{"id":"https://openalex.org/W2013963392","doi":"https://doi.org/10.1615/forumimmundisther.v2.i1.30","title":"Raf Kinase Inhibitory Protein: A Signal Transduction Modulator and Metastasis Suppressor","display_name":"Raf Kinase Inhibitory Protein: A Signal Transduction Modulator and Metastasis Suppressor","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2013963392","doi":"https://doi.org/10.1615/forumimmundisther.v2.i1.30","mag":"2013963392"},"language":"en","primary_location":{"id":"doi:10.1615/forumimmundisther.v2.i1.30","doi":"https://doi.org/10.1615/forumimmundisther.v2.i1.30","is_oa":false,"landing_page_url":"https://doi.org/10.1615/forumimmundisther.v2.i1.30","pdf_url":null,"source":{"id":"https://openalex.org/S20825486","display_name":"Forum on Immunopathological Diseases and Therapeutics","issn_l":"2151-8017","issn":["2151-8017","2151-8025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310315730","host_organization_name":"Begell House","host_organization_lineage":["https://openalex.org/P4310315730"],"host_organization_lineage_names":["Begell House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Forum on Immunopathological Diseases and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035583989","display_name":"Marsha Rich Rosner","orcid":"https://orcid.org/0000-0001-6586-8335","observed_orcids":["https://orcid.org/0000-0001-6586-8335"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marsha Rich Rosner","raw_affiliation_strings":["Ben May Department for Cancer Research, University of Chicago, Gordon Center for Integrative Sciences, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ben May Department for Cancer Research, University of Chicago, Gordon Center for Integrative Sciences, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051346833","display_name":"Eva M. Eves","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eva M. Eves","raw_affiliation_strings":["Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09251701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"1","first_page":"13","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.5654000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.5654000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.35280001163482666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.06400000303983688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rkip","display_name":"RKIP","score":0.9039999842643738},{"id":"https://openalex.org/keywords/pebp1","display_name":"PEBP1","score":0.8930000066757202},{"id":"https://openalex.org/keywords/phosphatidylethanolamine-binding-protein","display_name":"phosphatidylethanolamine-binding protein","score":0.8389999866485596},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7419999837875366},{"id":"https://openalex.org/keywords/raf-mek-erk-pathway","display_name":"Raf/MEK/ERK pathway","score":0.9459999799728394},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-signaling","display_name":"G protein-coupled receptor signaling","score":0.8100000023841858},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9980000257492065},{"id":"https://openalex.org/keywords/kinase-inhibition","display_name":"kinase inhibition","score":0.6919999718666077},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.5189999938011169},{"id":"https://openalex.org/keywords/metastasis-inhibition","display_name":"metastasis suppression","score":0.9359999895095825},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.5189999938011169},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.7480000257492065},{"id":"https://openalex.org/keywords/spindle-assembly-checkpoint","display_name":"spindle assembly checkpoint","score":0.9950000047683716},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.7979999780654907},{"id":"https://openalex.org/keywords/lin28","display_name":"Lin28","score":0.9919999837875366},{"id":"https://openalex.org/keywords/let-7-microrna","display_name":"let-7 microRNA","score":0.921999990940094},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7440000176429749},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C2778025950","wikidata":"https://www.wikidata.org/wiki/Q6823243","display_name":"Metastasis