{"id":"https://openalex.org/W2013916059","doi":"https://doi.org/10.1097/maj.0000000000000439","title":"Cardiovascular Safety Profile and Clinical Experience With High-Dose Domperidone Therapy for Nausea and Vomiting","display_name":"Cardiovascular Safety Profile and Clinical Experience With High-Dose Domperidone Therapy for Nausea and Vomiting","publication_year":2015,"publication_date":"2015-04-03","ids":{"openalex":"https://openalex.org/W2013916059","doi":"https://doi.org/10.1097/maj.0000000000000439","mag":"2013916059","pmid":"https://pubmed.ncbi.nlm.nih.gov/25828198","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4418779"},"language":"en","primary_location":{"id":"doi:10.1097/maj.0000000000000439","doi":"https://doi.org/10.1097/maj.0000000000000439","is_oa":true,"landing_page_url":"https://doi.org/10.1097/maj.0000000000000439","pdf_url":"http://www.amjmedsci.org/article/S0002962915300422/pdf","source":{"id":"https://openalex.org/S109361689","display_name":"The American Journal of the Medical Sciences","issn_l":"0002-9629","issn":["0002-9629","1538-2990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of the Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.amjmedsci.org/article/S0002962915300422/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110641331","display_name":"Arleen M. Ortiz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108700","display_name":"Cleveland Clinic Florida","ror":"https://ror.org/0155k7414","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4210108700"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arleen Ortiz","raw_affiliation_strings":["Department of Internal Medicine (AO, CJC, YG, IS, RWM), Texas Tech University Health Sciences Center, El Paso, Texas; and Department of Gastroenterology (AA), Cleveland Clinic, Weston, Florida","From the Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine (AO, CJC, YG, IS, RWM), Texas Tech University Health Sciences Center, El Paso, Texas; and Department of Gastroenterology (AA), Cleveland Clinic, Weston, Florida","institution_ids":["https://openalex.org/I4210108700","https://openalex.org/I926076166"]},{"raw_affiliation_string":"From the Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, Texas","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102814573","display_name":"Chad J. Cooper","orcid":"https://orcid.org/0000-0002-3691-0562","observed_orcids":["https://orcid.org/0000-0002-3691-0562","https://orcid.org/0000-0002-7802-5190"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4210108700","display_name":"Cleveland Clinic Florida","ror":"https://ror.org/0155k7414","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4210108700"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chad J. Cooper","raw_affiliation_strings":["Department of Gastroenterology (AA) , Cleveland Clinic , Weston , Florida","Department of Internal Medicine (AO, CJC, YG, IS, RWM) , Texas Tech University Health Sciences Center , El Paso , Texas ; and","From the Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology (AA) , Cleveland Clinic , Weston , Florida","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4210108700"]},{"raw_affiliation_string":"Department of Internal Medicine (AO, CJC, YG, IS, RWM) , Texas Tech University Health Sciences Center , El Paso , Texas ; and","institution_ids":["https://openalex.org/I926076166"]},{"raw_affiliation_string":"From the Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, Texas","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036852516","display_name":"Yvette Gomez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yvette Gomez","raw_affiliation_strings":["Department of Internal Medicine (AO, CJC, YG, IS, RWM) , Texas Tech University Health Sciences Center , El Paso , Texas ; and","From the Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine (AO, CJC, YG, IS, RWM) , Texas Tech University Health Sciences Center , El Paso , Texas ; and","institution_ids":["https://openalex.org/I926076166"]},{"raw_affiliation_string":"From the Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, Texas","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006433297","display_name":"Irene Sarosiek","orcid":"https://orcid.org/0000-0003-1678-7269","observed_orcids":["https://orcid.org/0000-0003-1678-7269"]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irene Sarosiek","raw_affiliation_strings":["From the Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, Texas","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005028574","display_name":"Richard W. McCallum","orcid":"https://orcid.org/0000-0002-6652-8049","observed_orcids":["https://orcid.org/0000-0002-6652-8049"]},"institutions":[{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard W. McCallum","raw_affiliation_strings":["From the Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, Texas","institution_ids":["https://openalex.org/I926076166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102255505","display_name":"Alicia