{"id":"https://openalex.org/W2013965516","doi":"https://doi.org/10.1093/jnci/89.2.139","title":"Prognostic Significance of Vascular Endothelial Growth Factor Protein in Node-Negative Breast Carcinoma","display_name":"Prognostic Significance of Vascular Endothelial Growth Factor Protein in Node-Negative Breast Carcinoma","publication_year":1997,"publication_date":"1997-01-15","ids":{"openalex":"https://openalex.org/W2013965516","doi":"https://doi.org/10.1093/jnci/89.2.139","mag":"2013965516","pmid":"https://pubmed.ncbi.nlm.nih.gov/8998183"},"language":"en","primary_location":{"id":"doi:10.1093/jnci/89.2.139","doi":"https://doi.org/10.1093/jnci/89.2.139","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/89.2.139","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031130464","display_name":"Giulio Maria Gasparini","orcid":"https://orcid.org/0000-0001-5091-5178","observed_orcids":["https://orcid.org/0000-0001-5091-5178","https://orcid.org/0000-0002-5137-8500"]},"institutions":[{"id":"https://openalex.org/I4210152245","display_name":"Ospedale San Bortolo","ror":"https://ror.org/05wd86d64","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210152245"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"G. Gasparini","raw_affiliation_strings":["Department of Oncology, St. Bortolo Regional Medical Centre, Vicenza, Italy","St. Bortolo Regional Medical Centre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, St. Bortolo Regional Medical Centre, Vicenza, Italy","institution_ids":["https://openalex.org/I4210152245"]},{"raw_affiliation_string":"St. Bortolo Regional Medical Centre","institution_ids":["https://openalex.org/I4210152245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109315317","display_name":"Emanuela Bonoldi","orcid":"https://orcid.org/0000-0002-1047-5005","observed_orcids":["https://orcid.org/0000-0002-1047-5005"]},"institutions":[{"id":"https://openalex.org/I4210152245","display_name":"Ospedale San Bortolo","ror":"https://ror.org/05wd86d64","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210152245"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E. Bonoldi","raw_affiliation_strings":["Institute of Pathology, St. Bortolo Regional Medical Centre, Vicenza, Italy","St. Bortolo Regional Medical Centre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, St. Bortolo Regional Medical Centre, Vicenza, Italy","institution_ids":["https://openalex.org/I4210152245"]},{"raw_affiliation_string":"St. Bortolo Regional Medical Centre","institution_ids":["https://openalex.org/I4210152245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108428123","display_name":"Carlo Gatti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141921","display_name":"Regional Medical Center","ror":"https://ror.org/03t78za89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210141921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Gatti","raw_affiliation_strings":["Laboratory of Radiotherapy, Regional Medical Centre, Venice, Italy","Regional Medical Centre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Radiotherapy, Regional Medical Centre, Venice, Italy","institution_ids":[]},{"raw_affiliation_string":"Regional Medical Centre","institution_ids":["https://openalex.org/I4210141921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041552981","display_name":"Orazio Vinante","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O. Vinante","raw_affiliation_strings":["Medical Oncology Unit, Medical Centre of Noale, Italy","Medical Centre of Noale"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit, Medical Centre of Noale, Italy","institution_ids":[]},{"raw_affiliation_string":"Medical Centre of Noale","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091245889","display_name":"Masakazu Toi","orcid":"https://orcid.org/0000-0003-1488-9958","observed_orcids":["https://orcid.org/0000-0003-1488-9958"]},"institutions":[{"id":"https://openalex.org/I3020605285","display_name":"Tokyo Metropolitan Komagome Hospital","ror":"https://ror.org/04eqd2f30","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3020605285"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Toi","raw_affiliation_strings":["Department of Surgery, Tokyo Metropolitan Komagome Hospital, Japan","Tokyo Metropolitan Komagome Hospital;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Tokyo Metropolitan Komagome Hospital, Japan","institution_ids":["https://openalex.org/I3020605285"]},{"raw_affiliation_string":"Tokyo Metropolitan Komagome Hospital;","institution_ids":["https://openalex.org/I3020605285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110197498","display_name":"T. Tominaga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3020605285","display_name":"Tokyo Metropolitan Komagome Hospital","ror":"https://ror.org/04eqd2f30","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3020605285"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Tominaga","raw_affiliation_strings":["Department of Surgery, Tokyo Metropolitan Komagome Hospital, Japan","Tokyo Metropolitan Komagome Hospital;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Tokyo Metropolitan Komagome Hospital, Japan","institution_ids":["https://openalex.org/I3020605285"]},{"raw_affiliation_string":"Tokyo