suppressor","level":4,"score":0.708264946937561},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6341170072555542},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6049328446388245},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6040942668914795},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5896219611167908},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5814223885536194},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5170869827270508},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5140131711959839},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.46340039372444153},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.43309712409973145},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.39798504114151},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20143678784370422},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11541920900344849}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1615/forumimmundisther.v2.i1.30","doi":"https://doi.org/10.1615/forumimmundisther.v2.i1.30","is_oa":false,"landing_page_url":"https://doi.org/10.1615/forumimmundisther.v2.i1.30","pdf_url":null,"source":{"id":"https://openalex.org/S20825486","display_name":"Forum on Immunopathological Diseases and Therapeutics","issn_l":"2151-8017","issn":["2151-8017","2151-8025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310315730","host_organization_name":"Begell House","host_organization_lineage":["https://openalex.org/P4310315730"],"host_organization_lineage_names":["Begell House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Forum on Immunopathological Diseases and Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1983442034","https://openalex.org/W2891115102","https://openalex.org/W1585296258","https://openalex.org/W1979008438","https://openalex.org/W1976649319","https://openalex.org/W2364020571","https://openalex.org/W2376226928","https://openalex.org/W1964630467","https://openalex.org/W1983784090","https://openalex.org/W109015560"],"abstract_inverted_index":{"Cells":[0],"have":[1,85,132],"a":[2,27,37,90,98,127,169,198],"multitude":[3],"of":[4,29,36,40,42,51,129,143,151,162,186,195],"controls":[5],"to":[6,18,47,101,107,137],"maintain":[7,48],"their":[8],"integrity":[9],"and":[10,63,75,94,104,141,145,157,177,184,202],"prevent":[11],"random":[12],"switching":[13],"from":[14],"one":[15],"biological":[16,52],"state":[17],"another.":[19],"Raf":[20],"Kinase":[21],"Inhibitory":[22],"protein":[23,32],"(RKIP":[24],"or":[25,149],"PEBP1),":[26],"member":[28],"the":[30,49,109,163,193],"phosphatidylethanolamine-binding":[31],"family,":[33],"is":[34,89,115],"representative":[35],"new":[38],"class":[39],"modulators":[41],"signaling":[43,111,140,170],"cascades":[44],"that":[45,87,96,181],"functions":[46,125],"balance":[50],"systems.":[53],"RKIP":[54,66,88,119,123,152,167,196],"inhibits":[55,168],"MAP":[56],"kinase":[57,92],"(Raf-MEK-ERK),":[58],"G":[59],"protein\u2013coupled":[60],"receptor":[61],"(GPCR),":[62],"NF-\u03baB-signaling":[64],"cascades.":[65],"targets":[67,180],"different":[68],"kinases":[69],"dependent":[70],"on":[71],"its":[72],"phosphorylation":[73],"state,":[74],"integrates":[76],"cross":[77],"talk":[78],"initiated":[79],"by":[80],"multiple":[81],"environmental":[82],"stimuli.":[83],"We":[84,131],"shown":[86],"unique":[91],"inhibitor":[93],"substrate":[95],"uses":[97],"flexible":[99],"pocket":[100],"integrate":[102],"ligand-binding":[103],"phosphorylation-dependent":[105],"interactions":[106],"modulate":[108],"MAPK":[110],"pathway.":[112],"This":[113],"mechanism":[114],"likely":[116],"conserved":[117],"among":[118],"homologues":[120],"in":[121,154],"eukaryotes.":[122],"also":[124],"as":[126,197],"suppressor":[128,201],"metastasis.":[130,146],"identified":[133],"two":[134],"mechanisms":[135],"leading":[136],"altered":[138],"cellular":[139],"potentiation":[142],"tumorigenesis":[144],"First,":[147],"loss":[148],"depletion":[150],"results":[153,191],"chromosomal":[155],"abnormalities":[156],"genomic":[158],"instability":[159],"via":[160],"disregulation":[161],"spindle":[164],"checkpoint.":[165],"Second,":[166],"cascade":[171],"involving":[172],"MAPK,":[173],"Myc,":[174],"LIN28,":[175],"let-7,":[176],"downstream":[178],"let-7":[179],"promotes":[182],"invasion":[183],"metastasis":[185,200],"breast":[187],"cancer":[188],"cells.":[189],"Our":[190],"highlight":[192],"importance":[194],"key":[199],"potential":[203],"therapeutic":[204],"agent.":[205]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2016-06-24T00:00:00"}