{"id":"https://openalex.org/W2013861515","doi":"https://doi.org/10.1016/j.nurt.2009.01.018","title":"Nanotechnology for Delivery of Drugs to the Brain for Epilepsy","display_name":"Nanotechnology for Delivery of Drugs to the Brain for Epilepsy","publication_year":2009,"publication_date":"2009-03-30","ids":{"openalex":"https://openalex.org/W2013861515","doi":"https://doi.org/10.1016/j.nurt.2009.01.018","mag":"2013861515","pmid":"https://pubmed.ncbi.nlm.nih.gov/19332327","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2673491"},"language":"en","primary_location":{"id":"doi:10.1016/j.nurt.2009.01.018","doi":"https://doi.org/10.1016/j.nurt.2009.01.018","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nurt.2009.01.018","pdf_url":"https://link.springer.com/content/pdf/10.1016/j.nurt.2009.01.018.pdf","source":{"id":"https://openalex.org/S75519821","display_name":"Neurotherapeutics","issn_l":"1878-7479","issn":["1878-7479","1933-7213"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotherapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://link.springer.com/content/pdf/10.1016/j.nurt.2009.01.018.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085753981","display_name":"Margaret F. Bennewitz","orcid":"https://orcid.org/0000-0002-2519-1603","observed_orcids":["https://orcid.org/0000-0002-2519-1603"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret F. Bennewitz","raw_affiliation_strings":["Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06520, USA","Department of Biomedical Engineering, Yale University, 414 Malone Engineering Center, New Haven,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06520, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University, 414 Malone Engineering Center, New Haven,","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012106344","display_name":"W. Mark Saltzman","orcid":"https://orcid.org/0000-0002-2163-549X","observed_orcids":["https://orcid.org/0000-0002-2163-549X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"W. Mark Saltzman","raw_affiliation_strings":["Department of Biomedical Engineering, Yale University, 414 Malone Engineering Center, 55 Prospect Street, 06520-8260, New Haven, CT","Department of Biomedical Engineering, Yale University, 414 Malone Engineering Center, New Haven,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University, 414 Malone Engineering Center, 55 Prospect Street, 06520-8260, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University, 414 Malone Engineering Center, New Haven,","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012106344"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":null,"fwci":3.3468,"has_fulltext":true,"cited_by_count":142,"citation_normalized_percentile":{"value":0.91852998,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"6","issue":"2","first_page":"323","last_page":"336"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.788100004196167,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.788100004196167,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.06849999725818634,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.05939999967813492,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.9269999861717224},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.9380000233650208},{"id":"https://openalex.org/keywords/drug-delivery-to-the-brain","display_name":"brain drug delivery","score":0.8679999709129333},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9739999771118164},{"id":"https://openalex.org/keywords/nanoparticles","display_name":"nanoparticles","score":0.7110000252723694},{"id":"https://openalex.org/keywords/drug-modification","display_name":"drug modification","score":0.6650000214576721},{"id":"https://openalex.org/keywords/seizure-control","display_name":"seizure control","score":0.3160000145435333}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7601598501205444},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.7390499114990234},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7030477523803711},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6462175846099854},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.541456937789917},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.5281016230583191},{"id":"https://openalex.org/C12770488","wikidata":"https://www.wikidata.org/wiki/Q188449","display_name":"Neurosurgery","level":2,"score":0.4708380699157715},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4416424334049225},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4076272249221802},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2390340268611908},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18047747015953064},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.13325586915016174},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.11721009016036987},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.11145398020744324},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.nurt.2009.01.018","doi":"https://doi.org/10.1016/j.nurt.2009.01.018","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nurt.2009.01.018","pdf_url":"https://link.springer.com/content/pdf/10.1016/j.nurt.2009.01.018.pdf","source":{"id":"https://openalex.org/S75519821","display_name":"Neurotherapeutics","issn_l":"1878-7479","issn":["1878-7479","1933-7213"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotherapeutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2673491","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2673491","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotherapeutics","raw_type":"Text"},{"id":"pmid:19332327","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19332327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.nurt.2009.01.018","doi":"https://doi.org/10.1016/j.nurt.2009.01.018","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nurt.2009.01.018","pdf_url":"https://link.springer.com/content/pdf/10.1016/j.nurt.2009.01.018.pdf","source":{"id":"https://openalex.org/S75519821","display_name":"Neurotherapeutics","issn_l":"1878-7479","issn":["1878-7479","1933-7213"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurotherapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3464917334","display_name":"Interdisciplinary