{"id":"https://openalex.org/W2014038560","doi":"https://doi.org/10.1097/00000539-200108000-00023","title":"The Influence of Inhaled Nitric Oxide on Cerebral Blood Flow and Metabolism in a Child with Traumatic Brain Injury","display_name":"The Influence of Inhaled Nitric Oxide on Cerebral Blood Flow and Metabolism in a Child with Traumatic Brain Injury","publication_year":2001,"publication_date":"2001-08-01","ids":{"openalex":"https://openalex.org/W2014038560","doi":"https://doi.org/10.1097/00000539-200108000-00023","mag":"2014038560","pmid":"https://pubmed.ncbi.nlm.nih.gov/11473859"},"language":"en","primary_location":{"id":"doi:10.1097/00000539-200108000-00023","doi":"https://doi.org/10.1097/00000539-200108000-00023","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000539-200108000-00023","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087753487","display_name":"Monica Shanta Vavilala","orcid":"https://orcid.org/0000-0002-2354-5279","observed_orcids":["https://orcid.org/0000-0002-2354-5279"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2802336062","display_name":"Harborview Medical Center","ror":"https://ror.org/059jq5127","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801852214","https://openalex.org/I2802336062"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Monica S. Vavilala","raw_affiliation_strings":["Department of Anesthesiology, Harborview Medical Center, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA. vavilala@u.washington.edu","Departments of *Anesthesiology, \u2020Pediatrics, and \u2021Neurological Surgery, University of Washington, Seattle, Washington","to Monica S. Vavilala, MD, Department of Anesthesiology, Harborview Medical Center, 325 Ninth Avenue, Box 359724, Seattle, WA 98104. Address email to [email\u00a0protected] washington.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Harborview Medical Center, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA. vavilala@u.washington.edu","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I2802336062"]},{"raw_affiliation_string":"Departments of *Anesthesiology, \u2020Pediatrics, and \u2021Neurological Surgery, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"to Monica S. Vavilala, MD, Department of Anesthesiology, Harborview Medical Center, 325 Ninth Avenue, Box 359724, Seattle, WA 98104. Address email to [email\u00a0protected] washington.edu","institution_ids":["https://openalex.org/I2802336062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010732987","display_name":"Joan S. Roberts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan S. Roberts","raw_affiliation_strings":["Departments of *Anesthesiology, \u2020Pediatrics, and \u2021Neurological Surgery, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Anesthesiology, \u2020Pediatrics, and \u2021Neurological Surgery, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034276057","display_name":"Anne Elizabeth Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne E. Moore","raw_affiliation_strings":["Departments of *Anesthesiology, \u2020Pediatrics, and \u2021Neurological Surgery, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Anesthesiology, \u2020Pediatrics, and \u2021Neurological Surgery, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113487176","display_name":"David W. Newell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David W. Newell","raw_affiliation_strings":["Departments of *Anesthesiology, \u2020Pediatrics, and \u2021Neurological Surgery, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Anesthesiology, \u2020Pediatrics, and \u2021Neurological Surgery, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056287768","display_name":"Arthur M. Lam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur M. Lam","raw_affiliation_strings":["Departments of *Anesthesiology, \u2020Pediatrics, and \u2021Neurological Surgery, University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of *Anesthesiology, \u2020Pediatrics, and \u2021Neurological Surgery, University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087753487"],"corresponding_institution_ids":["https://openalex.org/I201448701","https://openalex.org/I2802336062"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.1264202,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"93","issue":"2","first_page":"351","last_page":"353"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inhaled-nitric-oxide","display_name":"inhaled nitric oxide","score":0.9639999866485596},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cerebral-metabolism","display_name":"brain metabolism","score":0.7950000166893005},{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.7139999866485596},{"id":"https://openalex.org/keywords/diffuse-axonal-injury","display_name":"diffuse axonal injury","score":0.7409999966621399},{"id":"https://openalex.org/keywords/subarachnoid-hemorrhage","display_name":"subarachnoid hemorrhage","score":0.9359999895095825},{"id":"https://openalex.org/keywords/right-heart-failure","display_name":"right heart failure","score":0.6809999942779541},{"id":"https://openalex.org/keywords/cerebral-perfusion-pressure","display_name":"cerebral perfusion pressure","score":0.6710000038146973},{"id":"https://openalex.org/keywords/middle-cerebral-artery-blood-flow-velocity","display_name":"middle cerebral artery blood flow velocity","score":0.7540000081062317},{"id":"https://openalex.org/keywords/hyperventilation","display_name":"hyperventilation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.4740000069141388},{"id":"https://openalex.org/keywords/dobutamine","display_name":"dobutamine","score":0.6299999952316284},{"id":"https://openalex.org/keywords/intracranial-pressure-monitoring","display_name":"intracranial pressure monitoring","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9627267122268677},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7066656947135925},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.699542760848999},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.6449362635612488},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4999582767486572},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.43400630354881287},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22258791327476501},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.08778971433639526}],"mesh":[{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007427","descriptor_name":"Intracranial Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/00000539-200108000-00023","doi":"https://doi.org/10.1097/00000539-200108000-00023","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000539-200108000-00023","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},{"id":"doi:10.1213/00000539-200108000-00023","doi":"https://doi.org/10.1213/00000539-200108000-00023","is_oa":false,"landing_page_url":"https://doi.org/10.1213/00000539-200108000-00023","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia &amp; Analgesia","raw_type":"journal-article"},{"id":"pmid:11473859","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11473859","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and