{"id":"https://openalex.org/W2013963208","doi":"https://doi.org/10.1038/sj.cgt.7700735","title":"Antitumor efficacy and tumor-selective replication with a single intravenous injection of OAS403, an oncolytic adenovirus dependent on two prevalent alterations in human cancer","display_name":"Antitumor efficacy and tumor-selective replication with a single intravenous injection of OAS403, an oncolytic adenovirus dependent on two prevalent alterations in human cancer","publication_year":2004,"publication_date":"2004-07-02","ids":{"openalex":"https://openalex.org/W2013963208","doi":"https://doi.org/10.1038/sj.cgt.7700735","mag":"2013963208","pmid":"https://pubmed.ncbi.nlm.nih.gov/15232601"},"language":"en","primary_location":{"id":"doi:10.1038/sj.cgt.7700735","doi":"https://doi.org/10.1038/sj.cgt.7700735","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.cgt.7700735","pdf_url":null,"source":{"id":"https://openalex.org/S157451995","display_name":"Cancer Gene Therapy","issn_l":"0929-1903","issn":["0929-1903","1476-5500"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011433734","display_name":"Patricia C. Ryan","orcid":"https://orcid.org/0009-0008-5195-1670","observed_orcids":["https://orcid.org/0009-0008-5195-1670"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patricia C Ryan","raw_affiliation_strings":["Genetic Therapy, Inc., Gaithersburg, Maryland 20878, USA","Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Therapy, Inc., Gaithersburg, Maryland 20878, USA","institution_ids":[]},{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063381281","display_name":"John L. Jakubczak","orcid":"https://orcid.org/0000-0002-4888-6408","observed_orcids":["https://orcid.org/0000-0002-4888-6408"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John L Jakubczak","raw_affiliation_strings":["Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","institution_ids":[]},{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070832451","display_name":"David A. Stewart","orcid":"https://orcid.org/0009-0007-6776-1452","observed_orcids":["https://orcid.org/0009-0007-6776-1452","https://orcid.org/0009-0002-6999-1562"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David A Stewart","raw_affiliation_strings":["Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","institution_ids":[]},{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014392656","display_name":"Lynda K. Hawkins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lynda K Hawkins","raw_affiliation_strings":["Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","institution_ids":[]},{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100349408","display_name":"Cheng Cheng","orcid":"https://orcid.org/0000-0002-5947-3414","observed_orcids":["https://orcid.org/0000-0002-5947-3414"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cheng Cheng","raw_affiliation_strings":["Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","institution_ids":[]},{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112105790","display_name":"Lori Clarke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lori M Clarke","raw_affiliation_strings":["Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","institution_ids":[]},{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085330447","display_name":"Shanthi Ganesh","orcid":"https://orcid.org/0000-0001-9278-0865","observed_orcids":["https://orcid.org/0000-0001-9278-0865"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shanthi Ganesh","raw_affiliation_strings":["Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","institution_ids":[]},{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040979655","display_name":"Carl M. Hay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carl Hay","raw_affiliation_strings":["Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","institution_ids":[]},{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101897673","display_name":"Ying Huang","orcid":"https://orcid.org/0000-0002-1399-4281","observed_orcids":["https://orcid.org/0000-0002-1399-4281"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Huang","raw_affiliation_strings":["Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","institution_ids":[]},{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070548620","display_name":"Michele Kaloss","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michele Kaloss","raw_affiliation_strings":["Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","institution_ids":[]},{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003918487","display_name":"Anthony D. Marinov","orcid":"https://orcid.org/0000-0003-3876-747X","observed_orcids":["https://orcid.org/0000-0003-3876-747X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anthony Marinov","raw_affiliation_strings":["Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","institution_ids":[]},{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091746258","display_name":"Sandrina S. Phipps","orcid":"https://orcid.org/0009-0004-2417-4328","observed_orcids":["https://orcid.org/0009-0004-2417-4328"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandrina S Phipps","raw_affiliation_strings":["Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","institution_ids":[]},{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111879921","display_name":"P. Seshidhar Reddy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Seshidhar Reddy","raw_affiliation_strings":["Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","institution_ids":[]},{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029797069","display_name":"Pamela S. Shirley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pamela S Shirley","raw_affiliation_strings":["Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","institution_ids":[]},{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007153353","display_name":"Yelena Skripchenko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yelena Skripchenko","raw_affiliation_strings":["Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","institution_ids":[]},{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101578427","display_name":"Ling Xu","orcid":"https://orcid.org/0000-0002-9456-9390","observed_orcids":["https://orcid.org/0000-0002-9456-9390"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ling Xu","raw_affiliation_strings":["Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","institution_ids":[]},{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111654697","display_name":"Jingping Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingping Yang","raw_affiliation_strings":["Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","institution_ids":[]},{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070288477","display_name":"Suzanne