Pre-doctoral Training Program in Neuroengineering(RMI)","funder_award_id":"T90DK070068","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4619576733","display_name":"Interdisciplinary Pre-doctoral Training Program in Neuroengineering(RMI)","funder_award_id":"R90DK071501","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G683579447","display_name":"Microfluidic/controlled systems on brain microprobes","funder_award_id":"R01NS045236","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2013861515.pdf","grobid_xml":"https://content.openalex.org/works/W2013861515.grobid-xml"},"referenced_works_count":120,"referenced_works":["https://openalex.org/W24682425","https://openalex.org/W84182309","https://openalex.org/W99988922","https://openalex.org/W100162714","https://openalex.org/W205461530","https://openalex.org/W217497694","https://openalex.org/W1515543141","https://openalex.org/W1516954147","https://openalex.org/W1525069655","https://openalex.org/W1541185762","https://openalex.org/W1572038018","https://openalex.org/W1952264151","https://openalex.org/W1966544692","https://openalex.org/W1966940765","https://openalex.org/W1968066079","https://openalex.org/W1976138879","https://openalex.org/W1977539085","https://openalex.org/W1980800810","https://openalex.org/W1983090757","https://openalex.org/W1983818104","https://openalex.org/W1984795811","https://openalex.org/W1986129921","https://openalex.org/W1988486459","https://openalex.org/W1991562104","https://openalex.org/W1992865052","https://openalex.org/W2003841370","https://openalex.org/W2006472518","https://openalex.org/W2007516291","https://openalex.org/W2007719782","https://openalex.org/W2011139878","https://openalex.org/W2014537537","https://openalex.org/W2015541518","https://openalex.org/W2015615637","https://openalex.org/W2018121350","https://openalex.org/W2020096151","https://openalex.org/W2020855804","https://openalex.org/W2020882358","https://openalex.org/W2021246059","https://openalex.org/W2021347550","https://openalex.org/W2022047142","https://openalex.org/W2022981155","https://openalex.org/W2024808560","https://openalex.org/W2025797846","https://openalex.org/W2026685503","https://openalex.org/W2027177883","https://openalex.org/W2028131143","https://openalex.org/W2031364138","https://openalex.org/W2032735637","https://openalex.org/W2034307627","https://openalex.org/W2038670536","https://openalex.org/W2044228427","https://openalex.org/W2044855317","https://openalex.org/W2048203843","https://openalex.org/W2054435240","https://openalex.org/W2055542425","https://openalex.org/W2057097454","https://openalex.org/W2057741590","https://openalex.org/W2058862680","https://openalex.org/W2059183805","https://openalex.org/W2059505070","https://openalex.org/W2061928059","https://openalex.org/W2062625040","https://openalex.org/W2065817859","https://openalex.org/W2066680594","https://openalex.org/W2067557497","https://openalex.org/W2068491059","https://openalex.org/W2069118421","https://openalex.org/W2069289981","https://openalex.org/W2071921998","https://openalex.org/W2072742854","https://openalex.org/W2072758801","https://openalex.org/W2074544404","https://openalex.org/W2076900479","https://openalex.org/W2079078912","https://openalex.org/W2082640094","https://openalex.org/W2084976225","https://openalex.org/W2091094134","https://openalex.org/W2099435753","https://openalex.org/W2100014309","https://openalex.org/W2100516759","https://openalex.org/W2101312385","https://openalex.org/W2103475556","https://openalex.org/W2104241359","https://openalex.org/W2104290477","https://openalex.org/W2105060883","https://openalex.org/W2106013244","https://openalex.org/W2108379135","https://openalex.org/W2110418294","https://openalex.org/W2112829922","https://openalex.org/W2112937635","https://openalex.org/W2114149350","https://openalex.org/W2115626320","https://openalex.org/W2119784812","https://openalex.org/W2120919579","https://openalex.org/W2122218978","https://openalex.org/W2125541186","https://openalex.org/W2126114791","https://openalex.org/W2126487804","https://openalex.org/W2130894361","https://openalex.org/W2139154816","https://openalex.org/W2146228631","https://openalex.org/W2147460702","https://openalex.org/W2149016411","https://openalex.org/W2149791952","https://openalex.org/W2151308354","https://openalex.org/W2157418309","https://openalex.org/W2162324455","https://openalex.org/W2162618795","https://openalex.org/W2167235509","https://openalex.org/W2169879202","https://openalex.org/W2181569653","https://openalex.org/W2260642778","https://openalex.org/W2333038355","https://openalex.org/W2404144897","https://openalex.org/W2411764514","https://openalex.org/W2415116449","https://openalex.org/W2463514215","https://openalex.org/W3151281148","https://openalex.org/W4249986256","https://openalex.org/W6678177149"],"related_works":["https://openalex.org/W4283774493","https://openalex.org/W2168269378","https://openalex.org/W4396918730","https://openalex.org/W4389632916","https://openalex.org/W3188256152","https://openalex.org/W2922496801","https://openalex.org/W3046659580","https://openalex.org/W7165144550","https://openalex.org/W4200326337","https://openalex.org/W4390706507"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}