analgesia","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7400000095367432}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1981729244","https://openalex.org/W1981921202","https://openalex.org/W1983027100","https://openalex.org/W1989630714","https://openalex.org/W1994503827","https://openalex.org/W1995379325","https://openalex.org/W2033664897","https://openalex.org/W2051198738","https://openalex.org/W2093033612","https://openalex.org/W2127487809","https://openalex.org/W2143748013","https://openalex.org/W2165890590","https://openalex.org/W2169618038","https://openalex.org/W2185220614","https://openalex.org/W2280013815","https://openalex.org/W2920660444","https://openalex.org/W6686570917"],"related_works":["https://openalex.org/W2075113783","https://openalex.org/W7096838236","https://openalex.org/W2051488720","https://openalex.org/W2126261504","https://openalex.org/W1966745475","https://openalex.org/W1900412604","https://openalex.org/W2161258057","https://openalex.org/W4391589748","https://openalex.org/W3100915021","https://openalex.org/W2165890590"],"abstract_inverted_index":{"Case":[0],"Report":[1],"We":[2,715,1003,1038,1127],"present":[3],"a":[4,8,29,131,162,255,319,357,430,444,485,543,770,875,1007,1015,1041,1073,1080],"10-yr-old":[5],"girl":[6],"after":[7,458],"motor":[9],"vehicle":[10],"accident":[11],"(Glasgow":[12,492],"Coma":[13],"Scale":[14,494],"score":[15],"4T)":[16],"with":[17,56,92,102,168,213,420,429,577,689,710,819,864,941,973,1025,1075,1123],"acute":[18,942],"respiratory":[19,943],"syndrome,":[20],"pulmonary":[21,378],"hypertension":[22],"(PHTN),":[23],"and":[24,28,45,90,118,151,173,182,189,193,204,240,242,311,376,383,414,519,528,542,604,611,653,719,735,827,866,883,902,999,1036,1051,1057,1084,1125,1132,1138],"diffuse":[25],"axonal":[26],"injury":[27,713,951],"subarachnoid":[30],"hemorrhage":[31],"in":[32,225,313,346,352,359,366,389,398,402,409,467,525,545,558,568,617,634,649,655,683,708,757,766,772,794,817,832,842,862,874,923,958,997,1009,1023,1044,1055,1072,1082,1088,1096,1120],"whom":[33],"middle":[34],"cerebral":[35,132,237,559,569,599,636,675,773,795,855,868,913,967],"artery":[36,142,379],"blood":[37,361,417,560],"flow":[38,561],"velocities":[39],"(Vmca),":[40],"jugular":[41,257,264],"bulb":[42,258],"saturations":[43],"(SjO2),":[44],"intraparenchymal":[46],"intracranial":[47],"pressure":[48,134,380,418],"(ICP)":[49],"monitoring":[50,721,802,1134],"were":[51,145,187,287,462],"used":[52,146,716,743,919],"to":[53,129,147,199,202,221,231,243,318,335,394,432,455,484,552,565,598,639,644,788,888,890,920,1028,1047,1135],"guide":[54,244],"treatment":[55,101,280,929,937],"inhaled":[57,1113],"nitric":[58,474],"oxide":[59,475],"(INO).":[60],"During":[61,500],"the":[62,71,245,261,294,301,340,426,436,473,555,635,684,703,723,761,790,807,854,896,924,936,947,954,964,978,994,1063,1067,1102,1142],"first":[63,1064],"24":[64],"h":[65],"of":[66,135,247,281,315,321,332,424,453,534,596,663,672,687,695,706,728,748,763,776,780,792,800,809,822,836,840,877,880,898,911,938,949,956,971,982,986,1017,1066,1070],"intensive":[67],"care":[68],"unit":[69],"admission,":[70],"patient\u2019s":[72],"ICP":[73,471,801,903,1100,1133],"was":[74,127,177,197,211,219,229,283,298,334,447,482,814,825,829,961],"25\u201330":[75,250],"mm":[76,82,139,251,441],"Hg":[77],"despite":[78],"hyperventilation":[79,248,916,934,957,972],"(Paco2,":[80],"30\u201335":[81],"Hg),":[83,252],"mannitol":[84],"therapy":[85],"(serum":[86],"osmolality,":[87],"310":[88],"mosm/kg),":[89],"sedation":[91],"lorazepam":[93],"(20":[94],"\u03bcg":[95,106,113,121],"\u00b7":[96,98,107,109,114,116,122,124],"kg\u22121":[97,108,115,123],"h\u22121).":[99],"Despite":[100],"IV":[103,227],"phenylephrine":[104],"(1.0":[105],"min\u22121),":[110,117,125],"dopamine":[111],"(30":[112],"epinephrine":[119],"(0.1":[120],"it":[126,824,848,852,1110],"difficult":[128],"sustain":[130],"perfusion":[133],"at":[136,305,324],"least":[137],"60":[138],"Hg.":[140],"Pulmonary":[141],"catheter":[143,259],"findings":[144,589],"differentiate":[148],"between":[149,1034],"right":[150,262],"left":[152,183,194],"heart":[153],"failure.":[154],"On":[155,270],"hospital":[156,267,271,489],"day":[157,268,272,490],"2,":[158],"trans-thoracic":[159],"echocardiogram":[160],"revealed":[161],"torn":[163],"anterior":[164],"tricuspid":[165,170],"valve":[166],"leaflet":[167],