{"id":"https://openalex.org/W2013876581","doi":"https://doi.org/10.1016/j.chembiol.2014.10.017","title":"IgGA: A \u201cCross-Isotype\u201d Engineered Human Fc Antibody Domain that Displays Both IgG-like and IgA-like Effector Functions","display_name":"IgGA: A \u201cCross-Isotype\u201d Engineered Human Fc Antibody Domain that Displays Both IgG-like and IgA-like Effector Functions","publication_year":2014,"publication_date":"2014-12-01","ids":{"openalex":"https://openalex.org/W2013876581","doi":"https://doi.org/10.1016/j.chembiol.2014.10.017","mag":"2013876581","pmid":"https://pubmed.ncbi.nlm.nih.gov/25500223"},"language":"en","primary_location":{"id":"doi:10.1016/j.chembiol.2014.10.017","doi":"https://doi.org/10.1016/j.chembiol.2014.10.017","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2014.10.017","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1074552114004098/pdf","source":{"id":"https://openalex.org/S85134406","display_name":"Chemistry & Biology","issn_l":"1074-5521","issn":["1074-5521","1879-1301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S1074552114004098/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086642581","display_name":"William Kelton","orcid":"https://orcid.org/0000-0002-5513-6429","observed_orcids":["https://orcid.org/0000-0002-5513-6429"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Kelton","raw_affiliation_strings":["Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030226635","display_name":"Nishant Mehta","orcid":"https://orcid.org/0000-0002-7920-609X","observed_orcids":["https://orcid.org/0000-0002-7920-609X"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nishant Mehta","raw_affiliation_strings":["Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034505117","display_name":"Wissam Charab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wissam Charab","raw_affiliation_strings":["Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100444719","display_name":"Jiwon Lee","orcid":"https://orcid.org/0000-0001-7835-3621","observed_orcids":["https://orcid.org/0000-0001-7835-3621","https://orcid.org/0009-0003-2534-7799"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiwon Lee","raw_affiliation_strings":["Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101588373","display_name":"Chang\u2010Han Lee","orcid":"https://orcid.org/0000-0002-7156-4423","observed_orcids":["https://orcid.org/0000-0002-7156-4423"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chang-han Lee","raw_affiliation_strings":["Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059470222","display_name":"Takaaki Kojima","orcid":"https://orcid.org/0000-0001-7282-121X","observed_orcids":["https://orcid.org/0000-0001-7282-121X"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takaaki Kojima","raw_affiliation_strings":["Laboratory of Molecular Biotechnology, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biotechnology, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022320636","display_name":"Tae Hyun Kang","orcid":"https://orcid.org/0000-0002-7825-5877","observed_orcids":["https://orcid.org/0000-0002-7825-5877"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tae\u00a0Hyun Kang","raw_affiliation_strings":["Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047788420","display_name":"George Georgiou","orcid":"https://orcid.org/0000-0002-8823-3073","observed_orcids":["https://orcid.org/0000-0002-8823-3073"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"George Georgiou","raw_affiliation_strings":["Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA; Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA; Section of Molecular Genetics and Microbiology, University of Texas at Austin, Austin, TX 78712, USA; Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA. Electronic address: gg@che.utexas.edu","Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA","Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA","Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA","Section of Molecular Genetics and Microbiology, University of Texas at Austin, Austin, TX 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA; Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA; Section of Molecular Genetics and Microbiology, University of Texas at Austin, Austin, TX 78712, USA; Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA. Electronic address: gg@che.utexas.edu","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Section of Molecular Genetics and Microbiology, University of Texas at Austin, Austin, TX 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047788420"],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":null,"apc_paid":null,"fwci":4.4241,"has_fulltext":true,"cited_by_count":68,"citation_normalized_percentile":{"value":0.94110104,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"21","issue":"12","first_page":"1603","last_page":"1609"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/engineered-antibodies","display_name":"engineered antibodies","score":0.47999998927116394},{"id":"https://openalex.org/keywords/fcalphari","display_name":"Fc\u03b1RI","score":0.7889999747276306},{"id":"https://openalex.org/keywords/fc-gamma-receptor","display_name":"Fc gamma receptor","score":0.9459999799728394},{"id":"https://openalex.org/keywords/c1q-binding","display_name":"C1q binding","score":0.925000011920929},{"id":"https://openalex.org/keywords/complement-dependent-cytotoxicity","display_name":"complement-dependent cytotoxicity","score":0.9459999799728394},{"id":"https://openalex.org/keywords/neutrophil-activation","display_name":"neutrophil activation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.996999979019165},{"id":"https://openalex.org/keywords/her2-positive-cancer","display_name":"HER2-positive cancer","score":0.7400000095367432},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.890999972820282},{"id":"https://openalex.org/keywords/antibody-effector-functions","display_name":"antibody effector functions","score":0.7720000147819519},{"id":"https://openalex.org/keywords/iga-antibodies","display_name":"IgA antibodies","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7038850784301758},{"id":"https://openalex.org/C2777991845","wikidata":"https://www.wikidata.org/wiki/Q2396793","display_name":"Isotype","level":4,"score":0.7030547261238098},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.693602442741394},{"id":"https://openalex.org/C125823703","wikidata":"https://www.wikidata.org/wiki/Q1616930","display_name":"Fragment