Alvarez","orcid":"https://orcid.org/0000-0002-3219-8256","observed_orcids":["https://orcid.org/0000-0002-3219-8256"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4210108700","display_name":"Cleveland Clinic Florida","ror":"https://ror.org/0155k7414","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4210108700"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alicia Alvarez","raw_affiliation_strings":["Department of Gastroenterology, Cleveland Clinic, Weston, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Cleveland Clinic, Weston, Florida","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4210108700"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5005028574"],"corresponding_institution_ids":["https://openalex.org/I926076166"],"apc_list":{"value":2940,"currency":"USD","value_usd":2940},"apc_paid":{"value":2940,"currency":"USD","value_usd":2940},"fwci":6.7111,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.97143387,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"349","issue":"5","first_page":"421","last_page":"424"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/domperidone","display_name":"domperidone","score":1.0},{"id":"https://openalex.org/keywords/qtc-prolongation","display_name":"QTc prolongation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/cardiovascular-safety","display_name":"cardiovascular safety","score":0.703000009059906},{"id":"https://openalex.org/keywords/nausea-and-vomiting","display_name":"nausea and vomiting","score":0.8029999732971191},{"id":"https://openalex.org/keywords/diabetic-gastroparesis","display_name":"diabetic gastroparesis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/idiopathic-gastroparesis","display_name":"idiopathic gastroparesis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/drug-induced-cardiotoxicity","display_name":"drug-induced cardiotoxicity","score":0.5230000019073486},{"id":"https://openalex.org/keywords/ecg-monitoring","display_name":"ECG monitoring","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C2775995038","wikidata":"https://www.wikidata.org/wiki/Q424238","display_name":"Domperidone","level":3,"score":0.9495053291320801},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9328569769859314},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.8447659015655518},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.774604856967926},{"id":"https://openalex.org/C2780884295","wikidata":"https://www.wikidata.org/wiki/Q575136","display_name":"Antiemetic","level":3,"score":0.7187659740447998},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.618220329284668},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.5353930592536926},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35967597365379333},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.07897695899009705}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004294","descriptor_name":"Domperidone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004294","descriptor_name":"Domperidone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009325","descriptor_name":"Nausea","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009325","descriptor_name":"Nausea","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D009325","descriptor_name":"Nausea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013995","descriptor_name":"Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014839","descriptor_name":"Vomiting","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014839","descriptor_name":"Vomiting","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D014839","descriptor_name":"Vomiting","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018492","descriptor_name":"Dopamine Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018492","descriptor_name":"Dopamine Antagonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D066126","descriptor_name":"Cardiotoxicity","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D066126","descriptor_name":"Cardiotoxicity","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":true},{"descriptor_ui":"D066126","descriptor_name":"Cardiotoxicity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/maj.0000000000000439","doi":"https://doi.org/10.1097/maj.0000000000000439","is_oa":true,"landing_page_url":"https://doi.org/10.1097/maj.0000000000000439","pdf_url":"http://www.amjmedsci.org/article/S0002962915300422/pdf","source":{"id":"https://openalex.org/S109361689","display_name":"The American Journal of the Medical Sciences","issn_l":"0002-9629","issn":["0002-9629","1538-2990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of the Medical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4418779","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4418779","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Med Sci","raw_type":"Text"},{"id":"pmid:25828198","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25828198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of the medical sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1097/maj.0000000000000439","doi":"https://doi.org/10.1097/maj.0000000000000439","is_oa":true,"landing_page_url":"https://doi.org/10.1097/maj.0000000000000439","pdf_url":"http://www.amjmedsci.org/article/S0002962915300422/pdf","source":{"id":"https://openalex.org/S109361689","display_name":"The American Journal of the Medical Sciences","issn_l":"0002-9629","issn":["0002-9629","1538-2990"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of the Medical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8700000047683716,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013916059.pdf","grobid_xml":"https://content.openalex.org/works/W2013916059.