{"id":"https://openalex.org/W2013993869","doi":"https://doi.org/10.1158/1538-7445.am2011-2663","title":"Abstract 2663: Dual cytoprotective and cytotoxic functions of autophagy in the response ofbreast tumor cells to radiation and in radiosensitization by vitamin D3","display_name":"Abstract 2663: Dual cytoprotective and cytotoxic functions of autophagy in the response ofbreast tumor cells to radiation and in radiosensitization by vitamin D3","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2013993869","doi":"https://doi.org/10.1158/1538-7445.am2011-2663","mag":"2013993869"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-2663","doi":"https://doi.org/10.1158/1538-7445.am2011-2663","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-2663","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003165520","display_name":"Molly L. Bristol","orcid":"https://orcid.org/0000-0002-4259-8528","observed_orcids":["https://orcid.org/0000-0002-4259-8528"]},"institutions":[{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Molly L. Bristol","raw_affiliation_strings":["1VCU Massey Cancer Ctr., Richmond, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1VCU Massey Cancer Ctr., Richmond, VA","institution_ids":["https://openalex.org/I4390039382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019367459","display_name":"Xu Michael Di","orcid":"https://orcid.org/0000-0002-4556-0349","observed_orcids":["https://orcid.org/0000-0002-4556-0349"]},"institutions":[{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xu Di","raw_affiliation_strings":["1VCU Massey Cancer Ctr., Richmond, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1VCU Massey Cancer Ctr., Richmond, VA","institution_ids":["https://openalex.org/I4390039382"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041168206","display_name":"David A. Gewirtz","orcid":"https://orcid.org/0000-0003-0437-4934","observed_orcids":["https://orcid.org/0000-0003-0437-4934"]},"institutions":[{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Gewirtz","raw_affiliation_strings":["1VCU Massey Cancer Ctr., Richmond, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1VCU Massey Cancer Ctr., Richmond, VA","institution_ids":["https://openalex.org/I4390039382"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4390039382"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"2663","last_page":"2663"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9789999723434448},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.9390000104904175},{"id":"https://openalex.org/keywords/vitamin-d3","display_name":"vitamin D3","score":0.9300000071525574},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.9800000190734863},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9639999866485596},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.6200000047683716},{"id":"https://openalex.org/keywords/cytoprotection","display_name":"cytoprotection","score":0.8790000081062317},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5120000243186951},{"id":"https://openalex.org/keywords/autophagic-flux","display_name":"autophagic flux","score":0.8109999895095825},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.6919999718666077},{"id":"https://openalex.org/keywords/her2-overexpression","display_name":"HER2 overexpression","score":0.8600000143051147},{"id":"https://openalex.org/keywords/vitamin-d-receptor","display_name":"vitamin D receptor","score":0.8659999966621399},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hs578t-cells","display_name":"Hs578T cells","score":0.8420000076293945},{"id":"https://openalex.org/keywords/bt474-cells","display_name":"BT474 cells","score":0.9909999966621399}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.894530713558197},{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.6783485412597656},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.640883207321167},{"id":"https://openalex.org/C26114605","wikidata":"https://www.wikidata.org/wiki/Q7280368","display_name":"Radiation sensitivity","level":3,"score":0.5228232145309448},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4625377655029297},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.42867058515548706},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.37013691663742065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36602458357810974},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3654412031173706},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3652331233024597},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36516261100769043},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35076403617858887},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20592567324638367},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.14272230863571167},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10423979163169861},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.09546288847923279},