Metropolitan Komagome Hospital;","institution_ids":["https://openalex.org/I3020605285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001627390","display_name":"Massimo Gion","orcid":"https://orcid.org/0000-0001-9143-0353","observed_orcids":["https://orcid.org/0000-0001-9143-0353"]},"institutions":[{"id":"https://openalex.org/I4210141921","display_name":"Regional Medical Center","ror":"https://ror.org/03t78za89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210141921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Gion","raw_affiliation_strings":["Laboratory of Tumoral Biomarkers, Regional Medical Centre, Venice, Italy","Regional Medical Centre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Tumoral Biomarkers, Regional Medical Centre, Venice, Italy","institution_ids":[]},{"raw_affiliation_string":"Regional Medical Centre","institution_ids":["https://openalex.org/I4210141921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082754231","display_name":"Ruggero Dittadi","orcid":"https://orcid.org/0000-0003-2274-9648","observed_orcids":["https://orcid.org/0000-0003-2274-9648"]},"institutions":[{"id":"https://openalex.org/I4210141921","display_name":"Regional Medical Center","ror":"https://ror.org/03t78za89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210141921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Dittadi","raw_affiliation_strings":["Laboratory of Tumoral Biomarkers, Regional Medical Centre, Venice, Italy","Regional Medical Centre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Tumoral Biomarkers, Regional Medical Centre, Venice, Italy","institution_ids":[]},{"raw_affiliation_string":"Regional Medical Centre","institution_ids":["https://openalex.org/I4210141921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011668568","display_name":"Paolo Verderio","orcid":"https://orcid.org/0000-0002-9231-1281","observed_orcids":["https://orcid.org/0000-0002-9231-1281"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P. Verderio","raw_affiliation_strings":["Institute of Medical Statistics and Biometry, University of Milan, Italy","University of Milan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Statistics and Biometry, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"University of Milan","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063583733","display_name":"Patrizia Boracchi","orcid":"https://orcid.org/0000-0001-8506-2005","observed_orcids":["https://orcid.org/0000-0001-8506-2005"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P. Boracchi","raw_affiliation_strings":["Institute of Medical Statistics and Biometry, University of Milan, Italy","University of Milan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Statistics and Biometry, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"University of Milan","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108428122","display_name":"M. Hanatani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149441","display_name":"Toagosei (Japan)","ror":"https://ror.org/05rs18f71","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210149441"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Hanatani","raw_affiliation_strings":["Tsukuba Research Laboratory, Toagosei Co. Ltd, Ohkubo-Tsukuba, Ibaraki, Japan","Toagosei Co. Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsukuba Research Laboratory, Toagosei Co. Ltd, Ohkubo-Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I4210149441"]},{"raw_affiliation_string":"Toagosei Co. Ltd","institution_ids":["https://openalex.org/I4210149441"]}]},{"author_position":"middle","author":{"id":null,"display_name":"I. Matsubara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149441","display_name":"Toagosei (Japan)","ror":"https://ror.org/05rs18f71","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210149441"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"I. Matsubara","raw_affiliation_strings":["Tsukuba Research Laboratory, Toagosei Co. Ltd, Ohkubo-Tsukuba, Ibaraki, Japan","Toagosei Co. Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsukuba Research Laboratory, Toagosei Co. Ltd, Ohkubo-Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I4210149441"]},{"raw_affiliation_string":"Toagosei Co. Ltd","institution_ids":["https://openalex.org/I4210149441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028389456","display_name":"Hideo Suzuki","orcid":"https://orcid.org/0000-0002-1469-7449","observed_orcids":["https://orcid.org/0000-0002-1469-7449"]},"institutions":[{"id":"https://openalex.org/I4210149441","display_name":"Toagosei (Japan)","ror":"https://ror.org/05rs18f71","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210149441"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Suzuki","raw_affiliation_strings":["Tsukuba Research Laboratory, Toagosei Co. Ltd, Ohkubo-Tsukuba, Ibaraki, Japan","Toagosei Co. Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsukuba Research Laboratory, Toagosei Co. Ltd, Ohkubo-Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I4210149441"]},{"raw_affiliation_string":"Toagosei Co. Ltd","institution_ids":["https://openalex.org/I4210149441"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5031130464"],"corresponding_institution_ids":["https://openalex.org/I4210152245"],"apc_list":{"value":5436,"currency":"USD","value_usd":5436},"apc_paid":null,"fwci":8.434,"has_fulltext":false,"cited_by_count":495,"citation_normalized_percentile":{"value":0.9864012,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"89","issue":"2","first_page":"139","last_page":"147"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.05380000174045563,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9909999966621399},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8550000190734863},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.902999997138977},{"id":"https://openalex.org/keywords/relapse-free-survival","display_name":"relapse-free survival","score":0.8980000019073486},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hormone-receptors","display_name":"hormone receptors","score":0.6200000047683716},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.8640000224113464},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/breast-cancer-recurrence","display_name":"breast cancer recurrence","score":0.7319999933242798},{"id":"https://openalex.org/keywords/primary-tumor-tissue","display_name":"primary tumor tissue","score":0.5830000042915344},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.4749999940395355},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.3009999990463257},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.33399999141693115},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.6200000047683716},{"id":"https://openalex.org/keywords/tumor-infiltrating-macrophages","display_name":"tumor-infiltrating macrophages","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8313759565353394},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7586642503738403},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6731236577033997},{"id":"https://openalex.org/C3018521938","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast carcinoma","level":4,"score":0.6526873111724854},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.6495243310928345},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6355602741241455},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.574975848197937},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4856911599636078},{"id":"https://openalex.org/C2777982462","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant therapy","level":3,"score":0.48236793279647827},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.46585068106651306},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.45656025409698486},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.44610846042633057},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43654298782348633},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.43652939796447754},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.4164621829986572},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3397294282913208},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.08472698926925659}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/jnci/89.2.139","doi":"https://doi.org/10.1093/jnci/89.2.139","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/89.2.139","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},{"id":"pmid:8998183","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8998183","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Cancer Institute","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.334.2701","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.334.2701","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jnci.oxfordjournals.org/content/89/2/139.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W12613825","https://openalex.org/W32167704","https://openalex.org/W1044883788","https://openalex.org/W1505534997","https://openalex.org/W1530520430","https://openalex.org/W1537712767","https://openalex.org/W1748987851","https://openalex.org/W1837651204","https://openalex.org/W1889954278","https://openalex.org/W1969328947","https://openalex.org/W1970878726","https://openalex.org/W1971538947","https://openalex.org/W1980755389","https://openalex.org/W1981486175","https://openalex.org/W1985804036","https://openalex.org/W2000000541","https://openalex.org/W2010435021","https://openalex.org/W2011105444","https://openalex.org/W2022958969","https://openalex.org/W2028896946","https://openalex.org/W2030942281","https://openalex.org/W2038894713","https://openalex.org/W2043297474","https://openalex.org/W2043850275","https://openalex.org/W2045247659","https://openalex.org/W2047561204","https://openalex.org/W2049657894","https://openalex.org/W2056146626","https://openalex.org/W2058962195","https://openalex.org/W2060783173","https://openalex.org/W2063384143","https://openalex.org/W2064589399","https://openalex.org/W2064624801","https://openalex.org/W2064726235","https://openalex.org/W2076820945","https://openalex.org/W2083307394","https://openalex.org/W2093498435","https://openalex.org/W2098051886","https://openalex.org/W2098787760","https://openalex.org/W2106465230","https://openalex.org/W2122226633","https://openalex.org/W2123422145","https://openalex.org/W2123840402","https://openalex.org