{"id":"https://openalex.org/W2014015991","doi":"https://doi.org/10.1039/fd9929300035","title":"Protein hydration in aqueous solution","display_name":"Protein hydration in aqueous solution","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2014015991","doi":"https://doi.org/10.1039/fd9929300035","mag":"2014015991","pmid":"https://pubmed.ncbi.nlm.nih.gov/1283962"},"language":"en","primary_location":{"id":"doi:10.1039/fd9929300035","doi":"https://doi.org/10.1039/fd9929300035","is_oa":false,"landing_page_url":"https://doi.org/10.1039/fd9929300035","pdf_url":null,"source":{"id":"https://openalex.org/S193234216","display_name":"Faraday Discussions","issn_l":"1359-6640","issn":["1359-6640","1364-5498"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faraday Discuss.","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000254356","display_name":"Kurt W\u00fcthrich A","orcid":"https://orcid.org/0000-0001-8739-6965","observed_orcids":["https://orcid.org/0000-0001-8739-6965","https://orcid.org/0000-0003-2612-6616"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255162","display_name":"Institute of Molecular Biology and Biophysics","ror":"https://ror.org/02p702482","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255162"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Kurt W\u00fcthrich","raw_affiliation_strings":["Institut f\u00fcr Molekularbiologie und Biophysik, Eidgen\u00f6ssische Technische Hochschule-H\u00f6nggerberg, Z\u00fcrich, Switzerland","Institut f\u00fcr Molekularbiologie und Biophysik, Eidgenossische Technische Hochschule-Honggerberg, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Molekularbiologie und Biophysik, Eidgen\u00f6ssische Technische Hochschule-H\u00f6nggerberg, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255162"]},{"raw_affiliation_string":"Institut f\u00fcr Molekularbiologie und Biophysik, Eidgenossische Technische Hochschule-Honggerberg, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027778630","display_name":"Gottfried Otting","orcid":"https://orcid.org/0000-0002-0563-0146","observed_orcids":["https://orcid.org/0000-0002-0563-0146"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gottfried Otting","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103668302","display_name":"Edvards Liepinsh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edvards Liepinsh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.582,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.83176129,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"93","issue":"93","first_page":"35","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.41600000858306885,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.41600000858306885,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.19509999454021454,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14488","display_name":"Chemical and Physical Studies","score":0.18369999527931213,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-hydration","display_name":"protein hydration","score":0.9639999866485596},{"id":"https://openalex.org/keywords/basic-pancreatic-trypsin-inhibitor","display_name":"basic pancreatic trypsin inhibitor","score":0.9620000123977661},{"id":"https://openalex.org/keywords/oxytocin","display_name":"oxytocin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nuclear-overhauser-effect","display_name":"nuclear Overhauser effect","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cross-relaxation-rates","display_name":"cross-relaxation rates","score":0.796999990940094},{"id":"https://openalex.org/keywords/surface-hydration","display_name":"surface hydration","score":0.859000027179718},{"id":"https://openalex.org/keywords/aqueous-solutions","display_name":"aqueous solutions","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8587275743484497},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.6886531114578247},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.6678839921951294},{"id":"https://openalex.org/C119851462","wikidata":"https://www.wikidata.org/wiki/Q901095","display_name":"Nuclear Overhauser effect","level":3,"score":0.6473803520202637},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.5884249806404114},{"id":"https://openalex.org/C19549132","wikidata":"https://www.wikidata.org/wiki/Q11141463","display_name":"Two-dimensional nuclear magnetic resonance spectroscopy","level":2,"score":0.5178433060646057},{"id":"https://openalex.org/C105168689","wikidata":"https://www.wikidata.org/wiki/Q901969","display_name":"Globular protein","level":2,"score":0.5065008401870728},{"id":"https://openalex.org/C54516573","wikidata":"https://www.wikidata.org/wiki/Q2294","display_name":"Proton","level":2,"score":0.4976544678211212},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.46371105313301086},{"id":"https://openalex.org/C111429119","wikidata":"https://www.wikidata.org/wiki/Q899127","display_name":"Chemical shift","level":2,"score":0.45294517278671265},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.27324438095092773},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.18905293941497803},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1061508059501648},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D007611","descriptor_name":"Aprotinin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010121","descriptor_name":"Oxytocin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1039/fd9929300035","doi":"https://doi.org/10.1039/fd9929300035","is_oa":false,"landing_page_url":"https://doi.org/10.1039/fd9929300035","pdf_url":null,"source":{"id":"https://openalex.org/S193234216","display_name":"Faraday