{"id":"https://openalex.org/W2014007268","doi":"https://doi.org/10.1227/neu.0b013e318235d65f","title":"Bone Morphogenetic Proteins and Degenerative Disk Disease","display_name":"Bone Morphogenetic Proteins and Degenerative Disk Disease","publication_year":2011,"publication_date":"2011-10-04","ids":{"openalex":"https://openalex.org/W2014007268","doi":"https://doi.org/10.1227/neu.0b013e318235d65f","mag":"2014007268","pmid":"https://pubmed.ncbi.nlm.nih.gov/22426045"},"language":"en","primary_location":{"id":"doi:10.1227/neu.0b013e318235d65f","doi":"https://doi.org/10.1227/neu.0b013e318235d65f","is_oa":false,"landing_page_url":"https://doi.org/10.1227/neu.0b013e318235d65f","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061141842","display_name":"Khoi Duc Than","orcid":"https://orcid.org/0000-0003-2026-7004","observed_orcids":["https://orcid.org/0000-0003-2026-7004"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khoi D. Than","raw_affiliation_strings":["Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109-5338, USA","Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan 48109-5338, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108646983","display_name":"Shayan U. Rahman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shayan U. Rahman","raw_affiliation_strings":["Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059793665","display_name":"Monique J. Vanaman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monique J. Vanaman","raw_affiliation_strings":["Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007192173","display_name":"Anthony Wang","orcid":"https://orcid.org/0000-0002-9509-6257","observed_orcids":["https://orcid.org/0000-0002-9509-6257"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony C. Wang","raw_affiliation_strings":["Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109128886","display_name":"Chia-Ying Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chia-Ying Lin","raw_affiliation_strings":["Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010774128","display_name":"Huina Zhang","orcid":"https://orcid.org/0000-0002-4208-7680","observed_orcids":["https://orcid.org/0000-0002-4208-7680"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huina Zhang","raw_affiliation_strings":["Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019054853","display_name":"Frank La Marca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank La Marca","raw_affiliation_strings":["Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012309372","display_name":"Paul Park","orcid":"https://orcid.org/0000-0002-0375-396X","observed_orcids":["https://orcid.org/0000-0002-0375-396X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210111446","display_name":"A. Alfred Taubman Health Care Center","ror":"https://ror.org/01rh00978","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210111446","https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul Park","raw_affiliation_strings":["Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan","Paul Park, MD, Department of Neurosurgery, University of Michigan, 1500 E Medical Center Dr, Room 3552, Taubman Center, Ann Arbor, MI 48109-5338. E-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Paul Park, MD, Department of Neurosurgery, University of Michigan, 1500 E Medical Center Dr, Room 3552, Taubman Center, Ann Arbor, MI 48109-5338. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5012309372"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111446"],"apc_list":null,"apc_paid":null,"fwci":0.1621,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.16013629,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"70","issue":"4","first_page":"996","last_page":"1002"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11518","display_name":"Cervical and Thoracic Myelopathy","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-morphogenetic-proteins","display_name":"bone morphogenetic proteins","score":1.0},{"id":"https://openalex.org/keywords/intervertebral-disc-degeneration","display_name":"intervertebral disc degeneration","score":0.8199999928474426},{"id":"https://openalex.org/keywords/intervertebral-disc","display_name":"intervertebral disc","score":0.8899999856948853},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.9700000286102295},{"id":"https://openalex.org/keywords/bmp-7","display_name":"BMP-7","score":1.0},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8309999704360962},{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":0.7369999885559082},{"id":"https://openalex.org/keywords/adenoviral-gene-transfer","display_name":"adenoviral gene transfer","score":0.8080000281333923},{"id":"https://openalex.org/keywords/chondrogenesis","display_name":"chondrogenesis","score":0.7710000276565552},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8196993470191956},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.7692905068397522},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.6136696338653564},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6026767492294312},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4346058964729309},{"id":"https://openalex.org/C2778051963","wikidata":"https://www.wikidata.org/wiki/Q11773731","display_name":"Degenerative disc disease","level":3,"score":0.4312230050563812},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.42361170053482056},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4232240617275238},{"id":"https://openalex.org/C125349252","wikidata":"https://www.wikidata.org/wiki/Q14903102","display_name":"Bone morphogenetic protein 