{"id":"https://openalex.org/W2013869441","doi":"https://doi.org/10.1089/cbr.2004.19.738","title":"Comparison of Radiation Dose Estimation for Myeloablative Radioimmunotherapy for Relapsed or Recurrent Mantle Cell Lymphoma Using 131 I Tositumomab to That of Other Types of Non-Hodgkin's Lymphoma","display_name":"Comparison of Radiation Dose Estimation for Myeloablative Radioimmunotherapy for Relapsed or Recurrent Mantle Cell Lymphoma Using 131 I Tositumomab to That of Other Types of Non-Hodgkin's Lymphoma","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W2013869441","doi":"https://doi.org/10.1089/cbr.2004.19.738","mag":"2013869441","pmid":"https://pubmed.ncbi.nlm.nih.gov/15665621"},"language":"en","primary_location":{"id":"doi:10.1089/cbr.2004.19.738","doi":"https://doi.org/10.1089/cbr.2004.19.738","is_oa":false,"landing_page_url":"https://doi.org/10.1089/cbr.2004.19.738","pdf_url":null,"source":{"id":"https://openalex.org/S87235987","display_name":"Cancer Biotherapy and Radiopharmaceuticals","issn_l":"1084-9785","issn":["1084-9785","1557-8852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biotherapy and Radiopharmaceuticals","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112904741","display_name":"Joseph G. Rajendran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Rajendran","raw_affiliation_strings":["Department of Radiology and University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004025497","display_name":"Ajay K. Gopal","orcid":"https://orcid.org/0000-0003-3023-6834","observed_orcids":["https://orcid.org/0000-0003-3023-6834"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ajay Gopal","raw_affiliation_strings":["Department of Medical Oncology, University of Washington, Seattle, WA","Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109953395","display_name":"Lawrence D. Durack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence Durack","raw_affiliation_strings":["Pacific Northwest National Laboratories, Richland, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific Northwest National Laboratories, Richland, WA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076899086","display_name":"Darrell R. Fisher","orcid":"https://orcid.org/0000-0002-6526-1637","observed_orcids":["https://orcid.org/0000-0002-6526-1637"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darrell Fisher","raw_affiliation_strings":["Pacific Northwest National Laboratories, Richland, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific Northwest National Laboratories, Richland, WA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023180146","display_name":"Oliver W. Press","orcid":"https://orcid.org/0000-0002-3147-8037","observed_orcids":["https://orcid.org/0000-0002-3147-8037"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oliver Press","raw_affiliation_strings":["Department of Medical Oncology, University of Washington, Seattle, WA","Fred Hutchinson Cancer Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025579054","display_name":"Janet F. Eary","orcid":"https://orcid.org/0000-0002-8712-8300","observed_orcids":["https://orcid.org/0000-0002-8712-8300"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet Eary","raw_affiliation_strings":["Department of Radiology and University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1063,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.77630122,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"19","issue":"6","first_page":"738","last_page":"745"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mantle-cell-lymphoma","display_name":"mantle cell lymphoma","score":0.9779999852180481},{"id":"https://openalex.org/keywords/relapsed-refractory-lymphoma","display_name":"relapsed/refractory lymphoma","score":0.8489999771118164},{"id":"https://openalex.org/keywords/radioimmunotherapy","display_name":"radioimmunotherapy","score":0.9110000133514404},{"id":"https://openalex.org/keywords/131i-tositumomab","display_name":"131I-tositumomab","score":0.9440000057220459},{"id":"https://openalex.org/keywords/anti-cd20","display_name":"anti-CD20","score":0.8740000128746033},{"id":"https://openalex.org/keywords/myeloablative-therapy","display_name":"myeloablative therapy","score":0.8270000219345093},{"id":"https://openalex.org/keywords/radiation-dose-assessment","display_name":"radiation dose assessment","score":0.7379999756813049},{"id":"https://openalex.org/keywords/mird-schema","display_name":"MIRD schema","score":0.6470000147819519},{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":0.9549999833106995}],"concepts":[{"id":"https://openalex.org/C2776146153","wikidata":"https://www.wikidata.org/wiki/Q7281276","display_name":"Radioimmunotherapy","level":4,"score":0.9296348094940186},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8129034638404846},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.6162675619125366},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5427963137626648},{"id":"https://openalex.org/C151337348","wikidata":"https://www.wikidata.org/wiki/Q215313","display_name":"Absorbed dose","level":3,"score":0.522137463092804},{"id":"https://openalex.org/C2777525834","wikidata":"https://www.wikidata.org/wiki/Q268713","display_name":"Mantle cell lymphoma","level":3,"score":0.49696972966194153},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.463636577129364},{"id":"https://openalex.org/C75088862","wikidata":"https://www.wikidata.org/wiki/Q2291081","display_name":"Dosimetry","level":2,"score":0.42219728231430054},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3452337384223938},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0681140124797821},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004307","descriptor_name":"Dose-Response