{"id":"https://openalex.org/W2014038892","doi":"https://doi.org/10.1126/scitranslmed.3001433","title":"Channelopathies: Decoding Disease Pathogenesis","display_name":"Channelopathies: Decoding Disease Pathogenesis","publication_year":2010,"publication_date":"2010-07-28","ids":{"openalex":"https://openalex.org/W2014038892","doi":"https://doi.org/10.1126/scitranslmed.3001433","mag":"2014038892","pmid":"https://pubmed.ncbi.nlm.nih.gov/20668296"},"language":"en","primary_location":{"id":"doi:10.1126/scitranslmed.3001433","doi":"https://doi.org/10.1126/scitranslmed.3001433","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.3001433","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047902810","display_name":"Andr\u00e9 Terzic","orcid":"https://orcid.org/0000-0001-9210-009X","observed_orcids":["https://orcid.org/0000-0001-9210-009X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andre Terzic","raw_affiliation_strings":["Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007245688","display_name":"Carmen M. P\u00e9rez-Terzic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carmen Perez-Terzic","raw_affiliation_strings":["Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA","Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047902810"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":1.1716,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.75597855,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2","issue":"42","first_page":"42ps37","last_page":"42ps37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0794999971985817,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/channelopathies","display_name":"channelopathies","score":0.8029999732971191},{"id":"https://openalex.org/keywords/atp-sensitive-potassium-channels","display_name":"ATP-sensitive potassium channels","score":0.9679999947547913},{"id":"https://openalex.org/keywords/humanized-mouse-model","display_name":"humanized mice","score":0.8479999899864197},{"id":"https://openalex.org/keywords/mutation","display_name":"genetic mutations","score":0.6129999756813049},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.8309999704360962},{"id":"https://openalex.org/keywords/molecular-diagnosis","display_name":"molecular diagnosis","score":0.5559999942779541},{"id":"https://openalex.org/keywords/molecular-therapy","display_name":"molecular therapy","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7145780324935913},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5765438079833984},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4950832426548004},{"id":"https://openalex.org/C57273362","wikidata":"https://www.wikidata.org/wiki/Q576722","display_name":"Decoding methods","level":2,"score":0.44458526372909546},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.379124253988266},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.355225145816803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3081333041191101},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2629721164703369},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2599245309829712},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.10111218690872192}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053447","descriptor_name":"Channelopathies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053447","descriptor_name":"Channelopathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053447","descriptor_name":"Channelopathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D054086","descriptor_name":"KATP Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054086","descriptor_name":"KATP Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/scitranslmed.3001433","doi":"https://doi.org/10.1126/scitranslmed.3001433","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.3001433","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},{"id":"pmid:20668296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20668296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science translational medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1571734887","https://openalex.org/W1616019613","https://openalex.org/W1958062876","https://openalex.org/W1963635140","https://openalex.org/W1968584596","https://openalex.org/W1976205937","https://openalex.org/W1986890860","https://openalex.org/W1989885621","https://openalex.org/W2007569154","https://openalex.org/W2007935184","https://openalex.org/W2013014604","https://openalex.org/W2022446120","https://openalex.org/W2027045802","https://openalex.org/W2030026433","https://openalex.org/W2033349405","https://openalex.org/W2038353863","https://openalex.org/W2052446448","https://openalex.org/W2067067698","https://openalex.org/W2068722248","https://openalex.org/W2074580166","https://openalex.org/W2075712648","https://openalex.org/W2080607046","https://openalex.org/W2083584165","https://openalex.org/W2101772363","https://openalex.org/W2108706632","https://openalex.org/W2117669462","https://openalex.org/W2125595015","https://openalex.org/W2134991186","https://openalex.org/W2137087583","https://openalex.org/W2139669571","https://openalex.org/W2144221808","https://openalex.org/W2148959338","https://openalex.org/W2153121902","https://openalex.org/W2153298670","https://openalex.org/W2157171390"],"related_works":["https://openalex.org/W2030026433","https://openalex.org/W4297518692","https://openalex.org/W2033349405","https://openalex.org/W2124725518","https://openalex.org/W2941602208","https://openalex.org/W2065966626","https://openalex.org/W4412765697","https://openalex.org/W7207432569","https://openalex.org/W4400094484","https://openalex.org/W1977017927"],"abstract_inverted_index":{"The":[0],"deconvolution":[1],"of":[2,11,25,40,83,94],"corrupted":[3],"biological":[4],"pathways":[5],"in":[6,34,50,61,90],"disease":[7,87],"and":[8,75,103],"the":[9,23,37,41,81,91],"translation":[10],"patient-specific":[12],"molecular":[13,92],"mechanisms":[14],"into":[15],"tailored":[16],"management":[17],"algorithms":[18],"have":[19],"begun":[20],"to":[21,30,68],"extend":[22],"reach":[24],"individualized":[26],"medicine":[27,93],"from":[28],"principles":[29],"practice.":[31],"A":[32],"case":[33],"point":[35],"is":[36],"emergent":[38],"deciphering":[39],"pathobiology":[42],"underlying":[43],"life-threatening":[44],"human":[45],"diseases":[46],"caused":[47],"by":[48],"dysfunction":[49],"adenosine":[51],"triphosphate":[52],"(ATP)-sensitive":[53],"potassium":[54],"(K(ATP))":[55],"channels.":[56],"In":[57],"a":[58,70],"recent":[59],"paper":[60],"Science,":[62],"researchers":[63],"used":[64],"humanized":[65],"mouse":[66],"models":[67],"recapitulate":[69],"pathogenic":[71],"K(ATP)":[72,95],"channel":[73],"mutation":[74],"pinpoint":[76],"tissue-restricted":[77],"lesions":[78],"that":[79],"stratify":[80],"consequences":[82],"genetic":[84],"variation":[85],"on":[86],"traits.":[88],"Advances":[89],"channelopathies":[96],"offer":[97],"new":[98],"perspectives":[99],"for":[100],"personalized":[101],"diagnosis":[102],"therapy.":[104]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}