{"id":"https://openalex.org/W2013993362","doi":"https://doi.org/10.1007/s11626-015-9867-1","title":"Caloric restriction mimetic 2-deoxyglucose maintains cytoarchitecture and reduces tau phosphorylation in primary culture of mouse hippocampal pyramidal neurons","display_name":"Caloric restriction mimetic 2-deoxyglucose maintains cytoarchitecture and reduces tau phosphorylation in primary culture of mouse hippocampal pyramidal neurons","publication_year":2015,"publication_date":"2015-02-12","ids":{"openalex":"https://openalex.org/W2013993362","doi":"https://doi.org/10.1007/s11626-015-9867-1","mag":"2013993362","pmid":"https://pubmed.ncbi.nlm.nih.gov/25678460"},"language":"en","primary_location":{"id":"doi:10.1007/s11626-015-9867-1","doi":"https://doi.org/10.1007/s11626-015-9867-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11626-015-9867-1","pdf_url":null,"source":{"id":"https://openalex.org/S97150082","display_name":"In Vitro Cellular & Developmental Biology - Animal","issn_l":"1071-2690","issn":["1071-2690","1543-706X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Vitro Cellular & Developmental Biology - Animal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078450048","display_name":"M. S. Bele","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141641110","display_name":"Shivaji University","ror":"https://ror.org/01bsn4x02","country_code":"IN","type":"education","lineage":["https://openalex.org/I141641110"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"M. S. Bele","raw_affiliation_strings":["Cellular stress response laboratory, Cell Biology Division, Department of Zoology, Shivaji University, Kolhapur, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular stress response laboratory, Cell Biology Division, Department of Zoology, Shivaji University, Kolhapur, India","institution_ids":["https://openalex.org/I141641110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056731568","display_name":"K. A. Gajare","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141641110","display_name":"Shivaji University","ror":"https://ror.org/01bsn4x02","country_code":"IN","type":"education","lineage":["https://openalex.org/I141641110"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"K. A. Gajare","raw_affiliation_strings":["Cellular stress response laboratory, Cell Biology Division, Department of Zoology, Shivaji University, Kolhapur, India","Department of Zoology, The New College, Kolhapur, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular stress response laboratory, Cell Biology Division, Department of Zoology, Shivaji University, Kolhapur, India","institution_ids":["https://openalex.org/I141641110"]},{"raw_affiliation_string":"Department of Zoology, The New College, Kolhapur, India","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"A. A. Deshmukh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141641110","display_name":"Shivaji University","ror":"https://ror.org/01bsn4x02","country_code":"IN","type":"education","lineage":["https://openalex.org/I141641110"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"A. A. Deshmukh","raw_affiliation_strings":["Cellular stress response laboratory, Cell Biology Division, Department of Zoology, Shivaji University, Kolhapur, India","Department of Zoology, The New College, Kolhapur, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular stress response laboratory, Cell Biology Division, Department of Zoology, Shivaji University, Kolhapur, India","institution_ids":["https://openalex.org/I141641110"]},{"raw_affiliation_string":"Department of Zoology, The New College, Kolhapur, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I141641110"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":null,"fwci":0.6676,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.7012257,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"51","issue":"6","first_page":"546","last_page":"555"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/2-deoxy-d-glucose","display_name":"2-deoxyglucose","score":0.9950000047683716},{"id":"https://openalex.org/keywords/caloric-restriction-mimetics","display_name":"caloric restriction mimetics","score":0.906000018119812},{"id":"https://openalex.org/keywords/tau-phosphorylation","display_name":"tau phosphorylation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hippocampal-pyramidal-neurons","display_name":"hippocampal pyramidal neurons","score":0.949999988079071},{"id":"https://openalex.org/keywords/neuronal-cytoarchitecture","display_name":"neuronal cytoarchitecture","score":0.9169999957084656},{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3beta","display_name":"glycogen synthase kinase-3\u03b2","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cdk5","display_name":"cyclin-dependent kinase 5","score":0.9539999961853027},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.7609999775886536},{"id":"https://openalex.org/keywords/tauopathy","display_name":"tauopathy","score":0.8479999899864197},{"id":"https://openalex.org/keywords/axon-hillock","display_name":"axon hillock","score":0.5270000100135803},{"id":"https://openalex.org/keywords/neurite-morphology","display_name":"neurite morphology","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C163895629","wikidata":"https://www.wikidata.org/wiki/Q3009543","display_name":"Cytoarchitecture","level":2,"score":0.88759845495224},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7456353902816772},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6878877878189087},{"id":"https://openalex.org/C2780909259","wikidata":"https://www.wikidata.org/wiki/Q5260067","display_name":"Deoxyglucose","level":2,"score":0.6861043572425842},{"id":"https://openalex.org/C121738310","wikidata":"https://www.wikidata.org/wiki/Q18248262","display_name":"Cyclin-dependent