Discussions","issn_l":"1359-6640","issn":["1359-6640","1364-5498"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faraday Discuss.","raw_type":"journal-article"},{"id":"pmid:1283962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1283962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faraday discussions","raw_type":"Comparative Study"},{"id":"pmh:oai:openresearch-repository.anu.edu.au:1885/733807676","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1885/733807676","pdf_url":null,"source":{"id":"https://openalex.org/S4306402539","display_name":"ANU Open Research (Australian National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118347636","host_organization_name":"Australian National University","host_organization_lineage":["https://openalex.org/I118347636"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faraday Discussions","raw_type":"Journal article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W110285710","https://openalex.org/W1554093359","https://openalex.org/W1935237622","https://openalex.org/W1966041739","https://openalex.org/W1985598807","https://openalex.org/W1996911308","https://openalex.org/W2019005479","https://openalex.org/W2030321545","https://openalex.org/W2031348603","https://openalex.org/W2031647295","https://openalex.org/W2031969982","https://openalex.org/W2037255500","https://openalex.org/W2037797286","https://openalex.org/W2038540983","https://openalex.org/W2062510241","https://openalex.org/W2063040647","https://openalex.org/W2064248870","https://openalex.org/W2069279937","https://openalex.org/W2069298274","https://openalex.org/W2074490799","https://openalex.org/W2080354575","https://openalex.org/W2084624211","https://openalex.org/W2093347837","https://openalex.org/W2109703770","https://openalex.org/W2167041947","https://openalex.org/W2177205004","https://openalex.org/W2485718612","https://openalex.org/W2949250147","https://openalex.org/W4205761711","https://openalex.org/W4255331927"],"related_works":["https://openalex.org/W2093347837","https://openalex.org/W2135094857","https://openalex.org/W2188401326","https://openalex.org/W2046011150","https://openalex.org/W2021414245","https://openalex.org/W7097718428","https://openalex.org/W25081486","https://openalex.org/W2066594795","https://openalex.org/W1992043136","https://openalex.org/W2024893370"],"abstract_inverted_index":{"Proton":[0],"nuclear":[1,34],"magnetic":[2],"resonance":[3],"was":[4],"used":[5],"to":[6,14,23],"study":[7],"individual":[8,41],"molecules":[9,96,139,188],"of":[10,40,45,50,91,100,136,160,173,222],"hydration":[11,51,92,142,172,219],"water":[12,95,138,187,234],"bound":[13],"the":[15,24,46,68,73,77,98,101,109,118,133,137,175,180,193,236],"protein":[16,47,119,177,237],"basic":[17],"pancreatic":[18],"trypsin":[19],"inhibitor":[20],"(BPTI)":[21],"and":[22,48,60,71,112,179],"nonapeptide":[25],"oxytocin":[26,184],"in":[27,67,76,97,105,108,113,140,192,235],"aqueous":[28],"solution.":[29,114],"The":[30,81],"experimental":[31],"observations":[32],"are":[33,86,104,121,144,227],"Overhauser":[35],"effects":[36],"(NOE)":[37],"between":[38],"protons":[39,120],"amino":[42],"acid":[43],"residues":[44],"those":[49],"water.":[52],"These":[53],"NOEs":[54,116,207],"were":[55],"recorded":[56],"by":[57,72,123,186,198,229],"two-dimensional":[58],"(2D)":[59],"three":[61],"dimensional":[62],"(3D)":[63],"NOE":[64,202],"spectroscopy":[65],"(NOESY)":[66],"laboratory":[69],"frame,":[70],"corresponding":[74],"experiments":[75,151],"rotating":[78],"frame":[79],"(ROESY).":[80],"studies":[82],"show":[83],"that":[84,132],"there":[85],"two":[87],"qualitatively":[88],"different":[89],"types":[90],"sites.":[93],"Four":[94],"interior":[99],"BPTI":[102,178],"molecule":[103],"identical":[106],"locations":[107],"crystal":[110],"structure":[111],"Their":[115],"with":[117,152,189,208],"characterized":[122],"large":[124],"negative":[125],"cross-relaxation":[126],"rates":[127],"sigma":[128,201],"NOE,":[129],"which":[130],"indicates":[131],"residence":[134,169,190,213],"times":[135,191,214],"these":[141,168],"sites":[143],"longer":[145],"than":[146],"ca.":[147],"10":[148],"ns.":[149],"Additional":[150],"extrinsic":[153],"shift":[154],"reagents":[155],"established":[156],"an":[157],"upper":[158],"limit":[159],"20":[161],"ms":[162],"at":[163],"4":[164],"degrees":[165],"C":[166],"for":[167,205,216],"times.":[170],"Surface":[171],"both":[174],"globular":[176],"flexibly":[181],"disordered":[182],"polypeptide":[183,210],"is":[185],"subnanosecond":[194],"range,":[195],"as":[196],"evidenced":[197],"small":[199],"positive":[200],"values":[203],"observed":[204],"their":[206],"nearby":[209],"protons.":[211],"Short":[212],"prevail":[215],"all":[217],"surface":[218],"sites,":[220],"independent":[221],"whether":[223],"or":[224],"not":[225],"they":[226],"occupied":[228],"well":[230],"ordered,":[231],"X-ray":[232],"observable":[233],"single":[238],"crystals.":[239]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}