{"id":"https://openalex.org/W2013856845","doi":"https://doi.org/10.1097/aln.0000000000000149","title":"Beneficial Effects of Nitric Oxide on Outcomes after Cardiac Arrest and Cardiopulmonary Resuscitation in Hypothermia-treated Mice","display_name":"Beneficial Effects of Nitric Oxide on Outcomes after Cardiac Arrest and Cardiopulmonary Resuscitation in Hypothermia-treated Mice","publication_year":2014,"publication_date":"2014-02-04","ids":{"openalex":"https://openalex.org/W2013856845","doi":"https://doi.org/10.1097/aln.0000000000000149","mag":"2013856845","pmid":"https://pubmed.ncbi.nlm.nih.gov/24496125","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4346787"},"language":"en","primary_location":{"id":"doi:10.1097/aln.0000000000000149","doi":"https://doi.org/10.1097/aln.0000000000000149","is_oa":false,"landing_page_url":"https://doi.org/10.1097/aln.0000000000000149","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4346787","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056129308","display_name":"Kotaro Kida","orcid":"https://orcid.org/0000-0003-2248-175X","observed_orcids":["https://orcid.org/0000-0003-2248-175X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kotaro Kida","raw_affiliation_strings":["From the Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine (K.K., K.S., B.Y., K.D.B., and F.I.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (J.B.M.), Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine (K.K., K.S., B.Y., K.D.B., and F.I.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (J.B.M.), Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069602580","display_name":"Kazuhiro Shirozu","orcid":"https://orcid.org/0000-0003-2290-3764","observed_orcids":["https://orcid.org/0000-0003-2290-3764"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kazuhiro Shirozu","raw_affiliation_strings":["From the Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine (K.K., K.S., B.Y., K.D.B., and F.I.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (J.B.M.), Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine (K.K., K.S., B.Y., K.D.B., and F.I.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (J.B.M.), Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004313751","display_name":"Binglan Yu","orcid":"https://orcid.org/0000-0001-5496-2131","observed_orcids":["https://orcid.org/0000-0001-5496-2131"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Binglan Yu","raw_affiliation_strings":["From the Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine (K.K., K.S., B.Y., K.D.B., and F.I.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (J.B.M.), Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine (K.K., K.S., B.Y., K.D.B., and F.I.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (J.B.M.), Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077577798","display_name":"Joseph B. Mandeville","orcid":"https://orcid.org/0000-0002-4113-5396","observed_orcids":["https://orcid.org/0000-0002-4113-5396"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph B. Mandeville","raw_affiliation_strings":["From the Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine (K.K., K.S., B.Y., K.D.B., and F.I.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (J.B.M.), Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine (K.K., K.S., B.Y., K.D.B., and F.I.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (J.B.M.), Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109101301","display_name":"Kenneth D. Bloch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth D. Bloch","raw_affiliation_strings":["From the Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine (K.K., K.S., B.Y., K.D.B., and F.I.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (J.B.M.), Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine (K.K., K.S., B.Y., K.D.B., and F.I.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (J.B.M.), Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063212338","display_name":"Fumito Ichinose","orcid":"https://orcid.org/0000-0003-4535-1632","observed_orcids":["https://orcid.org/0000-0003-4535-1632"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fumito Ichinose","raw_affiliation_strings":["From the Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine (K.K., K.S., B.Y., K.D.B., and F.I.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (J.B.M.), Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine (K.K., K.S., B.Y., K.D.B., and F.I.