Relationship, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011829","descriptor_name":"Radiation Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016499","descriptor_name":"Radioimmunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019653","descriptor_name":"Myeloablative Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020522","descriptor_name":"Lymphoma, Mantle-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020522","descriptor_name":"Lymphoma, Mantle-Cell","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/cbr.2004.19.738","doi":"https://doi.org/10.1089/cbr.2004.19.738","is_oa":false,"landing_page_url":"https://doi.org/10.1089/cbr.2004.19.738","pdf_url":null,"source":{"id":"https://openalex.org/S87235987","display_name":"Cancer Biotherapy and Radiopharmaceuticals","issn_l":"1084-9785","issn":["1084-9785","1557-8852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Biotherapy and Radiopharmaceuticals","raw_type":"journal-article"},{"id":"pmid:15665621","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15665621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer biotherapy & radiopharmaceuticals","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2225502052","display_name":"Therapy of Lymphoma/Leukemia with Monoclonal Antibodies","funder_award_id":"P01CA044991","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6880936110","display_name":"OPTIMIZING RADIOIMMUNOTHERAPY FOR NON HODGKIN'S LYMPHOMA","funder_award_id":"K23CA085479","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306378","display_name":"Lymphoma Research Foundation","ror":"https://ror.org/02y7bdg71"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W59243403","https://openalex.org/W148711857","https://openalex.org/W1009164044","https://openalex.org/W1603051829","https://openalex.org/W1649244290","https://openalex.org/W1826464020","https://openalex.org/W1887748429","https://openalex.org/W1892026381","https://openalex.org/W1933173754","https://openalex.org/W1967889416","https://openalex.org/W1976070258","https://openalex.org/W1982952698","https://openalex.org/W1989071397","https://openalex.org/W2001819304","https://openalex.org/W2003160173","https://openalex.org/W2013770655","https://openalex.org/W2021009046","https://openalex.org/W2022407514","https://openalex.org/W2042746633","https://openalex.org/W2052000503","https://openalex.org/W2059348629","https://openalex.org/W2077007959","https://openalex.org/W2107617453","https://openalex.org/W2118829764","https://openalex.org/W2123185965","https://openalex.org/W2125466477","https://openalex.org/W2128997140","https://openalex.org/W2132433919","https://openalex.org/W2147581636","https://openalex.org/W2154351760","https://openalex.org/W2158122865","https://openalex.org/W2162635715","https://openalex.org/W2236439975","https://openalex.org/W2272255210","https://openalex.org/W2320751441","https://openalex.org/W2401363558","https://openalex.org/W2410491514"],"related_works":["https://openalex.org/W2087631306","https://openalex.org/W1778074652","https://openalex.org/W2185622143","https://openalex.org/W2764431123","https://openalex.org/W2943411441","https://openalex.org/W2123185965","https://openalex.org/W1967417752","https://openalex.org/W2899820134","https://openalex.org/W3129154693","https://openalex.org/W2755720753"],"abstract_inverted_index":{"UNLABELLED:":[0],"Patients":[1,159],"with":[2,48,154,204,214],"relapsed":[3,215],"or":[4,216],"refractory":[5,217],"mantle":[6],"cell":[7],"lymphoma":[8,157],"(MCL)":[9],"demonstrate":[10],"poor":[11],"survival":[12],"after":[13,73],"standard":[14],"treatment.":[15],"Myeloablative":[16,188],"radioimmunotherapy":[17],"(RIT)":[18],"using":[19,190],"(131)I":[20,78,168,191],"tositumomab":[21,79,192],"(anti-CD20)":[22],"has":[23],"the":[24,86,179,183],"ability":[25],"to":[26,31,84,152,174,178,200],"deliver":[27,175],"specific":[28],"radiation-absorbed":[29,185,197],"dose":[30,98],"antigen-bearing":[32],"tumor.":[33],"We":[34],"reviewed":[35],"normal":[36,180,195],"organ":[37,103,113,181,196],"radiation-":[38],"absorbed":[39,134],"doses":[40,135,198],"in":[41,194,202],"MCL":[42,49],"patients.":[43],"METHODS:":[44],"Records":[45],"of":[46,77,89,164,167],"patients":[47,72,153,203,213],"(n":[50],"=25),":[51],"who":[52],"received":[53,160],"myeloablative":[54],"RIT":[55,189],"between":[56],"January":[57],"1996":[58],"and":[59,131,208],"December":[60],"2003":[61],"were":[62,117],"reviewed.":[63],"Individual":[64],"patient":[65],"radiation":[66,97,133],"dosimetry":[67],"was":[68],"performed":[69],"on":[70,94],"all":[71],"a":[74,161],"trace-labeled":[75],"infusion":[76],"(mean":[80],"=":[81],"348":[82],"MBq),":[83],"calculate":[85],"required":[87],"amount":[88],"radioactivity":[90],"for":[91,108,115,171,211],"therapy,":[92],"based":[93],"medical":[95],"internal":[96],"(MIRD)":[99],"schema.":[100],"RESULTS:":[101],"Mean":[102],"residence":[104],"times":[105],"(hour)":[106],"corrected":[107],"computed":[109],"tomography":[110],"(CT)":[111],"derived":[112],"volumes":[114],"MCL,":[116],"as":[118],"follows:":[119],"Lungs:":[120,138],"9.0;":[121],"Liver:":[122,140],"12.4;":[123],"Kidneys:":[124,142],"1.7;":[125,145],"Spleen:":[126,144],"2.17;":[127],"Whole":[128,146],"Body:":[129,147],"62.4":[130],"mean":[132,162],"mGy/Mbq":[136],"were:":[137],"1.2;":[139],"1.1;":[141],"0.85;":[143],"0.21.":[148],"This":[149],"is":[150,209],"similar":[151,199],"other":[155,205],"non-Hodgkin's":[156,206],"(NHL).":[158],"activity":[163],"21":[165],"GBq":[166],"(range,":[169],"11.5-41.4)":[170],"therapy":[172],"estimated":[173],"25":[176],"Gy":[177],"receiving":[182],"highest":[184],"dose.":[186],"CONCLUSION:":[187],"results":[193],"those":[201],"lymphoma,":[207],"suitable":[210],"treating":[212],"MCL.":[218]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}