Forry\u2010Schaudies","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suzanne Forry-Schaudies","raw_affiliation_strings":["Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","institution_ids":[]},{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014349709","display_name":"Paul L. Hallenbeck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Paul L Hallenbeck","raw_affiliation_strings":["Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, 20878, USA","institution_ids":[]},{"raw_affiliation_string":"Genetic Therapy, Inc. (a Novartis Company), Gaithersburg, Maryland, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5014349709"],"corresponding_institution_ids":[],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":1.8946,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.84707457,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"11","issue":"8","first_page":"555","last_page":"569"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncolytic-adenovirus","display_name":"oncolytic adenovirus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-selective-replication","display_name":"tumor-selective replication","score":0.9330000281333923},{"id":"https://openalex.org/keywords/human-telomerase-reverse-transcriptase-promoter","display_name":"human telomerase reverse transcriptase promoter","score":0.9330000281333923},{"id":"https://openalex.org/keywords/adenovirus-e1a","display_name":"adenovirus E1A","score":0.8230000138282776},{"id":"https://openalex.org/keywords/e4","display_name":"E4","score":0.7749999761581421},{"id":"https://openalex.org/keywords/antitumor-efficacy","display_name":"antitumor efficacy","score":0.8330000042915344},{"id":"https://openalex.org/keywords/hepatocyte-toxicity","display_name":"hepatocyte cytotoxicity","score":0.6830000281333923},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.5109999775886536},{"id":"https://openalex.org/keywords/lncap-xenografts","display_name":"LNCaP xenografts","score":0.8539999723434448},{"id":"https://openalex.org/keywords/doxorubicin-combination-therapy","display_name":"doxorubicin combination therapy","score":0.8840000033378601},{"id":"https://openalex.org/keywords/metastatic-cancer","display_name":"metastatic cancer","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.9160166382789612},{"id":"https://openalex.org/C2777283488","wikidata":"https://www.wikidata.org/wiki/Q7095181","display_name":"Oncolytic adenovirus","level":4,"score":0.785488486289978},{"id":"https://openalex.org/C125593758","wikidata":"https://www.wikidata.org/wiki/Q15315135","display_name":"Telomerase reverse transcriptase","level":4,"score":0.7365744113922119},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6497891545295715},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.6376557350158691},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5798667669296265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.529328465461731},{"id":"https://openalex.org/C49744831","wikidata":"https://www.wikidata.org/wiki/Q600121","display_name":"Virotherapy","level":4,"score":0.4949445128440857},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.4707373380661011},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.46751290559768677},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4433674216270447},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.31354478001594543},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2656087875366211},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.06544515490531921},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/sj.cgt.7700735","doi":"https://doi.org/10.1038/sj.cgt.7700735","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.cgt.7700735","pdf_url":null,"source":{"id":"https://openalex.org/S157451995","display_name":"Cancer Gene Therapy","issn_l":"0929-1903","issn":["0929-1903","1476-5500"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Gene Therapy","raw_type":"journal-article"},{"id":"pmid:15232601","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15232601","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer gene therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W19273212","https://openalex.org/W39809497","https://openalex.org/W149654997","https://openalex.org/W1512409450","https://openalex.org/W1523998792","https://openalex.org/W1544229812","https://openalex.org/W1558969188","https://openalex.org/W1579265529","https://openalex.org/W1579361447","https://openalex.org/W1582164157","https://openalex.org/W1583739972","https://openalex.org/W1587107897","https://openalex.org/W1617085817","https://openalex.org/W1654953809","https://openalex.org/W1831598597","https://openalex.org/W1899760105","https://openalex.org/W1919304720","https://openalex.org/W1961949089","https://openalex.org/W1964810515","https://openalex.org/W1965609218","https://openalex.org/W1977265727","https://openalex.org/W1984696336","https://openalex.org/W1995117137","https://openalex.org/W1996593524","https://openalex.org/W1998071815","https://openalex.org/W1999551057","https://openalex.org/W2000208656","https://openalex.org/W2002883144","https://openalex.org/W2012801298","https://openalex.org/W2016647287","https://openalex.org/W2017757468","https://openalex.org/W2017961829","https://openalex.org/W2020222773","https://openalex.org/W2029426142","https://openalex.org/W2034277114","https://openalex.org/W2037745466","https://openalex.org/W2040811344","https://openalex.org/W2053727025","https://openalex.org/W2060753108","https://openalex.org/W2070065682","https://openalex.org/W2076637025","https://openalex.org/W2084359613","https://openalex.org/W2098264302","https://openalex.org/W2105871477","https://openalex.org/W2113169146","https://openalex.org/W2115346781","https://openalex.org/W2118764241","https://openalex.org/W2121672863","https://openalex.org/W2129484395","https://openalex.org/W2132002141","https://openalex.org/W2133916339","https://openalex.org/W2137745922","https://openalex.org/W2156487862","https://openalex.org/W2159395171","https://openalex.org/W2162659991","https://openalex.org/W2167857195","https://openalex.org/W2175831465","https://openalex.org/W2243597363","https://openalex.org/W2313635656","https://openalex.org/W2320037565","https://openalex.org/W2326792847","https://openalex.org/W2791873134","https://openalex.org/W3022719572","https://openalex.org/W3023326053","https://openalex.org/W4253422011"],"related_works":["https://openalex.org/W2023966374","https://openalex.org/W4255586911","https://openalex.org/W2127802827","https://openalex.org/W2022386076","https://openalex.org/W1971296225","https://openalex.org/W2022176005","https://openalex.org/W2000407190","https://openalex.org/W2026673655","https://openalex.org/W2136203847","https://openalex.org/W1974423981"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}