-7514"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gustavo Pastel\u00edn Hern\u00e1ndez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003040925","display_name":"Pastor Luna Ort\u00edz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pastor Luna Ortiz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040148467","display_name":"Edmundo Ch\u00e1vez Cosio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edmundo Ch\u00e1vez Cosio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2265,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.61982616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"76 Suppl 4","issue":null,"first_page":"S76","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.8569999933242798},{"id":"https://openalex.org/keywords/postconditioning","display_name":"postconditioning","score":0.9300000071525574},{"id":"https://openalex.org/keywords/st-elevation-myocardial-infarction","display_name":"ST-elevation myocardial infarction","score":0.902999997138977},{"id":"https://openalex.org/keywords/ischemic-preconditioning","display_name":"ischemic preconditioning","score":0.8650000095367432},{"id":"https://openalex.org/keywords/infarct-size-reduction","display_name":"infarct size reduction","score":0.9089999794960022},{"id":"https://openalex.org/keywords/coronary-angioplasty","display_name":"coronary angioplasty","score":0.8090000152587891},{"id":"https://openalex.org/keywords/no-reflow-phenomenon","display_name":"no-reflow phenomenon","score":0.8289999961853027},{"id":"https://openalex.org/keywords/myocardial-necrosis","display_name":"myocardial necrosis","score":0.7639999985694885},{"id":"https://openalex.org/keywords/oxygen-free-radicals","display_name":"oxygen free radicals","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8433831930160522},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.6805438995361328},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6476426124572754},{"id":"https://openalex.org/C2779311647","wikidata":"https://www.wikidata.org/wiki/Q17148404","display_name":"Ischemic preconditioning","level":3,"score":0.6363714337348938},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5607904195785522},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.5240576267242432},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5143314599990845},{"id":"https://openalex.org/C2780387585","wikidata":"https://www.wikidata.org/wiki/Q4816772","display_name":"Reperfusion therapy","level":3,"score":0.5096533298492432},{"id":"https://openalex.org/C2777798775","wikidata":"https://www.wikidata.org/wiki/Q207550","display_name":"Infarction","level":3,"score":0.46402767300605774},{"id":"https://openalex.org/C2779676291","wikidata":"https://www.wikidata.org/wiki/Q25325349","display_name":"Cardioprotection","level":3,"score":0.4166269600391388}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003097","descriptor_name":"Collateral Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015425","descriptor_name":"Myocardial Reperfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D015906","descriptor_name":"Angioplasty, Balloon, Coronary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019157","descriptor_name":"Ischemic Preconditioning, Myocardial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17469337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17469337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archivos de cardiologia de Mexico","raw_type":"Comparative