7","level":4,"score":0.4227978587150574},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4218234717845917},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3696816861629486},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32112622261047363},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2819632887840271},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.2223442792892456},{"id":"https://openalex.org/C44575665","wikidata":"https://www.wikidata.org/wiki/Q1293405","display_name":"Lumbar","level":2,"score":0.16878390312194824},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11794444918632507},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10756790637969971},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08982473611831665}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001416","descriptor_name":"Back Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001416","descriptor_name":"Back Pain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001416","descriptor_name":"Back Pain","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1227/neu.0b013e318235d65f","doi":"https://doi.org/10.1227/neu.0b013e318235d65f","is_oa":false,"landing_page_url":"https://doi.org/10.1227/neu.0b013e318235d65f","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},{"id":"pmid:22426045","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22426045","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7300000190734863}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5623473145","display_name":"Simvastatin to Retard Degenerative Disc Disease","funder_award_id":"R01AR056649","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1581461985","https://openalex.org/W1964178830","https://openalex.org/W1980095106","https://openalex.org/W1980791701","https://openalex.org/W1981589333","https://openalex.org/W1982546433","https://openalex.org/W1994368268","https://openalex.org/W1994738588","https://openalex.org/W1994834259","https://openalex.org/W1995612953","https://openalex.org/W1996290582","https://openalex.org/W2002435322","https://openalex.org/W2004232044","https://openalex.org/W2016941404","https://openalex.org/W2017708784","https://openalex.org/W2020364703","https://openalex.org/W2028115766","https://openalex.org/W2036906183","https://openalex.org/W2039982128","https://openalex.org/W2045185435","https://openalex.org/W2053173623","https://openalex.org/W2056488974","https://openalex.org/W2058667888","https://openalex.org/W2059297110","https://openalex.org/W2067364761","https://openalex.org/W2067909000","https://openalex.org/W2068200386","https://openalex.org/W2069330256","https://openalex.org/W2070757845","https://openalex.org/W2076466392","https://openalex.org/W2078509388","https://openalex.org/W2079622471","https://openalex.org/W2080136883","https://openalex.org/W2081904449","https://openalex.org/W2088142207","https://openalex.org/W2095245307","https://openalex.org/W2098980996","https://openalex.org/W2112529721","https://openalex.org/W2120032969","https://openalex.org/W2121848695","https://openalex.org/W2140568669","https://openalex.org/W2154461664","https://openalex.org/W2159527180","https://openalex.org/W2161134772","https://openalex.org/W2161278386","https://openalex.org/W2165237388","https://openalex.org/W2178526791","https://openalex.org/W4237446505"],"related_works":["https://openalex.org/W2898796282","https://openalex.org/W2283696319","https://openalex.org/W2073219075","https://openalex.org/W2810213335","https://openalex.org/W2460082603","https://openalex.org/W2113463221","https://openalex.org/W2171087459","https://openalex.org/W3176041731","https://openalex.org/W2746135417","https://openalex.org/W2508394972"],"abstract_inverted_index":{"Bone":[0],"morphogenetic":[1],"proteins":[2],"(BMPs)":[3],"are":[4,53,112,203],"involved":[5],"not":[6],"only":[7],"in":[8,12,19,97,100,103,134,159,179,185,211],"osteogenesis":[9],"but":[10],"also":[11,177],"chondrogenesis.":[13],"They":[14],"play":[15],"an":[16,32,123],"important":[17],"role":[18],"the":[20,25,42,55,76,83,140,145,182,190],"development":[21],"and":[22,46,82,99,106,110,116,153,209],"maintenance":[23],"of":[24,35,58,80,86,128,137,139,144,181,192],"intervertebral":[26],"disk":[27,48,119],"(IVD).":[28],"For":[29],"this":[30,121],"reason,":[31],"increasing":[33],"amount":[34],"research":[36],"has":[37,157,197],"been":[38],"performed":[39,69],"to":[40,88,93,96,130,169,194,205],"examine":[41],"relationship":[43],"between":[44],"BMPs":[45,59,92,193],"degenerative":[47],"disease":[49],"(DDD).":[50],"Moreover,":[51],"researchers":[52],"examining":[54],"safe":[56],"use":[57,191],"as":[60],"a":[61,70,198],"potential":[62],"treatment":[63],"for":[64],"diskogenic":[65],"back":[66],"pain.":[67],"We":[68,187],"literature":[71],"search":[72],"using":[73],"databases":[74],"from":[75],"US":[77],"National":[78,84],"Library":[79],"Medicine":[81],"Institutes":[85],"Health":[87],"identify":[89],"studies":[90,102,202],"relating":[91],"DDD.":[94,186],"According":[95],"vitro":[98],"vivo":[101],"different":[104],"animal":[105],"human":[107],"IVDs,":[108],"BMP-2":[109,129],"BMP-7":[111],"upregulated":[113],"with":[114,117,164],"aging":[115],"induced":[118],"injury;":[120],"represents":[122],"anabolic":[124],"response.":[125],"Direct":[126],"administration":[127],"IVD":[131,170],"cells":[132,171],"results":[133],"increased":[135],"production":[136],"components":[138],"extracellular":[141],"matrix.":[142],"Upregulation":[143],"BMP":[146],"pathway":[147],"via":[148,173],"other":[149],"agents,":[150],"namely":[151],"simvastatin":[152],"LIM":[154],"mineralization":[155],"protein-1,":[156],"resulted":[158,178],"similar":[160],"outcomes.":[161],"Adenoviruses":[162],"loaded":[163],"BMPs,":[165],"transfected":[166],"either":[167],"directly":[168],"or":[172],"articular":[174],"chondrocytic":[175],"vectors,":[176],"reversal":[180],"typical":[183],"findings":[184],"conclude":[188],"that":[189],"treat":[195],"DDD":[196],"promising":[199],"future.":[200],"Further":[201],"indicated":[204],"determine":[206],"optimal":[207],"delivery":[208],"efficacy":[210],"humans.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