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (J.B.M.), Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063212338"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055"],"apc_list":null,"apc_paid":null,"fwci":7.4655,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.97454467,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"120","issue":"4","first_page":"880","last_page":"889"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.878000020980835},{"id":"https://openalex.org/keywords/therapeutic-hypothermia","display_name":"therapeutic hypothermia","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cardiac-arrest","display_name":"cardiac arrest","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cardiopulmonary-resuscitation","display_name":"cardiopulmonary resuscitation","score":1.0},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-3","display_name":"nitric oxide synthase 3","score":0.9890000224113464},{"id":"https://openalex.org/keywords/inhaled-nitric-oxide","display_name":"inhaled nitric oxide","score":0.9089999794960022},{"id":"https://openalex.org/keywords/brain-injury","display_name":"brain injury","score":0.7760000228881836},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.9440000057220459},{"id":"https://openalex.org/keywords/survival-after-cardiac-arrest","display_name":"survival after cardiac arrest","score":0.6119999885559082},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.8809999823570251},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.5860000252723694},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6890000104904175},{"id":"https://openalex.org/keywords/cerebral-edema","display_name":"cerebral edema","score":0.4320000112056732},{"id":"https://openalex.org/keywords/cerebral-infarction","display_name":"cerebral infarction","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9631975889205933},{"id":"https://openalex.org/C2777055891","wikidata":"https://www.wikidata.org/wiki/Q185325","display_name":"Cardiopulmonary resuscitation","level":3,"score":0.8194460868835449},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7619640827178955},{"id":"https://openalex.org/C2777390192","wikidata":"https://www.wikidata.org/wiki/Q1036696","display_name":"Hypothermia","level":2,"score":0.7057796716690063},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.6263561248779297},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5452961325645447},{"id":"https://openalex.org/C172408975","wikidata":"https://www.wikidata.org/wiki/Q1989450","display_name":"Clinical death","level":4,"score":0.44012942910194397},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3988995850086212},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36253952980041504}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006323","descriptor_name":"Heart Arrest","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006323","descriptor_name":"Heart Arrest","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D007036","descriptor_name":"Hypothermia, Induced","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016887","descriptor_name":"Cardiopulmonary Resuscitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1097/aln.0000000000000149","doi":"https://doi.org/10.1097/aln.0000000000000149","is_oa":false,"landing_page_url":"https://doi.org/10.1097/aln.0000000000000149","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:24496125","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24496125","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3340810","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4346787","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4346787","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4346787","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Anesthesiology","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3340810","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4346787","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3141989531","display_name":"IMPACT OF HYDROGEN SULFIDE ON OUTCOME OF CARDIAC ARREST AND CARDIOPULMONARY RESUS","funder_award_id":"R01HL101930","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4183172709","display_name":null,"funder_award_id":"HL101930","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6390895466","display_name":null,"funder_award_id":"HL110378","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6839709970","display_name":"Improving Outcomes in Cardiac Arrest/CPR with Inhaled Nitric