Study"},{"id":"mag:201405681","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17469337","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2002186009","https://openalex.org/W925861188","https://openalex.org/W2078585146","https://openalex.org/W2050497761","https://openalex.org/W2016373465","https://openalex.org/W2364344336","https://openalex.org/W2115530738","https://openalex.org/W2159230430","https://openalex.org/W2354350325","https://openalex.org/W2049442049"],"abstract_inverted_index":{"After":[0],"prolonged":[1,242],"periods":[2],"of":[3,30,42,65,72,83,109,124,164,187,190,225,236,253,283,329,332,348],"ischemia":[4],"and":[5,56,68,152,222,342,355],"energy":[6],"depletion,":[7],"the":[8,19,31,84,103,107,121,127,162,174,178,185,191,196,220,223,226,262,280,289,313,346],"ischemic":[9,165,168,264],"myocardial":[10,134,150],"cell":[11],"can":[12,24,214],"be":[13,25,215,353],"jeopardized":[14],"by":[15,116,218,233,249,268,276,325],"specific":[16,92,117],"causes":[17,23,41,77,86],"within":[18],"reperfusion":[20,44,130,212,330,349],"period.":[21],"These":[22,75],"viewed":[26],"as":[27,271,273],"unwanted":[28],"aspects":[29],"recovery":[32],"process":[33],"itself":[34],"limiting":[35],"its":[36],"efficiency.":[37],"Three":[38],"potential":[39,76,334],"initial":[40,227],"immediate":[43],"injury,":[45],"aside":[46],"from":[47,161],"oxygen":[48],"radicals,":[49],"have":[50,146],"been":[51,204,208,297],"experimentally":[52],"investigated":[53],"in":[54,102,173,195,288,316,345],"detail,":[55],"are":[57,78],"briefly":[58],"discussed:":[59],"1.":[60],"re-energization;":[61],"2.":[62],"rapid":[63,70],"normalization":[64,71],"tissue":[66,73],"pH;":[67],"3.":[69],"osmolality.":[74],"not":[79,171],"entirely":[80],"independent.":[81],"Understanding":[82],"basic":[85],"has":[87,137,203,207,296],"opened":[88],"novel":[89],"perspectives":[90],"for":[91,132],"interference":[93],"with":[94,304],"these":[95],"serious":[96],"pathomechanisms.":[97],"The":[98],"experimental":[99,281],"results":[100],"obtained":[101],"last":[104],"years":[105],"encourage":[106],"development":[108],"therapeutic":[110],"approaches":[111],"to":[112,139,352],"reduce":[113,140],"infarct":[114],"size":[115],"measures":[118],"applied":[119,259],"during":[120,293,309],"early":[122],"phase":[123],"reperfusion.":[125],"In":[126],"clinical":[128,175,290,318,335],"setting,":[129],"therapy":[131],"acute":[133],"infarction":[135],"(AMI)":[136],"shown":[138],"mortality,":[141],"yet":[142],"it":[143,257],"may":[144],"also":[145],"deleterious":[147],"effects,":[148],"including":[149],"necrosis":[151],"no-reflow.":[153],"Almost":[154],"two":[155],"decades":[156],"ago,":[157],"great":[158],"hope":[159],"arose":[160],"description":[163],"preconditioning.":[166,277],"Unfortunately,":[167],"preconditioning":[169,230],"is":[170,181,231,247,258,270,331],"feasible":[172],"practice":[176],"because":[177],"coronary":[179,243,310],"artery":[180,244],"already":[182],"occluded":[183],"at":[184],"time":[186],"hospital":[188],"admission":[189],"AMI":[192],"patient.":[193],"Recently,":[194],"dog":[197],"model,":[198],"a":[199,241,250,322,326],"phenomenon":[200],"called":[201],"\"postconditioning\"":[202],"described.":[205],"It":[206,295],"reported":[209,298],"previouly":[210],"that":[211,274,301],"injury":[213,350],"significantly":[216],"reduced":[217],"modifying":[219],"conditions":[221],"composition":[224],"reperfusate.":[228],"Whereas":[229],"triggered":[232],"brief":[234],"episodes":[235],"ischemia-reperfusion":[237],"performed":[238],"just":[239],"before":[240],"occlusion,":[245],"postconditioning":[246,269,284,302],"induced":[248],"comparable":[251],"sequence":[252],"reversible":[254],"ischemia-reperfusion,":[255],"but":[256],"\"just":[260],"after":[261],"prolonged\"":[263],"insult.":[265],"Protection":[266],"afforded":[267],"potent":[272],"provided":[275],"Unlike":[278],"preconditioning,":[279],"design":[282],"allows":[285],"direct":[286],"application":[287],"practice,":[291],"especially":[292],"PTCA.":[294],"very":[299],"recently,":[300],"patients":[303],"ST":[305],"segment":[306],"elevation":[307],"AMI,":[308],"angioplasty":[311],"protects":[312],"human":[314],"heart":[315],"this":[317],"scenario.":[319],"Obtaining":[320],"such":[321],"beneficial":[323],"effect":[324],"simple":[327],"manipulation":[328],"major":[333],"interest.":[336],"Now":[337],"more":[338],"than":[339],"ever,":[340],"mechanistic":[341],"pharmacological":[343],"research":[344],"field":[347],"appears":[351],"necessary":[354],"clinically":[356],"relevant.":[357]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}