"wide-open":[169],"regurgitation,":[171],"PHTN,":[172,578],"biventricular":[174],"dysfunction.":[175],"There":[176,461],"no":[178,349,399,463,670,700,830,1092],"atrial":[179],"shunting.":[180],"Right":[181,192],"ventricular":[184,195],"ejection":[185],"fractions":[186],"19%":[188],"30%,":[190],"respectively.":[191,209],"failure":[196],"presumed":[198],"be":[200,336,760,846,1116,1136],"attributable":[201],"PTHN":[203],"resultant":[205],"septal":[206],"wall":[207],"motion,":[208],"PHTN":[210,282,922,939],"treated":[212],"hyperventilation,":[214],"which":[215,343],"decreases":[216,654],"ICP.":[217,736,811,833],"Epinephrine":[218],"discontinued":[220,448],"avoid":[222],"an":[223,344,364,407,421,513,566,631,745,764,815,1032,1052,1085],"increase":[224,232,345,365,388,408,557,567,765,816,946,996,1054,1087],"afterload;":[226],"dobutamine":[228],"administered":[230,299],"cardiac":[233,384,1048],"output.":[234],"To":[235],"assess":[236,789],"oxygen":[238],"delivery":[239],"extraction":[241],"degree":[246],"(ICP,":[249],"we":[253,405,750,1078,1090],"placed":[254],"retrograde":[256],"via":[260,300],"internal":[263],"vein":[265],"on":[266,488,515,586,674],"3.":[269],"4,":[273],"approval":[274],"for":[275,277,279,935,966,993,1118],"administration":[276,727,1119],"INO":[278,295,297,333,347,372,390,446,579,707,724,729,841,974,1026,1035,1071,1103,1143],"obtained.":[284],"Bilateral":[285],"Vmcas":[286],"insonated":[288],"by":[289,338,624,661,963],"using":[290],"transcranial":[291,717,1129],"Doppler":[292,718],"during":[293,472,601,651,657,722,1101,1141],"trial.":[296,1104,1144],"tracheal":[302],"tube":[303],"starting":[304],"5":[306,316],"parts":[307],"per":[308],"million":[309],"(ppm)":[310],"titrated":[312],"increments":[314],"ppm":[317,323,393,396,434,1030],"maximum":[320],"35":[322,395],"10-min":[325],"intervals":[326],"(Table":[327,478],"1).":[328,479],"The":[329,451,480,532,594,798,834,969,991,1020],"optimal":[330],"dose":[331,341,423],"determined":[337],"identifying":[339],"beyond":[342],"caused":[348],"further":[350,400],"decrease":[351,358,401,544,771,1022,1043,1081],"peripheral":[353],"vascular":[354,411,637],"resistance":[355,412],"(PVR),":[356],"systemic":[360,410,1018],"pressure,":[362],"or":[363,369,470,769,873,1011,1099],"Vmca,":[367,468,1097],"ICP,":[368],"SjO2.":[370],"At":[371],"10":[373,392,433,1029],"ppm,":[374],"PVR":[375,1045,1083],"mean":[377,415],"decreased":[381,428],"significantly":[382],"index":[385],"improved.":[386],"An":[387],"from":[391,620],"resulted":[397],"PVR.":[403],"However,":[404],"observed":[406],"(SVR)":[413],"arterial":[416],"(MABP)":[419],"increasing":[422,820],"INO;":[425],"SVR":[427,998,1024,1056],"taper":[431,1027],"while":[435],"MABP":[437,454,899,1000],"remained":[438],"increased":[439,733,810],"(154":[440],"Hg).":[442],"As":[443],"result,":[445],"shortly":[449],"thereafter.":[450],"return":[452],"normal":[456],"occurred":[457],"15":[459],"min.":[460],"clinically":[464,1093],"significant":[465,1094],"changes":[466,756,793,1050,1095],"SjO2,":[469,1098,1131],"(NO)":[476],"trial":[477,725],"patient":[481,844,960,1074],"transferred":[483],"rehabilitation":[486],"facility":[487],"14":[491],"Outcome":[493],"score,":[495],"4).Table":[496],"1:":[497],"Patient":[498],"Data":[499],"Inhaled":[501],"Nitric":[502],"Oxide":[503],"(INO)":[504],"AdministrationDiscussion":[505],"It":[506,857],"has":[507],"been":[508,742],"suggested":[509],"that":[510,554,615,628,861,1040,1112],"NO":[511,535,597,629,673,893,1114],"exerts":[512],"influence":[514,791],"basal":[516],"cerebrovascular":[517,704,838,980,1068],"tone":[518,522],"stimuli":[520],"mediated":[521],"(inducible":[523],"form)":[524],"both":[526],"conscious":[527],"anesthetized":[529],"states":[530],"(1\u20133).":[531],"mechanism":[533],"induced":[536],"vasodilation":[537,600],"involves":[538],"cyclic":[539],