kinase 5","level":5,"score":0.6345024108886719},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5940055847167969},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5774802565574646},{"id":"https://openalex.org/C2778198054","wikidata":"https://www.wikidata.org/wiki/Q15195154","display_name":"Hyperphosphorylation","level":3,"score":0.5772000551223755},{"id":"https://openalex.org/C182996813","wikidata":"https://www.wikidata.org/wiki/Q910847","display_name":"GSK-3","level":3,"score":0.5516102910041809},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.5392412543296814},{"id":"https://openalex.org/C2777739294","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tauopathy","level":4,"score":0.4895261228084564},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42531245946884155},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26739323139190674},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.25598013401031494},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20684054493904114},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.1417795717716217},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.11661827564239502},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1027323305606842},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071679","descriptor_name":"Glycogen Synthase Kinase 3 beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003847","descriptor_name":"Deoxyglucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D031204","descriptor_name":"Caloric Restriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051360","descriptor_name":"Cyclin-Dependent Kinase 5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11626-015-9867-1","doi":"https://doi.org/10.1007/s11626-015-9867-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11626-015-9867-1","pdf_url":null,"source":{"id":"https://openalex.org/S97150082","display_name":"In Vitro Cellular & Developmental Biology - Animal","issn_l":"1071-2690","issn":["1071-2690","1543-706X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Vitro Cellular & Developmental Biology - Animal","raw_type":"journal-article"},{"id":"pmid:25678460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25678460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In vitro cellular & developmental biology. Animal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":85,"referenced_works":["https://openalex.org/W94893350","https://openalex.org/W1153103303","https://openalex.org/W1481130297","https://openalex.org/W1496294957","https://openalex.org/W1508227800","https://openalex.org/W1563116834","https://openalex.org/W1577837690","https://openalex.org/W1600934558","https://openalex.org/W1601433695","https://openalex.org/W1608295855","https://openalex.org/W1839342733","https://openalex.org/W1905265488","https://openalex.org/W1964631519","https://openalex.org/W1964830067","https://openalex.org/W1964945625","https://openalex.org/W1966715692","https://openalex.org/W1970211336","https://openalex.org/W1971744915","https://openalex.org/W1973774127","https://openalex.org/W1979268652","https://openalex.org/W1979410803","https://openalex.org/W1984098639","https://openalex.org/W1988147607","https://openalex.org/W1992842030","https://openalex.org/W1998440070","https://openalex.org/W1999020480","https://openalex.org/W2002294558","https://openalex.org/W2002839290","https://openalex.org/W2010153201","https://openalex.org/W2011729587","https://openalex.org/W2020059513","https://openalex.org/W2024242026","https://openalex.org/W2024791530","https://openalex.org/W2029543048","https://openalex.org/W2032306001","https://openalex.org/W2036755018","https://openalex.org/W2043889745","https://openalex.org/W2044591435","https://openalex.org/W2045234528","https://openalex.org/W2048174395","https://openalex.org/W2049354825","https://openalex.org/W2049668864","https://openalex.org/W2051978668","https://openalex.org/W2060814375","https://openalex.org/W2061130462","https://openalex.org/W2061796433","https://openalex.org/W2063540863","https://openalex.org/W2068009600","https://openalex.org/W2078680897","https://openalex.org/W2079282983","https://openalex.org/W2079472896","https://openalex.org/W2082429191","https://openalex.org/W2087329033","https://openalex.org/W2088381487","https://openalex.org/W2090013938","https://openalex.org/W2093593565","https://openalex.org/W2103913931","https://openalex.org/W2104962877","https://openalex.org/W2108177092","https://openalex.org/W2110794118","https://openalex.org/W2111392801","https://openalex.org/W2112136536","https://openalex.org/W2115094443","https://openalex.org/W2120690437","https://openalex.org/W2128536686","https://openalex.org/W2129677617","https://openalex.org/W2130143704","https://openalex.org/W2130357785","https://openalex.org/W2137140827","https://openalex.org/W2137617843","https://openalex.org/W2139553041","https://openalex.org/W2141904505","https://openalex.org/W2142876370","https://openalex.org/W2143658086","https://openalex.org/W2145851982","https://openalex.org/W2149898458","https://openalex.org/W2156114958","https://openalex.org/W2167442881","https://openalex.org/W2315022798","https://openalex.org/W2324713830","https://openalex.org/W2331110091","https://openalex.org/W2332696659","https://openalex.org/W2400310660","https://openalex.org/W4230565756","https://openalex.org/W4293242696"],"related_works":["https://openalex.org/W2130265295","https://openalex.org/W2148784920","https://openalex.org/W7213905980","https://openalex.org/W1569078050","https://openalex.org/W4235001174","https://openalex.org/W2018470595","https://openalex.org/W2008946235","https://openalex.org/W4294891664","https://openalex.org/W2749988204","https://openalex.org/W2129631220"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}