{"id":"https://openalex.org/W2014036657","doi":"https://doi.org/10.1007/s10295-012-1096-y","title":"Modification of CusSR bacterial two-component systems by the introduction of an inducible positive feedback loop","display_name":"Modification of CusSR bacterial two-component systems by the introduction of an inducible positive feedback loop","publication_year":2012,"publication_date":"2012-02-11","ids":{"openalex":"https://openalex.org/W2014036657","doi":"https://doi.org/10.1007/s10295-012-1096-y","mag":"2014036657","pmid":"https://pubmed.ncbi.nlm.nih.gov/22327913"},"language":"en","primary_location":{"id":"doi:10.1007/s10295-012-1096-y","doi":"https://doi.org/10.1007/s10295-012-1096-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10295-012-1096-y","pdf_url":null,"source":{"id":"https://openalex.org/S107262989","display_name":"Journal of Industrial Microbiology & Biotechnology","issn_l":"1367-5435","issn":["1367-5435","1476-5535"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Industrial Microbiology and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074663909","display_name":"Sambandam Ravikumar","orcid":"https://orcid.org/0000-0001-7351-0421","observed_orcids":["https://orcid.org/0000-0001-7351-0421"]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sambandam Ravikumar","raw_affiliation_strings":["grid.267370.7 0000000405334667 School of Chemical Engineering and Bioengineering University of Ulsan 93 Daehakro 680-749 Nam-gu, Ulsan Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"grid.267370.7 0000000405334667 School of Chemical Engineering and Bioengineering University of Ulsan 93 Daehakro 680-749 Nam-gu, Ulsan Republic of Korea","institution_ids":["https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101424904","display_name":"V\u0103n D\u0169ng Ph\u1ea1m","orcid":"https://orcid.org/0000-0002-2880-3898","observed_orcids":["https://orcid.org/0000-0002-2880-3898"]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Van Dung Pham","raw_affiliation_strings":["grid.267370.7 0000000405334667 School of Chemical Engineering and Bioengineering University of Ulsan 93 Daehakro 680-749 Nam-gu, Ulsan Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"grid.267370.7 0000000405334667 School of Chemical Engineering and Bioengineering University of Ulsan 93 Daehakro 680-749 Nam-gu, Ulsan Republic of Korea","institution_ids":["https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100410174","display_name":"Seung\u2010Hwan Lee","orcid":"https://orcid.org/0000-0002-3964-3877","observed_orcids":["https://orcid.org/0000-0002-3964-3877"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seung Hwan Lee","raw_affiliation_strings":["Bio Research Center Sinseongno 19 305-600 Yuseong-gu, Daejeon Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bio Research Center Sinseongno 19 305-600 Yuseong-gu, Daejeon Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024815588","display_name":"Ik\u2010Keun Yoo","orcid":"https://orcid.org/0000-0003-3013-5312","observed_orcids":["https://orcid.org/0000-0003-3013-5312"]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ik-keun Yoo","raw_affiliation_strings":["grid.267370.7 0000000405334667 School of Chemical Engineering and Bioengineering University of Ulsan 93 Daehakro 680-749 Nam-gu, Ulsan Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"grid.267370.7 0000000405334667 School of Chemical Engineering and Bioengineering University of Ulsan 93 Daehakro 680-749 Nam-gu, Ulsan Republic of Korea","institution_ids":["https://openalex.org/I40542001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101850137","display_name":"Soon Ho Hong","orcid":"https://orcid.org/0000-0003-0035-7117","observed_orcids":["https://orcid.org/0000-0003-0035-7117"]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Soon Ho Hong","raw_affiliation_strings":["grid.267370.7 0000000405334667 School of Chemical Engineering and Bioengineering University of Ulsan 93 Daehakro 680-749 Nam-gu, Ulsan Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"grid.267370.7 0000000405334667 School of Chemical Engineering and Bioengineering University of Ulsan 93 Daehakro 680-749 Nam-gu, Ulsan Republic of Korea","institution_ids":["https://openalex.org/I40542001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2921,"currency":"USD","value_usd":2921},"apc_paid":null,"fwci":0.3148,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.49851318,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"39","issue":"6","first_page":"861","last_page":"868"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.6137999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.6137999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.37130001187324524,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/copper-sensing","display_name":"copper sensing","score":0.7009999752044678},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8659999966621399},{"id":"https://openalex.org/keywords/positive-feedback-loop","display_name":"positive feedback loop","score":0.9710000157356262},{"id":"https://openalex.org/keywords/copper-homeostasis","display_name":"copper homeostasis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/signal-amplification","display_name":"signal amplification","score":0.656000018119812},{"id":"https://openalex.org/keywords/promoter-regulation","display_name":"promoter regulation","score":0.4090000092983246},{"id":"https://openalex.org/keywords/synthetic-gene-circuits","display_name":"synthetic gene circuits","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C48207687","wikidata":"https://www.wikidata.org/wiki/Q918004","display_name":"Positive