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2011-2663","doi":"https://doi.org/10.1158/1538-7445.am2011-2663","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-2663","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8399999737739563}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4252544693","https://openalex.org/W572929299","https://openalex.org/W2030148643","https://openalex.org/W4246228956","https://openalex.org/W771226426","https://openalex.org/W2080329673","https://openalex.org/W2003243384","https://openalex.org/W2090109205","https://openalex.org/W1977717250","https://openalex.org/W1985367664"],"abstract_inverted_index":{"Abstract":[0],"Introduction:":[1],"While":[2],"chemotherapy":[3],"and":[4,18,41,64,76,167,181,268,322,343,370],"radiation":[5,40,175,230,269,272,292,321,353],"treatment":[6,120],"may":[7,67],"be":[8,68],"initially":[9],"effective":[10],"at":[11],"suppressing":[12],"breast":[13,131,188,212,331,356],"cancer":[14],"growth,":[15],"disease":[16],"recurrence":[17],"tumor":[19,43,132,189,213,332],"metastasis":[20],"are":[21],"major":[22],"clinical":[23],"problems.":[24],"A":[25],"number":[26],"of":[27,59,79,91,100,130,141,150,219,225,252,265,278,330,340,346,385,390],"strategies":[28,351],"have":[29],"been":[30],"developed":[31],"in":[32,55,93,152,163,184,209,249,294,304,355,359],"an":[33],"attempt":[34],"to":[35,39,87,108,119,203,229,243,246,255,259],"enhance":[36],"the":[37,57,74,77,80,89,96,110,139,169,210,220,250,262,266,305,328,338,344,386,391],"response":[38],"prevent":[42],"cell":[44,214,227,253,295,318],"recovery":[45,171],"by":[46,95,134,231,236,291,298,320,334,361,371],"interfering":[47],"with":[48,114,121,216,288],"cytoprotective":[49,69,148,341],"signaling.":[50],"Autophagy,":[51],"a":[52,146,238,247,275,314,324],"cellular":[53],"process":[54],"which":[56],"degradation":[58],"subcellular":[60],"organelles":[61],"generates":[62],"energy":[63],"metabolic":[65],"precursors,":[66],"or":[70,206,240,285],"cytotoxic,":[71],"depending":[72],"on":[73],"cells":[75,133,166,190,195,333],"nature":[78],"stressful":[81],"challenge.":[82],"Our":[83,126],"studies":[84,105,127,301],"were":[85,106],"designed":[86,107],"evaluate":[88],"involvement":[90],"autophagy":[92,115,142,151,157,183,208,244,260,279,289,309,342,348],"radiosensitization":[94,129],"hormonally":[97],"active":[98],"form":[99],"vitamin":[101,135,221],"D3,":[102],"1,25D3.":[103],"Additionally,":[104],"test":[109],"premise":[111],"that":[112,172,196,280,303],"interference":[113,287],"would":[116],"influence":[117],"sensitivity":[118,228],"1,25D3":[122,155,177,201,232,267],"+":[123],"radiation.":[124,335],"Results:":[125],"demonstrate":[128,302],"D":[136,222],"(1,25D3)":[137],"through":[138],"promotion":[140,345],"as":[143,145,160,191,193,313,323],"well":[144,159,192],"concurrent":[147],"function":[149,311],"irradiated":[153,164],"cells.":[154],"promoted":[156,182,274],"(as":[158],"autophagic":[161],"flux)":[162],"MCF7":[165,194],"suppressed":[168],"proliferative":[170],"occurs":[173],"after":[174],"alone.":[176],"also":[178],"enhanced":[179],"radiosensitivity":[180,205],"p53":[185],"mutant":[186],"Hs578t":[187],"overexpress":[197],"Her-2/neu.":[198],"In":[199,257],"contrast,":[200],"failed":[202],"alter":[204],"promote":[207],"BT474":[211],"line":[215],"low-level":[217],"expression":[218],"receptor.":[223],"Enhancement":[224],"MCF-7":[226],"was":[233,281],"not":[234],"attenuated":[235],"either":[237],"pharmacological":[239,284],"genetic":[241,286],"block":[242],"due":[245],"shift":[248],"mode":[251],"death":[254],"apoptosis.":[256],"contrast":[258],"mediating":[261,327],"cytotoxic":[263,347],"impact":[264],"combination":[270],"treatment,":[271],"alone":[273],"low":[276],"level":[277],"cytoprotective.":[282],"Specifically,":[283],"induced":[290],"resulted":[293],"killing":[296,319,329],"(primarily":[297],"apoptosis).":[299],"These":[300],"same":[306],"experimental":[307],"system,":[308],"can":[310],"both":[312],"mechanism":[315],"for":[316,326,352,364,394],"evading":[317],"pathway":[325],"Conclusions:":[336],"Both":[337],"suppression":[339],"represent":[349],"potential":[350],"sensitization":[354],"cancer.":[357],"Supported,":[358],"part,":[360],"American":[362,392],"Institute":[363],"Cancer":[365,395,405],"Research":[366],"Grant":[367],"#":[368],"06A058-REV":[369],"DOD":[372],"predoctoral":[373],"training":[374],"grant":[375],"W81XWH-09-1-0020.":[376],"Citation":[377],"Format:":[378],"{Authors}.":[379],"{Abstract":[380],"title}":[381],"[abstract].":[382],"In:":[383],"Proceedings":[384],"102nd":[387],"Annual":[388],"Meeting":[389],"Association":[393],"Research;":[396],"2011":[397],"Apr":[398],"2-6;":[399],"Orlando,":[400],"FL.":[401],"Philadelphia":[402],"(PA):":[403],"AACR;":[404],"Res":[406],"2011;71(8":[407],"Suppl):Abstract":[408],"nr":[409],"2663.":[410],"doi:10.1158/1538-7445.AM2011-2663":[411]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}