/W2132601924","https://openalex.org/W2150732175","https://openalex.org/W2155783433","https://openalex.org/W2265031510","https://openalex.org/W2296293854","https://openalex.org/W2320759850","https://openalex.org/W2324588265","https://openalex.org/W2324677651","https://openalex.org/W2325343629","https://openalex.org/W2344397643","https://openalex.org/W2396940271","https://openalex.org/W3143360378"],"related_works":["https://openalex.org/W2235360519","https://openalex.org/W1988997154","https://openalex.org/W2054607457","https://openalex.org/W2033759107","https://openalex.org/W7100113547","https://openalex.org/W1997733026","https://openalex.org/W2295421879","https://openalex.org/W2105346716","https://openalex.org/W1967070952","https://openalex.org/W2099011923"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,102,234,263,401],"clinical":[2,245],"outcome":[3,246],"is":[4,87],"generally":[5],"positive":[6],"for":[7,227,272,355,391,417],"patients":[8,65,304,418],"with":[9,29,163,169,202,210,212,219,419],"node-negative":[10,164,203,420],"breast":[11,165,204,421],"carcinoma":[12,205],"(i.e.,":[13,270],"those":[14,271],"who":[15,25,206,223],"do":[16],"not":[17,218],"have":[18,26],"detectable":[19,306],"metastases":[20],"in":[21,117,157,190,309,361,409],"the":[22,40,43,61,82,90,118,135,158,250,253,279,290,302,330,376,379],"lymph":[23],"nodes)":[24],"been":[27,208,225],"treated":[28,209],"surgery":[30,32,211],"or":[31,213,244],"plus":[33],"radiation":[34,215],"therapy.":[35],"In":[36,375],"about":[37],"30%":[38],"of":[39,51,54,69,77,94,104,120,137,151,161,179,185,193,231,252,281,292,301,348,383,407,415],"patients,":[41],"however,":[42],"disease":[44],"recurs,":[45],"and":[46,85,92,124,149,154,173,222,239,256,258,267,274,329,343,358,363,385],"they":[47],"are":[48,97,167,413],"at":[49,66],"risk":[50,68],"death.":[52],"Determination":[53],"valid":[55],"new":[56,78],"prognostic":[57,171,241,332,354,390],"indicators":[58],"would":[59],"improve":[60],"ability":[62],"to":[63,107,132,313,352],"identify":[64],"high":[67],"recurrence.":[70],"Breast":[71],"cancer":[72,166],"can":[73],"entail":[74],"substantial":[75],"development":[76],"blood":[79],"vessels":[80],"within":[81],"tumor":[83,105,195,339,341,410],"tissue,":[84],"it":[86],"known":[88,170],"that":[89,404],"growth":[91,122,140,147],"metastasis":[93],"solid":[95],"tumors":[96,160],"dependent":[98],"on":[99],"such":[100],"angiogenesis.":[101],"conversion":[103],"cells":[106],"an":[108],"angiogenic":[109,121],"phenotype":[110],"may":[111],"be":[112,353],"preceded":[113],"by":[114,249,278],"a":[115,144,180,228],"change":[116],"balance":[119],"factors":[123,172,333],"angiogenesis":[125],"inhibitors.":[126],"PURPOSE:":[127],"This":[128],"study":[129],"was":[130,276,388],"conducted":[131],"determine":[133],"if":[134],"levels":[136,184,406],"vascular":[138,152],"endothelial":[139,146],"factor":[141,148],"(VEGF)":[142],"protein,":[143],"potent":[145],"mediator":[150],"permeability":[153],"angiogenesis,":[155],"measured":[156,189],"primary":[159,194],"women":[162,201],"associated":[168],"patient":[174],"survival.":[175],"METHODS:":[176],"By":[177],"use":[178,251,280,291],"selective":[181],"enzymatic":[182],"immunoassay,":[183],"VEGF":[186,237,266,328,349,384,408],"protein":[187,316],"were":[188,247,325,350],"cytosolic":[191,405],"extracts":[192],"tissue":[196,411],"surgically":[197],"obtained":[198],"from":[199,289,298,311],"260":[200,303],"had":[207,224,305],"without":[214],"therapy":[216,221],"but":[217],"adjuvant":[220],"followed":[226],"median":[229],"time":[230],"66":[232],"months.":[233],"relationships":[235],"between":[236,265,327],"concentrations":[238],"other":[240,331],"dichotomous":[242],"variables":[243],"tested":[248],"Kolmogorov-Smirnov":[254],"test":[255],"univariate":[257,362],"multivariate":[259,364,377],"Cox":[260],"analyses,":[261],"respectively.":[262],"relationship":[264],"hormone":[268,344],"receptors":[269],"estrogen":[273,386],"progesterone)":[275],"examined":[277],"Spearman's":[282],"correlation":[283],"analyses.":[284],"All":[285],"P":[286,371,397],"values":[287,372],"resulted":[288],"two-sided":[293],"statistical":[294],"tests.":[295],"RESULTS:":[296],"Tumors":[297],"247":[299],"(95%)":[300],"VEGF,":[307],"ranging":[308],"concentration":[310],"5.0":[312],"6523":[314],"pg/mg":[315,319],"(median,":[317],"126.25":[318],"protein).":[320],"No":[321],"statistically":[322],"significant":[323],"associations":[324],"found":[326,351],"(e.g.,":[334],"age,":[335],"menopausal":[336],"status,":[337],"histologic":[338],"type,":[340],"size,":[342],"receptors)":[345],"examined.":[346],"Levels":[347],"both":[356],"relapse-free":[357],"overall":[359,392],"survival":[360,393],"analyses":[365],"(likelihood":[366,394],"ratio":[367,395],"tests;":[368],"all":[369],"four":[370],"<":[373],".001).":[374],"analysis,":[378],"first-order":[380],"interaction":[381],"term":[382],"receptor":[387],"also":[389],"test;":[396],"=":[398],".05).":[399],"CONCLUSIONS:":[400],"results":[402],"show":[403],"samples":[412],"indicative":[414],"prognosis":[416],"carcinoma.":[422]},"counts_by_year":[{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":20}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