feedback","level":2,"score":0.6864888668060303},{"id":"https://openalex.org/C544778455","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper","level":2,"score":0.5872759222984314},{"id":"https://openalex.org/C168167062","wikidata":"https://www.wikidata.org/wiki/Q1117970","display_name":"Component (thermodynamics)","level":2,"score":0.573504626750946},{"id":"https://openalex.org/C186886427","wikidata":"https://www.wikidata.org/wiki/Q5441213","display_name":"Feedback loop","level":2,"score":0.564422070980072},{"id":"https://openalex.org/C93586867","wikidata":"https://www.wikidata.org/wiki/Q62527","display_name":"Negative feedback","level":3,"score":0.5449080467224121},{"id":"https://openalex.org/C184670325","wikidata":"https://www.wikidata.org/wiki/Q512604","display_name":"Loop (graph theory)","level":2,"score":0.4684567451477051},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.4640558958053589},{"id":"https://openalex.org/C3017962763","wikidata":"https://www.wikidata.org/wiki/Q427492","display_name":"Feedback regulation","level":2,"score":0.42759114503860474},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39976611733436584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3498103618621826},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.33980923891067505},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.32836055755615234},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.25765925645828247},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1929638683795929},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1900080442428589},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11614453792572021},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.08296054601669312},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.07172489166259766},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C145420912","wikidata":"https://www.wikidata.org/wiki/Q853077","display_name":"Mathematics education","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004784","descriptor_name":"Environmental Monitoring","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10295-012-1096-y","doi":"https://doi.org/10.1007/s10295-012-1096-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10295-012-1096-y","pdf_url":null,"source":{"id":"https://openalex.org/S107262989","display_name":"Journal of Industrial Microbiology & Biotechnology","issn_l":"1367-5435","issn":["1367-5435","1476-5535"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Industrial Microbiology and Biotechnology","raw_type":"journal-article"},{"id":"pmid:22327913","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22327913","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of industrial microbiology & biotechnology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1547106545","https://openalex.org/W1606097256","https://openalex.org/W1645304047","https://openalex.org/W1958241309","https://openalex.org/W1974317826","https://openalex.org/W1974936441","https://openalex.org/W2019460535","https://openalex.org/W2021076430","https://openalex.org/W2058473414","https://openalex.org/W2060350357","https://openalex.org/W2062221023","https://openalex.org/W2107093868","https://openalex.org/W2108559568","https://openalex.org/W2116021469","https://openalex.org/W2137464895","https://openalex.org/W2147051160","https://openalex.org/W2147990023","https://openalex.org/W2148061480","https://openalex.org/W2154122150","https://openalex.org/W2155798202","https://openalex.org/W2613784664"],"related_works":["https://openalex.org/W2251911873","https://openalex.org/W2067976526","https://openalex.org/W3032859417","https://openalex.org/W2147990023","https://openalex.org/W2047213366","https://openalex.org/W4414867005","https://openalex.org/W4387103853","https://openalex.org/W2152287160","https://openalex.org/W2112854450","https://openalex.org/W2044965391"],"abstract_inverted_index":{"The":[0,21,62,90,118,133],"CusSR":[1,26,100],"two-component":[2],"system":[3],"(TCS)":[4],"is":[5,13,46],"a":[6,34,84,113],"copper-sensing":[7],"apparatus":[8],"of":[9,24,33,55,74,83,97,120,148],"E.":[10],"coli":[11],"that":[12],"responsible":[14],"for":[15,94,130],"regulating":[16],"the":[17,25,31,40,43,49,56,72,75,81,95,98,121,145],"copper-related":[18],"homeostatic":[19],"system.":[20],"dynamic":[22,146],"characteristics":[23,147],"network":[27,102],"were":[28],"modified":[29,99],"by":[30,48,68],"introduction":[32],"positive":[35],"feedback":[36,41,63],"loop.":[37],"To":[38],"construct":[39],"loop,":[42],"CusR,":[44],"which":[45,78,111],"activated":[47,67],"cusC":[50,57,76],"promoter,":[51,77],"was":[52,103,124,128],"cloned":[53],"downstream":[54],"promoter":[58],"and":[59,87,127],"reporter":[60,85],"protein.":[61],"loop":[64],"system,":[65],"once":[66],"environmental":[69],"copper,":[70],"triggers":[71],"activation":[73,96],"results":[79],"in":[80,116,136],"amplification":[82],"protein":[86],"CusR":[88],"expression.":[89],"threshold":[91],"copper":[92],"concentration":[93],"TCS":[101],"lowered":[104],"from":[105],"2,476.5":[106],"\u03bcg/l":[107],"to":[108,143],"247.7":[109],"\u03bcg/l,":[110],"indicates":[112],"tenfold":[114],"increase":[115],"sensitivity.":[117],"intensity":[119],"output":[122],"signal":[123],"increased":[125],"twofold,":[126],"maintained":[129],"16":[131],"h.":[132],"strategy":[134],"proposed":[135],"this":[137],"study":[138],"can":[139],"also":[140],"be":[141],"applied":[142],"modify":[144],"other":[149],"TCSs.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