crystallizable region","level":3,"score":0.601777970790863},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5731285810470581},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5531170964241028},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5238204598426819},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5131300091743469},{"id":"https://openalex.org/C2909900342","wikidata":"https://www.wikidata.org/wiki/Q1616930","display_name":"Immunoglobulin Fc Fragments","level":4,"score":0.5013899803161621},{"id":"https://openalex.org/C40677261","wikidata":"https://www.wikidata.org/wiki/Q21418091","display_name":"Antibody-dependent cell-mediated cytotoxicity","level":4,"score":0.49834680557250977},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.47014573216438293},{"id":"https://openalex.org/C2779931124","wikidata":"https://www.wikidata.org/wiki/Q417823","display_name":"Fc receptor","level":3,"score":0.42225149273872375},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35754430294036865},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.2825699746608734},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09548842906951904}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011961","descriptor_name":"Receptors, Fc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.chembiol.2014.10.017","doi":"https://doi.org/10.1016/j.chembiol.2014.10.017","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2014.10.017","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1074552114004098/pdf","source":{"id":"https://openalex.org/S85134406","display_name":"Chemistry & Biology","issn_l":"1074-5521","issn":["1074-5521","1879-1301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biology","raw_type":"journal-article"},{"id":"pmid:25500223","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25500223","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & biology","raw_type":"Journal Article"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/218296","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/218296","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/j.chembiol.2014.10.017","doi":"https://doi.org/10.1016/j.chembiol.2014.10.017","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2014.10.017","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1074552114004098/pdf","source":{"id":"https://openalex.org/S85134406","display_name":"Chemistry & Biology","issn_l":"1074-5521","issn":["1074-5521","1879-1301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310144","display_name":"Tertiary Education Commission","ror":"https://ror.org/05xhe5a74"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013876581.pdf","grobid_xml":"https://content.openalex.org/works/W2013876581.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1516451902","https://openalex.org/W1593975549","https://openalex.org/W1609910491","https://openalex.org/W1969824500","https://openalex.org/W1982183807","https://openalex.org/W1991656907","https://openalex.org/W2005519719","https://openalex.org/W2010779212","https://openalex.org/W2015795968","https://openalex.org/W2021529295","https://openalex.org/W2026968254","https://openalex.org/W2039578184","https://openalex.org/W2041944580","https://openalex.org/W2049000257","https://openalex.org/W2050233470","https://openalex.org/W2055507506","https://openalex.org/W2088569914","https://openalex.org/W2090770261","https://openalex.org/W2095940970","https://openalex.org/W2100461087","https://openalex.org/W2114286868","https://openalex.org/W2121080857","https://openalex.org/W2138694950","https://openalex.org/W2139419109","https://openalex.org/W2139887355","https://openalex.org/W2140590997","https://openalex.org/W2144980937","https://openalex.org/W2158608719","https://openalex.org/W2161464792","https://openalex.org/W2161567108","https://openalex.org/W2162305597","https://openalex.org/W2164678711","https://openalex.org/W2165437317","https://openalex.org/W2167363836"],"related_works":["https://openalex.org/W1942563940","https://openalex.org/W4318982021","https://openalex.org/W2190773785","https://openalex.org/W3111818309","https://openalex.org/W2303425311","https://openalex.org/W2394525831","https://openalex.org/W4308361886","https://openalex.org/W7095332588","https://openalex.org/W2588750449","https://openalex.org/W2938405616"],"abstract_inverted_index":{"All":[0],"clinically":[1],"approved":[2],"antibodies":[3,37,141],"are":[4],"of":[5,13,50,60,75,125,139],"the":[6,11,48,57,79,137],"IgG":[7,62],"isotype":[8],"and":[9,21,63,77,84,89,105,135],"mediate":[10],"clearance":[12],"target":[14],"cells":[15],"via":[16,32],"binding":[17,92],"to":[18,42,67,73,78,93,96,107],"Fc\u03b3":[19,81],"receptors":[20],"complement":[22],"(C1q).":[23],"Even":[24],"though":[25],"IgA":[26,36,121],"can":[27],"elicit":[28],"powerful":[29],"cytotoxic":[30],"action":[31],"Fc\u03b1RI":[33,68],"receptor":[34],"binding,":[35],"have":[38],"not":[39],"been":[40],"amenable":[41],"therapeutic":[43,133],"development.":[44],"Here,":[45],"we":[46],"report":[47],"engineering":[49,140],"a":[51],"\"cross-isotype\"":[52],"antibody,":[53],"IgGA,":[54],"which":[55],"combines":[56],"effector":[58,127,144],"functions":[59,128,145],"both":[61,103],"IgA.":[64],"IgGA":[65,113,126],"binds":[66],"with":[69,86],"an":[70],"affinity":[71],"comparable":[72],"that":[74,142],"IgA,":[76],"activating":[80],"receptors,":[82],"Fc\u03b3RI":[83],"Fc\u03b3RIIa,":[85],"high":[87],"affinity,":[88],"displays":[90],"increased":[91],"C1q":[94],"compared":[95],"IgG.":[97],"Unlike":[98],"trastuzumab-IgG,":[99],"trastuzumab-IgGA":[100],"potently":[101],"activates":[102],"neutrophils":[104],"macrophages":[106],"kill":[108],"Her2(+)":[109],"cancer":[110],"cells.":[111],"Furthermore,":[112],"mediates":[114],"greater":[115],"complement-dependent":[116],"cytotoxicity":[117],"than":[118],"IgG1":[119],"or":[120],"antibodies.":[122],"The":[123],"multitude":[124],"could":[129],"be":[130],"important":[131],"for":[132],"purposes":[134],"highlights":[136],"concept":[138],"combine":[143],"from":[146],"multiple":[147],"antibody":[148],"isotypes.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}