"guanosine":[540],"monophosphate":[541],"intracellular":[546],"calcium,":[547],"but":[548,933],"there":[549,698,813,828],"is":[550,563,606,694,849,858,908,917,1062,1107],"evidence":[551,910],"suggest":[553],"NO-associated":[556],"(CBF)":[562],"unrelated":[564],"metabolic":[570,774,796],"rate":[571,775],"(4).":[572],"In":[573,1059],"neurologically":[574],"intact":[575,912],"animals":[576],"did":[580,904],"not":[581,752,784,805,905],"show":[582,669],"any":[583],"adverse":[584,837],"effect":[585,1013],"CBF;":[587],"our":[588,843],"corroborate":[590],"these":[591,987],"observations":[592],"(5\u20137).":[593],"contribution":[595],"hypercapnia,":[602],"hypoxia,":[603],"autoregulation":[605,688],"uncertain.":[607],"Although":[608,666,737,812,1077],"Iadecola":[609],"(8)":[610],"others":[612,641],"have":[613,731,741,753,785,976],"demonstrated":[614],"increases":[616,682],"CBF":[618,650,656,734,767],"resulting":[619],"hypercapnia":[621],"are":[622,659,699,870,886,931,989],"inhibited":[623],"NOS":[625,664,690],"inhibitors,":[626],"suggesting":[627],"plays":[630],"important":[632,1108],"role":[633],"response":[638],"CO2,":[640],"investigators":[642],"failed":[643],"confirm":[645],"this":[646,907,959,1061],"(8\u201310).":[647],"Increases":[648],"hypoxia":[652],"hypocapnia":[658],"altered":[660],"inhibitors":[662],"(11\u201314).":[665],"earlier":[667],"studies":[668,985],"effects":[671,705,839,981,1069],"autoregulation,":[676],"Jones":[677],"et":[678],"al.":[679],"(14)":[680],"describe":[681],"lower":[685],"limit":[686],"inhibitors.":[691],"This":[692],"report":[693,1065,1079,1091],"value":[696],"because":[697,726,847,879,1109],"data":[701],"about":[702],"humans":[709],"traumatic":[711],"brain":[712],"(TBI).":[714],"SjO2":[720,738,758,818],"could":[730,740,751],"adversely":[732],"alone":[739,782,803],"as":[744,1014],"indirect":[746,909],"measure":[747],"CBF,":[749],"differentiated":[754],"whether":[755],"would":[759,783],"result":[762],"(hyperemia)":[768],"oxygen.":[777],"Similarly,":[778],"measurement":[779],"Vmca":[781,901],"allowed":[786],"us":[787],"rate.":[797],"use":[799,955],"does":[804],"identify":[806],"etiology":[808],"doses":[821],"INO,":[823],"small":[826],"change":[831,1008],"lack":[835],"may":[845,945,975],"metabolized":[850],"before":[851],"reaches":[853],"circulation.":[856],"also":[859],"possible":[860],"patients":[863,1122],"TBI":[865,1124],"hyperemia,":[867],"vessels":[869],"maximally":[871],"vasodilated":[872],"state":[876],"vasoparalysis":[878],"endogenous":[881],"NO,":[882],"hence":[884],"they":[885],"unresponsive":[887],"exposure":[889],"additional":[891],"exogenous":[892],"(15).":[894],"Within":[895],"range":[897],"studied,":[900],"increase;":[906],"autoregulation.":[914],"Short-term":[915],"commonly":[918],"treat":[921],"emergent":[925],"setting":[926],"when":[927],"other":[928],"modalities":[930],"unavailable":[932],"associated":[940],"syndrome":[944],"risk":[948],"lung":[950],"(16).":[952],"Additionally,":[953],"complicated":[962],"concern":[965],"ischemia.":[968],"interaction":[970],"masked":[977],"intrinsic":[979],"INO.":[983],"Further":[984],"interactions":[988],"indicated.":[990],"reason":[992],"apparent":[995],"remains":[1001],"unclear.":[1002],"excluded":[1004],"inadequate":[1005],"analgesia,":[1006],"stimulation,":[1010],"vasopressor":[1012],"cause":[1016],"hypertension.":[1019],"parallel":[1021],"suggests":[1031,1111],"association":[1033],"SVR.":[1037],"speculate":[1039],"sudden":[1042],"led":[1046],"conformational":[1049],"idiosyncratic":[1053,1086],"MABP.":[1058],"conclusion,":[1060],"TBI.":[1076],"SVR,":[1089],"Our":[1105],"observation":[1106],"might":[1115],"safe":[1117],"some":[1121],"hyperemia.":[1126],"found":[1128],"Doppler,":[1130],"complimentary":[1137],"useful":[1139],"monitors":[1140]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
