{"id":"https://openalex.org/W2014022984","doi":"https://doi.org/10.1097/aln.0b013e3181e6a195","title":"Preoperative Prolonged Steroid Use Is Not Associated with Intraoperative Blood Transfusion in Noncardiac Surgical Patients","display_name":"Preoperative Prolonged Steroid Use Is Not Associated with Intraoperative Blood Transfusion in Noncardiac Surgical Patients","publication_year":2010,"publication_date":"2010-07-07","ids":{"openalex":"https://openalex.org/W2014022984","doi":"https://doi.org/10.1097/aln.0b013e3181e6a195","mag":"2014022984","pmid":"https://pubmed.ncbi.nlm.nih.gov/20613467"},"language":"en","primary_location":{"id":"doi:10.1097/aln.0b013e3181e6a195","doi":"https://doi.org/10.1097/aln.0b013e3181e6a195","is_oa":false,"landing_page_url":"https://doi.org/10.1097/aln.0b013e3181e6a195","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025296632","display_name":"Alparslan Turan","orcid":"https://orcid.org/0000-0001-9862-9306","observed_orcids":["https://orcid.org/0000-0001-9862-9306"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alparslan Turan","raw_affiliation_strings":["Associate Professor of Anesthesiology","Cleveland Clinic Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor of Anesthesiology","institution_ids":[]},{"raw_affiliation_string":"Cleveland Clinic Foundation","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060045309","display_name":"Jarrod E. Dalton","orcid":"https://orcid.org/0000-0001-8336-1212","observed_orcids":["https://orcid.org/0000-0001-8336-1212"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jarrod E. Dalton","raw_affiliation_strings":["Senior Biostatistician, Departments of Quantitative Health Sciences and Outcomes Research, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Senior Biostatistician, Departments of Quantitative Health Sciences and Outcomes Research, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040655711","display_name":"Patricia L. Turner","orcid":"https://orcid.org/0000-0002-1508-3828","observed_orcids":["https://orcid.org/0000-0002-1508-3828"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia L. Turner","raw_affiliation_strings":["Assistant Professor, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042996287","display_name":"Daniel I. Sessler","orcid":"https://orcid.org/0000-0001-9932-3077","observed_orcids":["https://orcid.org/0000-0001-9932-3077"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel I. Sessler","raw_affiliation_strings":["Professor and Chair"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor and Chair","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068541699","display_name":"Andrea M. Kurz","orcid":"https://orcid.org/0000-0001-5887-3099","observed_orcids":["https://orcid.org/0000-0001-5887-3099"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea Kurz","raw_affiliation_strings":["Professor and Vice Chair"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor and Vice Chair","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052507237","display_name":"Leif Saager","orcid":"https://orcid.org/0000-0003-3416-4727","observed_orcids":["https://orcid.org/0000-0003-3416-4727"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leif Saager","raw_affiliation_strings":["Assistant Professor of Anesthesiology, Department of Outcomes Research, and","Cleveland Clinic Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor of Anesthesiology, Department of Outcomes Research, and","institution_ids":[]},{"raw_affiliation_string":"Cleveland Clinic Foundation","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9851,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.71885125,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"113","issue":"2","first_page":"285","last_page":"291"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11930","display_name":"Cardiac, Anesthesia and Surgical Outcomes","score":0.04809999838471413,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corticosteroid-use","display_name":"corticosteroid use","score":0.8709999918937683},{"id":"https://openalex.org/keywords/intraoperative-transfusion","display_name":"intraoperative blood transfusion","score":0.8690000176429749},{"id":"https://openalex.org/keywords/noncardiac-surgery","display_name":"non-cardiac surgery","score":0.921999990940094},{"id":"https://openalex.org/keywords/hypercoagulability","display_name":"hypercoagulability","score":0.8709999918937683},{"id":"https://openalex.org/keywords/postoperative-infection","display_name":"postoperative infection","score":0.7099999785423279},{"id":"https://openalex.org/keywords/surgical-site-infection","display_name":"surgical site infection","score":0.921999990940094},{"id":"https://openalex.org/keywords/thromboembolic-events","display_name":"thromboembolic events","score":0.8980000019073486},{"id":"https://openalex.org/keywords/intraoperative-bleeding","display_name":"intraoperative bleeding","score":0.6579999923706055},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9802269339561462},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5525781512260437},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5230579972267151},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.49692395329475403},{"id":"https://openalex.org/C17923572","wikidata":"https://www.wikidata.org/wiki/Q7250160","display_name":"Propensity score matching","level":2,"score":0.44373953342437744},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.4420197010040283},{"id":"https://openalex.org/C2909375446","wikidata":"https://www.wikidata.org/wiki/Q309438","display_name":"Steroid use","level":2,"score":0.4238548278808594},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4200159013271332},{"id":"https://openalex.org/C2780014101","wikidata":"https://www.wikidata.org/wiki/Q183605","display_name":"Blood