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W31078748","https://openalex.org/W292491791","https://openalex.org/W1590032415","https://openalex.org/W1982182190","https://openalex.org/W1983534004","https://openalex.org/W1988368217","https://openalex.org/W1995314888","https://openalex.org/W1999017572","https://openalex.org/W2001357215","https://openalex.org/W2005357164","https://openalex.org/W2006494999","https://openalex.org/W2030926336","https://openalex.org/W2036338907","https://openalex.org/W2039434484","https://openalex.org/W2044675671","https://openalex.org/W2068241878","https://openalex.org/W2102661460","https://openalex.org/W2104364676","https://openalex.org/W2122114281","https://openalex.org/W2135418973","https://openalex.org/W2169242778","https://openalex.org/W2209993874","https://openalex.org/W4247897741"],"related_works":["https://openalex.org/W7097938798","https://openalex.org/W4214776185","https://openalex.org/W2977635997","https://openalex.org/W2935020086","https://openalex.org/W1191096201","https://openalex.org/W1904184655","https://openalex.org/W2384019205","https://openalex.org/W2993461946","https://openalex.org/W2977368480","https://openalex.org/W4384824923"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Domperidone":[1],"is":[2],"a":[3,277],"dopamine":[4],"receptor":[5],"antagonist":[6],"with":[7,19,60,167,175,190,217],"peripheral":[8],"prokinetic":[9],"and":[10,63,88,103,143,193,201,253],"central":[11],"antiemetic":[12],"properties.":[13],"Prolongation":[14],"of":[15,22,58,112,149,179,185,228,256,280],"the":[16,32,176,205,272],"QTc":[17,94,207,233,252],"interval":[18],"chronic":[20,134],"use":[21],"oral":[23],"domperidone":[24,67,126,275],"in":[25,31,41,48,100,106],"standard":[26,177],"doses":[27,46],"has":[28,276],"been":[29],"reported":[30],"literature.":[33],"Our":[34,264],"goal":[35],"was":[36,56,95,151,210,247],"to":[37,70,157,164,171,239],"investigate":[38],"cardiac":[39,86],"toxicity":[40],"patients":[42,59,196,230],"receiving":[43,66,169],"2-fold":[44],"greater":[45],"than":[47],"previous":[49],"reports.":[50],"METHODS:":[51],"A":[52,110],"retrospective":[53],"chart":[54],"review":[55],"conducted":[57],"nausea":[61,192],"(N)":[62],"vomiting":[64,141,145],"(V)":[65],"from":[68,162,188,237],"2009":[69],"2013":[71],"under":[72],"an":[73],"Investigational":[74],"New":[75],"Drug":[76],"(IND)":[77],"protocol.":[78],"Patient":[79],"demographics,":[80],"indications":[81],"for":[82,127],"therapy,":[83],"clinical":[84,287],"outcomes,":[85],"symptoms":[87],"electrocardiogram":[89],"tracings":[90],"were":[91,124],"reviewed.":[92],"Prolonged":[93],"verified":[96],"if":[97],">470":[98],"milliseconds":[99,105,212,219],"females":[101],"(F)":[102],">450":[104],"males":[107],"(M).":[108],"RESULTS:":[109],"total":[111],"64":[113],"patients,":[114],"44":[115],"female":[116],"(37%":[117],"Hispanic,":[118],"60%":[119],"white,":[120],"3%":[121],"African":[122],"American),":[123],"taking":[125],"diabetic":[128],"gastroparesis":[129,132],"45%;":[130],"idiopathic":[131],"36%;":[133],"N&V":[135],"8%;":[136],"dumping":[137],"syndrome":[138],"5%;":[139],"cyclic":[140],"5%":[142],"conditioned":[144],"1%.":[146],"Mean":[147],"duration":[148],"therapy":[150],"8":[152],"months":[153,156],"(range,":[154],"3":[155],"4":[158],"years).":[159],"Doses":[160],"ranged":[161],"40":[163,180],"120":[165,172],"mg/d":[166],"90%":[168],"80":[170],"mg":[173],"compared":[174,216],"dose":[178,255],"mg.":[181],"Of":[182],"note,":[183],"73%":[184],"subjects":[186],"benefited":[187],"treatment":[189],"reduced":[191],"vomiting.":[194],"Thirty-seven":[195],"had":[197,231],"follow-up":[198,224],"electrocardiograms":[199],"available,":[200],"they":[202],"showed":[203],"that":[204,267],"mean":[206],"at":[208,223,234,268],"baseline":[209],"424":[211],"\u00b1":[213,220],"28.4":[214],"(SD)":[215,222],"435":[218],"27.2":[221],"(not":[225],"significant).":[226],"Ten":[227],"these":[229],"prolonged":[232,251],"F/U":[235],"ranging":[236],"453":[238],"509":[240],"milliseconds,":[241],"without":[242],"any":[243],"cardiovascular":[244,282],"complaints.":[245],"There":[246],"no":[248],"relationship":[249],"between":[250],"daily":[254],"domperidone,":[257],"body":[258],"mass":[259],"index":[260],"or":[261],"age.":[262],"CONCLUSIONS:":[263],"data":[265],"indicate":[266],"very":[269],"high":[270],"dosing,":[271],"prokinetic/antiemetic":[273],"agent":[274],"low":[278],"risk":[279],"adverse":[281],"events":[283],"while":[284],"exhibiting":[285],"good":[286],"efficacy.":[288]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