Oxide","funder_award_id":"R01HL110378","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1821665499","https://openalex.org/W1975941571","https://openalex.org/W1994379392","https://openalex.org/W2004019595","https://openalex.org/W2004160418","https://openalex.org/W2012154384","https://openalex.org/W2014114611","https://openalex.org/W2016928245","https://openalex.org/W2023169605","https://openalex.org/W2024051609","https://openalex.org/W2052048919","https://openalex.org/W2062642814","https://openalex.org/W2062743674","https://openalex.org/W2063092400","https://openalex.org/W2084343146","https://openalex.org/W2085091930","https://openalex.org/W2096257801","https://openalex.org/W2104869294","https://openalex.org/W2117676608","https://openalex.org/W2126997154","https://openalex.org/W2129289310","https://openalex.org/W2138917937","https://openalex.org/W2148703298","https://openalex.org/W2156663518","https://openalex.org/W2160281474","https://openalex.org/W2172074171","https://openalex.org/W2616215806","https://openalex.org/W3093949537","https://openalex.org/W4211191293"],"related_works":["https://openalex.org/W4395040868","https://openalex.org/W2275731155","https://openalex.org/W2806196165","https://openalex.org/W1017494063","https://openalex.org/W2014860730","https://openalex.org/W2172074171","https://openalex.org/W1986042915","https://openalex.org/W2085091930","https://openalex.org/W2048922599","https://openalex.org/W7098325295"],"abstract_inverted_index":{"BACKGROUND:":[0],"Therapeutic":[1],"hypothermia":[2,54,68,182,216],"(TH)":[3,117],"improves":[4,70,304],"neurological":[5],"outcomes":[6,71,305],"after":[7,32,55,72,121,158,183,206,280,306,314],"cardiac":[8],"arrest":[9],"(CA)":[10],"and":[11,24,82,98,146,302],"cardiopulmonary":[12],"resuscitation":[13],"(CPR).":[14],"Although":[15],"nitric":[16,28,46,65,86,130,191,225,258,296,325],"oxide":[17,29,47,66,87,131,192,226,259,297,309,326],"prevents":[18],"organ":[19],"injury":[20,145,267],"induced":[21],"by":[22],"ischemia":[23],"reperfusion,":[25],"role":[26],"of":[27,44,53,175,181,293],"during":[30,67,140,260,298],"TH":[31,261,270,299,318],"CPR":[33],"remains":[34,300],"unclear.":[35],"In":[36],"this":[37],"article,":[38],"the":[39,42,50,163,167,178,290],"authors":[40,58],"examined":[41,60],"impact":[43],"endogenous":[45,324],"synthesis":[48],"on":[49],"beneficial":[51,179,291,301],"effects":[52,180,292,313],"CA/CPR.":[56,159,307],"The":[57],"also":[59],"whether":[61],"or":[62,112,126,137,232],"not":[63],"inhaled":[64],"further":[69,303],"CA/CPR":[73,184,207,281,315],"in":[74,155,166,199,242],"mice":[75,81,83,157,202,211,245],"treated":[76,214],"with":[77,101,129,209,215,269],"TH.":[78,294],"METHODS:":[79],"Wild-type":[80],"deficient":[84],"for":[85,118,289],"synthase":[88],"3":[89],"(NOS3(\u2212/\u2212))":[90],"were":[91,213],"subjected":[92],"to":[93,114,172,188,322],"CA":[94],"at":[95,108,132,193,227],"37":[96,109],"\u00b0C":[97,110,116],"then":[99],"resuscitated":[100],"chest":[102],"compression.":[103],"Body":[104],"temperature":[105],"was":[106,153],"maintained":[107],"(normothermia)":[111],"reduced":[113],"33":[115],"24":[119],"h":[120],"resuscitation.":[122],"Mice":[123],"breathed":[124],"air":[125,127],"mixed":[128],"10,":[133],"20,":[134],"40,":[135],"60,":[136],"80":[138],"ppm":[139,195,237],"hypothermia.":[141],"To":[142],"evaluate":[143],"brain":[144,168,266],"cerebral":[147,277],"blood":[148,278],"flow,":[149],"magnetic":[150],"resonance":[151],"imaging":[152],"performed":[154],"wild-type":[156,244,255],"RESULTS:":[160],"Hypothermia":[161],"up-regulated":[162],"NOS3-dependent":[164],"signaling":[165],"(n":[169,185,203,218,229,234,246,262,272,282],"=":[170,186,204,219,230,235,247,263,273,283],"6":[171],"7).":[173],"Deficiency":[174],"NOS3":[176,286],"abolished":[177],"5":[187],"6).":[189,284],"Breathing":[190,224],"40":[194,228],"improved":[196,239],"survival":[197,240],"rate":[198],"hypothermia-treated":[200],"NOS3(\u2212/\u2212)":[201,210],"6)":[205],"compared":[208,268],"that":[212],"alone":[217,271],"6;":[220],"P":[221,250],"<":[222,251],"0.05).":[223],"9)":[231,236],"60":[233],"markedly":[238],"rates":[241],"TH-treated":[243,254],"51)":[248],"(both":[249],"0.05":[252],"vs.":[253],"mice).":[256],"Inhaled":[257,295],"7)":[264,274],"prevented":[265],"without":[275],"affecting":[276],"flow":[279],"CONCLUSIONS:":[285],"is":[287,319],"required":[288],"Nitric":[308],"breathing":[310],"exerts":[311],"protective":[312],"even":[316],"when":[317],"ineffective":[320],"due":[321],"impaired":[323],"production.":[327]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