transfusion","level":2,"score":0.41723647713661194},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.4151581823825836},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3880886435508728},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.241105318069458},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.13735780119895935},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001803","descriptor_name":"Blood Transfusion","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007431","descriptor_name":"Intraoperative Complications","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007431","descriptor_name":"Intraoperative Complications","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007431","descriptor_name":"Intraoperative Complications","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011300","descriptor_name":"Preoperative Care","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013505","descriptor_name":"Digestive System Surgical Procedures","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016063","descriptor_name":"Blood Loss, Surgical","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/aln.0b013e3181e6a195","doi":"https://doi.org/10.1097/aln.0b013e3181e6a195","is_oa":false,"landing_page_url":"https://doi.org/10.1097/aln.0b013e3181e6a195","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:20613467","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20613467","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1966261487","https://openalex.org/W1968139094","https://openalex.org/W1969623042","https://openalex.org/W1987917226","https://openalex.org/W1990189151","https://openalex.org/W1990760213","https://openalex.org/W1992844865","https://openalex.org/W1993500055","https://openalex.org/W1996019151","https://openalex.org/W1996162173","https://openalex.org/W2002145441","https://openalex.org/W2003158081","https://openalex.org/W2009376985","https://openalex.org/W2011986851","https://openalex.org/W2021613300","https://openalex.org/W2024920242","https://openalex.org/W2030889356","https://openalex.org/W2035063680","https://openalex.org/W2036460223","https://openalex.org/W2052189184","https://openalex.org/W2065303751","https://openalex.org/W2071740182","https://openalex.org/W2078761628","https://openalex.org/W2085510403","https://openalex.org/W2086875531","https://openalex.org/W2089698057","https://openalex.org/W2091296149","https://openalex.org/W2092900546","https://openalex.org/W2099328349","https://openalex.org/W2116856478","https://openalex.org/W2125879298","https://openalex.org/W2126856135","https://openalex.org/W2294639865"],"related_works":["https://openalex.org/W2595163944","https://openalex.org/W4408448471","https://openalex.org/W2067254687","https://openalex.org/W2417941752","https://openalex.org/W2914159199","https://openalex.org/W2066857998","https://openalex.org/W4386879287","https://openalex.org/W2894795675","https://openalex.org/W2074077957","https://openalex.org/W2089180842"],"abstract_inverted_index":{"BACKGROUND:":[0],"Prolonged":[1],"steroid":[2,28,90,131,165,219],"therapy":[3],"is":[4,232],"reportedly":[5],"associated":[6,31],"with":[7,32,66],"changes":[8],"in":[9,39,129,135,154,163],"coagulation,":[10],"suggesting":[11],"increased":[12,33],"intraoperative":[13,124],"bleeding":[14,85],"or":[15,37],"hypercoagulability.":[16],"The":[17,121,204,215],"aim":[18],"of":[19,57,104,113,123,146,206,217,234,245],"this":[20,46],"retrospective":[21],"study":[22,47],"was":[23,30,92,127,149,168],"to":[24,94,185,197,228],"assess":[25],"whether":[26],"long-term":[27],"use":[29,220,241],"transfusion":[34,126],"requirements,":[35],"infection,":[36,83],"hypercoagulability":[38],"adults":[40],"undergoing":[41],"noncardiac":[42],"surgery.":[43,105],"METHODS:":[44],"In":[45,238],"the":[48,54,74,110,130,140,155,164,243],"authors":[49],"evaluated":[50],"363,897":[51],"patients":[52,108],"from":[53],"American":[55],"College":[56],"Surgeons":[58],"National":[59],"Surgical":[60],"Quality":[61],"Improvement":[62],"Program":[63],"database.":[64],"Patients":[65],"current":[67],"pneumonia,":[68],"ventilator":[69],"dependence,":[70],"coma,":[71],"tumor":[72],"involving":[73],"central":[75],"nervous":[76],"system,":[77],"disseminated":[78],"cancer,":[79],"preoperative":[80],"open":[81],"wound/wound":[82],"and/or":[84],"disorders":[86],"were":[87,117,179],"excluded.":[88],"Each":[89],"user":[91,97,132],"matched":[93],"a":[95],"nonsteroid":[96,156],"based":[98],"on":[99,221],"propensity":[100],"score":[101],"and":[102,133,158,191,231,248],"type":[103],"RESULTS:":[106],"296,059":[107],"met":[109],"inclusion":[111],"criteria,":[112],"whom":[114],"7,760":[115],"(2.6%)":[116],"taking":[118],"steroids":[119],"preoperatively.":[120],"incidence":[122],"erythrocyte":[125],"3.6%":[128],"7.3%":[134],"non-steroid-user":[136],"groups.":[137],"After":[138],"matching,":[139],"mean":[141],"[95%":[142],"confidence":[143],"interval]":[144],"number":[145],"units":[147,153,162],"transfused":[148],"0.22":[150],"[0.19,":[151],"0.25]":[152],"group":[157,166],"0.19":[159],"[0.17,":[160],"0.22]":[161],"which":[167],"not":[169,211],"statistically":[170],"significant":[171],"(P":[172],"=":[173],"0.24,":[174],"Wald":[175],"test).":[176],"Steroid":[177],"users":[178],"24%":[180],"[2,":[181],"49]":[182],"more":[183,195],"likely":[184,196,227],"experience":[186,198],"30-day":[187],"postoperative":[188,199,207],"systemic":[189,247],"infection":[190,201],"21%":[192],"[3,":[193],"41]":[194],"wound":[200,249],"than":[202],"nonusers.":[203],"risks":[205],"thromboembolic":[208],"complications":[209],"did":[210],"differ":[212],"significantly.":[213],"CONCLUSIONS:":[214],"effect":[216],"prolonged":[218],"bleeding,":[222],"if":[223],"any,":[224],"thus":[225],"seems":[226],"be":[229],"small":[230],"probably":[233],"limited":[235],"clinical":[236],"consequence.":[237],"contrast,":[239],"corticosteroid":[240],"augments":[242],"risk":[244],"both":[246],"infections.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}