{"id":"https://openalex.org/W2013994076","doi":"https://doi.org/10.1186/cc7756","title":"Critical illness hyperglycemia: is failure of the beta-cell to meet extreme insulin demand indicative of dysfunction?","display_name":"Critical illness hyperglycemia: is failure of the beta-cell to meet extreme insulin demand indicative of dysfunction?","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2013994076","doi":"https://doi.org/10.1186/cc7756","mag":"2013994076","pmid":"https://pubmed.ncbi.nlm.nih.gov/19435475","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2689480"},"language":"en","primary_location":{"id":"doi:10.1186/cc7756","doi":"https://doi.org/10.1186/cc7756","is_oa":true,"landing_page_url":"https://doi.org/10.1186/cc7756","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc7756","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc7756","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070771680","display_name":"Garry M. Steil","orcid":"https://orcid.org/0000-0001-5418-5256","observed_orcids":["https://orcid.org/0000-0001-5418-5256"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garry M Steil","raw_affiliation_strings":["Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA","Children\u2019s Hospital - Boston, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Children\u2019s Hospital - Boston, Boston, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016520108","display_name":"Michael S. D. Agus","orcid":"https://orcid.org/0000-0001-6454-6828","observed_orcids":["https://orcid.org/0000-0001-6454-6828"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael SD Agus","raw_affiliation_strings":["Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA","Children\u2019s Hospital - Boston, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"Children\u2019s Hospital - Boston, Boston, USA","institution_ids":["https://openalex.org/I1288882113"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016520108"],"corresponding_institution_ids":["https://openalex.org/I1288882113"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":0.7262,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.75895132,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"13","issue":"2","first_page":"129","last_page":"129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11623","display_name":"Hyperglycemia and glycemic control in critically ill and hospitalized patients","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11623","display_name":"Hyperglycemia and glycemic control in critically ill and hospitalized patients","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.029400000348687172,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-cell-dysfunction","display_name":"beta-cell dysfunction","score":0.8939999938011169},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8149999976158142},{"id":"https://openalex.org/keywords/beta-cell-exhaustion","display_name":"beta-cell exhaustion","score":0.9570000171661377},{"id":"https://openalex.org/keywords/glucocorticoid-therapy","display_name":"glucocorticoid therapy","score":0.9369999766349792},{"id":"https://openalex.org/keywords/respiratory-failure","display_name":"respiratory failure","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cardiovascular-failure","display_name":"cardiovascular failure","score":0.9649999737739563},{"id":"https://openalex.org/keywords/pediatric-intensive-care","display_name":"pediatric intensive care","score":0.5619999766349792},{"id":"https://openalex.org/keywords/insulin-requirement","display_name":"insulin requirement","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.881645917892456},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6988061666488647},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5447916984558105},{"id":"https://openalex.org/C2776888751","wikidata":"https://www.wikidata.org/wiki/Q767485","display_name":"Respiratory failure","level":2,"score":0.5405359268188477},{"id":"https://openalex.org/C2993568657","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critical illness","level":3,"score":0.5314763188362122},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5059360861778259},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.48381251096725464},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4566068649291992},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.44812411069869995},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36347126960754395},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35450509190559387},{"id":"https://openalex.org/C2991859549","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critically ill","level":2,"score":0.1498587429523468},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016638","descriptor_name":"Critical Illness","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/cc7756","doi":"https://doi.org/10.1186/cc7756","is_oa":true,"landing_page_url":"https://doi.org/10.1186/cc7756","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc7756","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2689480","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2689480","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crit Care","raw_type":"Text"},{"id":"pmid:19435475","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19435475","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care (London, England)","raw_type":"Comment"}],"best_oa_location":{"id":"doi:10.1186/cc7756","doi":"https://doi.org/10.1186/cc7756","is_oa":true,"landing_page_url":"https://doi.org/10.1186/cc7756","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/cc7756","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7900000214576721,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5524335007","display_name":"General Clinical Research Center","funder_award_id":"M01RR002172","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7373791740","display_name":"SPECS: Safe Pediatric Euglycemia in Cardiac Surgery","funder_award_id":"R01HL088448","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000907652","display_name":"Boston Area Nutrition Obesity Research Center (NORC)","funder_award_id":"P30DK040561","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013994076.pdf","grobid_xml":"https://content.openalex.org/works/W2013994076.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1892916724","https://openalex.org/W1987735363","https://openalex.org/W1988096315","https://openalex.org/W2012613359","https://openalex.org/W2027219674","https://openalex.org/W2047680032","https://openalex.org/W2077742875","https://openalex.org/W2080855259","https://openalex.org/W2111456652","https://openalex.org/W2120884605","https://openalex.org/W2149288969"],"related_works":["https://openalex.org/W7097602554","https://openalex.org/W2120884605","https://openalex.org/W2082453390","https://openalex.org/W2893542930","https://openalex.org/W3031895477","https://openalex.org/W2159250166","https://openalex.org/W2085232868","https://openalex.org/W2088453224","https://openalex.org/W1979522027","https://openalex.org/W3031556511"],"abstract_inverted_index":{"In":[0],"the":[1,11,34,40],"recent":[2],"study":[3],"by":[4],"Preissig":[5],"and":[6,24],"Rigby":[7],"in":[8,18,47],"Critical":[9],"Care,":[10],"authors":[12],"argue":[13],"that":[14,39],"critical":[15],"illness":[16],"hyperglycemia":[17],"children":[19],"with":[20],"both":[21],"respiratory":[22],"failure":[23,26,32,41],"cardiovascular":[25],"is":[27,42],"due":[28],"to":[29,44,51],"a":[30,55],"primary":[31],"of":[33,58],"beta-cell.":[35],"However,":[36],"alternative":[37],"explanations":[38],"secondary":[43],"an":[45],"increase":[46],"insulin":[48],"resistance":[49],"leading":[50],"beta-cell":[52],"exhaustion,":[53],"or":[54],"negative":[56],"impact":[57],"exogenous":[59],"glucocorticoid":[60],"therapy,":[61],"may":[62],"be":[63],"equally":[64],"likely.":[65]},"counts_by_year":[{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
