{"id":"https://openalex.org/W2014009356","doi":"https://doi.org/10.1007/bf00402621","title":"The inhibition of free radical generation by human neutrophils through the synergistic effects of metronidazole with palmitoleic acid: a possible mechanism of action of metronidazole in rosacea and acne","display_name":"The inhibition of free radical generation by human neutrophils through the synergistic effects of metronidazole with palmitoleic acid: a possible mechanism of action of metronidazole in rosacea and acne","publication_year":1990,"publication_date":"1990-10-01","ids":{"openalex":"https://openalex.org/W2014009356","doi":"https://doi.org/10.1007/bf00402621","mag":"2014009356","pmid":"https://pubmed.ncbi.nlm.nih.gov/2150301"},"language":"en","primary_location":{"id":"doi:10.1007/bf00402621","doi":"https://doi.org/10.1007/bf00402621","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00402621","pdf_url":null,"source":{"id":"https://openalex.org/S33894392","display_name":"Archives of Dermatological Research","issn_l":"0003-9187","issn":["0003-9187","0340-3696","1432-069X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Dermatological Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009153839","display_name":"Hirohiko Akamatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Akamatsu","raw_affiliation_strings":["Department of Dermatology, Kansai Medical University, Moriguchi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Kansai Medical University, Moriguchi, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111599231","display_name":"M Oguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Oguchi","raw_affiliation_strings":["Department of Dermatology, Kansai Medical University, Moriguchi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Kansai Medical University, Moriguchi","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Nishijima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S. Nishijima","raw_affiliation_strings":["Department of Dermatology, Kansai Medical University, Moriguchi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Kansai Medical University, Moriguchi","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108198390","display_name":"Yasuo Asada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Asada","raw_affiliation_strings":["Department of Dermatology, Kansai Medical University, Moriguchi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Kansai Medical University, Moriguchi","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030723283","display_name":"Masatomo Takahashi","orcid":"https://orcid.org/0000-0002-2493-2684","observed_orcids":["https://orcid.org/0000-0002-2493-2684"]},"institutions":[{"id":"https://openalex.org/I160046202","display_name":"Shiga University of Medical Science","ror":"https://ror.org/00d8gp927","country_code":"JP","type":"education","lineage":["https://openalex.org/I160046202"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Takahashi","raw_affiliation_strings":["Department of Microbiology, Shiga University of Medical Science, Otsu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Shiga University of Medical Science, Otsu, Japan","institution_ids":["https://openalex.org/I160046202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025870982","display_name":"Tsutomu Ushijima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160046202","display_name":"Shiga University of Medical Science","ror":"https://ror.org/00d8gp927","country_code":"JP","type":"education","lineage":["https://openalex.org/I160046202"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Ushijima","raw_affiliation_strings":["Department of Microbiology, Shiga University of Medical Science, Otsu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Shiga University of Medical Science, Otsu, Japan","institution_ids":["https://openalex.org/I160046202"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113422152","display_name":"Y Niwa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Niwa","raw_affiliation_strings":["Department of Dermatology, Kansai Medical University, Moriguchi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Kansai Medical University, Moriguchi","institution_ids":["https://openalex.org/I126884977"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":4.4805,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.94210526,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"282","issue":"7","first_page":"449","last_page":"454"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metronidazole","display_name":"metronidazole","score":1.0},{"id":"https://openalex.org/keywords/palmitoleic-acid","display_name":"palmitoleic acid","score":1.0},{"id":"https://openalex.org/keywords/cutibacterium-acnes","display_name":"Propionibacterium acnes","score":0.9089999794960022},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.925000011920929},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9919999837875366},{"id":"https://openalex.org/keywords/free-radical-production","display_name":"free radical generation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.7210000157356262},{"id":"https://openalex.org/keywords/rosacea","display_name":"rosacea","score":0.7009999752044678},{"id":"https://openalex.org/keywords/acne-vulgaris","display_name":"acne","score":0.9480000138282776},{"id":"https://openalex.org/keywords/oxidative-tissue-injury","display_name":"oxidative tissue injury","score":0.8550000190734863},{"id":"https://openalex.org/keywords/xanthine-xanthine-oxidase-system","display_name":"xanthine-xanthine oxidase system","score":0.9240000247955322}],"concepts":[{"id":"https://openalex.org/C2777396551","wikidata":"https://www.wikidata.org/wiki/Q169569","display_name":"Metronidazole","level":3,"score":0.8591157793998718},{"id":"https://openalex.org/C2779900937","wikidata":"https://www.wikidata.org/wiki/Q2442109","display_name":"Propionibacterium acnes","level":3,"score":0.8211885690689087},{"id":"https://openalex.org/C2779641957","wikidata":"https://www.wikidata.org/wiki/Q412366","display_name":"Palmitoleic acid","level":4,"score":0.6259058117866516},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5791728496551514},{"id":"https://openalex.org/C2778081122","wikidata":"https://www.wikidata.org/wiki/Q831530","display_name":"Rosacea","level":3,"score":0.5203023552894592},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5106814503669739},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.4777607023715973},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47705474495887756},{"id":"https://openalex.org/C2777673923","wikidata":"https://www.wikidata.org/wiki/Q79928","display_name":"Acne","level":2,"score":0.46549972891807556},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.43126487731933594},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3461211919784546},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34046053886413574},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.277188777923584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2708948254585266},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21793219447135925},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.19507259130477905},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.18724772334098816},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.10420337319374084},{"id":"https://openalex.org/C2780809830","wikidata":"https://www.wikidata.org/wiki/Q407426","display_name":"Linoleic acid","level":3,"score":0.10346594452857971},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000152","descriptor_name":"Acne Vulgaris","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000152","descriptor_name":"Acne Vulgaris","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005229","descriptor_name":"Fatty Acids, Monounsaturated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008795","descriptor_name":"Metronidazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008795","descriptor_name":"Metronidazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010169","descriptor_name":"Palmitic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010169","descriptor_name":"Palmitic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011425","descriptor_name":"Propionibacterium acnes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011425","descriptor_name":"Propionibacterium acnes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012393","descriptor_name":"Rosacea","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012393","descriptor_name":"Rosacea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00402621","doi":"https://doi.org/10.1007/bf00402621","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00402621","pdf_url":null,"source":{"id":"https://openalex.org/S33894392","display_name":"Archives of Dermatological Research","issn_l":"0003-9187","issn":["0003-9187","0340-3696","1432-069X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Dermatological Research","raw_type":"journal-article"},{"id":"pmid:2150301","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2150301","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of dermatological research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W363209287","https://openalex.org/W1590052573","https://openalex.org/W1600610375","https://openalex.org/W1819732475","https://openalex.org/W1957020011","https://openalex.org/W1977610865","https://openalex.org/W2008200472","https://openalex.org/W2027347410","https://openalex.org/W2031449157","https://openalex.org/W2038377432","https://openalex.org/W2042016602","https://openalex.org/W2042530283","https://openalex.org/W2047457444","https://openalex.org/W2054817051","https://openalex.org/W2059678185","https://openalex.org/W2068371198","https://openalex.org/W2090109220","https://openalex.org/W2146742981","https://openalex.org/W2152311269","https://openalex.org/W2167878924","https://openalex.org/W2520875049"],"related_works":["https://openalex.org/W2167878924","https://openalex.org/W1972313086","https://openalex.org/W2049186038","https://openalex.org/W2088028997","https://openalex.org/W2091875969","https://openalex.org/W2050044655","https://openalex.org/W2414751458","https://openalex.org/W4405789144","https://openalex.org/W2440100600","https://openalex.org/W171000181"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
